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Gene: Apbb1ip (amyloid beta precursor protein binding family B member 1 interacting protein) Rattus norvegicus

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Symbol:

Apbb1ip

Name:

amyloid beta precursor protein binding family B member 1 interacting protein

RGD ID:

1304795

Description:

Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be part of T cell receptor complex. Predicted to be active in cytosol and plasma membrane. Orthologous to human APBB1IP (amyloid beta precursor protein binding family B member 1 interacting protein); PARTICIPATES IN integrin mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein; LOC307171

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	89,849,474 - 89,941,099 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	89,671,716 - 89,941,089 (+)	Ensembl				GRCr8
mRatBN7.2	17	84,941,404 - 85,033,020 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	84,982,243 - 85,033,010 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	88,465,265 - 88,517,387 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	92,300,651 - 92,352,775 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	86,317,449 - 86,369,569 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	90,098,953 - 90,149,192 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,099,025 - 90,149,894 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	91,762,064 - 91,812,342 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	96,476,962 - 96,527,635 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	83,861,327 - 83,910,596 (-)	NCBI		Celera
RGSC_v3.1	17	96,436,450 - 96,538,308 (+)	NCBI
Cytogenetic Map	17	q12.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

alpha-amanitin (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

CGP 52608 (ISO)

choline (ISO)

chromium(6+) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diquat (ISO)

diuron (EXP)

dorsomorphin (ISO)

ethanol (ISO)

ethylparaben (ISO)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

gentamycin (EXP)

ivermectin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

methoxychlor (EXP)

N(4)-hydroxycytidine (ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

O-methyleugenol (ISO)

oxaliplatin (EXP)

ozone (ISO)

paclitaxel (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

Soman (EXP)

sulforaphane (ISO)

temozolomide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IBA)

positive regulation of cell adhesion (ISO)

signal transduction (IEA)

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (ISO)

Cellular Component

cytoskeleton (IEA)

cytosol (IBA,ISO)

GABA-ergic synapse (IDA)

plasma membrane (IBA,IEA,ISO)

presynapse (IDA)

T cell receptor complex (ISO)

Molecular Function

protein binding (ISO)

protein-macromolecule adaptor activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

integrin mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Integrin activation.	Banno A and Ginsberg MH, Biochem Soc Trans. 2008 Apr;36(Pt 2):229-34. doi: 10.1042/BST0360229.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn.	Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:17403904

Genomics

Comparative Map Data

Apbb1ip
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	17	89,849,474 - 89,941,099 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	17	89,671,716 - 89,941,089 (+)	Ensembl				GRCr8
mRatBN7.2	17	84,941,404 - 85,033,020 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	17	84,982,243 - 85,033,010 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	17	88,465,265 - 88,517,387 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	17	92,300,651 - 92,352,775 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	17	86,317,449 - 86,369,569 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	90,098,953 - 90,149,192 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,099,025 - 90,149,894 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	17	91,762,064 - 91,812,342 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	17	96,476,962 - 96,527,635 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	17	83,861,327 - 83,910,596 (-)	NCBI		Celera
RGSC_v3.1	17	96,436,450 - 96,538,308 (+)	NCBI
Cytogenetic Map	17	q12.3	NCBI

APBB1IP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	26,438,341 - 26,567,803 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	26,438,341 - 26,568,449 (+)	Ensembl			hg38	GRCh38
GRCh37	10	26,727,270 - 26,856,732 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	26,767,272 - 26,896,738 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	10	26,767,271 - 26,896,736	NCBI
Celera	10	26,439,007 - 26,568,370 (+)	NCBI		Celera
Cytogenetic Map	10	p12.1	NCBI
HuRef	10	26,386,953 - 26,516,379 (+)	NCBI		HuRef
CHM1_1	10	26,728,114 - 26,857,331 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	26,462,982 - 26,592,541 (+)	NCBI		T2T-CHM13v2.0

Apbb1ip
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	22,645,983 - 22,765,671 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	22,664,106 - 22,765,665 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	22,755,971 - 22,875,653 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	22,774,094 - 22,875,653 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	22,629,847 - 22,731,173 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	22,626,079 - 22,727,017 (+)	NCBI		MGSCv36	mm8
Celera	2	22,505,057 - 22,606,795 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	15.15	NCBI

Apbb1ip
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955429	2,871,943 - 2,930,213 (-)	Ensembl
ChiLan1.0	NW_004955429	2,874,783 - 2,973,321 (-)	NCBI	ChiLan1.0	ChiLan1.0

APBB1IP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	39,028,529 - 39,260,808 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	39,061,515 - 39,266,134 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	26,613,897 - 26,740,670 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	26,978,997 - 27,104,802 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	27,030,218 - 27,104,483 (+)	Ensembl			panPan2	panpan1.1

APBB1IP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	7,151,443 - 7,250,412 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	7,151,443 - 7,212,200 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	5,904,528 - 6,003,956 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	5,341,344 - 5,447,384 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	5,340,392 - 5,439,018 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	4,718,182 - 4,817,518 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	4,797,415 - 4,896,884 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	4,962,631 - 5,062,108 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Apbb1ip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	25,744,213 - 25,844,462 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	1,950,017 - 2,009,575 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936484	1,909,547 - 2,009,596 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APBB1IP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	49,124,543 - 49,189,308 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	49,125,074 - 49,242,864 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	54,365,892 - 54,429,744 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APBB1IP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	26,163,881 - 26,289,713 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	26,122,428 - 26,289,708 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	32,109,310 - 32,240,467 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Apbb1ip
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624796	2,510,878 - 2,568,532 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624796	2,512,292 - 2,621,505 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Apbb1ip
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	14	1,690,565 - 1,779,867 (-)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	47
Count of miRNA genes:	46
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000024272
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300131	Bp193	Blood pressure QTL 193	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	17	68550040	93515804	Rat
1300148	Bp192	Blood pressure QTL 192	3.47		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	17	46050126	91050126	Rat
61466	Niddm12	Non-insulin dependent diabetes mellitus QTL 12	3.2	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	17	65154872	93515804	Rat
4889894	Eae33	Experimental allergic encephalomyelitis QTL 33	5.2	0.0001	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	17	55604597	93006569	Rat
2317038	Ginf3	Gastrointestinal inflammation QTL 3	2.89	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	17	54829503	93515804	Rat

Markers in Region

RH143782

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	85,000,481 - 85,000,603 (-)	MAPPER	mRatBN7.2
Rnor_6.0	17	90,131,524 - 90,131,645	NCBI	Rnor6.0
Rnor_5.0	17	91,794,933 - 91,795,054	UniSTS	Rnor5.0
RGSC_v3.4	17	96,494,633 - 96,494,754	UniSTS	RGSC3.4
Celera	17	83,893,747 - 83,893,868	UniSTS
RH 3.4 Map	17	868.7	UniSTS
Cytogenetic Map	17	q12.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
21	13	83	209	91	90	59	158	59	6	470	284	22	184	98	120	31	26	26

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039095819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC098839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024272 ⟹ ENSRNOP00000024272

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	89,890,675 - 89,941,089 (+)	Ensembl
mRatBN7.2 Ensembl	17	84,982,243 - 85,033,010 (+)	Ensembl
Rnor_6.0 Ensembl	17	90,099,025 - 90,149,894 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000024901 ⟹ ENSRNOP00000024901

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	89,671,716 - 89,940,930 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000153818 ⟹ ENSRNOP00000099178

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	89,671,724 - 89,737,485 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160283 ⟹ ENSRNOP00000100788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	89,885,471 - 89,941,089 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160721 ⟹ ENSRNOP00000108235

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	17	89,891,022 - 89,941,089 (+)	Ensembl

RefSeq Acc Id:

NM_001100577 ⟹ NP_001094047

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	89,891,022 - 89,941,099 (+)	NCBI
mRatBN7.2	17	84,982,941 - 85,033,020 (+)	NCBI
Rnor_6.0	17	90,098,953 - 90,149,192 (-)	NCBI
Rnor_5.0	17	91,762,064 - 91,812,342 (-)	NCBI
RGSC_v3.4	17	96,476,962 - 96,527,635 (+)	RGD
Celera	17	83,861,327 - 83,910,596 (-)	RGD

Sequence:

show sequence

ATGGGTGAATCAAATGAAGACATAGACCAGATGTTCAGCACTCTGCTGGGGGAGATGGATCTCT
TGACCCAGAGTTTAGGAGTGGACACTCTTCCTCCTGCAGAACCCAAGCCACCCCGAGAAGAGTT
TAACTTCAGTGTGGGGTTTAAGGATTTAAATGAGTCCTTAAATGCACTGGAAGACCAAGATTTA
GATGCCCTCATGGCAGATCTGGTAGCAGATATAAGTGAAGCCGAACAGAGAACCATCCAGGCTC
AGAAAGAGTCCTCTCAGAATCAAGGTCACTCAGCACTTCTGGAGGCCTCAGATGGCCAGGGTAC
AGCCCCAAGAGGTTATGGAGCAAATGCTGCTGCTTTTGATGTTAGCGACTACGAGGAAGCTTTA
CCACCTCCACCAGCAGATCCCATGCTAGACCTTCTACCCCCTCCACCTCCTCCTCCTCCTAAAC
CTCTCTCTAAAGAGGAAGAAGAAGCCCTAGCAAAGGCTGATAAGATTAAGTTGGCACTGGAAAA
GTTGAAGGAAGCCAAGGTTAAGAAGCTTGTAGTTAAGGTGCACATGGGTGACAACAGTACCAAG
TCACTGATGGTGGATGAGCGACAGTTGGCTCGGGATGTTCTCGACAATCTTTTTGAAAAAACCC
ACTGCGACTGCAATGTGGACTGGTGCCTTTATGAAATATATCCCGAATTGCAAATCGAGAGAAT
TTTCGAAGACCATGAAAATGTTGTTGAAGTCTTATCAGACTGGACAAGAGACACAGAGAACAGA
GTACTGTTTTTGGAGAAAGAGGAAAAATATGCTGTGTTTAAAAACCCTCAGAATTTCTACTTGG
ATAATAAGGGGAAAAAAGAAAAGGAAAGCAATGAGAAAATGAATGCTAAAAACAAAGAATACTT
ACTTGAGGAAAGTTTCTGTGGCACATCCATCATAGTACCGGAACTTGAAGGAGCTCTTTATTTG
AAAGAAGACGGGAAGAAGTCCTGGAAACGACGCTACTTTCTTCTGAGAGCTTCTGGAATCTATT
ATGTACCCAAAGGAAAGACAAAGACATCCCGAGACCTGGCGTGTTTCATACAGTTCGAAAATGT
TAACATTTACTATGGGATTCAGTGCAAAATGAAATACAAAGCACCCACTGACCACTGCTTTGTT
TTAAAGCATCCTCAAATTCAGAAGGAATCTCAGTACATCAAGTACCTTTGCTGTGATGACGCAA
GAACTCTCAGCCAGTGGGTTATGGGAATAAGGATCGCCAAGTACGGGAAAACTCTCTATGATAA
CTATCAGCGGGCTGTGGCTAGAGCTGGACTCGCCTCTCGGTGGACGAACCTGGGGACTGCCACT
ACACCAGCTCAGCCTGCTGCAGGACTTAAAACAGGCACCAGCCAGCCCAATGGTCCAATGCCCC
AGGCCGCGCCTTCCCCTGGTCCTCCTCTCCGAGAGACCCTGACACAAACTGAAACAACTAAGGA
TGAAAAGCAAGGCTTGGCTAACCACTCCCCAGGAGCAAGCAGGGAGAACCACCGCCCTAAGAGC
AGCCTGCTTCCACCACCCCCTCCAGTAAGACGATCTTCGGACACCTGTGGCAGCCCTGCCTTGC
CACCCAAAGCCAAGGGCCCTGGCAGCTGCACCTTCACCGCCCAGCCCGAGAACTTCCTGCCACC
ACCACCGCCCCCACCGCCCCAGGAGGACGACAACAGCATGCTACTCCCACCACCCCCACCCCTG
GCCTACCTCGATGAGCCACCGGATTTCGTGCCACCGCCCCCACCACCTGCAACTGTTGAAGACT
CTGCATTGCCACCCCCGCCGCCACCCCCACCCTGTCTCTCCCAGGAGATGACCAAGTCATCTCC
ATTGCCCGCCAAAAAGCTCCCAGTGCCCCCCAAGAGGCAAGAGAACCAAGGACTCCCTGGTGCC
CCAAGGAACACGGAGCAAGATTTTATGTCAGACCTCATGAAAGCATTGCAAAAGAAAAGAGGCA
ATGTACCCTAGAGACATGTCAGCATCTGGGACGCTCTCTAGCTAGATTCATATTTTGGTACTCT
GCTGTCATGCATCTTGTTCATTTTAGTAAAATGTTTTGCCACTAGAAATAATGTAAAAACTCTT
CACTGTTGTGCATACTGTGTTCATAGCCATTAGACTAGCTGTATTTGGAGTTTCTAACTGTATA
CATCCAAGCACACAAACATGCACATTCTGTATGTTTTCACCTGAATGGACTTTTATCTTGCAGT
ACAAGCTAACTGAAATGATATTCTGGATATGTTTCTGTGTGCTCAGAAGGCACAAATTTTTAAA
ATTAAAGTTTGTCTGAAAATAGTATTTATAGAAATAGTGTTTAAATTTTGTATGGTGTCAACAC
TACTTTATATTTGACTCTCAAAAAGTTTCAAATTCCTATGCCTCCTTAAGTCTTGTTCTATTTC
CTTCTTGGTGTCTGTAACCTACAGATATAGCAAAACAGGGAAAAGGAAAAAGAAAG

hide sequence

RefSeq Acc Id:

XM_039095818 ⟹ XP_038951746

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	89,849,474 - 89,940,939 (+)	NCBI
mRatBN7.2	17	84,941,404 - 85,032,870 (+)	NCBI

RefSeq Acc Id:

XM_039095819 ⟹ XP_038951747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	17	89,893,722 - 89,940,939 (+)	NCBI
mRatBN7.2	17	84,985,642 - 85,032,870 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094047	(Get FASTA)	NCBI Sequence Viewer
	XP_038951746	(Get FASTA)	NCBI Sequence Viewer
	XP_038951747	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98839	(Get FASTA)	NCBI Sequence Viewer
	EDL83938	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024272
	ENSRNOP00000024272.7
	ENSRNOP00000100788.1
	ENSRNOP00000108235.1

RefSeq Acc Id:

NP_001094047 ⟸ NM_001100577

- UniProtKB:

D3ZDZ1 (UniProtKB/TrEMBL), A6KS00 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGESNEDIDQMFSTLLGEMDLLTQSLGVDTLPPAEPKPPREEFNFSVGFKDLNESLNALEDQDL
DALMADLVADISEAEQRTIQAQKESSQNQGHSALLEASDGQGTAPRGYGANAAAFDVSDYEEAL
PPPPADPMLDLLPPPPPPPPKPLSKEEEEALAKADKIKLALEKLKEAKVKKLVVKVHMGDNSTK
SLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERIFEDHENVVEVLSDWTRDTENR
VLFLEKEEKYAVFKNPQNFYLDNKGKKEKESNEKMNAKNKEYLLEESFCGTSIIVPELEGALYL
KEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFV
LKHPQIQKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLASRWTNLGTAT
TPAQPAAGLKTGTSQPNGPMPQAAPSPGPPLRETLTQTETTKDEKQGLANHSPGASRENHRPKS
SLLPPPPPVRRSSDTCGSPALPPKAKGPGSCTFTAQPENFLPPPPPPPPQEDDNSMLLPPPPPL
AYLDEPPDFVPPPPPPATVEDSALPPPPPPPPCLSQEMTKSSPLPAKKLPVPPKRQENQGLPGA
PRNTEQDFMSDLMKALQKKRGNVP

hide sequence

Ensembl Acc Id:

ENSRNOP00000024272 ⟸ ENSRNOT00000024272

RefSeq Acc Id:	XP_038951746 ⟸ XM_039095818
- Peptide Label:	isoform X1
- UniProtKB:	A6KS00 (UniProtKB/TrEMBL), D3ZDZ1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038951747 ⟸ XM_039095819
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000099178 ⟸ ENSRNOT00000153818

Ensembl Acc Id:

ENSRNOP00000100788 ⟸ ENSRNOT00000160283

Ensembl Acc Id:

ENSRNOP00000024901 ⟸ ENSRNOT00000024901

Ensembl Acc Id:

ENSRNOP00000108235 ⟸ ENSRNOT00000160721

Protein Domains

PH Ras-associating

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDZ1-F1-model_v2	AlphaFold	D3ZDZ1	1-664	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304795	AgrOrtholog
BioCyc Gene	G2FUF-8485	BioCyc
Ensembl Genes	ENSRNOG00000017803	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024272	ENTREZGENE
	ENSRNOT00000024272.8	UniProtKB/TrEMBL
	ENSRNOT00000160283.1	UniProtKB/TrEMBL
	ENSRNOT00000160721.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7379029	IMAGE-MGC_LOAD
InterPro	GRB/APBB1IP	UniProtKB/TrEMBL
	PH_APBB1IP	UniProtKB/TrEMBL
	PH_like_dom	UniProtKB/TrEMBL
	Pleckstrin_homology	UniProtKB/TrEMBL
	Ras-assoc	UniProtKB/TrEMBL
	Ubiquitin-rel_dom	UniProtKB/TrEMBL
KEGG Report	rno:307171	UniProtKB/TrEMBL
MGC_CLONE	MGC:112894	IMAGE-MGC_LOAD
NCBI Gene	307171	ENTREZGENE
PANTHER	AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN	UniProtKB/TrEMBL
	PTHR11243	UniProtKB/TrEMBL
Pfam	PF00169	UniProtKB/TrEMBL
	RA_2	UniProtKB/TrEMBL
PhenoGen	Apbb1ip	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/TrEMBL
	PS50200	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017803	RatGTEx
SMART	SM00233	UniProtKB/TrEMBL
	SM00314	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF54236	UniProtKB/TrEMBL
UniProt	A0ABK0L790_RAT	UniProtKB/TrEMBL
	A0ABK0M025_RAT	UniProtKB/TrEMBL
	A6KS00	ENTREZGENE, UniProtKB/TrEMBL
	D3ZDZ1	ENTREZGENE, UniProtKB/TrEMBL
	Q4G016_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-27	Apbb1ip	amyloid beta precursor protein binding family B member 1 interacting protein	Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	Apbb1ip_predicted	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Apbb1ip_predicted	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - CTD

RGD Manual Annotations