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Gene: Wdr55 (WD repeat domain 55) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Wdr55

Name:

WD repeat domain 55

RGD ID:

1305640

Description:

Predicted to be involved in rRNA processing. Predicted to be located in nucleolus. Orthologous to human WDR55 (WD repeat domain 55); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC307494; LRRG00133; RGD1305640; similar to RIKEN cDNA 2410080P20; WD repeat-containing protein 55

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	WDR55 (WD repeat domain 55)	HGNC	HomoloGene, NCBI
Alliance orthologs ³
Mus musculus (house mouse):	Wdr55 (WD repeat domain 55)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	WDR55 (WD repeat domain 55)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wdr55 (WD repeat domain 55)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14722	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	JIP5	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	JIP5	Alliance	DIOPT (OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y44F5A.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	Y44F5A.1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	wdr55	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	wdr55	Alliance	DIOPT (OrthoFinder\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	28,649,386 - 28,652,854 (+)	NCBI	GRCr8	GRCr8		GRCr8
mRatBN7.2	18	28,375,366 - 28,378,834 (+)	NCBI	mRatBN7.2	mRatBN7.2
UTH_Rnor_SHR_Utx	18	28,502,515 - 28,505,983 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	29,264,589 - 29,268,057 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	28,599,817 - 28,603,285 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	29,605,217 - 29,608,730 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	18	29,309,024 - 29,312,537 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	29,461,320 - 29,464,833 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	28,095,873 - 28,099,386 (+)	NCBI		Celera
RGSC_v3.1	18	29,474,359 - 29,491,087 (+)	NCBI
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

bisphenol A (EXP)

paracetamol (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

rRNA processing (IEA,ISS)

Cellular Component

cytoplasm (IEA)

nucleolus (IEA,ISS)

nucleus (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:15489334	PMID:18769712	PMID:31505169

Genomics

Variants

Variants in Wdr55
17 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331735	Rf44	Renal function QTL 44	2.981		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	18	15642280	31610627	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	12216684	31644508	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
6903347	Bp350	Blood pressure QTL 350	4.4		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	31610627	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	12216684	31644508	Rat
1331775	Bp235	Blood pressure QTL 235	3.201		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	31610627	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	3811902	30809809	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	1	24	79	34	30	18	73	18	6	196	119	11	66	46	51	12	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC127460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BE097561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB729883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_001017932 ⟹ NP_001017932

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	28,649,386 - 28,652,854 (+)	NCBI
mRatBN7.2	18	28,375,366 - 28,378,834 (+)	NCBI
Rnor_6.0	18	29,605,217 - 29,608,730 (+)	NCBI
Rnor_5.0	18	29,309,024 - 29,312,537 (+)	NCBI
RGSC_v3.4	18	29,461,320 - 29,464,833 (+)	RGD
Celera	18	28,095,873 - 28,099,386 (+)	RGD

Sequence:

show sequence

TGCACTTCCGATCCGGCCTACTCGCGGAAGCAACTACTTAGGCCACGCCCCTATTCTTGTAGTT
TGTTCCCCAGCGCGCGTAGATCCTATGGACCCCACGTGTCAAGAGAGTCCTGCAGAGGACTCAA
ACAATGAAGAAGACCTTGACTCCACGAAGGCAGCACCCCGGATCCGTGATACCCCAGAAGACAT
CGTGCTGGAAGCGCCAGCCAGTGGCCTGGCGTTCCATCCGACTCGAGATCTGCTGGCAGCGGGG
GACGTGGATGGGGACGTGTTCGTCTTTGCCTACTCTTGTCAGGAGGGAGAAACCAAGGAGCTGT
GGTCCTCAGGACACCACCTCAAGTCCTGCCGAGCTGTTGTCTTCTCAGAGGATGGGCAGAAACT
TGTTACTGTCTCTAAGGACAAAGCAATCCATGTACTAGATGTGGAACAGGGACAATTGGAAAGA
CGGATTTCCAAGGCTCACAGTGCCCCCATTAACAGTCTGCTGCTCGTGGATGAGAATGTTCTGG
TTACTGGGGATGACACTGGTGGCATCCGGCTATGGGACCAGCGTAAAGAGGGCCCTTTGATGGA
TATGCGGCAGCATGAGGAGTATATTGCTGACATGGCTCTAGACCCAGCCAAAAAGCTGCTGCTG
ACAGCCAGCGGAGATGGCTGCCTTGGTGTCTTCAACATCAAGAGACGCCGGTTTGAGTTACTCT
CAGAGCCTCAGTCAGGAGATCTAACCTCCGTCGCCCTCATGAAATACGGGAAGAAGGTGGCCTG
TGGGTCTAGCGAAGGTACCATCTACCTCTTCAATTGGAACGGTTTCGGGGCCACAAGTGATCGC
TTTGCCCTGAGAGCGGAGTCCATCGACTGCATGGTTCCAGTCACTGAGAATCTGCTGTGCACTG
GCTCTACTGACGGAATCATCAGGGCTGTGAACATCCTGCCCAACCGAGTGGTAGGCACCGTGGG
CCAGCATGCCGGGGAGCCTGTGGAGGAGCTAGCCCTATCCCACTGTGGCCACTTTCTGGCCAGT
AGTGGCCATGACCAGCGCCTCAAATTTTGGGACATGACTCAGCTTCGAACTGTGGTTGTGGATG
ACTATCGTCGACGCAAGAAAAAAGGAGGGCCGCTTCGTGCCCTGAGCAGTAAAGCTTGGAGCAC
GGACGATTTCTTTGCAGGGTTGAGAGAAGATGAGGAGGAGGCCAAGGCTCCAGAGGAGGTGTCG
GGGGAGAGCGATGATGACAGTGACTGAGGGACAAGGAGCTGTTTTCTGGGACAGATTCCCTAAC
GGAATCTGTTGATGTTGTAGACTGATCCTGCTACCTTGAACAGGATAAGCTTAGCTCTACCACT
GAGCTACACCCCACTCCCCAGACAGGAGATCTCTATTCTACTGAATCATGTAAGACACACACGA
ACTCAGGGCCCCGAAGTAGGAGAGTATTTGTTCTGCCTATTGTAAAACAATCTCTACTACCACT
ATAGCAAGACAACACAGAAACATGTATACCAACCAGGGTTTTAATATAAATAAAACCGGTATAG
GAAAACAAGAACCATATAAGCCCAAACCAGTGACCAGTGGTGGGAGGAAGGGCTCTTTGGTTCA
GCCAGTTCTCCAAATAAAACACAGATTCATNGTAAAAAAAAAAAAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001017932	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A1L112	(Get FASTA)	NCBI Sequence Viewer
	AAI27461	(Get FASTA)	NCBI Sequence Viewer
	EDL76316	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001017932 ⟸ NM_001017932

- UniProtKB:

A1L112 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDPTCQESPAEDSNNEEDLDSTKAAPRIRDTPEDIVLEAPASGLAFHPTRDLLAAGDVDGDVFV
FAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHVLDVEQGQLERRISKAHSA
PINSLLLVDENVLVTGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCL
GVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFALRAESI
DCMVPVTENLLCTGSTDGIIRAVNILPNRVVGTVGQHAGEPVEELALSHCGHFLASSGHDQRLK
FWDMTQLRTVVVDDYRRRKKKGGPLRALSSKAWSTDDFFAGLREDEEEAKAPEEVSGESDDDSD

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Protein Domains

Protein RED C-terminal RED-like N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A1L112-F1-model_v2	AlphaFold	A1L112	1-384	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305640	AgrOrtholog
BioCyc Gene	G2FUF-7860	BioCyc
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:8367400	IMAGE-MGC_LOAD
InterPro	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_CS	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
	WDR55	UniProtKB/Swiss-Prot
	WDR55_POC1	UniProtKB/Swiss-Prot
KEGG Report	rno:307494	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:156524	IMAGE-MGC_LOAD
NCBI Gene	307494	ENTREZGENE
PANTHER	WD REPEAT-CONTAINING PROTEIN 55	UniProtKB/Swiss-Prot
	WD REPEAT-CONTAINING PROTEIN 55	UniProtKB/Swiss-Prot
Pfam	WDR55	UniProtKB/Swiss-Prot
PhenoGen	Wdr55	PhenoGen
PIRSF	WD_repeat_p55	UniProtKB/Swiss-Prot
PROSITE	WD_REPEATS_1	UniProtKB/Swiss-Prot
	WD_REPEATS_2	UniProtKB/Swiss-Prot
	WD_REPEATS_REGION	UniProtKB/Swiss-Prot
SMART	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50978	UniProtKB/Swiss-Prot
UniProt	A0A0H2UHX4_RAT	UniProtKB/TrEMBL
	A1L112	ENTREZGENE
	Q6QI75_RAT	UniProtKB/TrEMBL
	WDR55_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Wdr55	WD repeat domain 55	RGD1305640_predicted	similar to RIKEN cDNA 2410080P20 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305640_predicted	similar to RIKEN cDNA 2410080P20 (predicted)	LOC307494_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC307494_predicted	similar to RIKEN cDNA 2410080P20 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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