Symbol:
Iws1
Name:
interacts with SUPT6H, CTD assembly factor 1
RGD ID:
1304762
Description:
Predicted to be involved in gene expression; regulation of mRNA export from nucleus; and regulation of mRNA processing. Predicted to act upstream of or within in utero embryonic development. Predicted to be active in nucleus. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,4-methylenedioxymethamphetamine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
IWS1 homolog; IWS1 homolog (S. cerevisiae); IWS1, SUPT6H interacting protein; IWS1-like protein; LOC291705; MGC124986; protein IWS1 homolog; RGD1304762; similar to hypothetical protein FLJ10006
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
IWS1 (interacts with SUPT6H, CTD assembly factor 1)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Iws1 (IWS1, SUPT6 interacting protein)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Iws1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
IWS1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
IWS1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Iws1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
IWS1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
IWS1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Iws1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Iws1 (interacts with SUPT6H, CTD assembly factor 1)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PNP (purine nucleoside phosphorylase)
HGNC
OMA
Alliance orthologs 3
Mus musculus (house mouse):
Iws1 (IWS1, SUPT6 interacting protein)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
IWS1 (interacts with SUPT6H, CTD assembly factor 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
F13B12.1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
F13B12.1
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
CG9915
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Drosophila melanogaster (fruit fly):
CG9915
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
SPN1
Alliance
DIOPT (Ensembl Compara|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
SPN1
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):
iws1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 18 23,969,352 - 24,011,560 (+) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 18 23,969,733 - 24,010,415 (+) Ensembl GRCr8 mRatBN7.2 18 23,695,496 - 23,737,363 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 18 23,695,425 - 23,736,172 (+) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 18 23,823,597 - 23,861,406 (+) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 18 24,579,583 - 24,617,407 (+) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 18 23,918,579 - 23,956,389 (+) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 18 24,849,508 - 24,891,339 (+) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 18 24,849,545 - 24,880,317 (+) Ensembl rn6 Rnor6.0 Rnor_5.0 18 24,564,090 - 24,606,101 (+) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 18 24,489,571 - 24,524,125 (+) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 18 23,448,049 - 23,478,821 (+) NCBI Celera RGSC_v3.1 18 24,494,575 - 24,550,538 (+) NCBI Cytogenetic Map 18 p12 NCBI
JBrowse:
Only show annotations with direct experimental evidence (0 objects hidden)
Iws1 Rat (-)-epigallocatechin 3-gallate multiple interactions ISO IWS1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IWS1 mRNA CTD PMID:22079256 Iws1 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Iws1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Iws1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Iws1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Iws1 Rat 2,2',4,4'-Tetrabromodiphenyl ether decreases expression ISO IWS1 (Homo sapiens) 6480464 2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of IWS1 protein CTD PMID:31675489 Iws1 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Iws1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Iws1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Iws1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of IWS1 mRNA CTD PMID:19770486 Iws1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of IWS1 mRNA CTD PMID:34747641 Iws1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Iws1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of IWS1 mRNA CTD PMID:21570461 Iws1 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Iws1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Iws1 Rat 2,4,6-tribromophenol decreases expression ISO IWS1 (Homo sapiens) 6480464 2,4,6-tribromophenol results in decreased expression of IWS1 mRNA CTD PMID:31675489 Iws1 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of IWS1 mRNA CTD PMID:21346803 Iws1 Rat 3,3',5,5'-tetrabromobisphenol A decreases expression ISO IWS1 (Homo sapiens) 6480464 tetrabromobisphenol A results in decreased expression of IWS1 protein CTD PMID:31675489 Iws1 Rat 3,4-methylenedioxymethamphetamine affects expression EXP 6480464 N-Methyl-3,4-methylenedioxyamphetamine affects the expression of IWS1 mRNA CTD PMID:30071829 Iws1 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO IWS1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Iws1 Rat 4-hydroxyphenyl retinamide increases expression ISO Iws1 (Mus musculus) 6480464 Fenretinide results in increased expression of IWS1 mRNA CTD PMID:28973697 Iws1 Rat aflatoxin B1 increases expression ISO Iws1 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of IWS1 mRNA CTD PMID:19770486 Iws1 Rat aristolochic acid A decreases expression ISO IWS1 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of IWS1 mRNA CTD PMID:33212167 Iws1 Rat arsane affects methylation ISO IWS1 (Homo sapiens) 6480464 Arsenic affects the methylation of IWS1 gene CTD PMID:25304211 Iws1 Rat arsane multiple interactions ISO IWS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Iws1 Rat arsenic atom affects methylation ISO IWS1 (Homo sapiens) 6480464 Arsenic affects the methylation of IWS1 gene CTD PMID:25304211 Iws1 Rat arsenic atom multiple interactions ISO IWS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Iws1 Rat atrazine increases expression ISO IWS1 (Homo sapiens) 6480464 Atrazine results in increased expression of IWS1 mRNA CTD PMID:22378314 Iws1 Rat benzo[a]pyrene affects methylation ISO IWS1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of IWS1 promoter CTD PMID:27901495 Iws1 Rat benzo[a]pyrene diol epoxide I decreases expression ISO IWS1 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IWS1 mRNA CTD PMID:19150397 Iws1 Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of IWS1 mRNA CTD PMID:25181051 Iws1 Rat bisphenol A decreases expression ISO Iws1 (Mus musculus) 6480464 bisphenol A results in decreased expression of IWS1 mRNA CTD PMID:33221593 Iws1 Rat bisphenol A decreases expression ISO IWS1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of IWS1 protein CTD PMID:33376534|PMID:37567409 Iws1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IWS1 mRNA CTD PMID:34947998 Iws1 Rat bisphenol A increases expression ISO Iws1 (Mus musculus) 6480464 bisphenol A results in increased expression of IWS1 mRNA CTD PMID:40036665 Iws1 Rat bisphenol F multiple interactions ISO IWS1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Iws1 Rat cadmium atom multiple interactions ISO Iws1 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IWS1 more ... CTD PMID:37236586 Iws1 Rat cadmium dichloride multiple interactions ISO Iws1 (Mus musculus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IWS1 more ... CTD PMID:37236586 Iws1 Rat caffeine increases phosphorylation ISO IWS1 (Homo sapiens) 6480464 Caffeine results in increased phosphorylation of IWS1 protein CTD PMID:35688186 Iws1 Rat cannabidiol increases expression ISO IWS1 (Homo sapiens) 6480464 Cannabidiol results in increased expression of IWS1 mRNA CTD PMID:27918106 Iws1 Rat chlorpyrifos decreases expression ISO Iws1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of IWS1 mRNA CTD PMID:37019170 Iws1 Rat choline multiple interactions ISO Iws1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... CTD PMID:20938992 Iws1 Rat clobetasol decreases expression ISO Iws1 (Mus musculus) 6480464 Clobetasol results in decreased expression of IWS1 mRNA CTD PMID:27462272 Iws1 Rat coumarin affects phosphorylation ISO IWS1 (Homo sapiens) 6480464 coumarin affects the phosphorylation of IWS1 protein CTD PMID:35688186 Iws1 Rat cyclosporin A increases expression ISO Iws1 (Mus musculus) 6480464 Cyclosporine results in increased expression of IWS1 mRNA CTD PMID:19770486 Iws1 Rat decabromodiphenyl ether decreases expression ISO IWS1 (Homo sapiens) 6480464 decabromobiphenyl ether results in decreased expression of IWS1 protein CTD PMID:31675489 Iws1 Rat dexamethasone multiple interactions ISO IWS1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Iws1 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of IWS1 mRNA CTD PMID:24136188 Iws1 Rat folic acid multiple interactions ISO Iws1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... CTD PMID:20938992 Iws1 Rat folic acid decreases expression ISO Iws1 (Mus musculus) 6480464 Folic Acid results in decreased expression of IWS1 mRNA CTD PMID:25629700 Iws1 Rat FR900359 affects phosphorylation ISO IWS1 (Homo sapiens) 6480464 FR900359 affects the phosphorylation of IWS1 protein CTD PMID:37730182 Iws1 Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of IWS1 mRNA CTD PMID:33387578 Iws1 Rat hydrogen peroxide decreases expression ISO IWS1 (Homo sapiens) 6480464 Hydrogen Peroxide results in decreased expression of IWS1 mRNA CTD PMID:18951874 Iws1 Rat indometacin multiple interactions ISO IWS1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Iws1 Rat inulin multiple interactions ISO Iws1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of IWS1 mRNA CTD PMID:36331819 Iws1 Rat ivermectin decreases expression ISO IWS1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of IWS1 protein CTD PMID:32959892 Iws1 Rat L-methionine multiple interactions ISO Iws1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... CTD PMID:20938992 Iws1 Rat manganese atom multiple interactions ISO IWS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Iws1 Rat manganese(0) multiple interactions ISO IWS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Iws1 Rat manganese(II) chloride multiple interactions ISO IWS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Iws1 Rat methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of IWS1 mRNA CTD PMID:30467583 Iws1 Rat methylparaben increases expression ISO IWS1 (Homo sapiens) 6480464 methylparaben results in increased expression of IWS1 mRNA CTD PMID:31745603 Iws1 Rat ozone multiple interactions ISO IWS1 (Homo sapiens) 6480464 [Air Pollutants results in increased abundance of Ozone] which affects the expression of IWS1 mRNA CTD PMID:35430440 Iws1 Rat PCB138 multiple interactions ISO Iws1 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Iws1 Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Iws1 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of IWS1 mRNA CTD PMID:36331819 Iws1 Rat potassium chromate multiple interactions ISO IWS1 (Homo sapiens) 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IWS1 mRNA CTD PMID:22079256 Iws1 Rat potassium chromate decreases expression ISO IWS1 (Homo sapiens) 6480464 potassium chromate(VI) results in decreased expression of IWS1 mRNA CTD PMID:22079256 Iws1 Rat resveratrol decreases expression ISO Iws1 (Mus musculus) 6480464 resveratrol results in decreased expression of IWS1 protein CTD PMID:25505154 Iws1 Rat resveratrol multiple interactions ISO IWS1 (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of IWS1 mRNA CTD PMID:23557933 Iws1 Rat rotenone decreases expression ISO IWS1 (Homo sapiens) 6480464 Rotenone results in decreased expression of IWS1 protein CTD PMID:39603559 Iws1 Rat SB 431542 multiple interactions ISO IWS1 (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of IWS1 more ... CTD PMID:37664457 Iws1 Rat sodium arsenite multiple interactions ISO IWS1 (Homo sapiens) 6480464 [[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ... CTD PMID:39836092 Iws1 Rat Soman increases expression EXP 6480464 Soman results in increased expression of IWS1 mRNA CTD PMID:19281266 Iws1 Rat thimerosal decreases expression ISO IWS1 (Homo sapiens) 6480464 Thimerosal results in decreased expression of IWS1 mRNA CTD PMID:27188386 Iws1 Rat titanium dioxide decreases methylation ISO Iws1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of IWS1 gene CTD PMID:35295148 Iws1 Rat torcetrapib increases expression ISO IWS1 (Homo sapiens) 6480464 torcetrapib results in increased expression of IWS1 mRNA CTD PMID:23228038 Iws1 Rat trichostatin A affects expression ISO IWS1 (Homo sapiens) 6480464 trichostatin A affects the expression of IWS1 mRNA CTD PMID:28542535 Iws1 Rat tungsten decreases expression ISO Iws1 (Mus musculus) 6480464 Tungsten results in decreased expression of IWS1 mRNA CTD PMID:30912803 Iws1 Rat valproic acid affects expression ISO Iws1 (Mus musculus) 6480464 Valproic Acid affects the expression of IWS1 mRNA CTD PMID:17292431 Iws1 Rat valproic acid decreases methylation ISO IWS1 (Homo sapiens) 6480464 Valproic Acid results in decreased methylation of IWS1 gene CTD PMID:29154799