Commd8 (COMM domain containing 8) - Rat Genome Database

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Gene: Commd8 (COMM domain containing 8) Rattus norvegicus
Analyze
Symbol: Commd8
Name: COMM domain containing 8
RGD ID: 1305402
Description: Predicted to enable NF-kappaB binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol and nucleoplasm. Orthologous to human COMMD8 (COMM domain containing 8); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COMM domain-containing protein 8; LOC289603
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,403,000 - 36,413,577 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1436,403,022 - 36,413,574 (+)EnsemblGRCr8
mRatBN7.21436,049,040 - 36,059,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,049,004 - 36,059,617 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1436,384,743 - 36,395,287 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,689,505 - 37,700,049 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01436,177,839 - 36,188,383 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,612,408 - 38,622,586 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,612,408 - 38,622,580 (+)Ensemblrn6Rnor6.0
Rnor_5.01438,422,179 - 38,432,357 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41438,498,899 - 38,509,474 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1435,279,249 - 35,289,802 (+)NCBICelera
RGSC_v3.11438,501,291 - 38,511,889 (+)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Commd8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81436,403,000 - 36,413,577 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1436,403,022 - 36,413,574 (+)EnsemblGRCr8
mRatBN7.21436,049,040 - 36,059,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1436,049,004 - 36,059,617 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1436,384,743 - 36,395,287 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01437,689,505 - 37,700,049 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01436,177,839 - 36,188,383 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01438,612,408 - 38,622,586 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1438,612,408 - 38,622,580 (+)Ensemblrn6Rnor6.0
Rnor_5.01438,422,179 - 38,432,357 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41438,498,899 - 38,509,474 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1435,279,249 - 35,289,802 (+)NCBICelera
RGSC_v3.11438,501,291 - 38,511,889 (+)NCBI
Cytogenetic Map14p11NCBI
COMMD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38447,450,787 - 47,463,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl447,450,787 - 47,463,730 (-)Ensemblhg38GRCh38
GRCh37447,452,804 - 47,465,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36447,147,567 - 47,160,433 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34447,293,742 - 47,306,604NCBI
Celera447,901,361 - 47,914,236 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef446,772,235 - 46,785,168 (-)NCBIHuRef
CHM1_1447,451,829 - 47,464,690 (-)NCBICHM1_1
T2T-CHM13v2.0447,418,136 - 47,431,052 (-)NCBIT2T-CHM13v2.0
Commd8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39572,313,919 - 72,325,532 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl572,313,918 - 72,325,532 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38572,156,576 - 72,168,189 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl572,156,575 - 72,168,189 (-)Ensemblmm10GRCm38
MGSCv37572,548,239 - 72,559,422 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36572,436,135 - 72,447,318 (-)NCBIMGSCv36mm8
Celera569,410,075 - 69,421,258 (-)NCBICelera
Cytogenetic Map5C3.2NCBI
cM Map538.44NCBI
Commd8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554431,098,053 - 1,108,873 (+)Ensembl
ChiLan1.0NW_0049554431,098,053 - 1,108,873 (+)NCBIChiLan1.0ChiLan1.0
COMMD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2380,401,277 - 80,414,858 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1480,663,008 - 80,676,498 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0474,689,453 - 74,702,999 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1485,420,983 - 85,434,509 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl485,420,983 - 85,434,509 (+)EnsemblpanPan2panpan1.1
COMMD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11343,368,541 - 43,383,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1343,369,173 - 43,383,094 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1343,318,688 - 43,333,321 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01343,973,614 - 43,988,232 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1343,973,614 - 43,988,189 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11343,653,000 - 43,667,631 (-)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.01344,067,936 - 44,082,553 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Commd8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528532,683,424 - 32,695,345 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648213,599,479 - 13,614,819 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648213,602,221 - 13,614,776 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COMMD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl837,334,476 - 37,380,253 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1837,344,708 - 37,380,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2839,289,168 - 39,302,677 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COMMD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1272,792,932 - 2,805,804 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl272,792,995 - 2,805,136 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604748,834,091 - 48,846,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Commd8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476119,563,208 - 19,574,769 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476119,564,060 - 19,576,418 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Commd8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11128,979,103 - 28,989,576 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Commd8
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:433
Count of miRNA genes:251
Interacting mature miRNAs:303
Transcripts:ENSRNOT00000059516
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
RH133620  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21436,059,204 - 36,059,420 (+)MAPPERmRatBN7.2
Rnor_6.01438,622,198 - 38,622,413NCBIRnor6.0
Rnor_5.01438,431,969 - 38,432,184UniSTSRnor5.0
RGSC_v3.41438,509,086 - 38,509,301UniSTSRGSC3.4
Celera1435,289,414 - 35,289,629UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000059516   ⟹   ENSRNOP00000056274
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1436,403,022 - 36,413,574 (+)Ensembl
mRatBN7.2 Ensembl1436,049,004 - 36,059,617 (+)Ensembl
Rnor_6.0 Ensembl1438,612,408 - 38,622,580 (+)Ensembl
RefSeq Acc Id: NM_001106004   ⟹   NP_001099474
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,403,000 - 36,413,553 (+)NCBI
mRatBN7.21436,049,040 - 36,059,593 (+)NCBI
Rnor_6.01438,612,408 - 38,622,586 (+)NCBI
Rnor_5.01438,422,179 - 38,432,357 (+)NCBI
RGSC_v3.41438,498,899 - 38,509,474 (+)RGD
Celera1435,279,249 - 35,289,802 (+)RGD
Sequence:
RefSeq Acc Id: XM_039091711   ⟹   XP_038947639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81436,406,803 - 36,413,577 (+)NCBI
mRatBN7.21436,049,054 - 36,059,617 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099474 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947639 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI59415 (Get FASTA)   NCBI Sequence Viewer  
  EDL90001 (Get FASTA)   NCBI Sequence Viewer  
  EDL90002 (Get FASTA)   NCBI Sequence Viewer  
  EDL90003 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056274.3
RefSeq Acc Id: NP_001099474   ⟸   NM_001106004
- UniProtKB: B0K015 (UniProtKB/TrEMBL),   F7EMP1 (UniProtKB/TrEMBL),   A6JD80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056274   ⟸   ENSRNOT00000059516
RefSeq Acc Id: XP_038947639   ⟸   XM_039091711
- Peptide Label: isoform X1
- UniProtKB: A6JD81 (UniProtKB/TrEMBL)
Protein Domains
COMM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0K015-F1-model_v2 AlphaFold B0K015 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699302
Promoter ID:EPDNEW_R9827
Type:multiple initiation site
Name:Commd8_1
Description:COMM domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01438,612,408 - 38,612,468EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305402 AgrOrtholog
BioCyc Gene G2FUF-15843 BioCyc
Ensembl Genes ENSRNOG00000002320 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059516.4 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8368074 IMAGE-MGC_LOAD
InterPro COMM UniProtKB/TrEMBL
  COMMD4/6/7/8 UniProtKB/TrEMBL
  COMMD8 UniProtKB/TrEMBL
  COMMD8_HN UniProtKB/TrEMBL
KEGG Report rno:289603 UniProtKB/TrEMBL
MGC_CLONE MGC:188697 IMAGE-MGC_LOAD
NCBI Gene 289603 ENTREZGENE
PANTHER COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER UniProtKB/TrEMBL
  COMM DOMAIN-CONTAINING PROTEIN 8 UniProtKB/TrEMBL
Pfam COMMD8_HN UniProtKB/TrEMBL
  HCaRG UniProtKB/TrEMBL
PhenoGen Commd8 PhenoGen
PROSITE COMM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002320 RatGTEx
UniProt A6JD80 ENTREZGENE, UniProtKB/TrEMBL
  A6JD81 ENTREZGENE, UniProtKB/TrEMBL
  B0K015 ENTREZGENE, UniProtKB/TrEMBL
  F7EMP1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Commd8  COMM domain containing 8   Commd8_predicted  COMM domain containing 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Commd8_predicted  COMM domain containing 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED