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Gene: Adam23 (ADAM metallopeptidase domain 23) Rattus norvegicus

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Symbol:

Adam23

Name:

ADAM metallopeptidase domain 23

RGD ID:

1305739

Description:

Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADAM23 (ADAM metallopeptidase domain 23); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

a disintegrin and metallopeptidase domain 23; a disintegrin and metalloprotease domain 23; disintegrin and metalloproteinase domain-containing protein 23; LOC301460; MDC3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ADAM23 (ADAM metallopeptidase domain 23)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Adam23 (a disintegrin and metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Adam23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ADAM23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ADAM23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Adam23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ADAM23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ADAM23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Adam23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Adam23 (ADAM metallopeptidase domain 23)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DPP3 (dipeptidyl peptidase 3)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ADAM23 (ADAM metallopeptidase domain 23)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Adam23 (a disintegrin and metallopeptidase domain 23)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	adam23a (ADAM metallopeptidase domain 23a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mmd	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	unc-71	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	unc-71	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	adam23	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	adam23	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	72,356,479 - 72,503,545 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	72,356,479 - 72,503,545 (+)	Ensembl				GRCr8
mRatBN7.2	9	64,862,649 - 65,009,718 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	64,862,878 - 65,006,515 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	73,366,137 - 73,513,197 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	78,519,261 - 78,666,231 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	76,904,359 - 77,051,619 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	70,133,969 - 70,293,312 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	70,133,969 - 70,290,117 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	72,405,939 - 72,437,355 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	9	72,283,127 - 72,356,798 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	62,106,282 - 62,250,036 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	62,276,461 - 62,418,185 (+)	NCBI		Celera
RGSC_v3.1	9	62,253,263 - 62,397,018 (+)	NCBI
Cytogenetic Map	9	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

basal cell carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-methylenedioxymethamphetamine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

3-phenylprop-2-enal (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

aflatoxin M1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpyrifos (EXP,ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

fonofos (ISO)

furan (EXP)

glyphosate (EXP)

inulin (ISO)

lead(0) (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

Moniliformin (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pioglitazone (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

terbufos (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triclosan (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

proteolysis (IBA,IEA)

Cellular Component

glutamatergic synapse (IEA,ISO)

membrane (IEA)

plasma membrane (IEA)

presynaptic membrane (IBA,IEA,ISO)

Molecular Function

metalloendopeptidase activity (IBA,IEA)

metallopeptidase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Normalization and subtraction: two approaches to facilitate gene discovery.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.	Sagane K, etal., Gene 1999 Aug 5;236(1):79-86.

Additional References at PubMed

PMID:12477932	PMID:20133599	PMID:20439489	PMID:30598502

Genomics

Comparative Map Data

Adam23
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	72,356,479 - 72,503,545 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	72,356,479 - 72,503,545 (+)	Ensembl				GRCr8
mRatBN7.2	9	64,862,649 - 65,009,718 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	64,862,878 - 65,006,515 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	73,366,137 - 73,513,197 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	78,519,261 - 78,666,231 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	76,904,359 - 77,051,619 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	70,133,969 - 70,293,312 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	70,133,969 - 70,290,117 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	72,405,939 - 72,437,355 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	9	72,283,127 - 72,356,798 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	62,106,282 - 62,250,036 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	62,276,461 - 62,418,185 (+)	NCBI		Celera
RGSC_v3.1	9	62,253,263 - 62,397,018 (+)	NCBI
Cytogenetic Map	9	q32	NCBI

ADAM23
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	206,443,532 - 206,621,127 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	206,443,498 - 206,621,301 (+)	Ensembl			hg38	GRCh38
GRCh37	2	207,308,256 - 207,485,851 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	207,016,613 - 207,190,930 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	207,133,873 - 207,308,183	NCBI
Celera	2	201,069,803 - 201,244,105 (+)	NCBI		Celera
Cytogenetic Map	2	q33.3	NCBI
HuRef	2	199,158,213 - 199,335,374 (+)	NCBI		HuRef
CHM1_1	2	207,313,979 - 207,491,685 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	206,925,637 - 207,103,230 (+)	NCBI		T2T-CHM13v2.0

Adam23
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	63,484,880 - 63,635,263 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	63,485,050 - 63,635,435 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	63,445,717 - 63,596,111 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	63,445,891 - 63,596,276 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	63,492,478 - 63,643,089 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	63,380,180 - 63,530,791 (+)	NCBI		MGSCv36	mm8
Celera	1	63,968,074 - 64,119,559 (+)	NCBI		Celera
Cytogenetic Map	1	C2	NCBI
cM Map	1	32.31	NCBI

Adam23
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	8,361,908 - 8,518,281 (-)	Ensembl
ChiLan1.0	NW_004955457	8,362,639 - 8,518,281 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADAM23
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	109,052,185 - 109,229,555 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	109,066,822 - 109,244,454 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	93,677,971 - 93,855,647 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	211,806,877 - 211,983,896 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	211,806,871 - 211,980,399 (+)	Ensembl			panPan2	panpan1.1

ADAM23
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	14,997,150 - 15,164,341 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	14,996,854 - 15,161,008 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	15,854,239 - 16,041,791 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	14,913,443 - 15,100,933 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	14,933,217 - 15,098,305 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	14,864,838 - 15,052,024 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	14,838,455 - 15,025,624 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	14,835,710 - 15,023,250 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adam23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	163,142,518 - 163,311,113 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936631	2,778,849 - 2,946,187 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936631	2,777,595 - 2,946,191 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM23
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	109,695,282 - 109,886,148 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	109,695,250 - 109,886,154 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	121,305,485 - 121,465,206 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM23
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	92,218,999 - 92,390,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	92,219,253 - 92,391,091 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	106,990,067 - 107,162,304 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adam23
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624765	9,399,179 - 9,633,164 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624765	9,398,446 - 9,633,459 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Adam23
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	137,400,873 - 137,546,080 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Adam23
1076 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	34
Count of miRNA genes:	32
Interacting mature miRNAs:	32
Transcripts:	ENSRNOT00000040525
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	29567664	74567664	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1598849	Memor17	Memory QTL 17	2.2		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	57460497	78547958	Rat
1578659	Tspe1	Trichinella spiralis expulsion QTL 1	4.8		parasite quantity (VT:0010441)	logarithm of the intestinal adult Trichinella spiralis count (CMO:0002024)	9	68875497	73185088	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat

Markers in Region

D9Uia2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	72,363,997 - 72,364,182 (+)	Marker Load Pipeline
mRatBN7.2	9	64,870,167 - 64,870,352 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	70,141,259 - 70,141,443	NCBI	Rnor6.0
Rnor_5.0	9	72,429,881 - 72,430,065	UniSTS	Rnor5.0
RGSC_v3.4	9	62,113,571 - 62,113,756	RGD	RGSC3.4
RGSC_v3.4	9	62,113,572 - 62,113,756	UniSTS	RGSC3.4
Celera	9	62,283,750 - 62,283,934	UniSTS
RGSC_v3.1	9	62,260,553 - 62,260,738	RGD
Cytogenetic Map	9	q32	UniSTS

BF406113

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	64,997,543 - 64,997,746 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	70,281,151 - 70,281,353	NCBI	Rnor6.0
Rnor_5.0	9	72,291,891 - 72,292,093	UniSTS	Rnor5.0
RGSC_v3.4	9	62,241,070 - 62,241,272	UniSTS	RGSC3.4
Celera	9	62,409,240 - 62,409,442	UniSTS
RH 3.4 Map	9	536.1	UniSTS
Cytogenetic Map	9	q32	UniSTS

RH143531

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	65,006,343 - 65,006,505 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	70,289,946 - 70,290,107	NCBI	Rnor6.0
Rnor_5.0	9	72,283,137 - 72,283,298	UniSTS	Rnor5.0
RGSC_v3.4	9	62,249,865 - 62,250,026	UniSTS	RGSC3.4
Celera	9	62,418,014 - 62,418,175	UniSTS
RH 3.4 Map	9	536.1	UniSTS
Cytogenetic Map	9	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	159	91	90	59	72	59	6	335	172	11	138	80	92	31	14	14

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001029899	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001393708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008767090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF543743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473965	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040525 ⟹ ENSRNOP00000042857

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	72,356,479 - 72,503,545 (+)	Ensembl
mRatBN7.2 Ensembl	9	64,862,878 - 65,006,515 (+)	Ensembl
Rnor_6.0 Ensembl	9	70,133,969 - 70,290,117 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108943 ⟹ ENSRNOP00000094669

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	72,356,479 - 72,501,125 (+)	Ensembl
mRatBN7.2 Ensembl	9	64,862,878 - 65,006,434 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116238 ⟹ ENSRNOP00000088302

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	72,356,479 - 72,501,125 (+)	Ensembl
mRatBN7.2 Ensembl	9	64,862,878 - 65,006,434 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000161342 ⟹ ENSRNOP00000106999

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	72,356,479 - 72,503,545 (+)	Ensembl

RefSeq Acc Id:

NM_001029899 ⟹ NP_001025070

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	72,356,479 - 72,503,545 (+)	NCBI
mRatBN7.2	9	64,862,649 - 65,009,718 (+)	NCBI
Rnor_6.0	9	70,133,969 - 70,290,117 (+)	NCBI
Rnor_5.0	9	72,283,127 - 72,356,798 (-)	NCBI
Rnor_5.0	9	72,405,939 - 72,437,355 (-)	NCBI
RGSC_v3.4	9	62,106,282 - 62,250,036 (+)	RGD
Celera	9	62,276,461 - 62,418,185 (+)	RGD

Sequence:

show sequence

GGCTCCGCCCGCAGCCGCCCCGCAGCCCAGCCCGGCGCTCTCGCGGGTCACTCGGACCGGCGCC
CGGGAGCGATGAGCCATGAAGCCGCCCGGCAGCAGCTCCCGGCGGCCGCCCCTGACGGGCTGCA
GCCTGCCCGGCGCCTCCCGCGGCCCCGGCCGCTGCCCCGCCGGCCCGGTGCCGGCCCGCGCGCC
GCCCTGCCGCCTGCTCCTCGTCCTTCTCCTGCTGCCTGCGCTCGCCGCCTCGTCCCGGCCCCGT
GCCCGGGGGGCCGCTGCGCTCAGCGCTCTGCATTGGAATGAAACTGCAGAAAACAGCCCGGGAG
TTGTGGCAGATGAAGACAGCACATTGCAACAGAATGGCAGCAGAAATACCAGCTACAGCAGTGC
AGTGCAGAAAGAAATCACACTGCCCTCAAGACTGGTGTATTACATCAACCAGGACTCAGAAAGC
CCTTATCATGTTCTTGACACAAAGGCCAGACACCAACAGAAACACAATAAGGCTGTCCATCTGG
CCCAGGCAAGCTTCCAGATCGAAGCCTTTGGCTCCAAGTTCATTCTTGACCTCATACTGAACAA
TGGTTTACTATCTTCGGACTACGTGGAGATCCACTATGAGGACGGGAAGCAGATGTACTCTAAG
GGCGGAGAGCACTGCTACTACCATGGGAGCATCAGAGGTGTCAAGGACTCCAGGGTGGCTCTGT
CGACCTGCAATGGACTCCATGGCATGTTTGAGGATGACACTTTCGTGTATATGATAGAGCCTCT
GGAGCTGACTCATGATGAGAAAAGCACTGGCCGACCACACATAATCCAGAAAACCTTGGCAGGA
CAATATTCTAAGCAGATGAAGAATCTCAGCACAGATGGCAGTGACCAGTGGCCTTTGCTACCTG
AATTACAGTGGCTGAGAAGAAGGAAAAGAGCAGTTAATCCATCGCGAGGTGTGTTTGAAGAAAT
GAAGTATTTGGAGCTTATGATTGTTAACGATCACAAGACGTATAAGAAGCACCGCTCTTCTCAC
GCGCATACGAACAACTTCGCAAAGTCTGTGGTCAACCTTGTAGATTCTATTTACAAGGAACAGC
TCAACACCAGGGTTGTCCTGGTGGCTGTAGAGACCTGGACCGAGAAGGATCAAATTGACATCAC
CATCAACCCCGTGCAGATGCTTCATGAGTTCTCCAAGTACCGGCAACGTATCAAACAGCATGCA
GACGCGGTCCACCTTATCTCGCGTGTGACATTCCATTATAAGAGAAGCAGTCTGAGTTACTTCG
GAGGTGTGTGTTCCCGCGTAAAAGGGGTTGGTGTGAATGAGTACGGTCTTCCAATGGCAGTGGC
ACAAGTGTTATCGCAGAGCCTGGCTCAAAACCTTGGAATCCAGTGGGAACCTTCGAGCAGGAAG
CCAAAATGTGAATGCATAGAGTCCTGGGGCGGCTGCATCATGGAAGAAACAGGGGTGTCCCACT
CTCGAAAGTTCTCAAAGTGCAGCATTTTGGAGTACAGAGACTTTTTACAGAGAGGAGGCGGAGC
GTGTCTTTTCAATAGGCCGACTAAGCTGTTTGAGCCCACGGAATGTGGAAACGGATATGTGGAA
GCCGGGGAGGAATGCGATTGTGGTTTCCATGTGGAATGCTACGGAGTTTGCTGTAAGAAATGCT
CTCTCTCCAACGGGGCCCACTGCAGTGACGGCCCCTGTTGTAACAACACCTCGTGTCTTTTTCA
GTCACGAGGGTACGAATGTCGGGATGCCGTGAACAGCTGTGATATAACGGAGTACTGCACCGGA
GACTCTGGCCAGTGCCCGCCGAATCTGCATAAACAAGATGGCTACGCCTGCAATCAAAATCAGG
GTCGCTGCTACAATGGCGAGTGCAAGACAAGGGACAACCAATGCCAGTACATCTGGGGGACAAA
GGCTTCGGGGTCAGACAAGTTCTGCTATGAAAAGCTGAACACAGAAGGCACCGAGAAGGGCAAT
TGTGGCAAGGATGGAGACCGGTGGATTCAGTGCAGCAAACATGATGTGTTCTGTGGATTTCTGC
TTTGCACCAATCTTACCCGAGCTCCGCGTATTGGTCAACTTCAAGGAGAGATCATCCCGACTTC
CTTCTACCATCAAGGCCGAGTTATTGACTGCAGTGGTGCTCACGTAGTTTTAGACGATGATACA
GATGTGGGCTATGTAGAAGATGGGACTCCATGTGGCCCCTCCATGATGTGCTTAGATCGGAAGT
GCCTACAGATTCAAGCCCTAAATATGAGCAGCTGCCCACTTGACTCCAAGGGTAAAGTCTGCTC
AGGCCATGGGGTGTGTAGCAACGAAGCCACCTGCATCTGTGACTTCACTTGGGCAGGCACAGAC
TGCAGCATCCGGGATCCAGTTCGGAACCCCAACCCCCCAAAGGATGAAGGACCTAAGGTGAACA
TGGCCACAAGCAGGCTCATAGGGGCCGTGGCTGGCACCGTTCTGGCCCTGGGGGTGATTTTTGG
AGGCACAGGGTGGGGCATAGAAAACGTCAAGAAGAGGAGATTCGATCCCACTCAGCAAGGCCCC
ATCTGAATCAGCTGCACTGGAGGAGTGCCACCTTGCACTGTGGGGTTCTGGCAATGACATGCTT
TCCACCATGCTGCTGGAACTCTTAAGTCTGTAAACAAGACCATTGGGTGGTAATGACTACAGAG
CTCAAATCTGAGGACGGGGATGGGGTACAACACAACAGTCCCTTTTGGAAATAACTTCAAGTAA
CCCCCTCTATCACCTGTCAATAAAGGGGAGGGGTTAAAGACCACGTCATTATAAAAAAACTGTT
CAGAATCCTTTATTTTTCTTTCTTTTTAACTAAAGGAGAAGGGAGCAGCAACAAGTGCAA

hide sequence

RefSeq Acc Id:

NM_001393708 ⟹ NP_001380637

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	72,356,479 - 72,503,545 (+)	NCBI
mRatBN7.2	9	64,862,649 - 65,009,718 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001025070	(Get FASTA)	NCBI Sequence Viewer
	NP_001380637	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL98893	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000042857
	ENSRNOP00000042857.4
	ENSRNOP00000088302.2
	ENSRNOP00000094669.2
	ENSRNOP00000106999
	ENSRNOP00000106999.1

RefSeq Acc Id:	NP_001025070 ⟸ NM_001029899
- Peptide Label:	isoform 1
- UniProtKB:	D3ZT36 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKPPGSSSRRPPLTGCSLPGASRGPGRCPAGPVPARAPPCRLLLVLLLLPALAASSRPRARGAA ALSALHWNETAENSPGVVADEDSTLQQNGSRNTSYSSAVQKEITLPSRLVYYINQDSESPYHVL DTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYEDGKQMYSKGGEHC YYHGSIRGVKDSRVALSTCNGLHGMFEDDTFVYMIEPLELTHDEKSTGRPHIIQKTLAGQYSKQ MKNLSTDGSDQWPLLPELQWLRRRKRAVNPSRGVFEEMKYLELMIVNDHKTYKKHRSSHAHTNN FAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKDQIDITINPVQMLHEFSKYRQRIKQHADAVHL ISRVTFHYKRSSLSYFGGVCSRVKGVGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSRKPKCEC IESWGGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFEPTECGNGYVEAGEEC DCGFHVECYGVCCKKCSLSNGAHCSDGPCCNNTSCLFQSRGYECRDAVNSCDITEYCTGDSGQC PPNLHKQDGYACNQNQGRCYNGECKTRDNQCQYIWGTKASGSDKFCYEKLNTEGTEKGNCGKDG DRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHQGRVIDCSGAHVVLDDDTDVGYV EDGTPCGPSMMCLDRKCLQIQALNMSSCPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRD PVRNPNPPKDEGPKVNMATSRLIGAVAGTVLALGVIFGGTGWGIENVKKRRFDPTQQGPI hide sequence

Ensembl Acc Id:

ENSRNOP00000042857 ⟸ ENSRNOT00000040525

Ensembl Acc Id:

ENSRNOP00000088302 ⟸ ENSRNOT00000116238

Ensembl Acc Id:

ENSRNOP00000094669 ⟸ ENSRNOT00000108943

RefSeq Acc Id:	NP_001380637 ⟸ NM_001393708
- Peptide Label:	isoform 2
- UniProtKB:	A0A8I6AMQ9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000106999 ⟸ ENSRNOT00000161342

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZT36-F1-model_v2	AlphaFold	D3ZT36	1-828	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696712

Promoter ID:

EPDNEW_R7237

Type:

single initiation site

Name:

Adam23_1

Description:

ADAM metallopeptidase domain 23

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	70,134,063 - 70,134,123	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305739	AgrOrtholog
BioCyc Gene	G2FUF-27342	BioCyc
Ensembl Genes	ENSRNOG00000012424	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000040525	ENTREZGENE
	ENSRNOT00000040525.4	UniProtKB/TrEMBL
	ENSRNOT00000108943.2	UniProtKB/TrEMBL
	ENSRNOT00000116238.2	UniProtKB/TrEMBL
	ENSRNOT00000161342	ENTREZGENE
	ENSRNOT00000161342.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.390.10	UniProtKB/TrEMBL
	4.10.70.10	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ADAM_Cys-rich	UniProtKB/TrEMBL
	Blood-coag_inhib_Disintegrin	UniProtKB/TrEMBL
	Disintegrin_dom_sf	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_extracell	UniProtKB/TrEMBL
	MetalloPept_cat_dom	UniProtKB/TrEMBL
	Peptidase_M12B	UniProtKB/TrEMBL
	Peptidase_M12B_N	UniProtKB/TrEMBL
	Reprolysin_adamalysin	UniProtKB/TrEMBL
NCBI Gene	301460	ENTREZGENE
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/TrEMBL
	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23	UniProtKB/TrEMBL
Pfam	ADAM_CR	UniProtKB/TrEMBL
	Disintegrin	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	Pep_M12B_propep	UniProtKB/TrEMBL
	Reprolysin	UniProtKB/TrEMBL
PhenoGen	Adam23	PhenoGen
PROSITE	ADAM_MEPRO	UniProtKB/TrEMBL
	DISINTEGRIN_2	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012424	RatGTEx
SMART	ACR	UniProtKB/TrEMBL
	DISIN	UniProtKB/TrEMBL
Superfamily-SCOP	Disintegrin	UniProtKB/TrEMBL
	Metalloproteases ('zincins'), catalytic domain	UniProtKB/TrEMBL
UniProt	A0A8I6A4T9_RAT	UniProtKB/TrEMBL
	A0A8I6AMQ9	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LPK9_RAT	UniProtKB/TrEMBL
	D3ZT36	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Adam23	ADAM metallopeptidase domain 23	Adam23	a disintegrin and metallopeptidase domain 23	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-28	Adam23	a disintegrin and metallopeptidase domain 23	Adam23	a disintegrin and metallopeptidase domain 23 (predicted)	'predicted' is removed from gene name	2292626	APPROVED
2007-04-10	Adam23		Adam23_predicted	a disintegrin and metallopeptidase domain 23 (predicted)	Symbol updated	737654	APPROVED
2007-04-10	Adam23_predicted	a disintegrin and metallopeptidase domain 23 (predicted)	Adam23	a disintegrin and metalloprotease domain 23	Data merged from RGD:620415	737654	APPROVED
2006-03-30	Adam23_predicted	a disintegrin and metallopeptidase domain 23 (predicted)		a disintegrin and metalloprotease domain 23 (predicted)	Name updated	1299863	APPROVED
2005-01-12	Adam23_predicted	a disintegrin and metalloprotease domain 23 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	Adam23	a disintegrin and metalloprotease domain 23			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD