Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Srpk2 | Rat | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SRPK2 mRNA | CTD | PMID:22079256 | Srpk2 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of SRPK2 mRNA | CTD | PMID:22206623 | Srpk2 | Rat | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRPK2 mRNA | CTD | PMID:15329391 | Srpk2 | Rat | 14-Deoxy-11,12-didehydroandrographolide | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | 14-deoxy-11,12-didehydroandrographolide results in increased expression of SRPK2 mRNA | CTD | PMID:22101062 | Srpk2 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of SRPK2 mRNA | CTD | PMID:32145629 | Srpk2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SRPK2 mRNA | CTD | PMID:34747641 | Srpk2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of SRPK2 mRNA | CTD | PMID:21346803 | Srpk2 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of SRPK2 mRNA | CTD | PMID:21346803 | Srpk2 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of SRPK2 mRNA | CTD | PMID:39298647 | Srpk2 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Srpk2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of SRPK2 gene | CTD | PMID:31683443 | Srpk2 | Rat | 4-hydroxynon-2-enal | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | 4-hydroxy-2-nonenal results in increased expression of SRPK2 mRNA | CTD | PMID:19191707 | Srpk2 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of SRPK2 mRNA | CTD | PMID:28973697 | Srpk2 | Rat | aflatoxin B1 | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of SRPK2 mRNA | CTD | PMID:19770486 | Srpk2 | Rat | all-trans-retinoic acid | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Tretinoin results in decreased expression of SRPK2 mRNA | CTD | PMID:16788091 | Srpk2 | Rat | all-trans-retinoic acid | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [sodium arsenite co-treated with Tretinoin] results in increased expression of SRPK2 protein | CTD | PMID:39571964 | Srpk2 | Rat | antirheumatic drug | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SRPK2 mRNA | CTD | PMID:24449571 | Srpk2 | Rat | aristolochic acid A | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SRPK2 mRNA | CTD | PMID:33212167 | Srpk2 | Rat | arsane | affects methylation | ISO | SRPK2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SRPK2 gene | CTD | PMID:25304211 | Srpk2 | Rat | arsane | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Srpk2 | Rat | arsenic atom | affects methylation | ISO | SRPK2 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SRPK2 gene | CTD | PMID:25304211 | Srpk2 | Rat | arsenic atom | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Srpk2 | Rat | arsenite(3-) | decreases methylation | ISO | SRPK2 (Homo sapiens) | 6480464 | arsenite results in decreased methylation of SRPK2 promoter | CTD | PMID:23974009 | Srpk2 | Rat | arsenite(3-) | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | arsenite results in decreased expression of SRPK2 protein | CTD | PMID:37955338 | Srpk2 | Rat | benzo[a]pyrene | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SRPK2 mRNA | CTD | PMID:20064835|PMID:20106945 | Srpk2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SRPK2 mRNA | CTD | PMID:19150397 | Srpk2 | Rat | bis(2-chloroethyl) sulfide | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Mustard Gas results in decreased expression of SRPK2 mRNA | CTD | PMID:15674843 | Srpk2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SRPK2 mRNA | CTD | PMID:25181051 | Srpk2 | Rat | bisphenol A | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of SRPK2 gene | CTD | PMID:31601247 | Srpk2 | Rat | bisphenol A | decreases methylation | ISO | SRPK2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of SRPK2 gene | CTD | PMID:31601247 | Srpk2 | Rat | bisphenol A | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SRPK2 mRNA | CTD | PMID:33221593 | Srpk2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SRPK2 mRNA | CTD | PMID:30816183|PMID:32145629|PMID:32528016|PMID:34947998|PMID:41034487 | Srpk2 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SRPK2 gene | CTD | PMID:28505145 | Srpk2 | Rat | bisphenol A | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SRPK2 mRNA | CTD | PMID:25594700 | Srpk2 | Rat | bisphenol F | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of SRPK2 mRNA | CTD | PMID:38685157 | Srpk2 | Rat | Butylbenzyl phthalate | increases methylation | ISO | Srpk2 (Mus musculus) | 6480464 | butylbenzyl phthalate results in increased methylation of SRPK2 intron | CTD | PMID:28392331 | Srpk2 | Rat | butyric acid | affects localization | ISO | SRPK2 (Homo sapiens) | 6480464 | Butyric Acid affects the localization of SRPK2 protein | CTD | PMID:21555914 | Srpk2 | Rat | cadmium atom | multiple interactions | ISO | Srpk2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SRPK2 more ... | CTD | PMID:28111341 | Srpk2 | Rat | cadmium dichloride | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SRPK2 mRNA | CTD | PMID:26472689 | Srpk2 | Rat | cadmium dichloride | multiple interactions | ISO | Srpk2 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SRPK2 more ... | CTD | PMID:28111341 | Srpk2 | Rat | caffeine | increases phosphorylation | ISO | SRPK2 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of SRPK2 protein | CTD | PMID:35688186 | Srpk2 | Rat | carbon nanotube | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Nanotubes, Carbon results in decreased expression of SRPK2 mRNA | CTD | PMID:25554681 | Srpk2 | Rat | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of SRPK2 mRNA | CTD | PMID:23125180 | Srpk2 | Rat | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of SRPK2 mRNA | CTD | PMID:18668222 | Srpk2 | Rat | chlorpyrifos | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SRPK2 mRNA | CTD | PMID:37019170 | Srpk2 | Rat | ciguatoxin CTX1B | affects expression | ISO | Srpk2 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of SRPK2 mRNA | CTD | PMID:18353800 | Srpk2 | Rat | cisplatin | affects localization | ISO | SRPK2 (Homo sapiens) | 6480464 | Cisplatin affects the localization of SRPK2 protein | CTD | PMID:21157427 | Srpk2 | Rat | cisplatin | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [Cisplatin affects the localization of SRPK2 protein] which results in increased phosphorylation of SRSF2 protein; more ... | CTD | PMID:21157427|PMID:23613995 | Srpk2 | Rat | coumarin | affects phosphorylation | ISO | SRPK2 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of SRPK2 protein | CTD | PMID:35688186 | Srpk2 | Rat | crocidolite asbestos | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Asbestos, Crocidolite results in decreased expression of SRPK2 mRNA | CTD | PMID:29279043 | Srpk2 | Rat | Dibutyl phosphate | affects expression | ISO | SRPK2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SRPK2 mRNA | CTD | PMID:37042841 | Srpk2 | Rat | doxorubicin | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of SRPK2 mRNA; Doxorubicin results in decreased expression of SRPK2 more ... | CTD | PMID:38244039|PMID:39631538 | Srpk2 | Rat | enzyme inhibitor | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ... | CTD | PMID:23301498 | Srpk2 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of SRPK2 mRNA | CTD | PMID:24136188 | Srpk2 | Rat | fulvestrant | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] affects the methylation of SRPK2 gene | CTD | PMID:31601247 | Srpk2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SRPK2 mRNA | CTD | PMID:22061828 | Srpk2 | Rat | ivermectin | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SRPK2 protein | CTD | PMID:32959892 | Srpk2 | Rat | lead(0) | affects expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Lead affects the expression of SRPK2 mRNA | CTD | PMID:28903495 | Srpk2 | Rat | lipopolysaccharide | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of SRPK2 mRNA | CTD | PMID:12057914 | Srpk2 | Rat | manganese atom | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Srpk2 | Rat | manganese(0) | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Srpk2 | Rat | manganese(II) chloride | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:39836092 | Srpk2 | Rat | methotrexate | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of SRPK2 mRNA | CTD | PMID:24449571 | Srpk2 | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of SRPK2 gene | CTD | PMID:35440735 | Srpk2 | Rat | miconazole | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Miconazole results in decreased expression of SRPK2 mRNA | CTD | PMID:27462272 | Srpk2 | Rat | N-methylformamide | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | methylformamide analog results in increased expression of SRPK2 mRNA; methylformamide results in increased expression of more ... | CTD | PMID:17040096 | Srpk2 | Rat | N-nitrosodiethylamine | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Diethylnitrosamine results in decreased expression of SRPK2 mRNA | CTD | PMID:21527772 | Srpk2 | Rat | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of SRPK2 mRNA | CTD | PMID:22124623 | Srpk2 | Rat | paracetamol | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SRPK2 mRNA | CTD | PMID:22230336 | Srpk2 | Rat | paraquat | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | Paraquat affects the localization of and results in increased phosphorylation of SRPK2 protein; SRPK2 protein more ... | CTD | PMID:23613995 | Srpk2 | Rat | phenobarbital | affects expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of SRPK2 mRNA | CTD | PMID:19159669 | Srpk2 | Rat | phenobarbital | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Phenobarbital results in decreased expression of SRPK2 mRNA | CTD | PMID:23091169 | Srpk2 | Rat | phenobarbital | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SRPK2 mRNA | CTD | PMID:25270620 | Srpk2 | Rat | potassium chromate | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SRPK2 mRNA | CTD | PMID:22079256 | Srpk2 | Rat | potassium chromate | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SRPK2 mRNA | CTD | PMID:22079256 | Srpk2 | Rat | potassium dichromate | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of SRPK2 mRNA | CTD | PMID:23608068 | Srpk2 | Rat | propiconazole | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of SRPK2 mRNA | CTD | PMID:21278054 | Srpk2 | Rat | raloxifene | affects expression | EXP | | 6480464 | Raloxifene Hydrochloride affects the expression of SRPK2 mRNA | CTD | PMID:16079270 | Srpk2 | Rat | sodium arsenite | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of SRPK2 mRNA | CTD | PMID:32068019 | Srpk2 | Rat | sodium arsenite | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SRPK2 mRNA | CTD | PMID:36209798 | Srpk2 | Rat | sodium arsenite | multiple interactions | ISO | SRPK2 (Homo sapiens) | 6480464 | [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... | CTD | PMID:30528433|PMID:39571964|PMID:39836092 | Srpk2 | Rat | sodium arsenite | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SRPK2 protein | CTD | PMID:30528433 | Srpk2 | Rat | sodium arsenite | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SRPK2 mRNA | CTD | PMID:38568856 | Srpk2 | Rat | succimer | multiple interactions | ISO | Srpk2 (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SRPK2 mRNA | CTD | PMID:21641980 | Srpk2 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of SRPK2 mRNA | CTD | PMID:15336504 | Srpk2 | Rat | testosterone enanthate | affects expression | ISO | SRPK2 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of SRPK2 mRNA | CTD | PMID:17440010 | Srpk2 | Rat | tetrachloromethane | affects expression | ISO | Srpk2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of SRPK2 mRNA | CTD | PMID:17484886 | Srpk2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SRPK2 mRNA | CTD | PMID:34492290 | Srpk2 | Rat | toluene | increases expression | EXP | | 6480464 | Toluene results in increased expression of SRPK2 mRNA | CTD | PMID:22166486 | Srpk2 | Rat | toluene | decreases expression | EXP | | 6480464 | Toluene results in decreased expression of SRPK2 mRNA | CTD | PMID:22166486 | Srpk2 | Rat | trichloroethene | increases methylation | EXP | | 6480464 | Trichloroethylene results in increased methylation of SRPK2 gene | CTD | PMID:27618143 | Srpk2 | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of SRPK2 mRNA | CTD | PMID:30589522 | Srpk2 | Rat | triphenyl phosphate | affects expression | ISO | SRPK2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SRPK2 mRNA | CTD | PMID:37042841 | Srpk2 | Rat | troglitazone | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of SRPK2 mRNA | CTD | PMID:28973697 | Srpk2 | Rat | tungsten | decreases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Tungsten results in decreased expression of SRPK2 mRNA | CTD | PMID:30912803 | Srpk2 | Rat | valproic acid | decreases methylation | ISO | SRPK2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SRPK2 gene | CTD | PMID:29154799 | Srpk2 | Rat | valproic acid | affects expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SRPK2 mRNA | CTD | PMID:25979313 | Srpk2 | Rat | valproic acid | increases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SRPK2 mRNA | CTD | PMID:19101580|PMID:23179753 | Srpk2 | Rat | vitamin E | decreases expression | ISO | SRPK2 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of SRPK2 mRNA | CTD | PMID:19244175 | Srpk2 | Rat | zinc atom | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Zinc deficiency results in increased expression of SRPK2 mRNA | CTD | PMID:20857495 | Srpk2 | Rat | zinc(0) | increases expression | ISO | Srpk2 (Mus musculus) | 6480464 | Zinc deficiency results in increased expression of SRPK2 mRNA | CTD | PMID:20857495 | |






















