Tmprss11b (transmembrane serine protease 11B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tmprss11b (transmembrane serine protease 11B) Rattus norvegicus
Analyze
Symbol: Tmprss11b
Name: transmembrane serine protease 11B
RGD ID: 1303278
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Orthologous to human TMPRSS11B (transmembrane serine protease 11B); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: airway trypsin-like 5; airway trypsin-like protease 5; Hatl5; Tmprss11bnl; transmembrane protease serine 11B; transmembrane protease, serine 11B
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,738,760 - 21,763,896 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,738,760 - 21,762,107 (+)EnsemblGRCr8
mRatBN7.21421,383,936 - 21,407,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,383,862 - 21,408,817 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,740,535 - 21,760,392 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,059,465 - 23,079,322 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,590,547 - 21,610,408 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01424,103,768 - 24,125,260 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1424,103,954 - 24,123,253 (-)Ensemblrn6Rnor6.0
Rnor_5.01423,940,743 - 23,960,116 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,009,055 - 23,029,587 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,876,772 - 20,895,405 (+)NCBICelera
RGSC_v3.11423,009,054 - 23,029,587 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19199708   PMID:24498351  


Genomics

Comparative Map Data
Tmprss11b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,738,760 - 21,763,896 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,738,760 - 21,762,107 (+)EnsemblGRCr8
mRatBN7.21421,383,936 - 21,407,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,383,862 - 21,408,817 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,740,535 - 21,760,392 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,059,465 - 23,079,322 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,590,547 - 21,610,408 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01424,103,768 - 24,125,260 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1424,103,954 - 24,123,253 (-)Ensemblrn6Rnor6.0
Rnor_5.01423,940,743 - 23,960,116 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,009,055 - 23,029,587 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,876,772 - 20,895,405 (+)NCBICelera
RGSC_v3.11423,009,054 - 23,029,587 (+)NCBI
Cytogenetic Map14p21NCBI
TMPRSS11B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38468,226,653 - 68,245,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl468,226,653 - 68,245,694 (-)Ensemblhg38GRCh38
GRCh37469,092,371 - 69,111,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36468,774,966 - 68,794,004 (-)NCBIBuild 36Build 36hg18NCBI36
Celera466,551,717 - 66,570,749 (-)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef465,004,927 - 65,023,958 (-)NCBIHuRef
CHM1_1469,129,015 - 69,148,054 (-)NCBICHM1_1
T2T-CHM13v2.0471,666,935 - 71,685,995 (-)NCBIT2T-CHM13v2.0
Tmprss11b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39586,806,326 - 86,824,221 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl586,805,490 - 86,824,221 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38586,659,522 - 86,676,298 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl586,657,631 - 86,676,362 (-)Ensemblmm10GRCm38
MGSCv37587,088,547 - 87,105,323 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36587,732,998 - 87,750,911 (-)NCBIMGSCv36mm8
Celera583,879,850 - 83,896,603 (-)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
TMPRSS11B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2361,648,353 - 61,670,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1461,858,476 - 61,881,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0455,802,811 - 55,825,366 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1462,200,252 - 62,219,386 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl462,200,414 - 62,218,523 (+)EnsemblpanPan2panpan1.1
LOC482175
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11358,648,662 - 58,656,588 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1358,577,447 - 58,587,987 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01359,350,520 - 59,361,072 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11358,998,034 - 59,010,354 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01358,481,818 - 58,495,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01359,501,056 - 59,513,565 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmprss11b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528517,751,893 - 17,770,648 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936582315,088 - 333,814 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100513484
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl865,882,623 - 65,902,436 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1865,881,985 - 65,898,898 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,305,132 - 70,321,065 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103235709
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17734,885 - 748,755 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7734,900 - 748,477 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666066819,735 - 838,550 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss11b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v111279,966 - 293,486 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmprss11b
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000002743
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 1 7 17 19 30 5 8 5 1 45 19 4 12 15 58 25 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000002743   ⟹   ENSRNOP00000002743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,743,005 - 21,762,107 (+)Ensembl
mRatBN7.2 Ensembl1421,388,181 - 21,408,817 (+)Ensembl
Rnor_6.0 Ensembl1424,103,954 - 24,123,253 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118946   ⟹   ENSRNOP00000085141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,738,760 - 21,762,107 (+)Ensembl
mRatBN7.2 Ensembl1421,383,862 - 21,408,817 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126670   ⟹   ENSRNOP00000112127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,740,748 - 21,762,107 (+)Ensembl
RefSeq Acc Id: NM_001412524   ⟹   NP_001399453
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,738,760 - 21,762,107 (+)NCBI
mRatBN7.21421,383,936 - 21,407,283 (+)NCBI
RefSeq Acc Id: XM_063273446   ⟹   XP_063129516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,740,748 - 21,763,896 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001399453 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129516 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51905 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000085141
  ENSRNOP00000112127
GenBank Protein Q6IE14 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000002743   ⟸   ENSRNOT00000002743
Ensembl Acc Id: ENSRNOP00000085141   ⟸   ENSRNOT00000118946
RefSeq Acc Id: NP_001399453   ⟸   NM_001412524
- UniProtKB: A0A8I6A3C5 (UniProtKB/TrEMBL),   A0A8L2UHK6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129516   ⟸   XM_063273446
- Peptide Label: isoform X1
- UniProtKB: Q6IE14 (UniProtKB/Swiss-Prot),   A0A8L2UHK6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112127   ⟸   ENSRNOT00000126670
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE14-F1-model_v2 AlphaFold Q6IE14 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303278 AgrOrtholog
BioCyc Gene G2FUF-16079 BioCyc
Ensembl Genes ENSRNOG00000002002 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000118946 ENTREZGENE
  ENSRNOT00000126670 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  3.30.70.960 UniProtKB/Swiss-Prot
InterPro Pept_S1A_HAT/DESC1 UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  SEA_dom UniProtKB/Swiss-Prot
  SEA_dom_sf UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
NCBI Gene 365265 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEASE SERINE 11C ISOFORM X1 UniProtKB/Swiss-Prot
Pfam SEA UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Tmprss11b PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE SEA UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002002 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF82671 UniProtKB/Swiss-Prot
UniProt A0A8I6A3C5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHK6 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE14 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss11b  transmembrane serine protease 11B  Tmprss11b  transmembrane protease, serine 11B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-13 Tmprss11b  transmembrane protease, serine 11B  Tmprss11bnl  transmembrane protease, serine 11B N terminal like  Name and Symbol changed 629549 APPROVED
2013-08-02 Tmprss11bnl  transmembrane protease, serine 11B N terminal like  Tmprss11bnl  TMPRSS11B N terminal-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-06 Tmprss11bnl  TMPRSS11B N terminal-like  Tmprss11bnl  transmembrane protease, serine 11b N terminal like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-02-04 Tmprss11bnl  transmembrane protease, serine 11b N terminal like  Tmprss11b  transmembrane protease, serine 11b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Tmprss11b  transmembrane protease, serine 11b  Hatl5  airway trypsin-like 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Hatl5  airway trypsin-like 5      Symbol and Name status set to provisional 70820 PROVISIONAL