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Gene: Hcls1 (hematopoietic cell specific Lyn substrate 1) Rattus norvegicus

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Symbol:

Hcls1

Name:

hematopoietic cell specific Lyn substrate 1

RGD ID:

1304754

Description:

Predicted to enable several functions, including SH3 domain binding activity; actin filament binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of myeloid leukocyte differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in cortical actin cytoskeleton; plasma membrane; and site of polarized growth. Predicted to colocalize with actin filament. Orthologous to human HCLS1 (hematopoietic cell-specific Lyn substrate 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hematopoietic lineage cell-specific protein; LOC102552892; LOC288077; uncharacterized LOC102552892

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	77,322,873 - 77,346,333 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	77,322,873 - 77,346,387 (-)	Ensembl				GRCr8
mRatBN7.2	11	63,817,482 - 63,840,943 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	63,817,476 - 63,841,014 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	72,629,890 - 72,653,348 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	65,292,112 - 65,315,571 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	64,326,440 - 64,349,883 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	66,736,966 - 66,759,402 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	66,736,966 - 66,759,402 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	69,828,261 - 69,850,286 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	65,619,701 - 65,643,533 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	63,290,349 - 63,313,671 (-)	NCBI		Celera
RGSC_v3.1	11	65,677,289 - 65,701,122 (-)	NCBI
Cytogenetic Map	11	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-amphetamine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

bisphenol F (ISO)

bleomycin A2 (ISO)

butanal (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

clozapine (ISO)

Cuprizon (EXP,ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dimethylarsinic acid (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethylparaben (ISO)

Evodiamine (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

isotretinoin (ISO)

lead(0) (ISO)

lidocaine (EXP)

methylarsonic acid (ISO)

mitomycin C (ISO)

nickel atom (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (ISO)

potassium chromate (ISO)

progesterone (ISO)

quercetin (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

Soman (EXP)

temozolomide (ISO)

testosterone enanthate (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vincaleukoblastine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (IEA,ISO)

cell migration (IBA)

cellular response to cytokine stimulus (IEA,ISO)

erythrocyte differentiation (IEA,ISO)

granulocyte colony-stimulating factor signaling pathway (IEA,ISO)

negative regulation of leukocyte apoptotic process (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

nuclear transport (IEA,ISO)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of granulocyte differentiation (IEA,ISO)

positive regulation of macrophage differentiation (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

positive regulation of protein import into nucleus (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of actin filament polymerization (IBA,IEA,ISO)

response to hormone (IEA,ISO)

Cellular Component

actin filament (IBA)

cortical actin cytoskeleton (IBA)

cytoplasm (IEA,ISO)

cytosol (IEA,ISO)

nucleus (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

site of polarized growth (IBA)

transcription regulator complex (IEA,ISO)

Molecular Function

actin filament binding (IBA)

protein binding (ISO)

protein kinase binding (IEA,ISO)

protein-containing complex binding (IEA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA,ISO)

SH3 domain binding (IEA,ISO)

signaling adaptor activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9126384	PMID:10713104	PMID:12477932	PMID:19064729	PMID:23001182

Genomics

Comparative Map Data

Hcls1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	77,322,873 - 77,346,333 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	77,322,873 - 77,346,387 (-)	Ensembl				GRCr8
mRatBN7.2	11	63,817,482 - 63,840,943 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	63,817,476 - 63,841,014 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	72,629,890 - 72,653,348 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	65,292,112 - 65,315,571 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	64,326,440 - 64,349,883 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	66,736,966 - 66,759,402 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	66,736,966 - 66,759,402 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	69,828,261 - 69,850,286 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	65,619,701 - 65,643,533 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	63,290,349 - 63,313,671 (-)	NCBI		Celera
RGSC_v3.1	11	65,677,289 - 65,701,122 (-)	NCBI
Cytogenetic Map	11	q21	NCBI

HCLS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	121,631,399 - 121,660,903 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	121,631,399 - 121,660,927 (-)	Ensembl			hg38	GRCh38
GRCh37	3	121,350,246 - 121,379,750 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	122,832,936 - 122,862,405 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	122,832,936 - 122,862,405	NCBI
Celera	3	119,759,962 - 119,789,755 (-)	NCBI		Celera
Cytogenetic Map	3	q13.33	NCBI
HuRef	3	118,724,406 - 118,753,920 (-)	NCBI		HuRef
CHM1_1	3	121,313,816 - 121,343,335 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	124,351,297 - 124,380,795 (-)	NCBI		T2T-CHM13v2.0

Hcls1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	36,755,345 - 36,783,576 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	36,755,345 - 36,783,574 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	36,934,983 - 36,963,214 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	36,934,983 - 36,963,212 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	36,935,069 - 36,963,300 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	36,854,254 - 36,882,453 (+)	NCBI		MGSCv36	mm8
Celera	16	37,345,885 - 37,374,104 (+)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	26.3	NCBI

Hcls1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	20,999,485 - 21,020,531 (-)	Ensembl
ChiLan1.0	NW_004955427	20,999,934 - 21,020,401 (-)	NCBI	ChiLan1.0	ChiLan1.0

HCLS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	119,588,336 - 119,618,016 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	119,593,113 - 119,622,788 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	118,733,505 - 118,763,177 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	125,642,973 - 125,671,685 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	125,642,973 - 125,669,095 (-)	Ensembl			panPan2	panpan1.1

HCLS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	24,901,023 - 24,925,710 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	24,901,287 - 24,922,923 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	24,928,335 - 24,953,023 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	25,143,477 - 25,168,170 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	25,143,477 - 25,168,284 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	24,941,715 - 24,966,393 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	24,983,974 - 25,008,644 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	25,541,087 - 25,565,782 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hcls1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	129,438,045 - 129,456,556 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936536	8,065,464 - 8,083,923 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936536	8,065,489 - 8,084,777 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HCLS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	138,855,144 - 138,889,281 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	138,852,387 - 138,883,088 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	148,479,997 - 148,507,593 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HCLS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	59,225,768 - 59,255,744 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	59,225,750 - 59,256,243 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	107,069,101 - 107,100,618 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hcls1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	26,528,097 - 26,560,695 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624731	26,528,163 - 26,559,108 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hcls1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	21,807,463 - 21,831,026 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hcls1
300 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	376
Count of miRNA genes:	203
Interacting mature miRNAs:	229
Transcripts:	ENSRNOT00000003326
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	73308487	96070872	Rat
1598811	Bp291	Blood pressure QTL 291	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	33306008	78306008	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	58928336	99753367	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	36428416	81428416	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	73850894	99753367	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	34618760	79618760	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	58931822	92356038	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	57754837	96071021	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	67962184	99753367	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	73308315	99753367	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	51071021	96071021	Rat
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
1598841	Memor7	Memory QTL 7			exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	11	33306008	78306008	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	58272363	96350770	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	54415391	96071021	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	36749459	81749459	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	36749459	81749459	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	68599321	96497754	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	69855943	99753367	Rat

Markers in Region

AW213261

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	63,817,527 - 63,817,624 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	66,737,010 - 66,737,106	NCBI	Rnor6.0
Rnor_5.0	11	69,828,305 - 69,828,401	UniSTS	Rnor5.0
RGSC_v3.4	11	65,619,745 - 65,619,841	UniSTS	RGSC3.4
Celera	11	63,290,393 - 63,290,489	UniSTS
Cytogenetic Map	11	q22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	138	81	92	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001011898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003326 ⟹ ENSRNOP00000003326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	77,322,873 - 77,346,387 (-)	Ensembl
mRatBN7.2 Ensembl	11	63,817,476 - 63,841,014 (-)	Ensembl
Rnor_6.0 Ensembl	11	66,736,966 - 66,759,402 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000149017 ⟹ ENSRNOP00000101065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	77,322,873 - 77,346,387 (-)	Ensembl

RefSeq Acc Id:

NM_001011898 ⟹ NP_001011898

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	77,322,873 - 77,346,333 (-)	NCBI
mRatBN7.2	11	63,817,484 - 63,840,943 (-)	NCBI
Rnor_6.0	11	66,736,966 - 66,759,402 (-)	NCBI
Rnor_5.0	11	69,828,261 - 69,850,286 (-)	NCBI
RGSC_v3.4	11	65,619,701 - 65,643,533 (-)	RGD
Celera	11	63,290,349 - 63,313,671 (-)	RGD

Sequence:

show sequence

CGAAGAGCCAGAGTTTTAGCAACAAGGAAAGATGTGGAAGTCTGTAGTGGGGCACAATGTATCG
GTTTCCGTGGAGACCCAGGGTGATGACTGGGACACAGACCCTGACTTTGTGAATGACATCTCTG
AGAAGGAACAACGGTGGGGAGCCAAGACCATTGAGGGCTCTGGACGCACAGAGCATATCAACAT
CCACCAGCTGAGGAACAAAGTGTCCGAGGAGCATGACATTCTCAAGAAGAGAGAGCTGGAGTCG
GGGCCTAAAGCCTCCCATGGCTATGGGGGTCGGTTTGGAGTGGAAAGAGACCGGATGGACAAGA
GTGCCGTGGGCCACGAGTATGTTGCTGAAGTGGAGAAACACTCGTCTCAGACTGATGCCGCCAA
AGGCTTTGGGGGCAAATATGGAGTTGAGAGGGACCGGGCAGACAAGTCAGCGGTGGGCTTTGAC
TACAAAGGAGAGGTGGAGAAGCACGCATCTCAGAAAGATTACTCTCATGGCTTTGGTGGCCGCT
ACGGGGTAGAGAAGGATAAACGGGACAAAGCAGCTCTGGGATATGACTACAAGGGAGAGACGGA
GAAGCACGAGTCTCAGCGAGATTATGCCAAGGGCTTTGGTGGTCAATATGGAATCCAGAAAGAC
AGAGTGGATAAGAGTGCTGTTGGCTTCAATGAAATGGAGGCCCCAACCACGGCATATAAGAAGA
CAACACCCATAGAAGCTGCTTCCAGTGGTGCCCGTGGGCTGAAGGCAAAATTCGAGTCCATGGC
TGAGGAGAAGAGGAAGCGAGAAGAAGAAGAGAAGGCACAACAGATGGCCAGGCAGCAGCAAGAA
CGAAAGGCTATGGTGAAGATGAGCCGTGAAGCTCAGCAGCCATCCGTGCCTGTGGACGAGCCCG
CAGCACCAGCCCCGTTGCCCAAGAAGATCTCCTCAGAGGTCTGGCCTCCAGCAGAGAGTCACCT
ACCACCACAGTCCGAGCCCGTGGGAGGCAGAAGAGAATACCCTGTGCCCTCCCTGCCCACGAGA
CAGCCTCCACCTCAGAATCCCCTCGAGGACAATGAGGAGCCCCCAGCTCTGCCCCCTAGGACTC
CAGAAGGCCTCCAGGTGGTAGAAGAGCCAGTGTACGAAGCAGCACCCGAGCCCGAGCCTGAGCC
CGAGCCTGACTATGAGGATGTTGGAGAGTTAGATCGGCCGGATGAGGAAGCAGAGGGAGACTAT
GAGGATGTGCTGGAGCCCGAGGACACCCCTTCTCTATCCTACCAGGCTGGACACTCAGCTGGGG
CTGGCGGTGCAGGGATCTCTGCTGTAGCCCTTTATGATTACCAAGGAGAGGGAAGTGATGAGCT
GTCCTTTGACCCAGATGATGTCATCACTGACATTGAGATGGTTGATGAAGGCTGGTGGCGGGGC
CGATGTCATGGCCACTTTGGACTCTTTCCTGCAAACTATGTCAAGCTCCTCTGATGAGCTTGTC
TTTTAACCCCTGGTGTTCGAAGTTGCTCTGGCCCCCTCTTCCCACTCCATGGTACTGCTGCAAG
GACTTGACTGAACATCACGGGATGCCTAGAGCTCTAGCAGTCTGTCTTCTGCCTCTTTAAGAGC
CTTAGGTGGAACTGCTCGAGGCAGGGGTGGGGCTGAGGGGTGGGGTTGAGGGGTGGGGTTGAGG
TTTCCCTCTGTCCCTCTGTTTCCTCTCCTCCCTGGAGTAACTCATGGAATCATCTCGCAGCCCT
GCCTCTTTCAACCACACCCCAGCTCTGCTGACCTCTCTCTAGAGTGTTGGGATTCCCTCACCCC
GACCCTGAGTGCCAGCCTAGAGGGGAGGCTCTCACTGGGCTGCCTGATTCGCCCATGCTCTGCT
TTTGCTCATTTTTCTTCTCTTAAGATACAAATTGGAACTGCCCTTCTGTTTAGTCCTAAAACTG
AAAATAAAGCAAGACTGTGGCTTAGCTTTCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088123 ⟹ XP_038944051

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	77,322,873 - 77,346,136 (-)	NCBI
mRatBN7.2	11	63,817,482 - 63,840,743 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001011898	(Get FASTA)	NCBI Sequence Viewer
	XP_038944051	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79081	(Get FASTA)	NCBI Sequence Viewer
	EDM11252	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003326
	ENSRNOP00000003326.6
	ENSRNOP00000101065.1

RefSeq Acc Id:

NP_001011898 ⟸ NM_001011898

- UniProtKB:

Q68FX4 (UniProtKB/TrEMBL), F7F5Q9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWKSVVGHNVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEE
HDILKKRELESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVER
DRADKSAVGFDYKGEVEKHASQKDYSHGFGGRYGVEKDKRDKAALGYDYKGETEKHESQRDYAK
GFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGARGLKAKFESMAEEKRKREEEE
KAQQMARQQQERKAMVKMSREAQQPSVPVDEPAAPAPLPKKISSEVWPPAESHLPPQSEPVGGR
REYPVPSLPTRQPPPQNPLEDNEEPPALPPRTPEGLQVVEEPVYEAAPEPEPEPEPDYEDVGEL
DRPDEEAEGDYEDVLEPEDTPSLSYQAGHSAGAGGAGISAVALYDYQGEGSDELSFDPDDVITD
IEMVDEGWWRGRCHGHFGLFPANYVKLL

hide sequence

Ensembl Acc Id:

ENSRNOP00000003326 ⟸ ENSRNOT00000003326

RefSeq Acc Id:	XP_038944051 ⟸ XM_039088123
- Peptide Label:	isoform X1
- UniProtKB:	Q68FX4 (UniProtKB/TrEMBL), F7F5Q9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000101065 ⟸ ENSRNOT00000149017

Protein Domains

SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FX4-F1-model_v2	AlphaFold	Q68FX4	1-476	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698178

Promoter ID:

EPDNEW_R8702

Type:

multiple initiation site

Name:

Hcls1_1

Description:

hematopoietic cell specific Lyn substrate 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	66,759,449 - 66,759,509	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304754	AgrOrtholog
BioCyc Gene	G2FUF-21246	BioCyc
Ensembl Genes	ENSRNOG00000038881	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003326	ENTREZGENE
	ENSRNOT00000003326.7	UniProtKB/TrEMBL
	ENSRNOT00000149017.1	UniProtKB/TrEMBL
Gene3D-CATH	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7122756	IMAGE-MGC_LOAD
InterPro	Hs1_Cortactin	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
KEGG Report	rno:288077	UniProtKB/TrEMBL
MGC_CLONE	MGC:94041	IMAGE-MGC_LOAD
NCBI Gene	288077	ENTREZGENE
PANTHER	CORTACTIN AND DREBRIN	UniProtKB/TrEMBL
	PTHR10829:SF5	UniProtKB/TrEMBL
Pfam	HS1_rep	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Hcls1	PhenoGen
PRINTS	P67PHOX	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	CORTACTIN	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000038881	RatGTEx
SMART	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
UniProt	A0ABK0KZW1_RAT	UniProtKB/TrEMBL
	F7F5Q9	ENTREZGENE, UniProtKB/TrEMBL
	Q68FX4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Hcls1	hematopoietic cell specific Lyn substrate 1	LOC102552892	uncharacterized LOC102552892	Data merged from RGD:7632730	737654	PROVISIONAL
2013-12-18	LOC102552892	uncharacterized LOC102552892			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-06	Hcls1	hematopoietic cell specific Lyn substrate 1	Hcls1_predicted	hematopoietic cell specific Lyn substrate 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Hcls1_predicted	hematopoietic cell specific Lyn substrate 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD