Lect2 (leukocyte cell-derived chemotaxin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Lect2 (leukocyte cell-derived chemotaxin 2) Rattus norvegicus
Analyze
Symbol: Lect2
Name: leukocyte cell-derived chemotaxin 2
RGD ID: 1305404
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within negative regulation of Wnt signaling pathway. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human LECT2 (leukocyte cell derived chemotaxin 2); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leukocyte cell-derived chemotaxin-2; LOC361205
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,050,034 - 8,056,256 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,050,034 - 8,056,256 (+)EnsemblGRCr8
mRatBN7.2178,044,759 - 8,050,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,044,759 - 8,050,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx178,062,391 - 8,068,753 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,594,151 - 9,600,467 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,058,791 - 8,065,153 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,489,261 - 8,495,483 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,489,266 - 8,495,496 (+)Ensemblrn6Rnor6.0
Rnor_5.01710,665,529 - 10,671,751 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41713,995,034 - 14,001,255 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,138,788 - 8,145,029 (+)NCBICelera
RGSC_v3.11713,995,108 - 14,001,247 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Leukocyte Cell-Derived Chemotaxin 2 Retards Non-Small Cell Lung Cancer Progression Through Antagonizing MET and EGFR Activities. Hung WY, etal., Cell Physiol Biochem. 2018;51(1):337-355. doi: 10.1159/000495233. Epub 2018 Nov 19.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. Okabe H, etal., PLoS One. 2014 Jun 3;9(6):e98817. doi: 10.1371/journal.pone.0098817. eCollection 2014.
5. The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target. Ong HT, etal., Cancer Gene Ther. 2011 Jun;18(6):399-406. doi: 10.1038/cgt.2011.5. Epub 2011 Mar 11.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18644872   PMID:23352894  


Genomics

Comparative Map Data
Lect2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,050,034 - 8,056,256 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,050,034 - 8,056,256 (+)EnsemblGRCr8
mRatBN7.2178,044,759 - 8,050,983 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,044,759 - 8,050,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx178,062,391 - 8,068,753 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,594,151 - 9,600,467 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0178,058,791 - 8,065,153 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,489,261 - 8,495,483 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,489,266 - 8,495,496 (+)Ensemblrn6Rnor6.0
Rnor_5.01710,665,529 - 10,671,751 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41713,995,034 - 14,001,255 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,138,788 - 8,145,029 (+)NCBICelera
RGSC_v3.11713,995,108 - 14,001,247 (+)NCBI
Cytogenetic Map17p14NCBI
LECT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,946,904 - 135,954,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,922,279 - 135,954,983 (-)Ensemblhg38GRCh38
GRCh375135,282,593 - 135,290,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,310,499 - 135,318,622 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345135,310,498 - 135,318,622NCBI
Celera5131,407,331 - 131,415,454 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,471,057 - 130,479,180 (-)NCBIHuRef
CHM1_15134,715,226 - 134,723,349 (-)NCBICHM1_1
T2T-CHM13v2.05136,469,420 - 136,477,479 (-)NCBIT2T-CHM13v2.0
Lect2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,676,772 - 56,696,373 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,690,277 - 56,696,315 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381356,529,734 - 56,548,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,542,464 - 56,548,502 (-)Ensemblmm10GRCm38
MGSCv371356,643,821 - 56,649,899 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361356,552,087 - 56,558,122 (-)NCBIMGSCv36mm8
Celera1357,605,801 - 57,611,881 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.08NCBI
Lect2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540831,016,815 - 31,025,093 (-)Ensembl
ChiLan1.0NW_00495540831,016,955 - 31,068,998 (-)NCBIChiLan1.0ChiLan1.0
LECT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,234,396 - 131,240,247 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,373,956 - 129,379,807 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,338,344 - 131,347,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,478,111 - 137,486,448 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,478,111 - 137,486,448 (-)EnsemblpanPan2panpan1.1
LECT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,864,062 - 23,873,720 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,864,064 - 23,886,226 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1122,611,416 - 22,621,054 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01124,680,617 - 24,690,256 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,680,628 - 24,690,232 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,367,234 - 23,377,059 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,233,917 - 23,243,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,883,268 - 23,892,896 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lect2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213124,025,992 - 124,032,546 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365973,051,143 - 3,057,383 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365973,051,143 - 3,057,383 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LECT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2138,109,351 - 138,124,464 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12138,109,537 - 138,120,285 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,773,984 - 143,784,736 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LECT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,696,216 - 38,705,530 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2338,696,203 - 38,705,087 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603439,205,445 - 39,212,662 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lect2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473311,157,690 - 11,169,912 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473311,158,202 - 11,169,912 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lect2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11481,521,049 - 81,527,686 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lect2
69 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000016252
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
12 8 14 55 83 86 59 19 59 6 196 52 4 37 66 65 27

Sequence


Ensembl Acc Id: ENSRNOT00000016252   ⟹   ENSRNOP00000016252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,050,034 - 8,056,256 (+)Ensembl
mRatBN7.2 Ensembl178,044,759 - 8,050,983 (+)Ensembl
Rnor_6.0 Ensembl178,489,266 - 8,495,496 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098997   ⟹   ENSRNOP00000088602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,050,034 - 8,055,902 (+)Ensembl
mRatBN7.2 Ensembl178,044,759 - 8,050,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118322   ⟹   ENSRNOP00000091813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,044,759 - 8,048,292 (+)Ensembl
RefSeq Acc Id: NM_001108405   ⟹   NP_001101875
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,050,034 - 8,056,256 (+)NCBI
mRatBN7.2178,044,759 - 8,050,983 (+)NCBI
Rnor_6.0178,489,261 - 8,495,483 (+)NCBI
Rnor_5.01710,665,529 - 10,671,751 (+)NCBI
RGSC_v3.41713,995,034 - 14,001,255 (+)RGD
Celera178,138,788 - 8,145,029 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101875 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016252
  ENSRNOP00000016252.5
  ENSRNOP00000088602.1
RefSeq Acc Id: NP_001101875   ⟸   NM_001108405
- Peptide Label: precursor
- UniProtKB: D4A526 (UniProtKB/TrEMBL),   A6KAM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016252   ⟸   ENSRNOT00000016252
Ensembl Acc Id: ENSRNOP00000091813   ⟸   ENSRNOT00000118322
Ensembl Acc Id: ENSRNOP00000088602   ⟸   ENSRNOT00000098997

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A526-F1-model_v2 AlphaFold D4A526 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700287
Promoter ID:EPDNEW_R10810
Type:initiation region
Name:Lect2_1
Description:leukocyte cell-derived chemotaxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,489,345 - 8,489,405EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305404 AgrOrtholog
BioCyc Gene G2FUF-10268 BioCyc
Ensembl Genes ENSRNOG00000012189 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016252 ENTREZGENE
  ENSRNOT00000016252.8 UniProtKB/TrEMBL
  ENSRNOT00000098997.2 UniProtKB/TrEMBL
Gene3D-CATH 2.70.70.10 UniProtKB/TrEMBL
InterPro Dup_hybrid_motif UniProtKB/TrEMBL
  LECT2 UniProtKB/TrEMBL
  LECT2_chordata UniProtKB/TrEMBL
KEGG Report rno:361205 UniProtKB/TrEMBL
NCBI Gene 361205 ENTREZGENE
PANTHER LECT2 UniProtKB/TrEMBL
  LEUKOCYTE CELL-DERIVED CHEMOTAXIN-2 UniProtKB/TrEMBL
PhenoGen Lect2 PhenoGen
PIRSF LECT3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012189 RatGTEx
UniProt A0A8I6AA90_RAT UniProtKB/TrEMBL
  A6KAM7 ENTREZGENE, UniProtKB/TrEMBL
  D4A526 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Lect2  leukocyte cell-derived chemotaxin 2   Lect2_predicted  leukocyte cell-derived chemotaxin 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lect2_predicted  leukocyte cell-derived chemotaxin 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED