Perm1 (PPARGC1 and ESRR induced regulator, muscle 1) - Rat Genome Database

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Pathways
Gene: Perm1 (PPARGC1 and ESRR induced regulator, muscle 1) Rattus norvegicus
Analyze
Symbol: Perm1
Name: PPARGC1 and ESRR induced regulator, muscle 1
RGD ID: 1304931
Description: Predicted to be involved in regulation of DNA-templated transcription and response to muscle activity. Predicted to be active in cytoplasm and nucleus. Orthologous to human PERM1 (PPARGC1 and ESRR induced regulator, muscle 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC313776; LOC313776; PGC-1 and ERR-induced regulator in muscle protein 1; RGD1304931; similar to RIKEN cDNA 2310042D19; uncharacterized protein LOC313776
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,082,249 - 172,087,542 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5172,082,249 - 172,087,542 (+)EnsemblGRCr8
mRatBN7.25166,800,030 - 166,805,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,800,030 - 166,805,323 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,502,101 - 169,507,410 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,323,485 - 171,328,794 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,286,046 - 171,291,355 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,640,780 - 173,646,073 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,640,780 - 173,646,073 (+)Ensemblrn6Rnor6.0
Rnor_5.05177,114,820 - 177,120,113 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45173,050,659 - 173,055,952 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5165,001,875 - 165,007,168 (+)NCBICelera
RGSC_v3.15173,062,213 - 173,066,446 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:23836911  


Genomics

Comparative Map Data
Perm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,082,249 - 172,087,542 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5172,082,249 - 172,087,542 (+)EnsemblGRCr8
mRatBN7.25166,800,030 - 166,805,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,800,030 - 166,805,323 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5169,502,101 - 169,507,410 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,323,485 - 171,328,794 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,286,046 - 171,291,355 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,640,780 - 173,646,073 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,640,780 - 173,646,073 (+)Ensemblrn6Rnor6.0
Rnor_5.05177,114,820 - 177,120,113 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45173,050,659 - 173,055,952 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5165,001,875 - 165,007,168 (+)NCBICelera
RGSC_v3.15173,062,213 - 173,066,446 (+)NCBI
Cytogenetic Map5q36NCBI
PERM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381975,198 - 982,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1975,194 - 982,134 (-)Ensemblhg38GRCh38
GRCh371910,578 - 917,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361900,442 - 907,330 (-)NCBIBuild 36Build 36hg18NCBI36
Celera11,672,416 - 1,681,155 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1180,218 - 188,770 (-)NCBIHuRef
CHM1_11897,508 - 904,500 (-)NCBICHM1_1
T2T-CHM13v2.01403,907 - 411,933 (-)NCBIT2T-CHM13v2.0
Perm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394156,287,724 - 156,305,766 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4156,300,325 - 156,305,764 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384156,203,262 - 156,221,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4156,215,868 - 156,221,307 (+)Ensemblmm10GRCm38
MGSCv374155,590,036 - 155,595,416 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364155,590,036 - 155,595,416 (+)NCBIMGSCv36mm8
Celera4158,472,399 - 158,477,792 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map488.62NCBI
Perm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,732,734 - 9,735,881 (+)Ensembl
ChiLan1.0NW_0049554869,731,317 - 9,736,821 (+)NCBIChiLan1.0ChiLan1.0
PERM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,282,197 - 227,287,210 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,978,868 - 225,983,960 (+)NCBINHGRI_mPanPan1
PanPan1.11874,195 - 881,000 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1875,161 - 880,042 (-)EnsemblpanPan2panpan1.1
PERM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,202,318 - 56,207,617 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl556,202,939 - 56,204,453 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha556,280,377 - 56,285,677 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0556,405,851 - 56,411,158 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,406,283 - 56,410,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,396,933 - 56,402,232 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,288,850 - 56,294,145 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,678,872 - 56,684,172 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Perm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,393,164 - 27,397,556 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367372,067,432 - 2,072,784 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PERM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,308,187 - 63,341,843 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1663,336,116 - 63,341,747 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2657,942,534 - 57,945,240 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PERM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,445,002 - 130,457,663 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,452,807 - 130,458,732 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605435,082,206 - 35,086,973 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Perm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248188,526,953 - 8,537,071 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Perm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v114,448,264 - 4,452,771 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:96
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000027476
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
D5Got252  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85172,081,048 - 172,081,252 (+)Marker Load Pipeline
mRatBN7.25166,798,831 - 166,799,033 (+)MAPPERmRatBN7.2
Rnor_6.05173,639,582 - 173,639,783NCBIRnor6.0
Rnor_5.05177,113,622 - 177,113,823UniSTSRnor5.0
RGSC_v3.45173,049,461 - 173,049,662UniSTSRGSC3.4
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 87 59 6 348 187 10 135 78 90 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000027476   ⟹   ENSRNOP00000027476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5172,082,249 - 172,087,542 (+)Ensembl
mRatBN7.2 Ensembl5166,800,030 - 166,805,323 (+)Ensembl
Rnor_6.0 Ensembl5173,640,780 - 173,646,073 (+)Ensembl
RefSeq Acc Id: NM_001108001   ⟹   NP_001101471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,082,249 - 172,087,542 (+)NCBI
mRatBN7.25166,800,030 - 166,805,323 (+)NCBI
Rnor_6.05173,640,780 - 173,646,073 (+)NCBI
Rnor_5.05177,114,820 - 177,120,113 (+)NCBI
RGSC_v3.45173,050,659 - 173,055,952 (+)RGD
Celera5165,001,875 - 165,007,168 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101471 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL81368 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027476
  ENSRNOP00000027476.5
RefSeq Acc Id: NP_001101471   ⟸   NM_001108001
- UniProtKB: D3ZH76 (UniProtKB/TrEMBL),   A6IUW7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027476   ⟸   ENSRNOT00000027476

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH76-F1-model_v2 AlphaFold D3ZH76 1-788 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694346
Promoter ID:EPDNEW_R4870
Type:multiple initiation site
Name:Perm1_1
Description:PPARGC1 and ESRR induced regulator, muscle 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05173,640,782 - 173,640,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304931 AgrOrtholog
BioCyc Gene G2FUF-38858 BioCyc
Ensembl Genes ENSRNOG00000020244 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027476 ENTREZGENE
  ENSRNOT00000027476.7 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127541 IMAGE-MGC_LOAD
InterPro Perm1 UniProtKB/TrEMBL
KEGG Report rno:313776 UniProtKB/TrEMBL
MGC_CLONE MGC:95112 IMAGE-MGC_LOAD
NCBI Gene 313776 ENTREZGENE
PANTHER PGC-1 AND ERR-INDUCED REGULATOR IN MUSCLE PROTEIN 1 UniProtKB/TrEMBL
  PTHR47282 UniProtKB/TrEMBL
PhenoGen Perm1 PhenoGen
RatGTEx ENSRNOG00000020244 RatGTEx
UniProt A6IUW7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZH76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-04 Perm1  PPARGC1 and ESRR induced regulator, muscle 1  RGD1304931  similar to RIKEN cDNA 2310042D19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1304931  similar to RIKEN cDNA 2310042D19  RGD1304931_predicted  similar to RIKEN cDNA 2310042D19 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1304931_predicted  similar to RIKEN cDNA 2310042D19 (predicted)  LOC313776_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC313776_predicted  similar to RIKEN cDNA 2310042D19 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL