Gtpbp6 (GTP binding protein 6) - Rat Genome Database

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Gene: Gtpbp6 (GTP binding protein 6) Rattus norvegicus
Analyze
Symbol: Gtpbp6
Name: GTP binding protein 6 (Ensembl:GTP binding protein 6 (putative))
RGD ID: 1305954
Description: Predicted to enable ribosome binding activity. Predicted to be active in cytoplasm. Orthologous to human GTPBP6 (GTP binding protein 6 (putative)); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTP binding protein 6 (putative); LOC100912590; LOC363931; putative GTP-binding protein 6; putative GTP-binding protein 6-like; RGD1305954; similar to Pseudoautosomal GTP-binding protein-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,234,646 - 52,238,578 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,234,572 - 52,238,578 (+)EnsemblGRCr8
mRatBN7.21246,574,913 - 46,578,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,574,435 - 46,578,873 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1247,751,181 - 47,755,040 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,356,580 - 48,360,439 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,417,104 - 47,420,963 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,637,000 - 52,640,869 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,637,000 - 52,640,839 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1252,670,898 - 52,674,737 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,373,897 - 54,377,766 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41246,722,131 - 46,726,000 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1248,130,798 - 48,134,675 (+)NCBICelera
RGSC_v3.11246,589,062 - 46,592,902 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:34800366  


Genomics

Comparative Map Data
Gtpbp6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,234,646 - 52,238,578 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,234,572 - 52,238,578 (+)EnsemblGRCr8
mRatBN7.21246,574,913 - 46,578,873 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,574,435 - 46,578,873 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1247,751,181 - 47,755,040 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,356,580 - 48,360,439 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,417,104 - 47,420,963 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,637,000 - 52,640,869 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,637,000 - 52,640,839 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1252,670,898 - 52,674,737 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,373,897 - 54,377,766 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41246,722,131 - 46,726,000 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1248,130,798 - 48,134,675 (+)NCBICelera
RGSC_v3.11246,589,062 - 46,592,902 (+)NCBI
Cytogenetic Map12q16NCBI
GTPBP6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y304,759 - 318,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X304,759 - 318,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX303,346 - 318,846 (-)Ensemblhg38GRCh38
GRCh38.p14 EnsemblY303,346 - 318,846 (-)Ensemblhg38GRCh38
GRCh37Y171,426 - 180,887 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37X221,426 - 230,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X161,426 - 170,887 (-)NCBIBuild 36Build 36hg18NCBI36
Build 36Y161,426 - 170,887 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34Y161,425 - 170,887NCBI
CeleraX784,280 - 819,319 (+)NCBICelera
Cytogenetic MapX;YNCBI
CHM1_1X204,984 - 214,451 (-)NCBICHM1_1
T2T-CHM13v2.0Y132,137 - 148,937 (-)NCBIT2T-CHM13v2.0
T2T-CHM13v2.0X132,988 - 149,851 (-)NCBIT2T-CHM13v2.0
Gtpbp6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,251,842 - 110,256,063 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,251,841 - 110,256,063 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385110,103,976 - 110,108,331 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,103,975 - 110,108,197 (-)Ensemblmm10GRCm38
MGSCv375110,532,996 - 110,537,216 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365110,344,281 - 110,348,169 (-)NCBIMGSCv36mm8
Celera5107,230,450 - 107,234,671 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.3NCBI
Gtpbp6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955499585,712 - 591,991 (-)Ensembl
ChiLan1.0NW_004955499585,338 - 591,993 (-)NCBIChiLan1.0ChiLan1.0
LOC100969322
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X112,976 - 126,173 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1-v2Y46,857,149 - 46,871,958 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X116,640 - 129,818 (-)NCBINHGRI_mPanPan1
NHGRI_mPanPan1Y82,708 - 95,822 (-)NCBINHGRI_mPanPan1
GTPBP6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X324,576 - 349,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX324,244 - 337,221 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX66,158 - 88,002 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X33,104 - 54,892 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,842 - 55,210 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X35,607 - 47,655 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X45,792 - 59,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X36,770 - 58,387 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gtpbp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404953155,490 - 163,762 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366444,213,953 - 4,221,253 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110257936
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1Y6,985,633 - 6,999,844 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GTPBP6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605661,674 - 72,808 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gtpbp6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624834273,425 - 281,488 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624834272,883 - 281,443 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gtpbp6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11644,253,464 - 44,257,451 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:93
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000056632, ENSRNOT00000063905
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
RH134558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21246,578,686 - 46,578,868 (+)MAPPERmRatBN7.2
Rnor_6.01252,674,581 - 52,674,762NCBIRnor6.0
Rnor_6.01252,640,683 - 52,640,864NCBIRnor6.0
Rnor_5.01254,410,591 - 54,410,772UniSTSRnor5.0
Rnor_5.01254,377,580 - 54,377,761UniSTSRnor5.0
RGSC_v3.41246,725,814 - 46,725,995UniSTSRGSC3.4
Celera1248,134,489 - 48,134,670UniSTS
RH 3.4 Map12811.51UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 24 78 34 30 18 73 18 6 196 119 11 65 46 52 12 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056632   ⟹   ENSRNOP00000053471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1252,670,898 - 52,674,737 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000063905   ⟹   ENSRNOP00000059157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1252,637,000 - 52,640,839 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105776   ⟹   ENSRNOP00000080925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,234,572 - 52,238,578 (+)Ensembl
mRatBN7.2 Ensembl1246,574,435 - 46,578,873 (+)Ensembl
RefSeq Acc Id: NM_001135840   ⟹   NP_001129312
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,234,709 - 52,238,578 (+)NCBI
mRatBN7.21246,575,004 - 46,578,873 (+)NCBI
Rnor_6.01252,637,000 - 52,640,869 (+)NCBI
Rnor_5.01254,373,897 - 54,377,766 (+)NCBI
RGSC_v3.41246,722,131 - 46,726,000 (+)RGD
Celera1248,130,798 - 48,134,675 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089646   ⟹   XP_038945574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,234,646 - 52,236,657 (+)NCBI
mRatBN7.21246,574,913 - 46,576,978 (+)NCBI
RefSeq Acc Id: XM_039089647   ⟹   XP_038945575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,234,646 - 52,236,657 (+)NCBI
mRatBN7.21246,574,913 - 46,576,978 (+)NCBI
RefSeq Acc Id: XM_063271566   ⟹   XP_063127636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,234,646 - 52,237,383 (+)NCBI
RefSeq Acc Id: NP_001129312   ⟸   NM_001135840
- UniProtKB: A0A8I5ZU18 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059157   ⟸   ENSRNOT00000063905
RefSeq Acc Id: XP_038945575   ⟸   XM_039089647
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945574   ⟸   XM_039089646
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000053471   ⟸   ENSRNOT00000056632
Ensembl Acc Id: ENSRNOP00000080925   ⟸   ENSRNOT00000105776
RefSeq Acc Id: XP_063127636   ⟸   XM_063271566
- Peptide Label: isoform X3
Protein Domains
Hflx-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLF0-F1-model_v2 AlphaFold D3ZLF0 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305954 AgrOrtholog
BioCyc Gene G2FUF-18797 BioCyc
Ensembl Genes ENSRNOG00000037426 Ensembl
  ENSRNOG00000048168 Ensembl
  ENSRNOG00000062521 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000105776 ENTREZGENE
  ENSRNOT00000105776.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11060 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro G_HFLX_dom UniProtKB/TrEMBL
  GTP-bd UniProtKB/TrEMBL
  GTP-bd_M UniProtKB/TrEMBL
  GTPase_HflX UniProtKB/TrEMBL
  GTPase_HflX_N UniProtKB/TrEMBL
  GTPase_HflX_N_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 363931 ENTREZGENE
PANTHER GTP-BINDING PROTEIN 6-RELATED UniProtKB/TrEMBL
  PTHR10229 UniProtKB/TrEMBL
Pfam GTP-bdg_M UniProtKB/TrEMBL
  GTP-bdg_N UniProtKB/TrEMBL
  MMR_HSR1 UniProtKB/TrEMBL
PhenoGen Gtpbp6 PhenoGen
PROSITE G_HFLX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037426 RatGTEx
  ENSRNOG00000048168 RatGTEx
  ENSRNOG00000062521 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZU18 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Gtpbp6  GTP binding protein 6  Gtpbp6  GTP binding protein 6 (putative)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Gtpbp6  GTP binding protein 6 (putative)  LOC100912590  putative GTP-binding protein 6-like  Data merged from RGD:6486403 737654 PROVISIONAL
2012-07-05 LOC100912590  putative GTP-binding protein 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Gtpbp6  GTP binding protein 6 (putative)   Gtpbp6_predicted  GTP binding protein 6 (putative) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Gtpbp6_predicted  GTP binding protein 6 (putative) (predicted)  RGD1305954_predicted  similar to Pseudoautosomal GTP-binding protein-like protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305954_predicted  similar to Pseudoautosomal GTP-binding protein-like protein (predicted)  LOC363931_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC363931_predicted  similar to Pseudoautosomal GTP-binding protein-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL