Chit1 (chitinase 1) - Rat Genome Database

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Gene: Chit1 (chitinase 1) Rattus norvegicus
Analyze
Symbol: Chit1
Name: chitinase 1
RGD ID: 1305646
Description: Predicted to enable endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human CHIT1 (chitinase 1); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chitinase 1 (chitotriosidase); chitotriosidase variant 1; chitotriosidase variant 2; chitotriosidase variant 3; chitotriosidase variant 4; chitotriosidase variant 5; chitotriosidase-1; LOC289032
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp395
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,117,886 - 48,165,645 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1348,145,893 - 48,165,639 (+)EnsemblGRCr8
mRatBN7.21345,565,841 - 45,613,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,593,845 - 45,613,592 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1348,174,113 - 48,221,708 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,462,167 - 49,509,762 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,726,964 - 46,774,804 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1347,497,410 - 47,545,005 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1347,728,999 - 47,776,593 (+)NCBILyon_Normotensive
Lyon_Hypertensive1347,695,105 - 47,742,700 (+)NCBILyon_Hypertensive
F344_StmMcwi1347,651,506 - 47,699,258 (+)NCBIF344_StmMcwi
Rnor_6.01350,947,020 - 50,994,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,974,872 - 50,994,643 (+)Ensemblrn6Rnor6.0
Rnor_5.01356,000,134 - 56,046,972 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41347,095,240 - 47,109,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1345,894,357 - 45,941,716 (+)NCBICelera
RGSC_v3.11347,059,518 - 47,123,204 (+)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Serum chitotriosidase levels in patients with allergic and non-allergic asthma. Bargagli E, etal., Respiration. 2010;79(5):437-8. doi: 10.1159/000277664. Epub 2010 Jan 21.
2. Genome-Wide Screening of mRNA Expression in Leprosy Patients. Belone Ade F, etal., Front Genet. 2015 Nov 20;6:334. doi: 10.3389/fgene.2015.00334. eCollection 2015.
3. Serum chitotriosidase activity in pulmonary tuberculosis: response to treatment and correlations with clinical parameters. Cakır G, etal., Ann Lab Med. 2012 May;32(3):184-9. doi: 10.3343/alm.2012.32.3.184. Epub 2012 Apr 18.
4. Increased expression of acidic mammalian chitinase and chitotriosidase in the nasal mucosa of patients with allergic rhinitis. Cho WS, etal., Laryngoscope. 2010 May;120(5):870-5.
5. Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression. Choi YJ, etal., Respir Res. 2023 Mar 18;24(1):85. doi: 10.1186/s12931-023-02392-8.
6. Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis. Correale J and Fiol M, Mult Scler. 2011 May;17(5):521-31. doi: 10.1177/1352458510392619. Epub 2010 Dec 15.
7. Can Serum Chitotriosidase Levels, Immune, and Oxidative Stress Parameters Be Early Diagnostic Indicators in Patients With Silicosis? Ergün R, etal., J Occup Environ Med. 2023 Dec 1;65(12):e752-e758. doi: 10.1097/JOM.0000000000002973. Epub 2023 Sep 19.
8. Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice. Feng C, etal., BMC Pulm Med. 2021 Jan 19;21(1):31. doi: 10.1186/s12890-021-01396-8.
9. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, etal., Hypertension. 2013 Apr;61(4):850-6. doi: 10.1161/HYPERTENSIONAHA.111.01008. Epub 2013 Mar 4.
10. Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease. Fujisawa T, etal., J Rheumatol. 2019 Aug;46(8):935-942. doi: 10.3899/jrheum.180825. Epub 2019 May 15.
11. NOD2 expression, DNA damage and oxido-inflammatory status in atopic bronchial asthma: Exploring their nexus to disease severity. Gaballah HH, etal., Gene. 2018 Jun 20;660:128-135. doi: 10.1016/j.gene.2018.03.061. Epub 2018 Mar 21.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Effects of chitinase-1 inhibitor in obesity-induced and -aggravated asthma in a murine model. Han H, etal., Life Sci. 2023 Dec 1;334:122163. doi: 10.1016/j.lfs.2023.122163. Epub 2023 Oct 25.
15. Chitinase activation in patients with fungus-associated cystic fibrosis lung disease. Hector A, etal., J Allergy Clin Immunol. 2016 Oct;138(4):1183-1189.e4. doi: 10.1016/j.jaci.2016.01.031. Epub 2016 Apr 4.
16. Chitotriosidase inhibits allergic asthmatic airways via regulation of TGF-β expression and Foxp3+ Treg cells. Hong JY, etal., Allergy. 2018 Aug;73(8):1686-1699. doi: 10.1111/all.13426. Epub 2018 Mar 5.
17. Increased chitotriosidase activity in serum of leprosy patients: association with bacillary leprosy. Iyer A, etal., Clin Immunol. 2009 Jun;131(3):501-9. doi: 10.1016/j.clim.2009.02.003.
18. Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease. James AJ, etal., Am J Respir Crit Care Med. 2016 Jan 15;193(2):131-42. doi: 10.1164/rccm.201504-0760OC.
19. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. Koralewski R, etal., J Med Chem. 2020 Dec 24;63(24):15527-15540. doi: 10.1021/acs.jmedchem.0c01179. Epub 2020 Oct 20.
20. Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling. Lee CG, etal., J Immunol. 2012 Sep 1;189(5):2635-44. doi: 10.4049/jimmunol.1201115. Epub 2012 Jul 23.
21. Kasugamycin Is a Novel Chitinase 1 Inhibitor with Strong Antifibrotic Effects on Pulmonary Fibrosis. Lee JH, etal., Am J Respir Cell Mol Biol. 2022 Sep;67(3):309-319. doi: 10.1165/rcmb.2021-0156OC.
22. Human chitotriosidase polymorphisms G354R and A442V associated with reduced enzyme activity. Lee P, etal., Blood Cells Mol Dis. 2007 Nov-Dec;39(3):353-60. doi: 10.1016/j.bcmd.2007.06.013. Epub 2007 Aug 10.
23. Longitudinal and Comparative Measures of Serum Chitotriosidase and YKL-40 in Patients With Idiopathic Pulmonary Fibrosis. Majewski S, etal., Front Immunol. 2022 Feb 10;13:760776. doi: 10.3389/fimmu.2022.760776. eCollection 2022.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. Role of acidic mammalian chitinase and chitotriosidase in nasal polyps. Park SK, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):462-6. doi: 10.1016/j.otohns.2009.06.013.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
29. Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis. Poh TY, etal., Chest. 2020 Aug;158(2):512-522. doi: 10.1016/j.chest.2020.02.048. Epub 2020 Mar 14.
30. The Role of Chitinases in Chronic Airway Inflammation Associated with Tobacco Smoke Exposure. Przysucha N, etal., Cells. 2022 Nov 25;11(23):3765. doi: 10.3390/cells11233765.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae. Sharma L, etal., J Immunol. 2018 Jul 15;201(2):615-626. doi: 10.4049/jimmunol.1701782. Epub 2018 Jun 11.
35. Chitotriosidase activity in sarcoidosis and some other pulmonary diseases. Tercelj M, etal., Scand J Clin Lab Invest. 2009;69(5):575-8. doi: 10.1080/00365510902829362.
Additional References at PubMed
PMID:11085997   PMID:17852345   PMID:19725875   PMID:23558346   PMID:24155872   PMID:35094663  


Genomics

Comparative Map Data
Chit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,117,886 - 48,165,645 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1348,145,893 - 48,165,639 (+)EnsemblGRCr8
mRatBN7.21345,565,841 - 45,613,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,593,845 - 45,613,592 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1348,174,113 - 48,221,708 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,462,167 - 49,509,762 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,726,964 - 46,774,804 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1347,497,410 - 47,545,005 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1347,728,999 - 47,776,593 (+)NCBILyon_Normotensive
Lyon_Hypertensive1347,695,105 - 47,742,700 (+)NCBILyon_Hypertensive
F344_StmMcwi1347,651,506 - 47,699,258 (+)NCBIF344_StmMcwi
Rnor_6.01350,947,020 - 50,994,644 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,974,872 - 50,994,643 (+)Ensemblrn6Rnor6.0
Rnor_5.01356,000,134 - 56,046,972 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41347,095,240 - 47,109,367 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1345,894,357 - 45,941,716 (+)NCBICelera
RGSC_v3.11347,059,518 - 47,123,204 (+)NCBI
Cytogenetic Map13q13NCBI
CHIT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,216,079 - 203,230,099 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,212,827 - 203,273,641 (-)Ensemblhg38GRCh38
GRCh371203,185,207 - 203,198,801 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,452,418 - 201,465,399 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341199,917,451 - 199,930,433NCBI
Celera1176,314,462 - 176,328,121 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,350,361 - 174,364,019 (-)NCBIHuRef
CHM1_11204,607,543 - 204,621,196 (-)NCBICHM1_1
T2T-CHM13v2.01202,478,845 - 202,492,868 (-)NCBIT2T-CHM13v2.0
Chit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,038,980 - 134,079,279 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,038,980 - 134,079,278 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381134,111,242 - 134,151,541 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,111,242 - 134,151,540 (+)Ensemblmm10GRCm38
MGSCv371136,007,819 - 136,048,013 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361135,927,653 - 135,967,847 (+)NCBIMGSCv36mm8
Celera1136,728,484 - 136,764,033 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.12NCBI
Chit1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,229,356 - 39,241,540 (-)Ensembl
ChiLan1.0NW_00495540639,229,161 - 39,253,328 (-)NCBIChiLan1.0ChiLan1.0
CHIT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,148,307 - 46,167,361 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,115,349 - 46,134,406 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,816,396 - 178,875,895 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,112,412 - 183,126,052 (-)NCBIPanPan1.1PanPan1.1panPan2
Chit1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,138,798 - 72,151,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,376,768 - 1,385,616 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,373,727 - 1,385,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHIT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,927,720 - 113,941,433 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19113,927,715 - 113,941,445 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,386,204 - 125,431,735 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHIT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,120,089 - 26,133,093 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605526,896,486 - 26,909,524 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chit1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,612,293 - 7,625,535 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248077,612,263 - 7,625,782 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Chit1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1101,531,168 - 1,579,037 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chit1
510 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:210
Count of miRNA genes:128
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000035658
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134778041850392939Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
AW531798  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21345,613,356 - 45,613,561 (+)MAPPERmRatBN7.2
Rnor_6.01350,994,408 - 50,994,612NCBIRnor6.0
Rnor_5.01356,046,736 - 56,046,940UniSTSRnor5.0
RGSC_v3.41347,109,132 - 47,109,336UniSTSRGSC3.4
Celera1345,941,481 - 45,941,685UniSTS
RH 3.4 Map13183.9UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 150 230 86 85 60 107 54 22 442 299 11 202 75 92 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001079689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ286232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ923320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000035658   ⟹   ENSRNOP00000036477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1348,148,471 - 48,165,639 (+)Ensembl
mRatBN7.2 Ensembl1345,604,183 - 45,613,592 (+)Ensembl
Rnor_6.0 Ensembl1350,977,431 - 50,994,643 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080768   ⟹   ENSRNOP00000070204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1348,145,893 - 48,165,639 (+)Ensembl
mRatBN7.2 Ensembl1345,593,845 - 45,613,592 (+)Ensembl
Rnor_6.0 Ensembl1350,974,872 - 50,994,643 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099352   ⟹   ENSRNOP00000096437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1348,145,893 - 48,165,457 (+)Ensembl
mRatBN7.2 Ensembl1345,593,845 - 45,613,415 (+)Ensembl
RefSeq Acc Id: NM_001079689   ⟹   NP_001073157
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,145,889 - 48,165,634 (+)NCBI
mRatBN7.21345,593,845 - 45,613,592 (+)NCBI
Dahl_SR_JrHsd1347,525,238 - 47,545,005 (+)NCBI
Lyon_Normotensive1347,756,808 - 47,776,593 (+)NCBI
Lyon_Hypertensive1347,722,933 - 47,742,700 (+)NCBI
F344_StmMcwi1347,679,511 - 47,699,258 (+)NCBI
Rnor_6.01350,974,872 - 50,994,643 (+)NCBI
Rnor_5.01356,000,134 - 56,046,972 (+)NCBI
RGSC_v3.41347,095,240 - 47,109,367 (+)RGD
Celera1345,922,360 - 45,941,716 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270846   ⟹   NP_001257775
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,145,889 - 48,165,634 (+)NCBI
mRatBN7.21345,593,845 - 45,613,592 (+)NCBI
Dahl_SR_JrHsd1347,525,238 - 47,545,005 (+)NCBI
Lyon_Normotensive1347,756,808 - 47,776,593 (+)NCBI
Lyon_Hypertensive1347,722,933 - 47,742,700 (+)NCBI
F344_StmMcwi1347,679,511 - 47,699,258 (+)NCBI
Rnor_6.01350,974,872 - 50,994,643 (+)NCBI
Rnor_5.01356,000,134 - 56,046,972 (+)NCBI
Celera1345,922,360 - 45,941,716 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270847   ⟹   NP_001257776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,145,889 - 48,165,634 (+)NCBI
mRatBN7.21345,593,845 - 45,613,592 (+)NCBI
Dahl_SR_JrHsd1347,525,238 - 47,545,005 (+)NCBI
Lyon_Normotensive1347,756,808 - 47,776,593 (+)NCBI
Lyon_Hypertensive1347,722,933 - 47,742,700 (+)NCBI
F344_StmMcwi1347,679,511 - 47,699,258 (+)NCBI
Rnor_6.01350,974,872 - 50,994,643 (+)NCBI
Rnor_5.01356,000,134 - 56,046,972 (+)NCBI
Celera1345,922,360 - 45,941,716 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270848   ⟹   NP_001257777
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,117,886 - 48,165,634 (+)NCBI
mRatBN7.21345,565,841 - 45,613,592 (+)NCBI
Dahl_SR_JrHsd1347,497,410 - 47,545,005 (+)NCBI
Lyon_Normotensive1347,728,999 - 47,776,593 (+)NCBI
Lyon_Hypertensive1347,695,105 - 47,742,700 (+)NCBI
F344_StmMcwi1347,651,506 - 47,699,258 (+)NCBI
Rnor_6.01350,947,020 - 50,994,643 (+)NCBI
Rnor_5.01356,000,134 - 56,046,972 (+)NCBI
Celera1345,894,357 - 45,941,716 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090436   ⟹   XP_038946364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,152,126 - 48,165,645 (+)NCBI
mRatBN7.21345,600,095 - 45,613,593 (+)NCBI
RefSeq Acc Id: XM_039090437   ⟹   XP_038946365
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81348,152,114 - 48,165,457 (+)NCBI
mRatBN7.21345,600,086 - 45,613,415 (+)NCBI
RefSeq Acc Id: NP_001073157   ⟸   NM_001079689
- Peptide Label: precursor
- UniProtKB: A0S5V8 (UniProtKB/TrEMBL),   A6ICA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257777   ⟸   NM_001270848
- Peptide Label: precursor
- UniProtKB: A0S5V8 (UniProtKB/TrEMBL),   A6ICA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257775   ⟸   NM_001270846
- Peptide Label: precursor
- UniProtKB: A0S5V8 (UniProtKB/TrEMBL),   A6ICA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257776   ⟸   NM_001270847
- Peptide Label: precursor
- UniProtKB: A0S5V8 (UniProtKB/TrEMBL),   A6ICA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070204   ⟸   ENSRNOT00000080768
Ensembl Acc Id: ENSRNOP00000036477   ⟸   ENSRNOT00000035658
RefSeq Acc Id: XP_038946365   ⟸   XM_039090437
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AV32 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946364   ⟸   XM_039090436
- Peptide Label: isoform X1
- UniProtKB: F7ER89 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096437   ⟸   ENSRNOT00000099352
Protein Domains
Chitin-binding type-2   GH18

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0S5V8-F1-model_v2 AlphaFold A0S5V8 1-464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305646 AgrOrtholog
BioCyc Gene G2FUF-18253 BioCyc
Ensembl Genes ENSRNOG00000028072 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035658 ENTREZGENE
  ENSRNOT00000035658.7 UniProtKB/TrEMBL
  ENSRNOT00000080768 ENTREZGENE
  ENSRNOT00000080768.3 UniProtKB/TrEMBL
  ENSRNOT00000099352 ENTREZGENE
  ENSRNOT00000099352.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.50.10 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro Chitin-bd_dom_sf UniProtKB/TrEMBL
  Chitin-bd_peritrophin-A UniProtKB/TrEMBL
  Chitinase_II UniProtKB/TrEMBL
  Chitinase_insertion UniProtKB/TrEMBL
  Glyco_hydro18cat UniProtKB/TrEMBL
  Glyco_hydro_18_chit_AS UniProtKB/TrEMBL
  Glyco_hydro_catalytic_core UniProtKB/TrEMBL
  Glycosyl_Hydrlase_18 UniProtKB/TrEMBL
KEGG Report rno:289032 UniProtKB/TrEMBL
NCBI Gene 289032 ENTREZGENE
PANTHER CHITINASE UniProtKB/TrEMBL
  CHITOTRIOSIDASE-1 UniProtKB/TrEMBL
Pfam CBM_14 UniProtKB/TrEMBL
  Glyco_hydro_18 UniProtKB/TrEMBL
PhenoGen Chit1 PhenoGen
PROSITE CHIT_BIND_II UniProtKB/TrEMBL
  CHITINASE_18 UniProtKB/TrEMBL
  GH18_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028072 RatGTEx
SMART Glyco_18 UniProtKB/TrEMBL
Superfamily-SCOP Chitin_bind_PerA UniProtKB/TrEMBL
  Glyco_hydro_cat UniProtKB/TrEMBL
  SSF54556 UniProtKB/TrEMBL
UniProt A0A8I6AV32 ENTREZGENE, UniProtKB/TrEMBL
  A0S5V8 ENTREZGENE, UniProtKB/TrEMBL
  A6ICA4 ENTREZGENE, UniProtKB/TrEMBL
  F7ER89 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Chit1  chitinase 1  Chit1  chitinase 1 (chitotriosidase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Chit1  chitinase 1 (chitotriosidase)   Chit1_predicted  chitinase 1 (chitotriosidase) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Chit1_predicted  chitinase 1 (chitotriosidase) (predicted)      Symbol and Name status set to approved 70820 APPROVED