Tecrl (trans-2,3-enoyl-CoA reductase-like) - Rat Genome Database

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Gene: Tecrl (trans-2,3-enoyl-CoA reductase-like) Rattus norvegicus
Analyze
Symbol: Tecrl
Name: trans-2,3-enoyl-CoA reductase-like
RGD ID: 1304608
Description: Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in sphingolipid metabolic process and very long-chain fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 3. Orthologous to human TECRL (trans-2,3-enoyl-CoA reductase like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC364134; Srd5a2l2; steroid 5 alpha-reductase 2-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81425,086,930 - 25,159,957 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1425,086,930 - 25,159,957 (+)EnsemblGRCr8
mRatBN7.21424,732,241 - 24,805,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1424,732,241 - 24,805,272 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1425,028,452 - 25,107,679 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01426,340,883 - 26,420,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01424,873,115 - 24,952,344 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01426,662,851 - 26,735,878 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1426,662,965 - 26,737,657 (+)Ensemblrn6Rnor6.0
Rnor_5.01426,494,055 - 26,567,265 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41426,619,939 - 26,693,786 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1424,130,792 - 24,204,475 (+)NCBICelera
RGSC_v3.11426,619,939 - 26,693,730 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endoplasmic reticulum  (IBA,IEA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27861123  


Genomics

Comparative Map Data
Tecrl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81425,086,930 - 25,159,957 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1425,086,930 - 25,159,957 (+)EnsemblGRCr8
mRatBN7.21424,732,241 - 24,805,272 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1424,732,241 - 24,805,272 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1425,028,452 - 25,107,679 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01426,340,883 - 26,420,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01424,873,115 - 24,952,344 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01426,662,851 - 26,735,878 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1426,662,965 - 26,737,657 (+)Ensemblrn6Rnor6.0
Rnor_5.01426,494,055 - 26,567,265 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41426,619,939 - 26,693,786 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1424,130,792 - 24,204,475 (+)NCBICelera
RGSC_v3.11426,619,939 - 26,693,730 (+)NCBI
Cytogenetic Map14p21NCBI
TECRL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38464,276,298 - 64,409,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl464,275,257 - 64,409,495 (-)Ensemblhg38GRCh38
GRCh37465,142,016 - 65,275,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36464,826,015 - 64,957,773 (-)NCBIBuild 36Build 36hg18NCBI36
Celera462,604,385 - 62,735,641 (-)NCBICelera
Cytogenetic Map4q13.1NCBI
HuRef461,053,712 - 61,185,436 (-)NCBIHuRef
CHM1_1465,180,738 - 65,311,988 (-)NCBICHM1_1
T2T-CHM13v2.0467,713,307 - 67,846,464 (-)NCBIT2T-CHM13v2.0
Tecrl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39583,425,969 - 83,503,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl583,425,992 - 83,503,042 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38583,278,122 - 83,355,195 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl583,278,145 - 83,355,195 (-)Ensemblmm10GRCm38
MGSCv37583,707,147 - 83,784,220 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36584,352,709 - 84,429,756 (-)NCBIMGSCv36mm8
Celera580,520,270 - 80,597,434 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.0NCBI
Tecrl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554478,075,443 - 8,190,199 (+)Ensembl
ChiLan1.0NW_0049554478,075,470 - 8,189,509 (+)NCBIChiLan1.0ChiLan1.0
TECRL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2365,472,420 - 65,604,949 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1465,694,986 - 65,827,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0459,639,203 - 59,771,739 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1466,013,408 - 66,145,315 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl466,013,408 - 66,144,853 (+)EnsemblpanPan2panpan1.1
TECRL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11355,257,460 - 55,373,317 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1355,184,174 - 55,373,095 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1355,164,997 - 55,280,775 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01355,861,941 - 55,979,160 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1355,860,622 - 55,979,065 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11355,585,137 - 55,699,847 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01355,088,444 - 55,204,222 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01356,081,094 - 56,196,843 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tecrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528520,998,366 - 21,081,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365823,561,496 - 3,644,501 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365823,561,496 - 3,644,519 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TECRL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl862,539,800 - 62,645,996 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1862,542,452 - 62,646,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2866,238,671 - 66,330,000 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TECRL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.174,414,168 - 4,536,561 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl74,414,303 - 4,536,551 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660664,635,171 - 4,755,442 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tecrl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247614,902,630 - 5,014,478 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247614,902,630 - 5,014,680 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tecrl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11139,776,772 - 39,840,986 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tecrl
761 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:50
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000002621
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 61 41 37 49 19 11 19 5 115 82 31 6 40 30

Sequence


Ensembl Acc Id: ENSRNOT00000002621   ⟹   ENSRNOP00000002621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1425,086,930 - 25,159,957 (+)Ensembl
mRatBN7.2 Ensembl1424,732,241 - 24,805,272 (+)Ensembl
Rnor_6.0 Ensembl1426,662,965 - 26,737,657 (+)Ensembl
RefSeq Acc Id: NM_001108860   ⟹   NP_001102330
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81425,086,930 - 25,159,957 (+)NCBI
mRatBN7.21424,732,241 - 24,805,272 (+)NCBI
Rnor_6.01426,662,851 - 26,735,878 (+)NCBI
Rnor_5.01426,494,055 - 26,567,265 (+)NCBI
RGSC_v3.41426,619,939 - 26,693,786 (+)RGD
Celera1424,130,792 - 24,204,475 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102330 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89849 (Get FASTA)   NCBI Sequence Viewer  
  EDL89850 (Get FASTA)   NCBI Sequence Viewer  
  EDL89851 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002621
  ENSRNOP00000002621.4
RefSeq Acc Id: NP_001102330   ⟸   NM_001108860
- UniProtKB: D4A1Y9 (UniProtKB/TrEMBL),   A6JCS7 (UniProtKB/TrEMBL),   A6JCS8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002621   ⟸   ENSRNOT00000002621
Protein Domains
3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal   TECR-like N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1Y9-F1-model_v2 AlphaFold D4A1Y9 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699262
Promoter ID:EPDNEW_R9787
Type:single initiation site
Name:Tecrl_1
Description:trans-2,3-enoyl-CoA reductase-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01426,663,003 - 26,663,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304608 AgrOrtholog
BioCyc Gene G2FUF-16042 BioCyc
Ensembl Genes ENSRNOG00000001912 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002621 ENTREZGENE
  ENSRNOT00000002621.7 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro 3-oxo-5_a-steroid_4-DH_C UniProtKB/TrEMBL
  SRD5A/TECR UniProtKB/TrEMBL
  TECR-like_N UniProtKB/TrEMBL
KEGG Report rno:364134 UniProtKB/TrEMBL
NCBI Gene 364134 ENTREZGENE
PANTHER PTHR10556 UniProtKB/TrEMBL
  TRANS-2,3-ENOYL-COA REDUCTASE-LIKE UniProtKB/TrEMBL
Pfam Steroid_dh UniProtKB/TrEMBL
  TECR_N UniProtKB/TrEMBL
PhenoGen Tecrl PhenoGen
PROSITE S5A_REDUCTASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001912 RatGTEx
UniProt A6JCS7 ENTREZGENE, UniProtKB/TrEMBL
  A6JCS8 ENTREZGENE, UniProtKB/TrEMBL
  D4A1Y9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-25 Tecrl  trans-2,3-enoyl-CoA reductase-like  Srd5a2l2  steroid 5 alpha-reductase 2-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Srd5a2l2  steroid 5 alpha-reductase 2-like 2   Srd5a2l2_predicted  steroid 5 alpha-reductase 2-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Srd5a2l2_predicted  steroid 5 alpha-reductase 2-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED