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Gene: Dmrt3 (doublesex and mab-3 related transcription factor 3) Rattus norvegicus

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Symbol:

Dmrt3

Name:

doublesex and mab-3 related transcription factor 3

RGD ID:

1306043

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in adult locomotory behavior; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be active in nucleus. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; azoxystrobin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC293976

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	232,670,642 - 232,690,557 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	232,675,059 - 232,688,833 (+)	Ensembl				GRCr8
mRatBN7.2	1	223,244,340 - 223,264,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	223,248,747 - 223,262,530 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	231,696,334 - 231,710,133 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	238,626,427 - 238,640,213 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	231,447,200 - 231,460,981 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	243,589,607 - 243,602,926 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	243,589,607 - 243,602,926 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	250,848,350 - 250,861,669 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	229,044,302 - 229,058,689 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	220,451,183 - 220,464,645 (+)	NCBI		Celera
RGSC_v3.1	1	229,206,114 - 229,222,715 (+)	NCBI
Cytogenetic Map	1	q51	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

primary ovarian insufficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

alpha-Zearalanol (EXP)

arsenite(3-) (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

chlorpyrifos (EXP)

Cuprizon (EXP)

dorsomorphin (ISO)

entinostat (ISO)

glyphosate (EXP)

imidacloprid (EXP)

methylmercury chloride (ISO)

paracetamol (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

thiabendazole (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult locomotory behavior (IBA)

adult walking behavior (ISO)

cell differentiation (IEA)

DNA-templated transcription (IEA)

male sex differentiation (ISO)

regulation of DNA-templated transcription (IEA)

regulation of odontogenesis of dentin-containing tooth (ISO)

regulation of transcription by RNA polymerase II (IBA)

sex differentiation (IBA,IEA)

transmission of nerve impulse (ISO)

ventral spinal cord interneuron specification (ISO)

Cellular Component

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

metal ion binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17605809	PMID:17803355	PMID:22932389	PMID:23056351

Genomics

Comparative Map Data

Dmrt3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	232,670,642 - 232,690,557 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	232,675,059 - 232,688,833 (+)	Ensembl				GRCr8
mRatBN7.2	1	223,244,340 - 223,264,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	223,248,747 - 223,262,530 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	231,696,334 - 231,710,133 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	238,626,427 - 238,640,213 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	231,447,200 - 231,460,981 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	243,589,607 - 243,602,926 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	243,589,607 - 243,602,926 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	250,848,350 - 250,861,669 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	229,044,302 - 229,058,689 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	220,451,183 - 220,464,645 (+)	NCBI		Celera
RGSC_v3.1	1	229,206,114 - 229,222,715 (+)	NCBI
Cytogenetic Map	1	q51	NCBI

DMRT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	976,655 - 991,732 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	976,373 - 991,746 (+)	Ensembl			hg38	GRCh38
GRCh37	9	976,655 - 991,732 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	966,964 - 981,732 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	966,963 - 981,732	NCBI
Celera	9	894,871 - 909,644 (+)	NCBI		Celera
Cytogenetic Map	9	p24.3	NCBI
HuRef	9	929,719 - 944,508 (+)	NCBI		HuRef
CHM1_1	9	977,145 - 991,912 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	977,925 - 992,996 (+)	NCBI		T2T-CHM13v2.0

Dmrt3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	25,587,609 - 25,601,285 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	25,587,665 - 25,601,285 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	25,610,246 - 25,623,921 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	25,610,301 - 25,623,921 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	25,685,027 - 25,698,411 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	25,677,634 - 25,691,016 (+)	NCBI		MGSCv36	mm8
Celera	19	26,405,156 - 26,418,520 (+)	NCBI		Celera
Cytogenetic Map	19	B	NCBI
cM Map	19	20.5	NCBI

Dmrt3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	5,455,449 - 5,470,343 (+)	Ensembl
ChiLan1.0	NW_004955434	5,455,449 - 5,470,343 (+)	NCBI	ChiLan1.0	ChiLan1.0

DMRT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	123,588,955 - 123,607,298 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	123,594,898 - 123,613,241 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	786,402 - 801,114 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	980,586 - 994,885 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

DMRT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	89,798,215 - 89,813,140 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	89,798,100 - 89,812,328 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	90,265,734 - 90,280,606 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	90,346,567 - 90,361,456 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	90,346,567 - 90,360,657 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	89,994,340 - 90,009,257 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	89,704,994 - 89,719,915 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	90,474,207 - 90,489,149 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dmrt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	137,236,171 - 137,250,587 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936503	3,922,417 - 3,936,493 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936503	3,922,417 - 3,936,493 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DMRT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	220,820,556 - 220,834,034 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	220,819,525 - 220,834,080 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DMRT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	78,528,709 - 78,543,509 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	78,529,443 - 78,543,419 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	66,909,248 - 66,924,674 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dmrt3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624736	5,648,318 - 5,661,584 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624736	5,648,318 - 5,662,301 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dmrt3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	25,712,501 - 25,725,417 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dmrt3
211 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	221
Count of miRNA genes:	152
Interacting mature miRNAs:	177
Transcripts:	ENSRNOT00000021792
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	243666627	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
5508828	Leukc3	Leukocyte quantity QTL 3			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	1	227535119	233480676	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	223964326	248681945	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	193964073	238964073	Rat
8693661	Alc34	Alcohol consumption QTL 34	2.2	0.611	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	238041033	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	194575422	239575422	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	193400541	238400541	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	160574007	235238518	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	221820316	234540296	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	192995199	237995199	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	197807365	233480676	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	193400541	238400541	Rat
634340	Hcar5	Hepatocarcinoma resistance QTL 5	8		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	223964326	236074012	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
8693618	Alc25	Alcohol consumption QTL 25	3	0.28	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	217412367	238041033	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	191260175	236260175	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
2325727	Pia41	Pristane induced arthritis QTL 41			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	188241285	233241285	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
2	1	4	82	12	26	3	6	3	2	32	13	2	79	14	63	23	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001437873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063287107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000021792 ⟹ ENSRNOP00000021792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	232,675,059 - 232,688,833 (+)	Ensembl
mRatBN7.2 Ensembl	1	223,248,747 - 223,262,530 (+)	Ensembl
Rnor_6.0 Ensembl	1	243,589,607 - 243,602,926 (+)	Ensembl

RefSeq Acc Id:

NM_001106358 ⟹ NP_001099828

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	232,675,059 - 232,688,833 (+)	NCBI
mRatBN7.2	1	223,248,747 - 223,262,530 (+)	NCBI
Rnor_6.0	1	243,589,607 - 243,602,926 (+)	NCBI
Rnor_5.0	1	250,848,350 - 250,861,669 (+)	NCBI
RGSC_v3.4	1	229,044,302 - 229,058,689 (+)	RGD
Celera	1	220,451,183 - 220,464,645 (+)	RGD

Sequence:

show sequence

GGCTCAGACCGTAATCAGAGCTCTCCTCGGCCCGGTGCAGCTGCCCTGAGAGCCTCGGCGTGGG
AGGACCAGCGGGTGGAGTTTGCTCCGGGGAGAGCGGCGAGCAGAGAGGCGGCGCGCGTGGGGAC
CCGCGGGCTGAGAGCACCATCGGAGCGGAGGAGACTGCAGCCGTACCTCCGGCTGCTGCCGACC
TTCCCGGGCCTCCGAGCTCCGCGCTCCAGCTCCCGCCGTCGACCAGGGGGAGCCCTGGGCATGA
ACGGCTACGGCTCCCCCTACCTGTACATGGGCGGCCCGGTGTCGCAGCCGCCGCGGGCGCCCTT
GCAGCGGACGCCCAAGTGCGCGCGCTGCCGGAACCACGGGGTGCTATCCTGGCTTAAGGGCCAC
AAGCGCTACTGTCGCTTCAAGGACTGCACCTGCGAGAAGTGCATCCTGATCATCGAGCGGCAGC
GGGTGATGGCGGCGCAGGTGGCGCTGCGGCGGCAGCAGGCCAACGAGAGCCTGGAGAGCCTCAT
CCCGGACTCGCTGCGGGCTCTGCCAGGGCCTCCGCCGCCGGGGGACGCCGCGGCCACCGCCGCC
ACCGCCTCGCAGTCGTCCCCAGCCTCCCAGGCGTCCCAGCCGCCGGCGCCGCCTCGTCCCGCCA
CCGAGTTGGCCGCGGCCGCTGCGCTGCGCTGGGTCGCCGAGCCCCAGCCCGGGACGCTGCCAGC
GCAGATTGCTAAGCCAGATTTGACTGAAGACCGACTTGGGGACAGCAGTTCAGCAGACAATGCT
GCGGAGTCCTTCAGTGACAAAGACACCGACCAGAGGAGCTCCCCAGATGTGGTCAAAAGCAAGA
ACTGCTTCACTCCGGAGAGCCCCGAGATCGTGTCCGTGGATGAAGGTGGGTACGCCGTGCAGAA
AAACGGGGGCAACCCGGAGAGCTGCCCTGACAGCCCCAAGTACCACGCTGAGCAGAGCCATCTC
CTGATCGAGGGCCCGTCAGGGACCGTCTCTCTGCCCTTCAGCTTGAAAGCCAACCGGCCACCCC
TGGAAGTGTTGAAGAAAATCTTTCCCAACCAGAAGCCCACTGTACTGGAGCTCATCCTGAAAGG
CTGCGGGGGCGACCTGGTCAGTGCCGTGGAGGTCCTGCTGTCCAGTCGGTCCTCCGCGGCTGGG
GCGGAGCGGACGGCCGAAGAGAGCCTGGTGCTGCCCTCCAGCGGCCATATCTTTGAACACACGC
TGGGCTCCTACCCTATCTCTTCCTCCAAGTGGTCCGTGGGCTCTGCCTTCCGAGTCCCTGACAC
CTTACGCTTTTCCGCGGACTCCAGCAACGTGGTCCCCAACCCCTTGGCCGTGCCCCTGCAACAT
CCTTTCCCCCAGCCACCCCGGTATCCGCTGATGCTGAGGAATACTTTGGCCAGAAACCAGTCGA
GCCCCTTTTTGCCCAATGACGTCACCCTGTGGAATACCATGACACTGCAGCAGCAGTACCAGCT
GAGGTCCCAGTATGTCAGTCCATTTCCCAGTAACTCCACTAGCGTCTTCCGGAGCTCGCCCGTG
CTCTCCTCTCGCACCACAGAAGACCCTCGGATCTCTATCCCCGACGATGGGTGTCCAATCGTGG
CAAAGCAGTCCATTTACACAGAGGATGACTATGATGAGAGGTCCGACTCCTCGGATTCTAGAAT
ACTCAACACGTCATCCTAAAGTGTACCTGTGGGTGGTGACTGGGTGACATTTTGTGTGTGCTGG
ACCTCTCCCCCCCGCCCCCGCCCCAGGGAGAGTCCACTAATACTGTATACTCTTTCTTCCTGTT
TGACAAAGTGACTGTGCTTGGTAGTCTTATACATTAGCAATAAAAACATAACTTATTTAATTTC
CTGCACTTCACTGGAAAATGCCAAATAGCTCTGCTCTGTGGATTTAGTGCTGAATGTTGTAAAT
GAGTTTAAAGCTGAGGACTGCCTGGGGAGGCCGGGCCAGTGGGGGATTTAATTGGGGGTGGGGG
TCAGCTTTACTCCTAAGTTCAACCTGGAATGTTCCGTGAAATAGTATACTTGAATGCCATTTTG
TAAAAGAGGATTCCTCAGGATACCGGAAACCTTAGGGAGTGGCTCTATTGCCAGCCGACAAAGA
GTAGGGACACTCATGTTACTCCCGTTCTAAAGAGAGACTGCACTCAGGCTAGCTCGGACGGCAC
AGGCTCATATTTAAGCTCGGACAGTTTTCAGAGACAAACTCCATTAAGAATCATTCTTTTCACG
TGGCCGAATCGAAACATGTGTAATGTCAGTATAAAGCCAACCCCAGCTGTGAACTGCATGAAAC
GTGTCGCCGCGGAAACGAACACAAGATTAAGCTTTGTCAGGTTAATGTAGCATGCTAAGTAAGG
ACTCTAGAAAAATAAACTAAGGACAT

hide sequence

RefSeq Acc Id:

XM_039108987 ⟹ XP_038964915

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	232,670,642 - 232,690,557 (+)	NCBI
mRatBN7.2	1	223,244,340 - 223,264,254 (+)	NCBI

RefSeq Acc Id:

XM_063287107 ⟹ XP_063143177

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	232,674,789 - 232,690,557 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099828	(Get FASTA)	NCBI Sequence Viewer
	NP_001424802	(Get FASTA)	NCBI Sequence Viewer
	XP_038964915	(Get FASTA)	NCBI Sequence Viewer
	XP_063143177	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D4A218	(Get FASTA)	NCBI Sequence Viewer
	EDM13051	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021792
	ENSRNOP00000021792.5

RefSeq Acc Id:

NP_001099828 ⟸ NM_001106358

- UniProtKB:

D4A218 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIER
QRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAAATAATASQSSPASQASQPPAPPRP
ATELAAAAALRWVAEPQPGTLPAQIAKPDLTEDRLGDSSSADNAAESFSDKDTDQRSSPDVVKS
KNCFTPESPEIVSVDEGGYAVQKNGGNPESCPDSPKYHAEQSHLLIEGPSGTVSLPFSLKANRP
PLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSAAGAERTAEESLVLPSSGHIFEH
TLGSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPNPLAVPLQHPFPQPPRYPLMLRNTLARNQ
SSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLSSRTTEDPRISIPDDGCPI
VAKQSIYTEDDYDERSDSSDSRILNTSS

hide sequence

Ensembl Acc Id:

ENSRNOP00000021792 ⟸ ENSRNOT00000021792

RefSeq Acc Id:	XP_038964915 ⟸ XM_039108987
- Peptide Label:	isoform X1
- UniProtKB:	D4A218 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063143177 ⟸ XM_063287107
- Peptide Label:	isoform X1

Protein Domains

DMA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A218-F1-model_v2	AlphaFold	D4A218	1-476	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690833

Promoter ID:

EPDNEW_R1358

Type:

single initiation site

Name:

Dmrt3_1

Description:

doublesex and mab-3 related transcription factor 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	243,589,697 - 243,589,757	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306043	AgrOrtholog
BioCyc Gene	G2FUF-56069	BioCyc
Ensembl Genes	ENSRNOG00000016284	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000021792	ENTREZGENE
	ENSRNOT00000021792.6	UniProtKB/Swiss-Prot
Gene3D-CATH	4.10.1040.10	UniProtKB/Swiss-Prot
InterPro	DM_DNA-bd	UniProtKB/Swiss-Prot
	DM_DNA-bd_sf	UniProtKB/Swiss-Prot
	DMA	UniProtKB/Swiss-Prot
	DMRT/dsx/mab-3	UniProtKB/Swiss-Prot
	UBA-like_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:293976	UniProtKB/Swiss-Prot
NCBI Gene	293976	ENTREZGENE
PANTHER	DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 3	UniProtKB/Swiss-Prot
	PTHR12322	UniProtKB/Swiss-Prot
Pfam	DMA	UniProtKB/Swiss-Prot
	PF00751	UniProtKB/Swiss-Prot
PhenoGen	Dmrt3	PhenoGen
PROSITE	DM_1	UniProtKB/Swiss-Prot
	DM_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016284	RatGTEx
SMART	SM00301	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46934	UniProtKB/Swiss-Prot
	SSF82927	UniProtKB/Swiss-Prot
UniProt	D4A218	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Dmrt3	doublesex and mab-3 related transcription factor 3	Dmrt3_predicted	doublesex and mab-3 related transcription factor 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Dmrt3_predicted	doublesex and mab-3 related transcription factor 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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