Irgm (immunity-related GTPase M) - Rat Genome Database

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Gene: Irgm (immunity-related GTPase M) Rattus norvegicus
Analyze
Symbol: Irgm
Name: immunity-related GTPase M
RGD ID: 1305163
Description: Predicted to enable several functions, including G protein activity; anion binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including positive regulation of leukocyte activation; positive regulation of macroautophagy; and regulation of defense response. Predicted to act upstream of or within several processes, including innate immune response; regulation of innate immune response; and regulation of protein localization to nucleus. Predicted to be located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and vacuole. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and mitochondrial membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ifggd3; Ifi1; immunity-related GTPase family M protein; immunity-related GTPase family, M; interferon inducible protein 1; interferon-gamma-inducible GTPase Ifggd3 protein; LOC303090
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,734,640 - 33,742,720 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1033,732,961 - 33,743,228 (-)EnsemblGRCr8
mRatBN7.21033,233,513 - 33,241,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,233,455 - 33,241,578 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1037,913,410 - 37,921,342 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,451,824 - 6,459,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,907,048 - 32,914,980 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,213,885 - 34,221,968 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,213,936 - 34,221,928 (-)Ensemblrn6Rnor6.0
Rnor_5.01033,997,565 - 34,005,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41034,132,512 - 34,140,450 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1032,619,552 - 32,627,490 (-)NCBICelera
RGSC_v3.11034,133,560 - 34,141,499 (-)NCBI
Cytogenetic Map10q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,2-dimethylhydrazine  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alpha-phellandrene  (ISO)
Aroclor 1254  (ISO)
Bavachinin  (ISO)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
ciguatoxin CTX1B  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hexaconazole  (ISO)
indole-3-methanol  (EXP)
lipopolysaccharide  (ISO)
metam  (ISO)
nefazodone  (EXP)
nevirapine  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 203580  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagosome assembly  (IBA,IEA,ISO)
autophagosome maturation  (IEA,ISO,ISS)
autophagy  (IEA)
CAMKK-AMPK signaling cascade  (ISO)
cellular response to interferon-beta  (IBA)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (ISO)
defense response  (ISO)
defense response to bacterium  (IEA,ISO,ISS)
defense response to Gram-negative bacterium  (ISO)
immune system process  (IEA)
innate immune response  (IBA,IEA,ISO,ISS)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cGAS/STING signaling pathway  (ISO)
negative regulation of defense response to virus  (IEA,ISO,ISS)
negative regulation of hematopoietic stem cell proliferation  (IEA,ISO,ISS)
negative regulation of inflammatory response  (IEA,ISO,ISS)
negative regulation of NLRP3 inflammasome complex assembly  (IEA,ISO,ISS)
negative regulation of type I interferon production  (IEA,ISO,ISS)
negative regulation of type II interferon production  (IEA,ISO,ISS)
nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of autophagosome maturation  (IEA,ISO)
positive regulation of autophagy  (IEA,ISO,ISS)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO,ISS)
positive regulation of lysosome organization  (ISO)
positive regulation of macrophage activation  (IEA,ISO,ISS)
positive regulation of mitochondrial fission  (ISO)
positive regulation of mitophagy  (IEA,ISO,ISS)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of type II interferon-mediated signaling pathway  (IEA,ISO)
positive regulation of xenophagy  (ISO)
protein destabilization  (ISO)
protein lipidation involved in autophagosome assembly  (ISO)
protein stabilization  (ISO)
protein targeting to vacuole involved in autophagy  (ISO)
protein-containing complex assembly  (ISO)
regulation of mitochondrial fission  (IEA,ISO,ISS)
regulation of protein complex stability  (ISO)
regulation of protein-containing complex assembly  (ISO)
response to bacterium  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11457893   PMID:12477932   PMID:16888103   PMID:19144319   PMID:20072621   PMID:22892676   PMID:23012479   PMID:25891078   PMID:28389568  


Genomics

Comparative Map Data
Irgm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81033,734,640 - 33,742,720 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1033,732,961 - 33,743,228 (-)EnsemblGRCr8
mRatBN7.21033,233,513 - 33,241,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1033,233,455 - 33,241,578 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1037,913,410 - 37,921,342 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0106,451,824 - 6,459,756 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01032,907,048 - 32,914,980 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01034,213,885 - 34,221,968 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1034,213,936 - 34,221,928 (-)Ensemblrn6Rnor6.0
Rnor_5.01033,997,565 - 34,005,641 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41034,132,512 - 34,140,450 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1032,619,552 - 32,627,490 (-)NCBICelera
RGSC_v3.11034,133,560 - 34,141,499 (-)NCBI
Cytogenetic Map10q21NCBI
IRGM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,846,521 - 150,902,402 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5150,846,521 - 150,900,736 (+)Ensemblhg38GRCh38
GRCh375150,226,083 - 150,281,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,207,879 - 150,208,424 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5146,307,411 - 146,309,557 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,371,946 - 145,374,092 (+)NCBIHuRef
CHM1_15149,658,892 - 149,661,038 (+)NCBICHM1_1
T2T-CHM13v2.05151,383,019 - 151,438,900 (+)NCBIT2T-CHM13v2.0
Irgm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391148,756,072 - 48,762,247 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1148,752,795 - 48,762,510 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381148,865,245 - 48,871,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1148,861,968 - 48,871,683 (-)Ensemblmm10GRCm38
MGSCv371148,678,751 - 48,684,848 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361148,708,672 - 48,714,769 (-)NCBIMGSCv36mm8
Celera1153,447,611 - 53,453,702 (-)NCBICelera
Cytogenetic Map11B1.2NCBI
cM Map1128.84NCBI
Irgm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,312,059 - 2,344,362 (+)Ensembl
ChiLan1.0NW_0049554082,338,510 - 2,344,566 (+)NCBIChiLan1.0ChiLan1.0
IRGM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,078,470 - 146,134,350 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,218,016 - 144,273,896 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,274,097 - 146,329,979 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,276,981 - 152,332,575 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5152,278,581 - 152,308,182 (+)EnsemblpanPan2panpan1.1
LOC606863
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.111506,981 - 523,338 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl11509,636 - 510,829 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha11568,312 - 569,505 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.011470,804 - 485,519 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.111443,994 - 445,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.011531,575 - 532,768 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.011692,999 - 694,192 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101972667
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213142,480,944 - 142,493,084 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365044,055,091 - 4,056,089 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRGM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,449,576 - 53,451,373 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,239,475 - 24,271,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irgm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473341,241,488 - 41,248,162 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Irgm
108 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:162
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000045545
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH131017  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21033,233,683 - 33,233,865 (+)MAPPERmRatBN7.2
Rnor_6.01034,214,060 - 34,214,241NCBIRnor6.0
Rnor_5.01033,997,736 - 33,997,917UniSTSRnor5.0
RGSC_v3.41034,132,683 - 34,132,864UniSTSRGSC3.4
Celera1032,619,723 - 32,619,904UniSTS
RH 3.4 Map10347.1UniSTS
Cytogenetic Map10q21UniSTS
RH133553  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10345.1UniSTS
Cytogenetic Map10q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 355 192 11 139 80 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000045545   ⟹   ENSRNOP00000047579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1033,734,641 - 33,742,578 (-)Ensembl
mRatBN7.2 Ensembl1033,233,514 - 33,241,451 (-)Ensembl
Rnor_6.0 Ensembl1034,213,936 - 34,221,928 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106065   ⟹   ENSRNOP00000094495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1033,734,632 - 33,743,228 (-)Ensembl
mRatBN7.2 Ensembl1033,233,455 - 33,241,578 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000127882   ⟹   ENSRNOP00000099006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1033,732,961 - 33,742,720 (-)Ensembl
RefSeq Acc Id: NM_001012007   ⟹   NP_001012007
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,734,640 - 33,742,578 (-)NCBI
mRatBN7.21033,233,513 - 33,241,451 (-)NCBI
Rnor_6.01034,213,889 - 34,221,827 (-)NCBI
Rnor_5.01033,997,565 - 34,005,641 (-)NCBI
RGSC_v3.41034,132,512 - 34,140,450 (-)RGD
Celera1032,619,552 - 32,627,490 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246178   ⟹   XP_006246240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,734,640 - 33,742,720 (-)NCBI
mRatBN7.21033,233,513 - 33,241,594 (-)NCBI
Rnor_6.01034,213,885 - 34,221,968 (-)NCBI
Rnor_5.01033,997,565 - 34,005,641 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246179   ⟹   XP_006246241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81033,734,640 - 33,742,710 (-)NCBI
mRatBN7.21033,233,513 - 33,241,594 (-)NCBI
Rnor_6.01034,213,885 - 34,221,968 (-)NCBI
Rnor_5.01033,997,565 - 34,005,641 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001012007   ⟸   NM_001012007
- UniProtKB: Q6AYC2 (UniProtKB/Swiss-Prot),   A6HDU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246241   ⟸   XM_006246179
- Peptide Label: isoform X2
- UniProtKB: J7NUQ1 (UniProtKB/TrEMBL),   A0A8I6AM97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246240   ⟸   XM_006246178
- Peptide Label: isoform X1
- UniProtKB: Q6AYC2 (UniProtKB/Swiss-Prot),   A6HDU6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047579   ⟸   ENSRNOT00000045545
Ensembl Acc Id: ENSRNOP00000094495   ⟸   ENSRNOT00000106065
Ensembl Acc Id: ENSRNOP00000099006   ⟸   ENSRNOT00000127882
Protein Domains
IRG-type G

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYC2-F1-model_v2 AlphaFold Q6AYC2 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697135
Promoter ID:EPDNEW_R7660
Type:initiation region
Name:Irgm_2
Description:immunity-related GTPase M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7661  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,221,810 - 34,221,870EPDNEW
RGD ID:13697136
Promoter ID:EPDNEW_R7661
Type:single initiation site
Name:Irgm_1
Description:immunity-related GTPase M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7660  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01034,221,971 - 34,222,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305163 AgrOrtholog
BioCyc Gene G2FUF-25326 BioCyc
Ensembl Genes ENSRNOG00000031138 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045545 ENTREZGENE
  ENSRNOT00000045545.4 UniProtKB/Swiss-Prot
  ENSRNOT00000127882 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7125255 IMAGE-MGC_LOAD
InterPro G_IRG_dom UniProtKB/Swiss-Prot
  Immunity-related_GTPase-like UniProtKB/Swiss-Prot
  IRG UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:303090 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94096 IMAGE-MGC_LOAD
NCBI Gene 303090 ENTREZGENE
PANTHER IMMUNITY-RELATED GTPASE FAMILY M PROTEIN UniProtKB/Swiss-Prot
  INTERFERON-INDUCIBLE GTPASE UniProtKB/Swiss-Prot
Pfam IIGP UniProtKB/Swiss-Prot
PhenoGen Irgm PhenoGen
PROSITE G_IRG UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031138 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6AM97 ENTREZGENE, UniProtKB/TrEMBL
  A6HDU6 ENTREZGENE, UniProtKB/TrEMBL
  IRGM_RAT UniProtKB/Swiss-Prot
  J7NUQ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYC2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Irgm  immunity-related GTPase M  Irgm  immunity-related GTPase family, M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Irgm  immunity-related GTPase family, M  Ifi1  interferon inducible protein 1  Symbol and Name updated 1299863 APPROVED
2005-12-06 Ifi1  interferon inducible protein 1  Ifi1_predicted  interferon inducible protein 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ifi1_predicted  interferon inducible protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED