Adam33 (ADAM metallopeptidase domain 33) - Rat Genome Database

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Gene: Adam33 (ADAM metallopeptidase domain 33) Rattus norvegicus
Analyze
Symbol: Adam33
Name: ADAM metallopeptidase domain 33
RGD ID: 1305278
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and rhinitis. Orthologous to human ADAM33 (ADAM metallopeptidase domain 33); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 33; a disintegrin and metalloprotease domain 33; disintegrin and metalloproteinase domain-containing protein 33; LOC311425
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,715,428 - 138,736,392 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,724,046 - 138,736,347 (-)EnsemblGRCr8
mRatBN7.23118,262,395 - 118,283,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,271,029 - 118,283,461 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,165,309 - 122,177,628 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,764,513 - 130,776,826 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,421,421 - 128,433,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,595,018 - 123,607,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,595,560 - 123,607,352 (-)Ensemblrn6Rnor6.0
Rnor_5.03130,094,363 - 130,106,835 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,727,883 - 118,752,218 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,080,790 - 117,093,950 (-)NCBICelera
RGSC_v3.13118,633,395 - 118,670,271 (-)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen. Cheng L, etal., Clin Exp Allergy. 2004 Aug;34(8):1192-201.
3. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. Foley SC, etal., J Allergy Clin Immunol. 2007 Apr;119(4):863-71. Epub 2007 Mar 6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation. Jie Z, etal., Respir Physiol Neurobiol. 2009 Sep 30;168(3):289-94. Epub 2009 Jul 25.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. ADAM33 gene polymorphisms in chronic obstructive pulmonary disease. Pabst S, etal., Eur J Med Res. 2009 Dec 7;14 Suppl 4:182-6.
9. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases Qiu YM, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2007 Jul;30(7):518-21.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Sadeghnejad A, etal., Respir Res. 2009 Mar 12;10:21.
14. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
15. Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. Su D, etal., BMC Med Genet. 2008 Sep 9;9:82.
16. A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia. Vergara CI, etal., Int Arch Allergy Immunol. 2010;152(1):32-40. Epub 2009 Nov 24.
17. Lack of association between ADAM33 gene and asthma in a Chinese population. Wang P, etal., Int J Immunogenet. 2006 Aug;33(4):303-6.
18. Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. Wang X, etal., BMC Med Genet. 2009 Dec 10;10:132.
Additional References at PubMed
PMID:8889548   PMID:23934418   PMID:27720670  


Genomics

Comparative Map Data
Adam33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,715,428 - 138,736,392 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,724,046 - 138,736,347 (-)EnsemblGRCr8
mRatBN7.23118,262,395 - 118,283,456 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,271,029 - 118,283,461 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,165,309 - 122,177,628 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,764,513 - 130,776,826 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,421,421 - 128,433,740 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,595,018 - 123,607,549 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,595,560 - 123,607,352 (-)Ensemblrn6Rnor6.0
Rnor_5.03130,094,363 - 130,106,835 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,727,883 - 118,752,218 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,080,790 - 117,093,950 (-)NCBICelera
RGSC_v3.13118,633,395 - 118,670,271 (-)NCBI
Cytogenetic Map3q36NCBI
ADAM33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,667,975 - 3,682,010 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,667,962 - 3,682,246 (-)Ensemblhg38GRCh38
GRCh37203,648,622 - 3,662,657 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,596,620 - 3,610,738 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34203,596,620 - 3,610,738NCBI
Celera203,710,486 - 3,724,619 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,596,952 - 3,611,071 (-)NCBIHuRef
CHM1_1203,648,928 - 3,663,053 (-)NCBICHM1_1
T2T-CHM13v2.0203,698,909 - 3,712,954 (-)NCBIT2T-CHM13v2.0
Adam33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,892,739 - 130,905,734 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,892,511 - 130,905,734 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382131,050,819 - 131,063,814 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,050,591 - 131,063,814 (-)Ensemblmm10GRCm38
MGSCv372130,876,553 - 130,889,550 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362130,742,550 - 130,755,255 (-)NCBIMGSCv36mm8
Celera2132,275,541 - 132,288,553 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.26NCBI
Adam33
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,524,354 - 14,533,700 (-)Ensembl
ChiLan1.0NW_00495541514,523,517 - 14,535,701 (-)NCBIChiLan1.0ChiLan1.0
ADAM33
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,631,265 - 4,645,369 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,628,093 - 4,642,173 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,750,158 - 3,764,262 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,507,630 - 3,521,720 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,508,620 - 3,521,628 (-)EnsemblpanPan2panpan1.1
ADAM33
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,668,377 - 17,682,217 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,668,500 - 17,681,209 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2417,489,886 - 17,512,110 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02418,080,386 - 18,101,065 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,086,847 - 18,100,334 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,673,802 - 17,695,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,793,269 - 17,807,567 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,113,989 - 18,134,652 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Adam33
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,573,648 - 166,587,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648515,007,485 - 15,017,497 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648515,005,329 - 15,018,063 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM33
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,023,091 - 32,037,880 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11732,023,102 - 32,038,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,350,589 - 36,365,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,352,514 - 34,366,694 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,353,505 - 34,366,559 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607110,083,660 - 10,097,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam33
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,766,306 - 4,775,501 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247414,764,508 - 4,778,174 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Adam33
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15110,787,667 - 110,799,663 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Adam33
198 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:99
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000028854, ENSRNOT00000051404
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Mgh15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83138,728,542 - 138,728,660 (+)Marker Load Pipeline
mRatBN7.23118,275,508 - 118,275,626 (+)MAPPERmRatBN7.2
Rnor_6.03123,599,592 - 123,599,709NCBIRnor6.0
Rnor_5.03130,098,937 - 130,099,054UniSTSRnor5.0
RGSC_v3.43118,756,978 - 118,757,096RGDRGSC3.4
RGSC_v3.43118,732,359 - 118,732,477RGDRGSC3.4
RGSC_v3.43118,756,979 - 118,757,096UniSTSRGSC3.4
RGSC_v3.43118,732,360 - 118,732,477UniSTSRGSC3.4
Celera3117,085,365 - 117,085,482UniSTS
RGSC_v3.13118,662,552 - 118,662,669RGD
RH 3.4 Map31013.0UniSTS
RH 3.4 Map31013.0RGD
RH 2.0 Map3691.0RGD
SHRSP x BN Map357.4399RGD
Cytogenetic Map3q36UniSTS
BF386688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,271,022 - 118,271,180 (+)MAPPERmRatBN7.2
Rnor_6.03123,595,106 - 123,595,263NCBIRnor6.0
Rnor_5.03130,094,451 - 130,094,608UniSTSRnor5.0
RGSC_v3.43118,727,874 - 118,728,031UniSTSRGSC3.4
Celera3117,080,878 - 117,081,035UniSTS
RH 3.4 Map31013.1UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 66 135 91 90 59 29 59 6 286 128 11 114 78 92 31 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000028854   ⟹   ENSRNOP00000028854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,724,929 - 138,736,347 (-)Ensembl
mRatBN7.2 Ensembl3118,271,477 - 118,283,296 (-)Ensembl
Rnor_6.0 Ensembl3123,595,560 - 123,607,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051404   ⟹   ENSRNOP00000040646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,724,046 - 138,736,347 (-)Ensembl
mRatBN7.2 Ensembl3118,271,477 - 118,283,296 (-)Ensembl
Rnor_6.0 Ensembl3123,595,560 - 123,607,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109257   ⟹   ENSRNOP00000082476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3118,271,029 - 118,283,461 (-)Ensembl
RefSeq Acc Id: NM_001395113   ⟹   NP_001382042
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,724,046 - 138,736,347 (-)NCBI
mRatBN7.23118,271,012 - 118,283,313 (-)NCBI
RefSeq Acc Id: XR_005501875
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,724,062 - 138,736,372 (-)NCBI
mRatBN7.23118,271,031 - 118,283,456 (-)NCBI
RefSeq Acc Id: XR_005501876
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,718,248 - 138,736,372 (-)NCBI
mRatBN7.23118,265,226 - 118,283,456 (-)NCBI
RefSeq Acc Id: XR_005501877
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,715,428 - 138,736,372 (-)NCBI
mRatBN7.23118,262,395 - 118,283,456 (-)NCBI
RefSeq Acc Id: XR_005501878
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,715,428 - 138,736,372 (-)NCBI
mRatBN7.23118,262,395 - 118,283,456 (-)NCBI
RefSeq Acc Id: XR_005501879
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,724,062 - 138,736,376 (-)NCBI
mRatBN7.23118,271,012 - 118,283,456 (-)NCBI
RefSeq Acc Id: XR_005501880
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,726,238 - 138,736,376 (-)NCBI
mRatBN7.23118,273,204 - 118,283,340 (-)NCBI
RefSeq Acc Id: XR_005501881
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,726,843 - 138,736,392 (-)NCBI
mRatBN7.23118,273,636 - 118,283,366 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80219 (Get FASTA)   NCBI Sequence Viewer  
  EDL80220 (Get FASTA)   NCBI Sequence Viewer  
  EDL80221 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028854.8
  ENSRNOP00000040646
  ENSRNOP00000040646.6
Ensembl Acc Id: ENSRNOP00000040646   ⟸   ENSRNOT00000051404
Ensembl Acc Id: ENSRNOP00000028854   ⟸   ENSRNOT00000028854
Ensembl Acc Id: ENSRNOP00000082476   ⟸   ENSRNOT00000109257
RefSeq Acc Id: NP_001382042   ⟸   NM_001395113
- Peptide Label: precursor
- UniProtKB: F1M8J6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8J6-F1-model_v2 AlphaFold F1M8J6 1-796 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692450
Promoter ID:EPDNEW_R2967
Type:initiation region
Name:Adam33_1
Description:ADAM metallopeptidase domain 33
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,607,361 - 123,607,421EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305278 AgrOrtholog
BioCyc Gene G2FUF-47831 BioCyc
Ensembl Genes ENSRNOG00000021242 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028854.8 UniProtKB/TrEMBL
  ENSRNOT00000051404 ENTREZGENE
  ENSRNOT00000051404.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene 311425 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 33 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam33 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021242 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt F1M1Q3_RAT UniProtKB/TrEMBL
  F1M8J6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adam33  ADAM metallopeptidase domain 33  Adam33  a disintegrin and metallopeptidase domain 33   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Adam33  a disintegrin and metallopeptidase domain 33   Adam33_predicted  a disintegrin and metallopeptidase domain 33 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Adam33_predicted  a disintegrin and metallopeptidase domain 33 (predicted)    a disintegrin and metalloprotease domain 33 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Adam33_predicted  a disintegrin and metalloprotease domain 33 (predicted)      Symbol and Name status set to approved 70820 APPROVED