Gene: Spock3 (SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3) Rattus norvegicus
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Symbol:
Spock3
Name:
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3
RGD ID:
1305672
Description:
Predicted to enable several functions, including calcium ion binding activity; collagen binding activity; and metalloendopeptidase inhibitor activity. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Orthologous to human SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC306404; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3; sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3; testican-3
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Spock3 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1)
HGNC
OrthoDB
Homo sapiens (human):
BARHL2 (BarH like homeobox 2)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Spock3 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
spock3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Cow
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|SonicParanoid)
Caenorhabditis elegans (roundworm):
test-1
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|SonicParanoid)
Caenorhabditis elegans (roundworm):
test-1
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
spock3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
spock3
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 16 31,149,698 - 31,582,280 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 16 31,149,702 - 31,582,398 (-) Ensembl GRCr8 mRatBN7.2 16 26,382,895 - 26,815,943 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 16 26,383,383 - 26,815,205 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 16 29,739,811 - 30,166,034 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 16 33,174,030 - 33,600,260 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 16 29,125,663 - 29,558,060 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 16 28,372,067 - 28,716,762 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 16 28,372,411 - 28,716,885 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 16 28,243,878 - 28,508,371 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 Rnor_5.0 16 28,585,376 - 28,585,974 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 16 29,337,211 - 29,751,950 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 16 26,444,211 - 26,865,494 (-) NCBI Celera RGSC_v3.1 16 29,338,682 - 29,751,934 (-) NCBI Cytogenetic Map 16 p13 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Spock3 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 1,2-dichloroethane decreases expression ISO Spock3 (Mus musculus) 6480464 ethylene dichloride results in decreased expression of SPOCK3 mRNA CTD PMID:28960355 Spock3 Rat 17beta-estradiol increases expression ISO SPOCK3 (Homo sapiens) 6480464 Estradiol results in increased expression of SPOCK3 mRNA CTD PMID:19429434 Spock3 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO SPOCK3 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPOCK3 mRNA CTD PMID:21296121 Spock3 Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPOCK3 mRNA CTD PMID:32109520 Spock3 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Spock3 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPOCK3 mRNA CTD PMID:21570461|PMID:24680724 Spock3 Rat 2,3,7,8-Tetrachlorodibenzofuran decreases expression EXP 6480464 2,3,7,8-tetrachlorodibenzofuran results in decreased expression of SPOCK3 mRNA CTD PMID:32109520 Spock3 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Spock3 (Mus musculus) 6480464 2,2',4,4',5-brominated diphenyl ether affects the expression of SPOCK3 mRNA CTD PMID:38648751 Spock3 Rat 3-Nitrobenzanthrone decreases expression ISO SPOCK3 (Homo sapiens) 6480464 3-nitrobenzanthrone results in decreased expression of SPOCK3 mRNA CTD PMID:34036453 Spock3 Rat 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of SPOCK3 mRNA CTD PMID:24780913 Spock3 Rat acetohydrazide decreases expression ISO Spock3 (Mus musculus) 6480464 acetylhydrazine results in decreased expression of SPOCK3 mRNA CTD PMID:15282401 Spock3 Rat aflatoxin B1 decreases expression ISO SPOCK3 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of SPOCK3 mRNA CTD PMID:22100608|PMID:32234424|PMID:35690182 Spock3 Rat all-trans-retinoic acid increases expression ISO SPOCK3 (Homo sapiens) 6480464 Tretinoin results in increased expression of SPOCK3 mRNA CTD PMID:21934132 Spock3 Rat antirheumatic drug increases expression ISO SPOCK3 (Homo sapiens) 6480464 Antirheumatic Agents results in increased expression of SPOCK3 mRNA CTD PMID:24449571 Spock3 Rat aristolochic acid A decreases expression ISO SPOCK3 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of SPOCK3 mRNA CTD PMID:33212167 Spock3 Rat benzo[a]pyrene multiple interactions ISO Spock3 (Mus musculus) 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to SPOCK3 promoter] CTD PMID:19654925 Spock3 Rat benzo[a]pyrene decreases expression ISO SPOCK3 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat benzo[a]pyrene increases methylation ISO SPOCK3 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SPOCK3 promoter CTD PMID:27901495 Spock3 Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SPOCK3 more ... CTD PMID:23359474 Spock3 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SPOCK3 more ... CTD PMID:23359474 Spock3 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPOCK3 mRNA CTD PMID:25181051|PMID:34947998|PMID:41034487 Spock3 Rat Butylbenzyl phthalate increases methylation ISO Spock3 (Mus musculus) 6480464 butylbenzyl phthalate results in increased methylation of SPOCK3 intron CTD PMID:28392331 Spock3 Rat cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of SPOCK3 promoter CTD PMID:22457795 Spock3 Rat CGP 52608 multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to SPOCK3 gene] CTD PMID:28238834 Spock3 Rat chlordecone increases expression ISO Spock3 (Mus musculus) 6480464 Chlordecone results in increased expression of SPOCK3 mRNA CTD PMID:33711761 Spock3 Rat copper(II) sulfate increases expression ISO SPOCK3 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of SPOCK3 mRNA CTD PMID:19549813 Spock3 Rat dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of SPOCK3 more ... CTD PMID:23359474 Spock3 Rat dioxygen increases expression ISO Spock3 (Mus musculus) 6480464 Oxygen deficiency results in increased expression of SPOCK3 mRNA CTD PMID:24205000 Spock3 Rat dorsomorphin multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Spock3 Rat ethanol affects splicing ISO Spock3 (Mus musculus) 6480464 Ethanol affects the splicing of SPOCK3 mRNA CTD PMID:30319688 Spock3 Rat ethylparaben increases expression ISO SPOCK3 (Homo sapiens) 6480464 ethyl-p-hydroxybenzoate results in increased expression of SPOCK3 mRNA CTD PMID:37690743 Spock3 Rat fenamidone decreases expression ISO Spock3 (Mus musculus) 6480464 fenamidone results in decreased expression of SPOCK3 mRNA CTD PMID:27029645 Spock3 Rat folic acid decreases expression ISO Spock3 (Mus musculus) 6480464 Folic Acid results in decreased expression of SPOCK3 mRNA CTD PMID:25629700 Spock3 Rat folic acid increases expression ISO SPOCK3 (Homo sapiens) 6480464 Folic Acid results in increased expression of SPOCK3 mRNA CTD PMID:21867686 Spock3 Rat fulvestrant decreases methylation ISO SPOCK3 (Homo sapiens) 6480464 Fulvestrant results in decreased methylation of SPOCK3 gene CTD PMID:31601247 Spock3 Rat Lasiocarpine decreases expression ISO SPOCK3 (Homo sapiens) 6480464 lasiocarpine results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat N-methyl-4-phenylpyridinium decreases expression ISO SPOCK3 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPOCK3 mRNA CTD PMID:24810058 Spock3 Rat N-Nitrosopyrrolidine decreases expression ISO SPOCK3 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat O-methyleugenol decreases expression ISO SPOCK3 (Homo sapiens) 6480464 methyleugenol results in decreased expression of SPOCK3 mRNA CTD PMID:32234424|PMID:35690182 Spock3 Rat okadaic acid decreases expression ISO SPOCK3 (Homo sapiens) 6480464 Okadaic Acid results in decreased expression of SPOCK3 mRNA CTD PMID:38832940 Spock3 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SPOCK3 mRNA CTD PMID:33387578 Spock3 Rat paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of SPOCK3 mRNA CTD PMID:32680482 Spock3 Rat PCB138 multiple interactions ISO Spock3 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Spock3 Rat phenylmercury acetate increases expression ISO SPOCK3 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of SPOCK3 mRNA CTD PMID:26272509 Spock3 Rat phenylmercury acetate multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Spock3 Rat raloxifene increases expression ISO SPOCK3 (Homo sapiens) 6480464 Raloxifene Hydrochloride results in increased expression of SPOCK3 mRNA CTD PMID:19429434 Spock3 Rat SB 431542 multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386 Spock3 Rat sodium arsenate increases expression ISO Spock3 (Mus musculus) 6480464 sodium arsenate results in increased expression of SPOCK3 mRNA CTD PMID:21795629 Spock3 Rat sodium arsenite affects methylation ISO SPOCK3 (Homo sapiens) 6480464 sodium arsenite affects the methylation of SPOCK3 gene CTD PMID:28589171 Spock3 Rat titanium dioxide decreases expression ISO Spock3 (Mus musculus) 6480464 titanium dioxide results in decreased expression of SPOCK3 mRNA CTD PMID:29264374 Spock3 Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of SPOCK3 mRNA CTD PMID:33387578 Spock3 Rat trichostatin A increases expression ISO SPOCK3 (Homo sapiens) 6480464 trichostatin A results in increased expression of SPOCK3 mRNA CTD PMID:24935251|PMID:27188386 Spock3 Rat valproic acid affects expression ISO SPOCK3 (Homo sapiens) 6480464 Valproic Acid affects the expression of SPOCK3 mRNA CTD PMID:25979313 Spock3 Rat valproic acid decreases expression ISO Spock3 (Mus musculus) 6480464 Valproic Acid results in decreased expression of SPOCK3 mRNA CTD PMID:24896083 Spock3 Rat valproic acid increases expression ISO SPOCK3 (Homo sapiens) 6480464 Valproic Acid results in increased expression of SPOCK3 mRNA CTD PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 Spock3 Rat valproic acid multiple interactions ISO SPOCK3 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... CTD PMID:27188386