Klf16 (KLF transcription factor 16) - Rat Genome Database

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Gene: Klf16 (KLF transcription factor 16) Rattus norvegicus
Analyze
Symbol: Klf16
Name: KLF transcription factor 16
RGD ID: 1305966
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within G protein-coupled dopamine receptor signaling pathway. Predicted to be located in nucleus. Orthologous to human KLF16 (KLF transcription factor 16); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Krueppel-like factor 16; Kruppel-like factor 16; LOC366828; LOC690820; MGC187751; similar to Transcription factor BTEB4 (Basic transcription element binding-protein 4) (BTE-binding protein 4) (Krueppel-like factor 16) (Dopamine receptor-regulating factor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,789,185 - 9,799,004 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,775,042 - 9,798,999 (+)EnsemblGRCr8
mRatBN7.279,138,503 - 9,148,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,138,503 - 9,148,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,016,798 - 12,026,599 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,892,312 - 13,902,113 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,758,326 - 11,768,126 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,006,710 - 12,016,529 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,006,710 - 12,016,524 (+)Ensemblrn6Rnor6.0
Rnor_5.0712,174,235 - 12,184,054 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,638,982 - 10,658,693 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,320,617 - 7,330,425 (+)NCBICelera
RGSC_v3.1710,653,978 - 10,656,966 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11390978   PMID:12477932   PMID:38653384  


Genomics

Comparative Map Data
Klf16
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,789,185 - 9,799,004 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl79,775,042 - 9,798,999 (+)EnsemblGRCr8
mRatBN7.279,138,503 - 9,148,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,138,503 - 9,148,317 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx712,016,798 - 12,026,599 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,892,312 - 13,902,113 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,758,326 - 11,768,126 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,006,710 - 12,016,529 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,006,710 - 12,016,524 (+)Ensemblrn6Rnor6.0
Rnor_5.0712,174,235 - 12,184,054 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4710,638,982 - 10,658,693 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera77,320,617 - 7,330,425 (+)NCBICelera
RGSC_v3.1710,653,978 - 10,656,966 (+)NCBI
Cytogenetic Map7q11NCBI
KLF16
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,852,399 - 1,876,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,852,399 - 1,863,579 (-)Ensemblhg38GRCh38
GRCh37191,852,398 - 1,863,578 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,803,398 - 1,814,564 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34191,803,398 - 1,814,496NCBI
Celera191,786,480 - 1,797,646 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,624,071 - 1,636,584 (-)NCBIHuRef
CHM1_1191,852,027 - 1,863,203 (-)NCBICHM1_1
T2T-CHM13v2.0191,823,714 - 1,847,856 (-)NCBIT2T-CHM13v2.0
Klf16
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,402,955 - 80,413,130 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,402,958 - 80,413,155 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381080,567,121 - 80,577,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,567,124 - 80,577,321 (-)Ensemblmm10GRCm38
MGSCv371080,029,866 - 80,040,041 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361079,970,264 - 79,980,423 (-)NCBIMGSCv36mm8
Celera1081,584,920 - 81,595,095 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Klf16
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554956,178,565 - 6,189,469 (+)NCBIChiLan1.0ChiLan1.0
KLF16
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,223,021 - 6,234,313 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,453,986 - 5,465,287 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019850,840 - 862,130 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,832,876 - 1,858,726 (-)NCBIPanPan1.1PanPan1.1panPan2
KLF16
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,102,968 - 57,110,795 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,894,945 - 56,904,879 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02057,833,113 - 57,843,031 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,831,783 - 57,842,179 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,890,092 - 56,900,008 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,369,935 - 57,379,846 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,571,141 - 57,581,071 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,765,959 - 216,773,397 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365881,061,386 - 1,068,351 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF16
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,680,020 - 76,690,841 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1276,680,219 - 76,690,823 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,457,928 - 77,468,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF16
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,657,265 - 1,668,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,659,316 - 1,668,327 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660817,159,757 - 7,170,928 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf16
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248286,933,630 - 6,942,347 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248286,933,480 - 6,944,238 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf16
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11154,309,708 - 154,319,869 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf16
50 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:159
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000045421
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
D10Bwg1364e  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,130,515 - 9,130,708 (+)MAPPERmRatBN7.2
Rnor_6.0711,998,727 - 11,998,919NCBIRnor6.0
Rnor_5.0712,166,252 - 12,166,444UniSTSRnor5.0
RGSC_v3.4710,641,673 - 10,641,865UniSTSRGSC3.4
Celera77,312,561 - 7,312,753UniSTS
Cytogenetic Map7q11UniSTS
RH128456  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,130,518 - 9,130,734 (+)MAPPERmRatBN7.2
Rnor_6.0711,998,730 - 11,998,945NCBIRnor6.0
Rnor_5.0712,166,255 - 12,166,470UniSTSRnor5.0
RGSC_v3.4710,641,676 - 10,641,891UniSTSRGSC3.4
Celera77,312,564 - 7,312,779UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024576   ⟹   ENSRNOP00000024576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,775,042 - 9,798,095 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045421   ⟹   ENSRNOP00000051080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl79,789,185 - 9,798,999 (+)Ensembl
mRatBN7.2 Ensembl79,138,503 - 9,148,317 (+)Ensembl
Rnor_6.0 Ensembl712,006,710 - 12,016,524 (+)Ensembl
RefSeq Acc Id: NM_001127604   ⟹   NP_001121076
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,789,185 - 9,799,004 (+)NCBI
mRatBN7.279,138,503 - 9,148,322 (+)NCBI
Rnor_6.0712,006,710 - 12,016,529 (+)NCBI
Rnor_5.0712,174,235 - 12,184,054 (+)NCBI
RGSC_v3.4710,638,982 - 10,658,693 (+)RGD
Celera77,320,617 - 7,330,425 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001121076 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66458 (Get FASTA)   NCBI Sequence Viewer  
  EDL89265 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051080
  ENSRNOP00000051080.3
RefSeq Acc Id: NP_001121076   ⟸   NM_001127604
- UniProtKB: A0A9K3Y7C3 (UniProtKB/TrEMBL),   B2GUY9 (UniProtKB/TrEMBL),   F1LRP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051080   ⟸   ENSRNOT00000045421
Ensembl Acc Id: ENSRNOP00000024576   ⟸   ENSRNOT00000024576
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GUY9-F1-model_v2 AlphaFold B2GUY9 1-251 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695014
Promoter ID:EPDNEW_R5539
Type:multiple initiation site
Name:Klf16_1
Description:Kruppel-like factor 16
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0712,006,699 - 12,006,759EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305966 AgrOrtholog
BioCyc Gene G2FUF-34952 BioCyc
Ensembl Genes ENSRNOG00000033694 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045421 ENTREZGENE
  ENSRNOT00000045421.5 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9026732 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:690820 UniProtKB/TrEMBL
MGC_CLONE MGC:187751 IMAGE-MGC_LOAD
NCBI Gene Klf16 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 16 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf16 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033694 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A9K3Y7C3 ENTREZGENE, UniProtKB/TrEMBL
  B2GUY9 ENTREZGENE, UniProtKB/TrEMBL
  F1LRP4 ENTREZGENE
UniProt Secondary F1LRP4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf16  KLF transcription factor 16  Klf16  Kruppel-like factor 16  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-20 Klf16  Kruppel-like factor 16   LOC690820  similar to Transcription factor BTEB4 (Basic transcription element binding-protein 4) (BTE-binding protein 4) (Krueppel-like factor 16) (Dopamine receptor-regulating factor)  Data merged from RGD:1591012 737654 APPROVED
2008-04-30 Klf16  Kruppel-like factor 16   Klf16_predicted  Kruppel-like factor 16 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC690820  similar to Transcription factor BTEB4 (Basic transcription element binding-protein 4) (BTE-binding protein 4) (Krueppel-like factor 16) (Dopamine receptor-regulating factor)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Klf16_predicted  Kruppel-like factor 16 (predicted)      Symbol and Name status set to approved 70820 APPROVED