Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Cerk | Rat | 1,1-dichloroethene | increases expression | ISO | Cerk (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of CERK mRNA | CTD | PMID:26682919 | Cerk | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Cerk (Mus musculus) | 6480464 | 1,2-Dimethylhydrazine results in increased expression of CERK mRNA | CTD | PMID:22206623 | Cerk | Rat | 17beta-estradiol | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of CERK mRNA | CTD | PMID:20660070 | Cerk | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of CERK mRNA | CTD | PMID:34747641 | Cerk | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of CERK mRNA | CTD | PMID:30851411 | Cerk | Rat | 2-methylcholine | affects expression | ISO | CERK (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of CERK mRNA | CTD | PMID:21179406 | Cerk | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of CERK mRNA | CTD | PMID:25380136 | Cerk | Rat | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Cerk (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of CERK exon | CTD | PMID:33297965 | Cerk | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Cerk (Mus musculus) | 6480464 | bisphenol S affects the methylation of CERK gene | CTD | PMID:31683443 | Cerk | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of CERK mRNA | CTD | PMID:30047161 | Cerk | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of CERK mRNA | CTD | PMID:31881176 | Cerk | Rat | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of CERK mRNA | CTD | PMID:30047161 | Cerk | Rat | Aroclor 1254 | decreases expression | ISO | Cerk (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of CERK mRNA | CTD | PMID:23650126 | Cerk | Rat | arsane | affects methylation | ISO | CERK (Homo sapiens) | 6480464 | Arsenic affects the methylation of CERK gene | CTD | PMID:25304211 | Cerk | Rat | arsane | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CERK more ... | CTD | PMID:39836092 | Cerk | Rat | arsane | affects expression | ISO | CERK (Homo sapiens) | 6480464 | Arsenic affects the expression of CERK mRNA | CTD | PMID:25304211 | Cerk | Rat | arsenic atom | affects methylation | ISO | CERK (Homo sapiens) | 6480464 | Arsenic affects the methylation of CERK gene | CTD | PMID:25304211 | Cerk | Rat | arsenic atom | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CERK more ... | CTD | PMID:39836092 | Cerk | Rat | arsenic atom | affects expression | ISO | CERK (Homo sapiens) | 6480464 | Arsenic affects the expression of CERK mRNA | CTD | PMID:25304211 | Cerk | Rat | arsenite(3-) | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to CERK mRNA] | CTD | PMID:32406909 | Cerk | Rat | atrazine | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Atrazine results in decreased expression of CERK mRNA | CTD | PMID:22378314 | Cerk | Rat | azoxystrobin | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ... | CTD | PMID:33854195 | Cerk | Rat | benzene | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Benzene results in increased expression of CERK mRNA | CTD | PMID:19162166 | Cerk | Rat | benzo[a]pyrene | decreases expression | ISO | Cerk (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of CERK mRNA | CTD | PMID:19770486 | Cerk | Rat | benzo[a]pyrene | affects methylation | ISO | CERK (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of CERK 3' UTR; Benzo(a)pyrene affects the methylation of CERK intron | CTD | PMID:27901495|PMID:30157460 | Cerk | Rat | benzo[e]pyrene | increases methylation | ISO | CERK (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of CERK intron | CTD | PMID:30157460 | Cerk | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Cerk | Rat | bisphenol A | increases expression | ISO | Cerk (Mus musculus) | 6480464 | bisphenol A results in increased expression of CERK mRNA | CTD | PMID:26063408|PMID:32156529 | Cerk | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of CERK mRNA | CTD | PMID:25181051 | Cerk | Rat | Butylbenzyl phthalate | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Cerk | Rat | cadmium atom | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CERK more ... | CTD | PMID:39012411 | Cerk | Rat | cadmium dichloride | multiple interactions | EXP | | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of CERK more ... | CTD | PMID:39012411 | Cerk | Rat | calcium atom | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | Calcium affects the reaction [CERK protein results in increased phosphorylation of Ceramides] | CTD | PMID:16269826 | Cerk | Rat | calcium(0) | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | Calcium affects the reaction [CERK protein results in increased phosphorylation of Ceramides] | CTD | PMID:16269826 | Cerk | Rat | ceramide 1-phosphate | affects abundance | ISO | CERK (Homo sapiens) | 6480464 | CERK protein affects the abundance of ceramide 1-phosphate | CTD | PMID:15899891 | Cerk | Rat | chlorpyrifos | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ... | CTD | PMID:33854195 | Cerk | Rat | copper(II) sulfate | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of CERK mRNA | CTD | PMID:19549813 | Cerk | Rat | cyclosporin A | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of CERK mRNA | CTD | PMID:20106945 | Cerk | Rat | DDE | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of CERK mRNA | CTD | PMID:38568856 | Cerk | Rat | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of CERK mRNA | CTD | PMID:21266533 | Cerk | Rat | dibutyl phthalate | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Cerk | Rat | diethyl phthalate | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Cerk | Rat | diisobutyl phthalate | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Cerk | Rat | diisononyl phthalate | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ... | CTD | PMID:39150890 | Cerk | Rat | dimethyl sulfoxide | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Dimethyl Sulfoxide results in increased expression of CERK mRNA | CTD | PMID:39709020 | Cerk | Rat | dorsomorphin | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Cerk | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of CERK mRNA | CTD | PMID:29391264 | Cerk | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of CERK mRNA | CTD | PMID:33387578 | Cerk | Rat | glyphosate | affects methylation | EXP | | 6480464 | Glyphosate affects the methylation of CERK gene | CTD | PMID:35440735 | Cerk | Rat | glyphosate | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ... | CTD | PMID:33854195 | Cerk | Rat | hydrogen peroxide | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Hydrogen Peroxide results in increased expression of CERK mRNA | CTD | PMID:39709020 | Cerk | Rat | hypochlorous acid | decreases expression | ISO | Cerk (Mus musculus) | 6480464 | Hypochlorous Acid results in decreased expression of CERK mRNA | CTD | PMID:19376150 | Cerk | Rat | imidacloprid | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ... | CTD | PMID:33854195 | Cerk | Rat | inulin | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CERK mRNA | CTD | PMID:36331819 | Cerk | Rat | magnesium atom | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | Magnesium affects the reaction [CERK protein results in increased phosphorylation of Ceramides] | CTD | PMID:16269826 | Cerk | Rat | manganese atom | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CERK more ... | CTD | PMID:39836092 | Cerk | Rat | manganese(0) | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CERK more ... | CTD | PMID:39836092 | Cerk | Rat | manganese(II) chloride | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CERK more ... | CTD | PMID:39836092 | Cerk | Rat | methapyrilene | increases methylation | ISO | CERK (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of CERK intron | CTD | PMID:30157460 | Cerk | Rat | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of CERK mRNA | CTD | PMID:30047161 | Cerk | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of CERK gene | CTD | PMID:35440735 | Cerk | Rat | methyl methanesulfonate | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of CERK mRNA | CTD | PMID:23649840 | Cerk | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of CERK gene | CTD | PMID:33148267 | Cerk | Rat | nitrates | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of CERK more ... | CTD | PMID:35964746 | Cerk | Rat | okadaic acid | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Okadaic Acid results in decreased expression of CERK mRNA | CTD | PMID:38832940 | Cerk | Rat | paracetamol | affects expression | ISO | Cerk (Mus musculus) | 6480464 | Acetaminophen affects the expression of CERK mRNA | CTD | PMID:17562736 | Cerk | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CERK mRNA | CTD | PMID:33387578 | Cerk | Rat | paracetamol | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of CERK mRNA | CTD | PMID:22230336 | Cerk | Rat | paracetamol | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of CERK mRNA | CTD | PMID:21420995 | Cerk | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CERK mRNA | CTD | PMID:36331819 | Cerk | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of CERK gene | CTD | PMID:33148267 | Cerk | Rat | pirinixic acid | decreases expression | ISO | Cerk (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of CERK mRNA | CTD | PMID:17426115 | Cerk | Rat | pirinixic acid | increases expression | ISO | Cerk (Mus musculus) | 6480464 | pirinixic acid results in increased expression of CERK mRNA | CTD | PMID:23811191 | Cerk | Rat | pirinixic acid | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Cerk | Rat | progesterone | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of CERK mRNA | CTD | PMID:20660070 | Cerk | Rat | rac-lactic acid | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of CERK mRNA | CTD | PMID:30851411 | Cerk | Rat | resveratrol | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of CERK mRNA | CTD | PMID:23557933 | Cerk | Rat | rotenone | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Rotenone results in increased expression of CERK mRNA | CTD | PMID:29955902 | Cerk | Rat | rotenone | increases expression | ISO | Cerk (Mus musculus) | 6480464 | Rotenone results in increased expression of CERK mRNA | CTD | PMID:32937126 | Cerk | Rat | SB 431542 | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Cerk | Rat | sodium arsenite | decreases methylation | ISO | Cerk (Mus musculus) | 6480464 | sodium arsenite results in decreased methylation of CERK gene | CTD | PMID:32068019 | Cerk | Rat | sodium arsenite | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CERK more ... | CTD | PMID:39836092 | Cerk | Rat | sodium dodecyl sulfate | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Sodium Dodecyl Sulfate results in increased expression of CERK mRNA | CTD | PMID:31734321 | Cerk | Rat | succimer | multiple interactions | ISO | Cerk (Mus musculus) | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CERK mRNA | CTD | PMID:21641980 | Cerk | Rat | temozolomide | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of CERK mRNA | CTD | PMID:31758290 | Cerk | Rat | tetrachloromethane | increases expression | ISO | Cerk (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of CERK mRNA | CTD | PMID:27339419 | Cerk | Rat | thiabendazole | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with more ... | CTD | PMID:33854195 | Cerk | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of CERK mRNA | CTD | PMID:34492290 | Cerk | Rat | titanium dioxide | decreases methylation | ISO | Cerk (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of CERK gene | CTD | PMID:35295148 | Cerk | Rat | trichostatin A | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of CERK mRNA | CTD | PMID:24935251|PMID:26272509 | Cerk | Rat | trichostatin A | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Cerk | Rat | triphenyl phosphate | affects expression | ISO | CERK (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of CERK mRNA | CTD | PMID:37042841 | Cerk | Rat | valproic acid | affects expression | ISO | CERK (Homo sapiens) | 6480464 | Valproic Acid affects the expression of CERK mRNA | CTD | PMID:25979313 | Cerk | Rat | valproic acid | multiple interactions | ISO | CERK (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Cerk | Rat | valproic acid | decreases expression | ISO | CERK (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of CERK mRNA | CTD | PMID:23179753|PMID:24383497|PMID:26272509|PMID:28001369 | Cerk | Rat | vinclozolin | decreases expression | EXP | | 6480464 | vinclozolin results in decreased expression of CERK mRNA | CTD | PMID:23034163 | Cerk | Rat | vitamin E | increases expression | ISO | CERK (Homo sapiens) | 6480464 | Vitamin E results in increased expression of CERK mRNA | CTD | PMID:19244175 | | |||||||||||||||||||






















