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Gene: Gpt2 (glutamic--pyruvic transaminase 2) Rattus norvegicus

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Symbol:

Gpt2

Name:

glutamic--pyruvic transaminase 2

RGD ID:

1305462

Description:

Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to testosterone. Located in extracellular space. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2); PARTICIPATES IN alanine, aspartate and glutamate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alanine aminotransferase 2; ALT2; Cc2-5; glutamic pyruvate transaminase (alanine aminotransferase) 2; glutamic pyruvate transaminase 2; glutamic-pyruvate transaminase 2; LOC307759

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPT2 (glutamic--pyruvic transaminase 2)	HGNC	Ensembl, HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpt2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPT2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPT2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpt2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPT2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPT2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpt2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Gpt2 (glutamic--pyruvic transaminase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GPT2 (glutamic--pyruvic transaminase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	GPT2 (glutamic--pyruvic transaminase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	gpt2 (glutamic pyruvate transaminase (alanine aminotransferase) 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG1640	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ALT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ALT2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C32F10.8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gpt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gpt2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	37,700,023 - 37,734,551 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	37,691,901 - 37,733,917 (-)	Ensembl				GRCr8
mRatBN7.2	19	21,526,800 - 21,561,314 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	21,517,621 - 21,560,610 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	23,215,489 - 23,248,192 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	28,410,012 - 28,442,715 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	31,372,800 - 31,405,503 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	22,599,003 - 22,633,529 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	22,590,881 - 22,632,071 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	33,605,445 - 33,644,015 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	22,884,586 - 22,915,553 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	21,389,431 - 21,420,291 (-)	NCBI		Celera
RGSC_v3.1	19	22,889,411 - 22,920,379 (-)	NCBI
Cytogenetic Map	19	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (IEP,ISO)

Chronic Hepatitis C (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 73 (ISO)

intellectual disability (ISO)

liver cancer (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

neurodevelopmental disorder with spastic paraplegia and microcephaly (ISO)

Neurodevelopmental Disorders (ISO)

obesity (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-nitropyrene (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-diaminobutyric acid (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol AF (ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chloroprene (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

corosolic acid (ISO)

Cuprizon (EXP)

cyclophosphamide (ISO)

cyclosporin A (ISO)

DDE (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

diclofenac (ISO)

diquat (ISO)

disulfiram (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

gamma-hexachlorocyclohexane (ISO)

glafenine (EXP)

GSK-J4 (ISO)

hydrogen peroxide (ISO)

indometacin (EXP)

lipopolysaccharide (ISO)

menadione (ISO)

methapyrilene (ISO)

methotrexate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

motexafin gadolinium (ISO)

N(4)-hydroxycytidine (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

neomycin (ISO)

nimesulide (EXP)

ochratoxin A (ISO)

okadaic acid (ISO)

oxycodone (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

prothioconazole (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulforaphane (EXP)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thapsigargin (ISO)

thiram (ISO)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP)

trovafloxacin (ISO)

Tungsten carbide (ISO)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

zinc acetate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2-oxoglutarate metabolic process (ISO)

cellular response to insulin stimulus (IEP)

gluconeogenesis (IMP)

L-alanine catabolic process (IEA)

L-alanine metabolic process (ISO)

response to starvation (IEP)

response to testosterone (IEP)

Cellular Component

cytoplasm (IEA)

extracellular space (IDA)

mitochondrion (ISO)

Molecular Function

L-alanine:2-oxoglutarate aminotransferase activity (IEA,ISO)

pyridoxal phosphate binding (IEA)

transaminase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

alanine, aspartate and glutamate metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Alanine aminotransferase regulation by androgens in non-hepatic tissues.	Coss CC, etal., Pharm Res. 2012 Apr;29(4):1046-56. doi: 10.1007/s11095-011-0649-5. Epub 2011 Dec 14.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver.	Jadhao SB, etal., Hepatology. 2004 May;39(5):1297-302. doi: 10.1002/hep.20182.
4.	Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis.	Liu R, etal., Liver Int. 2009 Mar;29(3):337-43. doi: 10.1111/j.1478-3231.2008.01862.x. Epub 2008 Aug 14.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level.	Qian K, etal., Diabetes Metab Res Rev. 2015 Sep;31(6):562-71. doi: 10.1002/dmrr.2655. Epub 2015 Jun 17.
7.	Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans.	Rafter I, etal., Int J Mol Med. 2012 Nov;30(5):1241-9. doi: 10.3892/ijmm.2012.1106. Epub 2012 Aug 23.
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12.	Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity.	Yang RZ, etal., Hepatology. 2009 Feb;49(2):598-607. doi: 10.1002/hep.22657.

Additional References at PubMed

PMID:11863375	PMID:18614015	PMID:34800366

Genomics

Comparative Map Data

Gpt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	37,700,023 - 37,734,551 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	37,691,901 - 37,733,917 (-)	Ensembl				GRCr8
mRatBN7.2	19	21,526,800 - 21,561,314 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	21,517,621 - 21,560,610 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	23,215,489 - 23,248,192 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	28,410,012 - 28,442,715 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	31,372,800 - 31,405,503 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	22,599,003 - 22,633,529 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	22,590,881 - 22,632,071 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	33,605,445 - 33,644,015 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	22,884,586 - 22,915,553 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	21,389,431 - 21,420,291 (-)	NCBI		Celera
RGSC_v3.1	19	22,889,411 - 22,920,379 (-)	NCBI
Cytogenetic Map	19	p11	NCBI

GPT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	46,884,362 - 46,931,289 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	46,882,857 - 46,931,298 (+)	Ensembl			hg38	GRCh38
GRCh37	16	46,918,274 - 46,965,201 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	45,475,809 - 45,522,699 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	45,475,808 - 45,522,699	NCBI
Celera	16	31,426,465 - 31,473,333 (+)	NCBI		Celera
Cytogenetic Map	16	q11.2	NCBI
HuRef	16	32,808,713 - 32,855,581 (+)	NCBI		HuRef
CHM1_1	16	48,325,402 - 48,372,269 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	52,681,247 - 52,728,152 (+)	NCBI		T2T-CHM13v2.0

Gpt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	86,219,090 - 86,255,531 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	86,219,205 - 86,254,189 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	85,492,576 - 85,528,902 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	85,492,576 - 85,527,560 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	88,016,516 - 88,051,457 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	88,382,722 - 88,417,663 (+)	NCBI		MGSCv36	mm8
Celera	8	89,788,449 - 89,823,364 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.61	NCBI

Gpt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	8,250,759 - 8,285,227 (-)	Ensembl
ChiLan1.0	NW_004955474	8,248,622 - 8,285,449 (-)	NCBI	ChiLan1.0	ChiLan1.0

GPT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	56,344,084 - 56,390,987 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	62,249,073 - 62,295,908 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	27,150,159 - 27,197,006 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	46,040,439 - 46,086,840 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	46,040,439 - 46,086,840 (+)	Ensembl			panPan2	panpan1.1

GPT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	8,238,295 - 8,250,789 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	8,390,680 - 8,414,551 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	8,352,399 - 8,376,276 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	8,350,919 - 8,376,461 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	8,180,716 - 8,204,556 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	8,261,783 - 8,285,636 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	8,277,131 - 8,301,012 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Gpt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	59,289,309 - 59,326,531 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	262,920 - 297,459 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	262,558 - 299,766 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	37,625,436 - 37,669,663 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	37,625,428 - 37,669,695 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	32,865,392 - 32,909,952 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	32,743,850 - 32,791,299 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	32,744,065 - 32,791,479 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	43,782,468 - 43,830,157 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624914	459,701 - 501,765 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624914	460,240 - 501,087 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Gpt2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	14,231,346 - 14,264,269 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Gpt2
275 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	458
Count of miRNA genes:	242
Interacting mature miRNAs:	274
Transcripts:	ENSRNOT00000022851, ENSRNOT00000071992
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	5748064	50748064	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
61407	Scl12	Serum cholesterol level QTL 12		0.001	blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	19	30099383	47207961	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	91	59	6	354	191	11	142	80	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY325245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000077275 ⟹ ENSRNOP00000069387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,700,023 - 37,733,293 (-)	Ensembl
mRatBN7.2 Ensembl	19	21,526,800 - 21,559,733 (-)	Ensembl
Rnor_6.0 Ensembl	19	22,600,868 - 22,632,071 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000078348 ⟹ ENSRNOP00000071498

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,691,901 - 37,727,673 (-)	Ensembl
mRatBN7.2 Ensembl	19	21,517,621 - 21,554,447 (-)	Ensembl
Rnor_6.0 Ensembl	19	22,590,881 - 22,626,653 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099582 ⟹ ENSRNOP00000090767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,700,023 - 37,733,917 (-)	Ensembl
mRatBN7.2 Ensembl	19	21,526,800 - 21,560,610 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111228 ⟹ ENSRNOP00000091514

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,691,901 - 37,722,883 (-)	Ensembl
mRatBN7.2 Ensembl	19	21,517,621 - 21,549,661 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115000 ⟹ ENSRNOP00000095516

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,692,069 - 37,732,959 (-)	Ensembl
mRatBN7.2 Ensembl	19	21,526,963 - 21,559,863 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143312 ⟹ ENSRNOP00000100936

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	37,704,542 - 37,732,959 (-)	Ensembl

RefSeq Acc Id:

NM_001012057 ⟹ NP_001012057

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	37,700,023 - 37,732,759 (-)	NCBI
mRatBN7.2	19	21,526,800 - 21,559,533 (-)	NCBI
Rnor_6.0	19	22,600,883 - 22,631,743 (-)	NCBI
Rnor_5.0	19	33,605,445 - 33,644,015 (-)	NCBI
RGSC_v3.4	19	22,884,586 - 22,915,553 (-)	RGD
Celera	19	21,389,431 - 21,420,291 (-)	RGD

Sequence:

show sequence

CCAGGGTTAACCTCGGAAGATTCGCGATGCAGCGGGCAGCGGTGCTGGTGCGGCGGGGCTCCTG
CCCCCGCGCCTCGGGCCCCTGGGGCCGTAGTCACAGCAGCGCTGCAGCCGAAGCCTCGGCGGCG
CTCAAGGTGCGACCAGAGCGTAGCCCTCGAGACCGCATCCTCACCCTGGAGTCCATGAACCCGC
AGGTGAAGGCCGTGGAGTACGCTGTGCGGGGACCCATCGTGCTCAAGGCCGGCGAGATCGAGAT
GGAGCTGCAGCGGGGTATCAAAAAACCATTCACTGAGGTAATCCGAGCCAACATTGGGGATGCC
CATGCTATGGGCCAGCAGCCAATCACCTTCCTTCGTCAGGTGATGGCTCTCTGCACCTACCCGA
ACCTGCTAAACAGCCCCAGCTTCCCGGAAGATGCTAAGAAGCGAGCGCGGCGGATCCTGCAGGC
TTGCGGTGGAAACAGCCTGGGGTCTTACAGTGCGAGCCAGGGCGTTAACTGTATCCGAGAGGAC
GTGGCAGCCTTTATCACCAGGAGAGATGGTGTACCTGCAGACCCAGACAACATTTACCTGACTA
CTGGAGCGAGCGACGGTATTTCTACGATCCTGAAGCTCCTGGTCTCCGGCGGTGGCAAGTCACG
GACCGGGGTGATGATCCCCATCCCACAGTACCCCTTGTACTCCGCGGTCATCTCCGAGCTCGAC
GCCATCCAGGTGAACTACTATCTGGATGAGGACAACTGCTGGGCTTTGAACGTGGACGAGCTCC
GGCGGGCACTGCGGCAAGCTAAAGACCACTGTGACCCTAAAGTTCTCTGCATCATCAACCCCGG
AAACCCCACAGGCCAGGTACAAAGCAGAAAGTGCATAGAAGATGTGATTCACTTTGCCTGGGAA
GAGAAGCTTTTTCTCCTGGCTGACGAGGTATACCAGGACAACGTGTACTCTCCGGACTGCAGAT
TCCACTCCTTTAAGAAAGTGCTTTACCAGATGGGGCCTGAGTACTCGAGTAATGTGGAGCTTGC
CTCCTTCCACTCCACCTCCAAGGGCTACATGGGCGAATGCGGCTACAGAGGAGGCTACATGGAG
GTGATCAATTTGCACCCCGAGATCAAAGGCCAGCTGGTTAAGCTCCTCTCGGTCCGCCTCTGTC
CGCCAGTGTCTGGACAGGCCGCGATGGACATTGTTGTGAATCCACCGGTGCCAGGAGAGGAGTC
CTTTGAGCAATTCACCAGGGAAAAAGAATCCGTCCTTGGTAATCTGGCCAAAAAAGCAAAGCTG
ACAGAAGATCTGTTTAACCAAGTCCCGGGGATCCAGTGCAACCCCTTGCAAGGAGCCATGTATG
CATTCCCTCGGATTCTCATCCCTGCCAAGGCCGTGGAGGCAGCTCAGTCCCATAAAATGGCTCC
AGATATGTTTTACTGCATGAAACTCCTGGAAGAAACTGGCATCTGTGTCGTGCCTGGCAGTGGC
TTTGGACAGCGAGAAGGCACCTACCACTTCAGAATGACAATTCTCCCTCCAGTGGAGAAACTGA
AGACAGTACTCCACAAGGTGAAAGATTTTCACCTGAAGTTCCTGGAGAAGTACTCATGAGGATG
CCTCTGCACCAGAGAGAGACCCCAATACCACCCAGGCCTTCCTCATGGACTCTGCCTCAGACCT
CATGCAGGTCACCAACCCTGTTCATCATCATTTTCCAAGGAGACTTCTTTCTTTGTGCCTTGAT
GTTCGAGAGTTCTTCTGAGCAAACAGTGATTTTGCAATGTC

hide sequence

RefSeq Acc Id:

XM_008772405 ⟹ XP_008770627

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	37,700,028 - 37,733,112 (-)	NCBI
mRatBN7.2	19	21,526,800 - 21,559,877 (-)	NCBI
Rnor_6.0	19	22,599,003 - 22,632,080 (-)	NCBI

Sequence:

show sequence

GTGCGAATGCAGGGAGCCTGGAGGTGCGGGTGCCAGGCGCCAGGATGCGGTGGCCGGTTACCGT
GTTGGGGAGCAGCCCAGGCTCACCATAAACGGCGCGGTGCCGACGGTCCGGAGGAGAGAGAGGG
TTAACCTCGGAAGATTCGCGATGCAGCGGGCAGCGGTGCTGGTGCGGCGGGGCTCCTGCCCCCG
CGCCTCGGGCCCCTGGGGCCGTAGTCACAGCAGCGCTGCAGCCGAAGCCTCGGCGGCGCTCAAG
GTGCGACCAGAGCGTAGCCCTCGAGACCGCATCCTCACCCTGGAGTCCATGAACCCGCAGGTGA
AGGCCGTGGAGTACGCTGTGCGGGGACCCATCGTGCTCAAGGCCGGCGAGATCGAGATGGAGCT
GCAGCGGGGTATCAAAAAACCATTCACTGAGGTAATCCGAGCCAACATTGGGGATGCCCATGCT
ATGGGCCAGCAGCCAATCACCTTCCTTCGTCAGGTGATGGCTCTCTGCACCTACCCGAACCTGC
TAAACAGCCCCAGCTTCCCGGAAGATGCTAAGAAGCGAGCGCGGCGGATCCTGCAGGCTTGCGG
TGGAAACAGCCTGGGGTCTTACAGTGCGAGCCAGGGCGTTAACTGTATCCGAGAGGACGTGGCA
GCCTTTATCACCAGGAGAGATGGTGTACCTGCAGACCCAGACAACATTTACCTGACTACTGGAG
CGAGCGACGGTATTTCTACGATCCTGAAGCTCCTGGTCTCCGGCGGTGGCAAGTCACGGACCGG
GGTGATGATCCCCATCCCACAGTACCCCTTGTACTCCGCGGTCATCTCCGAGCTCGACGCCATC
CAGGTGAACTACTATCTGGATGAGGACAACTGCTGGGCTTTGAACGTGGACGAGCTCCGGCGGG
CACTGCGGCAAGCTAAAGACCACTGTGACCCTAAAGTTCTCTGCATCATCAACCCCGGAAACCC
CACAGGCCAGGTACAAAGCAGAAAGTGCATAGAAGATGTGATTCACTTTGCCTGGGAAGAGAAG
CTTTTTCTCCTGGCTGACGAGGTATACCAGGACAACGTGTACTCTCCGGACTGCAGATTCCACT
CCTTTAAGAAAGTGCTTTACCAGATGGGGCCTGAGTACTCGAGTAATGTGGAGCTTGCCTCCTT
CCACTCCACCTCCAAGGGCTACATGGGCGAATGCGGCTACAGAGGAGGCTACATGGAGGTGATC
AATTTGCACCCCGAGATCAAAGGCCAGCTGGTTAAGCTCCTCTCGGTCCGCCTCTGTCCGCCAG
TGTCTGGACAGGCCGCGATGGACATTGTTGTGAATCCACCGGTGCCAGGAGAGGAGTCCTTTGA
GCAATTCACCAGGGAAAAAGAATCCGTCCTTGGTAATCTGGCCAAAAAAGCAAAGCTGACAGAA
GATCTGTTTAACCAAGTCCCGGGGATCCAGTGCAACCCCTTGCAAGGAGCCATGTATGCATTCC
CTCGGATTCTCATCCCTGCCAAGGCCGTGGAGGCAGCTCAGTCCCATAAAATGGCTCCAGATAT
GTTTTACTGCATGAAACTCCTGGAAGAAACTGGCATCTGTGTCGTGCCTGGCAGTGGCTTTGGA
CAGCGAGAAGGCACCTACCACTTCAGAATGACAATTCTCCCTCCAGTGGAGAAACTGAAGACAG
TACTCCACAAGGTGAAAGATTTTCACCTGAAGTTCCTGGAGAAGTACTCATGAGGATGCCTCTG
CACCAGAGAGAGACCCCAATACCACCCAGGCCTTCCTCATGGACTCTGCCTCAGACCTCATGCA
GGTCACCAACCCTGTTCATCATCATTTTCCAAGGAGACTTCTTTCTTTGTGCCTTGATGTTCGA
GAGTTCTTCTGAGCAAACAGTGATTTTGCAATGTCTCCCGGGCCCTGTTTTTTTTTTTTTTTTT
TTAAATGCCACCAAAGTAGTCAACCTGCTTGGCAGATGTAATTGAGATTCTCTGACTTGCTGTT
CTGTTTGGAAAGTACTTTTGGGTTTTAAGCAGCCAGGCTACATTGAAATGAGATATTTCAGATC
TGGAGAAACAAGCAGGTGTTGGGAAATACGTGACTTAACATGATAAGGGCTGGGTTCCAGAAAC
CAACAGTGAGATCTGTGAAATAAAACCCTTACCAGTGTGGCAGCGCAGCGTTTTGGACAGTAAA
CCTGCAAGTCTAGTGAGGACTCAGAGAAAGCTGTAGCACAGCACAGACAACATGGAAGTCAGTA
GTAGGACAGGGCTCATCAGAGACCAGGTTAGATTACACTGGCTTACCCTACAGCAGTTTTCTCC
AGGTTTGGCTGAGCCTTTATGCACACCATTGCCCTCTGCTGGTGGCAGCCGAGATAAGCAAGGA
CTGAAAATGGATCCTTTCACAAGGCCCTGAAGGTTTTTTAACTGTTTCAAACTGACTCTGGTTC
GTCCGTAACTAACGGATCATGGTGCCTGGTTACACTGGCTGCCAAGAAGGAGCACATGCAATCT
GATTCCGTGTTCTCGTCACATCAGTTTCCTGCCTCCCTCCCTGATCAGAGGACAGCAGCTTATA
TCATCGGCCATCCCTGTGGGTCACAAGGTAGCAGCCACCAATCAAGTGTATTCCTTGAATTAGC
ACACCTGGGTGGGCCGTGTGCACACCCAGGACATTGGTGCTACAGGGAAAGCCAGGCCAGGTTT
TCCTCTCCATCTCTTAACCGTCCCTGTCCTTCAGTGAGAGTGCGGGACTCCAGCTCAGGAGTCT
GGGTACCCAGGGGAGCTTAAGGAGCCAGAGAGAGAAGGAAGTAGCACAAGAATGGAAACAGCCT
CCTGCCCTAGAATCCCACACTGCAGGGGGCGCAACTGAGAAAAAGAACTTCAAGTTGTTAACAC
TCACGGGCAAGCGAGAGGCACCTTACTGTGGAGGAAACAGCCACATCCACAACAGGATGCAATG
CTCTATAACTTTTCCTTTAAAGCCGAAAAGCTAGCATGTATGCTTGCTGGGCATTTGATCCAGA
TGTGCTCCGGAGTTCTGAGATTCTTCCATGAAAGGTTAACTAGAGGCTAGTATATTTTTTATAT
TTTTGTAACAATTGGCTTTTTTCATGGGGGGTGGGGGGGTGGAGGTGGAAGAGTTTAGTATTTA
TAGGCCTAACGAGTCCAATAATTTTTATAAGTGTCTTCAGACTATGGACAATCCTCCAAATTTT
GCAAATGTTTACATGTTTTTTTTTAAGATGATAAATACGCTTGATTTGCTTTTTAAATAAAAGT
TTTAGCTGTTCTAAGAGATTAACTTCAAGTAGGAATGAATGCTGGTTATGGTAGTTGGGATTTT
CTACAGGTTCTGTTCCCATGCCTTTTCTACGCCGGCCTCACTCAAGAGCCCTCATGTGGGTGTG
GCTGTGAAGCCTGAACAGGCTGGACCTGGACAGCCCCACCTCAGAGACATTGTTTCCACTTGGA
TGTGAGCAGGCACAGGCCTGCCTGCCCTTTGCTACTCATCATTATCAGTTCTTCCAGCCTCCTT
GGCGTGGGTCCTGGTCATAGCCCTGCTGGGAGGCTCTGAACAATAAAACATGATCAGCTTGGTC
AATAAAATCTAAAAGTTGCGTGGGGCTGAGTATGGTGGCACACTTTAATCCCAGCACCGGGGAG
GCAGAGGCAGCCTGGTGTCTGTGAGTTTGAGTCCTGTCTGATTTACATAGTAAGACCCTGTCAC
AACAAAATTGAAAACAACTACAGAAGCAATAAATAGTTGAGTGGATGTCACTAATTAAA

hide sequence

RefSeq Acc Id:

XM_008772406 ⟹ XP_008770628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	37,700,028 - 37,734,551 (-)	NCBI
mRatBN7.2	19	21,526,800 - 21,561,314 (-)	NCBI
Rnor_6.0	19	22,599,003 - 22,633,529 (-)	NCBI

Sequence:

show sequence

GAGGTTGGCAGAATTCTCACACTGGTTCCCTGGCCTGTGGAGTGAGGGCTATTATGGCTGGGAA
GGCTAAATGGAAGCCCTTAGAGCTGCCTCTGCCAAAGAAAATAGTGAGCCAAAACCAGTATTGT
ATTCCTGGAGGAACTGCAGAAATTACACCTCCATCAAGGACTTGAAAGATGCAGGGTGGTGGTT
CCCACATCTCCCTTTAACTCTCTATCTGGCCAGTGCAGAAGACAGATGGATCATGGAGAATGAC
AGCTGACTATTGAAAGCTAAACCAGGGTTAACCTCGGAAGATTCGCGATGCAGCGGGCAGCGGT
GCTGGTGCGGCGGGGCTCCTGCCCCCGCGCCTCGGGCCCCTGGGGCCGTAGTCACAGCAGCGCT
GCAGCCGAAGCCTCGGCGGCGCTCAAGGTGCGACCAGAGCGTAGCCCTCGAGACCGCATCCTCA
CCCTGGAGTCCATGAACCCGCAGGTGAAGGCCGTGGAGTACGCTGTGCGGGGACCCATCGTGCT
CAAGGCCGGCGAGATCGAGATGGAGCTGCAGCGGGGTATCAAAAAACCATTCACTGAGGTAATC
CGAGCCAACATTGGGGATGCCCATGCTATGGGCCAGCAGCCAATCACCTTCCTTCGTCAGGTGA
TGGCTCTCTGCACCTACCCGAACCTGCTAAACAGCCCCAGCTTCCCGGAAGATGCTAAGAAGCG
AGCGCGGCGGATCCTGCAGGCTTGCGGTGGAAACAGCCTGGGGTCTTACAGTGCGAGCCAGGGC
GTTAACTGTATCCGAGAGGACGTGGCAGCCTTTATCACCAGGAGAGATGGTGTACCTGCAGACC
CAGACAACATTTACCTGACTACTGGAGCGAGCGACGGTATTTCTACGATCCTGAAGCTCCTGGT
CTCCGGCGGTGGCAAGTCACGGACCGGGGTGATGATCCCCATCCCACAGTACCCCTTGTACTCC
GCGGTCATCTCCGAGCTCGACGCCATCCAGGTGAACTACTATCTGGATGAGGACAACTGCTGGG
CTTTGAACGTGGACGAGCTCCGGCGGGCACTGCGGCAAGCTAAAGACCACTGTGACCCTAAAGT
TCTCTGCATCATCAACCCCGGAAACCCCACAGGCCAGGTACAAAGCAGAAAGTGCATAGAAGAT
GTGATTCACTTTGCCTGGGAAGAGAAGCTTTTTCTCCTGGCTGACGAGGTATACCAGGACAACG
TGTACTCTCCGGACTGCAGATTCCACTCCTTTAAGAAAGTGCTTTACCAGATGGGGCCTGAGTA
CTCGAGTAATGTGGAGCTTGCCTCCTTCCACTCCACCTCCAAGGGCTACATGGGCGAATGCGGC
TACAGAGGAGGCTACATGGAGGTGATCAATTTGCACCCCGAGATCAAAGGCCAGCTGGTTAAGC
TCCTCTCGGTCCGCCTCTGTCCGCCAGTGTCTGGACAGGCCGCGATGGACATTGTTGTGAATCC
ACCGGTGCCAGGAGAGGAGTCCTTTGAGCAATTCACCAGGGAAAAAGAATCCGTCCTTGGTAAT
CTGGCCAAAAAAGCAAAGCTGACAGAAGATCTGTTTAACCAAGTCCCGGGGATCCAGTGCAACC
CCTTGCAAGGAGCCATGTATGCATTCCCTCGGATTCTCATCCCTGCCAAGGCCGTGGAGGCAGC
TCAGTCCCATAAAATGGCTCCAGATATGTTTTACTGCATGAAACTCCTGGAAGAAACTGGCATC
TGTGTCGTGCCTGGCAGTGGCTTTGGACAGCGAGAAGGCACCTACCACTTCAGAATGACAATTC
TCCCTCCAGTGGAGAAACTGAAGACAGTACTCCACAAGGTGAAAGATTTTCACCTGAAGTTCCT
GGAGAAGTACTCATGAGGATGCCTCTGCACCAGAGAGAGACCCCAATACCACCCAGGCCTTCCT
CATGGACTCTGCCTCAGACCTCATGCAGGTCACCAACCCTGTTCATCATCATTTTCCAAGGAGA
CTTCTTTCTTTGTGCCTTGATGTTCGAGAGTTCTTCTGAGCAAACAGTGATTTTGCAATGTCTC
CCGGGCCCTGTTTTTTTTTTTTTTTTTTTAAATGCCACCAAAGTAGTCAACCTGCTTGGCAGAT
GTAATTGAGATTCTCTGACTTGCTGTTCTGTTTGGAAAGTACTTTTGGGTTTTAAGCAGCCAGG
CTACATTGAAATGAGATATTTCAGATCTGGAGAAACAAGCAGGTGTTGGGAAATACGTGACTTA
ACATGATAAGGGCTGGGTTCCAGAAACCAACAGTGAGATCTGTGAAATAAAACCCTTACCAGTG
TGGCAGCGCAGCGTTTTGGACAGTAAACCTGCAAGTCTAGTGAGGACTCAGAGAAAGCTGTAGC
ACAGCACAGACAACATGGAAGTCAGTAGTAGGACAGGGCTCATCAGAGACCAGGTTAGATTACA
CTGGCTTACCCTACAGCAGTTTTCTCCAGGTTTGGCTGAGCCTTTATGCACACCATTGCCCTCT
GCTGGTGGCAGCCGAGATAAGCAAGGACTGAAAATGGATCCTTTCACAAGGCCCTGAAGGTTTT
TTAACTGTTTCAAACTGACTCTGGTTCGTCCGTAACTAACGGATCATGGTGCCTGGTTACACTG
GCTGCCAAGAAGGAGCACATGCAATCTGATTCCGTGTTCTCGTCACATCAGTTTCCTGCCTCCC
TCCCTGATCAGAGGACAGCAGCTTATATCATCGGCCATCCCTGTGGGTCACAAGGTAGCAGCCA
CCAATCAAGTGTATTCCTTGAATTAGCACACCTGGGTGGGCCGTGTGCACACCCAGGACATTGG
TGCTACAGGGAAAGCCAGGCCAGGTTTTCCTCTCCATCTCTTAACCGTCCCTGTCCTTCAGTGA
GAGTGCGGGACTCCAGCTCAGGAGTCTGGGTACCCAGGGGAGCTTAAGGAGCCAGAGAGAGAAG
GAAGTAGCACAAGAATGGAAACAGCCTCCTGCCCTAGAATCCCACACTGCAGGGGGCGCAACTG
AGAAAAAGAACTTCAAGTTGTTAACACTCACGGGCAAGCGAGAGGCACCTTACTGTGGAGGAAA
CAGCCACATCCACAACAGGATGCAATGCTCTATAACTTTTCCTTTAAAGCCGAAAAGCTAGCAT
GTATGCTTGCTGGGCATTTGATCCAGATGTGCTCCGGAGTTCTGAGATTCTTCCATGAAAGGTT
AACTAGAGGCTAGTATATTTTTTATATTTTTGTAACAATTGGCTTTTTTCATGGGGGGTGGGGG
GGTGGAGGTGGAAGAGTTTAGTATTTATAGGCCTAACGAGTCCAATAATTTTTATAAGTGTCTT
CAGACTATGGACAATCCTCCAAATTTTGCAAATGTTTACATGTTTTTTTTTAAGATGATAAATA
CGCTTGATTTGCTTTTTAAATAAAAGTTTTAGCTGTTCTAAGAGATTAACTTCAAGTAGGAATG
AATGCTGGTTATGGTAGTTGGGATTTTCTACAGGTTCTGTTCCCATGCCTTTTCTACGCCGGCC
TCACTCAAGAGCCCTCATGTGGGTGTGGCTGTGAAGCCTGAACAGGCTGGACCTGGACAGCCCC
ACCTCAGAGACATTGTTTCCACTTGGATGTGAGCAGGCACAGGCCTGCCTGCCCTTTGCTACTC
ATCATTATCAGTTCTTCCAGCCTCCTTGGCGTGGGTCCTGGTCATAGCCCTGCTGGGAGGCTCT
GAACAATAAAACATGATCAGCTTGGTCAATAAAATCTAAAAGTTGCGTGGGGCTGAGTATGGTG
GCACACTTTAATCCCAGCACCGGGGAGGCAGAGGCAGCCTGGTGTCTGTGAGTTTGAGTCCTGT
CTGATTTACATAGTAAGACCCTGTCACAACAAAATTGAAAACAACTACAGAAGCAATAAATAGT
TGAGTGGATGTCACTAATTAAA

hide sequence

RefSeq Acc Id:

XM_063278018 ⟹ XP_063134088

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	37,700,028 - 37,733,181 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012057	(Get FASTA)	NCBI Sequence Viewer
	XP_008770627	(Get FASTA)	NCBI Sequence Viewer
	XP_008770628	(Get FASTA)	NCBI Sequence Viewer
	XP_063134088	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP92646	(Get FASTA)	NCBI Sequence Viewer
	EDL87488	(Get FASTA)	NCBI Sequence Viewer
	EDL87489	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069387
	ENSRNOP00000069387.2
	ENSRNOP00000071498.1
	ENSRNOP00000090767
	ENSRNOP00000090767.1
	ENSRNOP00000091514.1
	ENSRNOP00000095516.2
	ENSRNOP00000100936.1

RefSeq Acc Id:

NP_001012057 ⟸ NM_001012057

- UniProtKB:

A0A8I6ARL0 (UniProtKB/TrEMBL), A6KDD7 (UniProtKB/TrEMBL), A0A8I6ACI1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MQRAAVLVRRGSCPRASGPWGRSHSSAAAEASAALKVRPERSPRDRILTLESMNPQVKAVEYAV
RGPIVLKAGEIEMELQRGIKKPFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLNSPSFP
EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDGVPADPDNIYLTTGASDGIST
ILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEDNCWALNVDELRRALRQAKD
HCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLY
QMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAM
DIVVNPPVPGEESFEQFTREKESVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPA
KAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLHKVKD
FHLKFLEKYS

hide sequence

RefSeq Acc Id:	XP_008770628 ⟸ XM_008772406
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ARL0 (UniProtKB/TrEMBL), A6KDD7 (UniProtKB/TrEMBL), A0A8I6ACI1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQRAAVLVRRGSCPRASGPWGRSHSSAAAEASAALKVRPERSPRDRILTLESMNPQVKAVEYAV RGPIVLKAGEIEMELQRGIKKPFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLNSPSFP EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDGVPADPDNIYLTTGASDGIST ILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEDNCWALNVDELRRALRQAKD HCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLY QMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAM DIVVNPPVPGEESFEQFTREKESVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPA KAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLHKVKD FHLKFLEKYS hide sequence

RefSeq Acc Id:	XP_008770627 ⟸ XM_008772405
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ARL0 (UniProtKB/TrEMBL), A6KDD7 (UniProtKB/TrEMBL), A0A8I6ACI1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MQRAAVLVRRGSCPRASGPWGRSHSSAAAEASAALKVRPERSPRDRILTLESMNPQVKAVEYAV RGPIVLKAGEIEMELQRGIKKPFTEVIRANIGDAHAMGQQPITFLRQVMALCTYPNLLNSPSFP EDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAFITRRDGVPADPDNIYLTTGASDGIST ILKLLVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEDNCWALNVDELRRALRQAKD HCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLY QMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAM DIVVNPPVPGEESFEQFTREKESVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPA KAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLHKVKD FHLKFLEKYS hide sequence

Ensembl Acc Id:

ENSRNOP00000069387 ⟸ ENSRNOT00000077275

Ensembl Acc Id:

ENSRNOP00000071498 ⟸ ENSRNOT00000078348

Ensembl Acc Id:

ENSRNOP00000095516 ⟸ ENSRNOT00000115000

Ensembl Acc Id:

ENSRNOP00000091514 ⟸ ENSRNOT00000111228

Ensembl Acc Id:

ENSRNOP00000090767 ⟸ ENSRNOT00000099582

RefSeq Acc Id:	XP_063134088 ⟸ XM_063278018
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ARL0 (UniProtKB/TrEMBL), A6KDD7 (UniProtKB/TrEMBL), A0A8I6ACI1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000100936 ⟸ ENSRNOT00000143312

Protein Domains

Aminotransferase class I/classII large

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TP13-F1-model_v2	AlphaFold	Q7TP13	1-789	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700991

Promoter ID:

EPDNEW_R11514

Type:

initiation region

Name:

Gpt2_1

Description:

glutamic--pyruvic transaminase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	22,632,046 - 22,632,106	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305462	AgrOrtholog
BioCyc Gene	G2FUF-6211	BioCyc
BioCyc Pathway	ALANINE-DEG3-PWY [L-alanine degradation III]	BioCyc
	ALANINE-SYN2-PWY [L-alanine biosynthesis II]	BioCyc
BioCyc Pathway Image	ALANINE-DEG3-PWY	BioCyc
	ALANINE-SYN2-PWY	BioCyc
Ensembl Genes	ENSRNOG00000059579	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000077275	ENTREZGENE
	ENSRNOT00000077275.3	UniProtKB/TrEMBL
	ENSRNOT00000078348.3	UniProtKB/TrEMBL
	ENSRNOT00000099582	ENTREZGENE
	ENSRNOT00000099582.2	UniProtKB/TrEMBL
	ENSRNOT00000111228.2	UniProtKB/TrEMBL
	ENSRNOT00000115000.2	UniProtKB/TrEMBL
	ENSRNOT00000143312.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.1970	UniProtKB/TrEMBL
	3.40.640.10	UniProtKB/TrEMBL
	3.90.1150.10	UniProtKB/TrEMBL
InterPro	ALAT1/2-like	UniProtKB/TrEMBL
	Aminotransferase_I/II	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major_dom	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major_sub1	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major_sub2	UniProtKB/TrEMBL
KEGG Report	rno:307759	UniProtKB/TrEMBL
NCBI Gene	307759	ENTREZGENE
PANTHER	ALANINE AMINOTRANSFERASE 2	UniProtKB/TrEMBL
	PTHR11751	UniProtKB/TrEMBL
Pfam	Aminotran_1_2	UniProtKB/TrEMBL
PhenoGen	Gpt2	PhenoGen
RatGTEx	ENSRNOG00000059579	RatGTEx
Superfamily-SCOP	PyrdxlP-dep_Trfase_major	UniProtKB/TrEMBL
UniProt	A0A0G2JV84_RAT	UniProtKB/TrEMBL
	A0A8I6ACI1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6ARL0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GJ17_RAT	UniProtKB/TrEMBL
	A0ABK0L7X6_RAT	UniProtKB/TrEMBL
	A6KDD7	ENTREZGENE, UniProtKB/TrEMBL
	Q7TP13_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-22	Gpt2	glutamic--pyruvic transaminase 2	Gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	Gpt2_predicted	glutamic pyruvate transaminase (alanine aminotransferase) 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gpt2_predicted	glutamic pyruvate transaminase (alanine aminotransferase) 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways