Srpk2 (SRSF protein kinase 2) - Rat Genome Database

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Pathways
Gene: Srpk2 (SRSF protein kinase 2) Rattus norvegicus
Analyze
Symbol: Srpk2
Name: SRSF protein kinase 2
RGD ID: 1305107
Description: Predicted to enable several functions, including 14-3-3 protein binding activity; ATP binding activity; and magnesium ion binding activity. Predicted to be involved in several processes, including R-loop processing; nuclear speck organization; and regulation of viral genome replication. Is active in presynapse. Orthologous to human SRPK2 (SRSF protein kinase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296753; serine/arginine-rich protein specific kinase 2; serine/threonine-protein kinase SRPK2; SFRS protein kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8412,356,983 - 12,548,345 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl412,357,053 - 12,548,342 (+)EnsemblGRCr8
mRatBN7.2411,464,684 - 11,655,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,464,674 - 11,655,990 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx416,687,771 - 16,806,340 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0412,510,835 - 12,629,425 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,859,761 - 10,978,332 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,994,025 - 8,187,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl48,066,737 - 8,185,935 (+)Ensemblrn6Rnor6.0
Rnor_5.048,001,928 - 8,193,168 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,918,521 - 7,039,871 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera47,148,433 - 7,267,472 (+)NCBICelera
RGSC_v3.146,918,542 - 7,039,871 (+)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
miconazole  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
ochratoxin A  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
raloxifene  (EXP)
sodium arsenite  (ISO)
succimer  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2. Arancibia D, etal., Cells. 2019 Oct 29;8(11):1333. doi: 10.3390/cells8111333.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9446799   PMID:9472028   PMID:12417631   PMID:12477932   PMID:18559500   PMID:19592491   PMID:19906640   PMID:20498328   PMID:22658674   PMID:22681889   PMID:26167880   PMID:28076779  


Genomics

Comparative Map Data
Srpk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8412,356,983 - 12,548,345 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl412,357,053 - 12,548,342 (+)EnsemblGRCr8
mRatBN7.2411,464,684 - 11,655,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,464,674 - 11,655,990 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx416,687,771 - 16,806,340 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0412,510,835 - 12,629,425 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,859,761 - 10,978,332 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,994,025 - 8,187,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl48,066,737 - 8,185,935 (+)Ensemblrn6Rnor6.0
Rnor_5.048,001,928 - 8,193,168 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.446,918,521 - 7,039,871 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera47,148,433 - 7,267,472 (+)NCBICelera
RGSC_v3.146,918,542 - 7,039,871 (+)NCBI
Cytogenetic Map4q11NCBI
SRPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387105,114,740 - 105,399,357 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7105,110,704 - 105,399,308 (-)Ensemblhg38GRCh38
GRCh377104,756,821 - 105,029,838 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367104,544,059 - 104,816,577 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347104,350,774 - 104,623,292NCBI
Celera799,562,462 - 99,834,859 (-)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef799,117,123 - 99,299,796 (-)NCBIHuRef
CHM1_17104,690,144 - 104,962,686 (-)NCBICHM1_1
T2T-CHM13v2.07106,428,390 - 106,713,586 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27104,117,494 - 104,389,934 (-)NCBI
Srpk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39523,708,262 - 23,889,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl523,708,262 - 23,889,615 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38523,503,356 - 23,684,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl523,503,264 - 23,684,617 (-)Ensemblmm10GRCm38
MGSCv37523,009,174 - 23,122,389 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36523,015,180 - 23,128,395 (-)NCBIMGSCv36mm8
Celera520,441,421 - 20,555,098 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.36NCBI
Srpk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554109,811,584 - 9,942,323 (-)Ensembl
ChiLan1.0NW_0049554109,807,936 - 10,034,760 (-)NCBIChiLan1.0ChiLan1.0
SRPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26141,962,885 - 142,249,435 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17190,232,854 - 190,519,404 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0797,102,226 - 97,378,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17109,834,478 - 110,119,558 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7109,834,478 - 109,989,050 (-)EnsemblpanPan2panpan1.1
SRPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11814,991,187 - 15,243,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1814,999,422 - 15,236,393 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1814,642,234 - 14,889,552 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01815,295,582 - 15,546,667 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1815,302,732 - 15,541,047 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11815,079,634 - 15,328,371 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01815,002,645 - 15,251,931 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01815,282,883 - 15,531,664 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srpk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511857,405,767 - 57,550,172 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647918,541,248 - 18,670,914 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647918,541,167 - 18,675,039 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9105,006,987 - 105,264,731 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19105,009,550 - 105,264,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29115,729,526 - 115,831,344 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SRPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12174,032,668 - 74,312,887 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2174,034,136 - 74,201,243 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604229,604,750 - 29,946,732 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srpk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473924,127,562 - 24,369,217 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Srpk2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16152,663,209 - 152,823,701 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srpk2
1444 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:105
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000063994
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat

Markers in Region
RH130578  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2411,655,707 - 11,655,889 (+)MAPPERmRatBN7.2
Rnor_6.048,185,648 - 8,185,829NCBIRnor6.0
Rnor_5.048,191,361 - 8,191,542UniSTSRnor5.0
RGSC_v3.447,039,586 - 7,039,767UniSTSRGSC3.4
Celera47,267,187 - 7,267,368UniSTS
RH 3.4 Map423.1UniSTS
Cytogenetic Map4q11UniSTS
RH129727  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8412,547,213 - 12,547,401 (+)Marker Load Pipeline
mRatBN7.2411,654,861 - 11,655,049 (+)MAPPERmRatBN7.2
Rnor_6.048,184,802 - 8,184,989NCBIRnor6.0
Rnor_5.048,190,515 - 8,190,702UniSTSRnor5.0
RGSC_v3.447,038,740 - 7,038,927UniSTSRGSC3.4
Celera47,266,341 - 7,266,528UniSTS
RH 3.4 Map414.0UniSTS
Cytogenetic Map4q11UniSTS
BF395851  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8412,462,965 - 12,463,196 (+)Marker Load Pipeline
mRatBN7.2411,570,610 - 11,570,841 (+)MAPPERmRatBN7.2
Rnor_6.048,099,781 - 8,100,011NCBIRnor6.0
Rnor_5.048,106,574 - 8,106,804UniSTSRnor5.0
RGSC_v3.446,951,744 - 6,951,974UniSTSRGSC3.4
Celera47,182,592 - 7,182,822UniSTS
RH 3.4 Map40.0UniSTS
Cytogenetic Map4q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF102149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000063994   ⟹   ENSRNOP00000059855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl412,429,736 - 12,548,342 (+)Ensembl
mRatBN7.2 Ensembl411,537,385 - 11,655,990 (+)Ensembl
Rnor_6.0 Ensembl48,066,737 - 8,185,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076429   ⟹   ENSRNOP00000068064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl48,166,082 - 8,184,587 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080811   ⟹   ENSRNOP00000070149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl412,483,521 - 12,547,967 (+)Ensembl
mRatBN7.2 Ensembl411,591,166 - 11,655,977 (+)Ensembl
Rnor_6.0 Ensembl48,066,907 - 8,184,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106508   ⟹   ENSRNOP00000096635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl412,367,691 - 12,548,342 (+)Ensembl
mRatBN7.2 Ensembl411,464,674 - 11,655,990 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108014   ⟹   ENSRNOP00000080095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl412,367,691 - 12,548,342 (+)Ensembl
mRatBN7.2 Ensembl411,475,893 - 11,655,988 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162564   ⟹   ENSRNOP00000102557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl412,368,257 - 12,547,967 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170847   ⟹   ENSRNOP00000111066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl412,357,053 - 12,547,217 (+)Ensembl
RefSeq Acc Id: NM_001106575   ⟹   NP_001100045
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,429,743 - 12,548,345 (+)NCBI
mRatBN7.2411,537,385 - 11,655,993 (+)NCBI
Rnor_6.048,066,737 - 8,185,933 (+)NCBI
Rnor_5.048,001,928 - 8,193,168 (+)NCBI
RGSC_v3.446,918,521 - 7,039,871 (+)RGD
Celera47,148,433 - 7,267,472 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235903   ⟹   XP_006235965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,423,383 - 12,548,345 (+)NCBI
mRatBN7.2411,538,163 - 11,654,614 (+)NCBI
Rnor_6.048,064,325 - 8,187,455 (+)NCBI
Rnor_5.048,001,928 - 8,193,168 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592513   ⟹   XP_017448002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,356,983 - 12,548,345 (+)NCBI
mRatBN7.2411,464,684 - 11,654,614 (+)NCBI
Rnor_6.047,994,025 - 8,187,455 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107226   ⟹   XP_038963154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
mRatBN7.2411,475,526 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107228   ⟹   XP_038963156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
mRatBN7.2411,475,268 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107229   ⟹   XP_038963157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
mRatBN7.2411,475,526 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107231   ⟹   XP_038963159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
mRatBN7.2411,475,277 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_039107232   ⟹   XP_038963160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,357,237 - 12,548,345 (+)NCBI
mRatBN7.2411,464,684 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_039107233   ⟹   XP_038963161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
mRatBN7.2411,475,282 - 11,655,991 (+)NCBI
RefSeq Acc Id: XM_039107234   ⟹   XP_038963162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,368,210 - 12,548,345 (+)NCBI
mRatBN7.2411,475,991 - 11,654,614 (+)NCBI
RefSeq Acc Id: XM_063285697   ⟹   XP_063141767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,368,216 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285698   ⟹   XP_063141768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,356,984 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285699   ⟹   XP_063141769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,356,983 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285700   ⟹   XP_063141770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,368,216 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285701   ⟹   XP_063141771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,356,984 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285702   ⟹   XP_063141772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285703   ⟹   XP_063141773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,423,383 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285704   ⟹   XP_063141774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,429,598 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285705   ⟹   XP_063141775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,366,735 - 12,548,345 (+)NCBI
RefSeq Acc Id: XM_063285706   ⟹   XP_063141776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8412,507,476 - 12,548,345 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100045 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426740 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426741 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426742 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426743 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426744 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426745 (Get FASTA)   NCBI Sequence Viewer  
  NP_001426746 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235965 (Get FASTA)   NCBI Sequence Viewer  
  XP_017448002 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963154 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963156 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963157 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963159 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963161 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963162 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141767 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141768 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141769 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141772 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141773 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141774 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141775 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141776 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61879 (Get FASTA)   NCBI Sequence Viewer  
  EDL99396 (Get FASTA)   NCBI Sequence Viewer  
  EDL99397 (Get FASTA)   NCBI Sequence Viewer  
  EDL99398 (Get FASTA)   NCBI Sequence Viewer  
  EDL99399 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059855
  ENSRNOP00000059855.2
  ENSRNOP00000070149
  ENSRNOP00000070149.2
  ENSRNOP00000080095
  ENSRNOP00000080095.2
  ENSRNOP00000096635
  ENSRNOP00000096635.2
  ENSRNOP00000102557
  ENSRNOP00000102557.1
  ENSRNOP00000111066
  ENSRNOP00000111066.1
RefSeq Acc Id: NP_001100045   ⟸   NM_001106575
- UniProtKB: B1WBT4 (UniProtKB/TrEMBL),   F7FC44 (UniProtKB/TrEMBL),   A6K588 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235965   ⟸   XM_006235903
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448002   ⟸   XM_017592513
- Peptide Label: isoform X3
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070149   ⟸   ENSRNOT00000080811
Ensembl Acc Id: ENSRNOP00000059855   ⟸   ENSRNOT00000063994
Ensembl Acc Id: ENSRNOP00000068064   ⟸   ENSRNOT00000076429
RefSeq Acc Id: XP_038963160   ⟸   XM_039107232
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963156   ⟸   XM_039107228
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963159   ⟸   XM_039107231
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963161   ⟸   XM_039107233
- Peptide Label: isoform X9
- UniProtKB: A6K588 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963154   ⟸   XM_039107226
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963157   ⟸   XM_039107229
- Peptide Label: isoform X5
- UniProtKB: A6K588 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963162   ⟸   XM_039107234
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000080095   ⟸   ENSRNOT00000108014
Ensembl Acc Id: ENSRNOP00000096635   ⟸   ENSRNOT00000106508
RefSeq Acc Id: XP_063141769   ⟸   XM_063285699
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063141768   ⟸   XM_063285698
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141771   ⟸   XM_063285701
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063141772   ⟸   XM_063285702
- Peptide Label: isoform X14
RefSeq Acc Id: XP_063141775   ⟸   XM_063285705
- Peptide Label: isoform X17
- UniProtKB: A0A0G2JX62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141767   ⟸   XM_063285697
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063141770   ⟸   XM_063285700
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063141773   ⟸   XM_063285703
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063141774   ⟸   XM_063285704
- Peptide Label: isoform X16
- UniProtKB: A6K588 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141776   ⟸   XM_063285706
- Peptide Label: isoform X18
Ensembl Acc Id: ENSRNOP00000102557   ⟸   ENSRNOT00000162564
Ensembl Acc Id: ENSRNOP00000111066   ⟸   ENSRNOT00000170847
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX62-F1-model_v2 AlphaFold A0A0G2JX62 1-712 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692800
Promoter ID:EPDNEW_R3324
Type:multiple initiation site
Name:Srpk2_1
Description:SRSF protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.048,066,724 - 8,066,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305107 AgrOrtholog
BioCyc Gene G2FUF-46010 BioCyc
Ensembl Genes ENSRNOG00000010601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063994 ENTREZGENE
  ENSRNOT00000063994.5 UniProtKB/TrEMBL
  ENSRNOT00000080811 ENTREZGENE
  ENSRNOT00000080811.3 UniProtKB/TrEMBL
  ENSRNOT00000106508 ENTREZGENE
  ENSRNOT00000106508.2 UniProtKB/TrEMBL
  ENSRNOT00000108014 ENTREZGENE
  ENSRNOT00000108014.2 UniProtKB/TrEMBL
  ENSRNOT00000162564 ENTREZGENE
  ENSRNOT00000162564.1 UniProtKB/TrEMBL
  ENSRNOT00000170847 ENTREZGENE
  ENSRNOT00000170847.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7125533 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  SRPK UniProtKB/TrEMBL
KEGG Report rno:296753 UniProtKB/TrEMBL
MGC_CLONE MGC:187443 IMAGE-MGC_LOAD
NCBI Gene 296753 ENTREZGENE
PANTHER PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED UniProtKB/TrEMBL
  SRSF PROTEIN KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Srpk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010601 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2JX62 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPE5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM61 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LBD7_RAT UniProtKB/TrEMBL
  A0ABK0LZ35_RAT UniProtKB/TrEMBL
  A6K588 ENTREZGENE, UniProtKB/TrEMBL
  B1WBT4 ENTREZGENE, UniProtKB/TrEMBL
  F7FC44 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Srpk2  SRSF protein kinase 2  Srpk2  SFRS protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Srpk2  SFRS protein kinase 2  Srpk2  Srsf protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srpk2  Srsf protein kinase 2  Srpk2  SFRS protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Srpk2  SFRS protein kinase 2  Srpk2  serine/arginine-rich protein specific kinase 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Srpk2  serine/arginine-rich protein specific kinase 2   Srpk2_predicted  serine/arginine-rich protein specific kinase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Srpk2_predicted  serine/arginine-rich protein specific kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED