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Gene: Crtam (cytotoxic and regulatory T cell molecule) Rattus norvegicus

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Symbol:

Crtam

Name:

cytotoxic and regulatory T cell molecule

RGD ID:

1304602

Description:

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including detection of tumor cell; establishment of T cell polarity; and regulation of T cell activation. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. Orthologous to human CRTAM (cytotoxic and regulatory T cell molecule); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; thioacetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cytotoxic and regulatory T-cell molecule; LOC300649

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	50,237,210 - 50,274,472 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	50,237,210 - 50,274,472 (-)	Ensembl				GRCr8
mRatBN7.2	8	41,340,117 - 41,377,381 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	41,340,837 - 41,377,343 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	46,840,546 - 46,870,745 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	45,119,140 - 45,149,353 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	42,986,717 - 43,016,914 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	45,152,584 - 45,216,082 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	45,153,308 - 45,215,974 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	43,681,605 - 43,694,465 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	8	43,634,852 - 43,653,181 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	43,943,971 - 43,981,609 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	40,939,600 - 40,975,292 (-)	NCBI		Celera
RGSC_v3.1	8	43,953,456 - 43,984,145 (-)	NCBI
Cytogenetic Map	8	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

crocidolite asbestos (ISO)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

GSK-J4 (ISO)

hydrogen sulfide (ISO)

lipopolysaccharide (ISO)

metam (ISO)

methapyrilene (ISO)

methcathinone (ISO)

methylarsonic acid (ISO)

Moniliformin (ISO)

monosodium L-glutamate (ISO)

nickel atom (ISO)

PCB138 (ISO)

phorbol 13-acetate 12-myristate (ISO)

progesterone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activated T cell proliferation (ISO)

cell recognition (IBA,IEA,ISO)

detection of stimulus (IEA,ISO)

detection of tumor cell (IBA,IEA,ISO)

establishment of T cell polarity (IEA,ISO)

heterophilic cell-cell adhesion (IEA,ISO)

lymphocyte migration into lymphoid organs (IEA,ISO)

negative regulation of activated T cell proliferation (IEA,ISO)

positive regulation of cytokine production (IEA,ISO)

positive regulation of natural killer cell mediated cytotoxicity (IEA,ISO)

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target (IBA,IEA,ISO)

positive regulation of type II interferon production (IEA,ISO)

regulation of CD8-positive, alpha-beta T cell activation (IEA,ISO)

regulation of T cell activation (IEA,ISO)

regulation of T cell differentiation (IEA,ISO)

T cell mediated cytotoxicity (ISO)

Cellular Component

immunological synapse (IEA,ISO)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

synapse (IEA)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

signaling receptor binding (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15811952	PMID:18329370	PMID:19752223	PMID:23583034	PMID:23871486	PMID:24687959

Genomics

Comparative Map Data

Crtam
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	50,237,210 - 50,274,472 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	50,237,210 - 50,274,472 (-)	Ensembl				GRCr8
mRatBN7.2	8	41,340,117 - 41,377,381 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	41,340,837 - 41,377,343 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	46,840,546 - 46,870,745 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	45,119,140 - 45,149,353 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	42,986,717 - 43,016,914 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	45,152,584 - 45,216,082 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	45,153,308 - 45,215,974 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	43,681,605 - 43,694,465 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Rnor_5.0	8	43,634,852 - 43,653,181 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	43,943,971 - 43,981,609 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	40,939,600 - 40,975,292 (-)	NCBI		Celera
RGSC_v3.1	8	43,953,456 - 43,984,145 (-)	NCBI
Cytogenetic Map	8	q22	NCBI

CRTAM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	122,838,500 - 122,872,643 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	122,829,482 - 122,872,643 (+)	Ensembl			hg38	GRCh38
GRCh37	11	122,709,208 - 122,743,351 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	122,214,465 - 122,248,557 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	11	119,868,568 - 119,902,622 (+)	NCBI		Celera
Cytogenetic Map	11	q24.1	NCBI
HuRef	11	118,652,105 - 118,686,168 (+)	NCBI		HuRef
CHM1_1	11	122,595,116 - 122,629,182 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	122,866,290 - 122,900,405 (+)	NCBI		T2T-CHM13v2.0

Crtam
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	40,880,987 - 40,915,922 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	40,880,987 - 40,915,924 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	40,972,798 - 41,004,628 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	40,969,691 - 41,004,628 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	40,780,881 - 40,812,669 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	40,723,867 - 40,755,655 (-)	NCBI		MGSCv36	mm8
Celera	9	38,200,659 - 38,232,057 (-)	NCBI		Celera
Cytogenetic Map	9	A5.1	NCBI
cM Map	9	21.79	NCBI

Crtam
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	23,675,906 - 23,709,262 (+)	Ensembl
ChiLan1.0	NW_004955412	23,676,171 - 23,706,250 (+)	NCBI	ChiLan1.0	ChiLan1.0

CRTAM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	123,554,754 - 123,573,433 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	124,659,524 - 124,678,180 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	117,671,581 - 117,705,818 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	121,591,738 - 121,625,744 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	121,591,738 - 121,625,738 (+)	Ensembl			panPan2	panpan1.1

CRTAM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	11,458,360 - 11,485,469 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	11,458,008 - 11,485,448 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	11,513,935 - 11,544,437 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	11,408,765 - 11,439,292 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	11,408,887 - 11,436,339 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	11,512,278 - 11,542,814 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	11,451,291 - 11,481,815 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	11,489,452 - 11,520,016 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Crtam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	104,481,329 - 104,490,360 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936542	7,402,879 - 7,411,510 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRTAM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	49,783,909 - 49,811,312 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	49,782,166 - 49,811,314 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	55,129,405 - 55,156,171 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRTAM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	114,233,767 - 114,265,780 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	114,234,357 - 114,265,994 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	11,860,131 - 11,886,947 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crtam
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624880	2,229,201 - 2,240,068 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Crtam
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	35,559,604 - 35,572,582 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Crtam
290 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	93
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000010792
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
61337	Bp22	Blood pressure QTL 22	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	51589833	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	34125902	55607752	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat

Expression

RNA-SEQ Expression

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alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	4	23	88	55	56	26	91	26	6	222	137	7	67	44	66	30	6	6

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001413479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010792 ⟹ ENSRNOP00000010792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	50,237,210 - 50,274,472 (-)	Ensembl
mRatBN7.2 Ensembl	8	41,340,837 - 41,377,343 (-)	Ensembl
Rnor_6.0 Ensembl	8	45,153,308 - 45,215,974 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111821 ⟹ ENSRNOP00000079714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	50,237,210 - 50,274,472 (-)	Ensembl
mRatBN7.2 Ensembl	8	41,340,837 - 41,377,343 (-)	Ensembl

RefSeq Acc Id:

NM_001106813 ⟹ NP_001100283

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	50,237,210 - 50,274,472 (-)	NCBI
mRatBN7.2	8	41,340,117 - 41,377,381 (-)	NCBI
Rnor_6.0	8	45,152,584 - 45,215,977 (-)	NCBI
Rnor_5.0	8	43,634,852 - 43,653,181 (-)	NCBI
Rnor_5.0	8	43,681,605 - 43,694,465 (-)	NCBI
RGSC_v3.4	8	43,943,971 - 43,981,609 (-)	RGD
Celera	8	40,939,600 - 40,975,292 (-)	RGD

Sequence:

show sequence

AGCATGTGGTGGGGAACCCTCAGTTTGCTGTTCTGCGTGCCCGTGCAAGCAGCCTTTCTCAACA
TGGAGACCATCGAGGTGGAGGAAGGCCAGACGCTCAACCTCACATGTGTTACTTCTCTGACGAA
AAATGCCTCTCTCCAGTGGCTGGCCCCCTCAGGGTTCACCATTTTTTTAAATCAGCATCCTGCT
TTAAAAAGTTCCAAATACCAGCTTCTCCACCATTCAGCTACACAGCTCTCCGTTAGCGTGTCCA
ATGTAACTCTACGAGAGGAAGGTGTGTATACGTGCTTACATTACGGGAGTTCCGTGAAGACGAA
GCAAGTTAGAGTGACCGTGTTAGTGACGCCTTTCCAGCCAACTGTGGAAGCTTTGGTTCTCAGA
AGACAGAACGGAGAGAAATCTGTTGTGCTGAAGTGTTCCACAGAGAGAAGCAAGCCCCCTCCGC
AGGTCACCTGGCTCCTGGGGGGCGGTCTGGAGATCGATGAAACAACCTCAGAGGCCCCTGAGCA
GAGCTCTCTCTCCTCCCAAGCCCTCCAGCAGCCCACGAGTACAGTCTCAATGATGGAAAATTCC
AGTATGCCGGAGACTGACAAGGAAGAGAAAGAACATGCCACTCAAGACCCTGTCATGATCACTG
CCAGTGCTCAGCATTCAGGGCTGGCCAGGAGGAATAGTGGCATCCTGCTGCTCACGCTGGTGTC
CTTCCTCATTTTCATCCTCTTCATCATCATTCAGCTCTTCATCATGAAGCTTCGTAAAGCGCAC
GTGATATGGAAGAAGGAAAGTGAAATTTCAGAGCAAGCTCTAGAAAGCTACAGATCAAGATCCA
ACAATGAGGAAACATCTTCCCAGGAGAATAACAGCCAGGCCTCACAGTCTAAGCATTGCATGAA
CTACATCATGCGGTTATACTCGGGAGCCAAAACAAAGAAGAGTGCCCGGCATTGGAAGATGGAG
GGCAAGCACAGTCGTGTCCCCGAGAGTATTGTGTAGTGTTCCCAGTGATAGAAGATAGGATTTC
GGGGCAGCTGTATCAGGCCCTGGAAAGAATCATAAGTACTGTGACATAAAAATAAGATGTCCAC
TGAGTACAGTTCAAGACAGCGTCCATTGAGCCAGGGCAGCCACATGAGGACCAAGCCATGGACA
GAAAGCTCCTCCTTGAAAGACAAACATAGAAAGAACCTATTGTGACTGACACTACCTCAGAGCC
GGAGGACTCTGCTAAGTCTTTTGGATCAGGGTCAAAATGACCAGTGAGCATCTGACCTCGAAGG
GAGCAGCAGTTTTTAGATATGGGGCTGGAGTGGAACTATTTGAATTGGTTTAAAATCTTTCCTT
CTGGTCAAGAAGGACTTAAGCATGAGAAGGACCCAAAGAAGACCTGAGCTACCAGCAGCCTACT
CTCAAGACAGGCTCTAGGAAGAGGCCATGTGGGCAACAGAGAAAAGTGGGATGTCACAGCATGC
AGTGGACATGACCACCCAGAGATCCACAACCCTCAATACCAGAGCTGAATTCAGCTGCCAAGGG
GCTTCCTTACAAACTGTGAGCCAACCTGACAGGCAGTTCTTAACCAAATTACACCATGGCAAGG
GCATGGACAGAAGCAAACCGCGAGTTTGGTTGACAGACTGTTGAATTCATGAATGGTTTTTAGA
ACTTTAATAAAGACTGGAGTGTATCTTTTTTAGAGGCTGTCATGCCCATTGGT

hide sequence

RefSeq Acc Id:

NM_001413479 ⟹ NP_001400408

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	50,237,210 - 50,274,472 (-)	NCBI
mRatBN7.2	8	41,340,117 - 41,377,381 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100283	(Get FASTA)	NCBI Sequence Viewer
	NP_001400408	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95237	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010792
	ENSRNOP00000010792.7
	ENSRNOP00000079714
	ENSRNOP00000079714.1

RefSeq Acc Id:	NP_001100283 ⟸ NM_001106813
- Peptide Label:	isoform 2 precursor
- UniProtKB:	D3ZLP3 (UniProtKB/TrEMBL), A6J3R4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MWWGTLSLLFCVPVQAAFLNMETIEVEEGQTLNLTCVTSLTKNASLQWLAPSGFTIFLNQHPAL KSSKYQLLHHSATQLSVSVSNVTLREEGVYTCLHYGSSVKTKQVRVTVLVTPFQPTVEALVLRR QNGEKSVVLKCSTERSKPPPQVTWLLGGGLEIDETTSEAPEQSSLSSQALQQPTSTVSMMENSS MPETDKEEKEHATQDPVMITASAQHSGLARRNSGILLLTLVSFLIFILFIIIQLFIMKLRKAHV IWKKESEISEQALESYRSRSNNEETSSQENNSQASQSKHCMNYIMRLYSGAKTKKSARHWKMEG KHSRVPESIV hide sequence

Ensembl Acc Id:

ENSRNOP00000010792 ⟸ ENSRNOT00000010792

Ensembl Acc Id:

ENSRNOP00000079714 ⟸ ENSRNOT00000111821

RefSeq Acc Id:	NP_001400408 ⟸ NM_001413479
- Peptide Label:	isoform 1 precursor
- UniProtKB:	A0A8I5ZNM6 (UniProtKB/TrEMBL)

Protein Domains

Ig-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZLP3-F1-model_v2	AlphaFold	D3ZLP3	1-330	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304602	AgrOrtholog
BioCyc Gene	G2FUF-30825	BioCyc
Ensembl Genes	ENSRNOG00000008153	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000010792	ENTREZGENE
	ENSRNOT00000010792.8	UniProtKB/TrEMBL
	ENSRNOT00000111821	ENTREZGENE
	ENSRNOT00000111821.2	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	CD80_C2-set	UniProtKB/TrEMBL
	CRTAM	UniProtKB/TrEMBL
	Ig-like	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	Ig_V-set	UniProtKB/TrEMBL
KEGG Report	rno:300649	UniProtKB/TrEMBL
NCBI Gene	300649	ENTREZGENE
PANTHER	CYTOTOXIC AND REGULATORY T-CELL MOLECULE	UniProtKB/TrEMBL
	CYTOTOXIC AND REGULATORY T-CELL MOLECULE	UniProtKB/TrEMBL
Pfam	C2-set_2	UniProtKB/TrEMBL
	V-set	UniProtKB/TrEMBL
PhenoGen	Crtam	PhenoGen
PROSITE	IG_LIKE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008153	RatGTEx
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A8I5ZNM6	ENTREZGENE, UniProtKB/TrEMBL
	A6J3R4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZLP3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Crtam	cytotoxic and regulatory T cell molecule	Crtam_predicted	cytotoxic and regulatory T cell molecule (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Crtam_predicted	cytotoxic and regulatory T cell molecule (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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