Mmadhc (metabolism of cobalamin associated D) - Rat Genome Database

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Gene: Mmadhc (metabolism of cobalamin associated D) Rattus norvegicus
Analyze
Symbol: Mmadhc
Name: metabolism of cobalamin associated D
RGD ID: 1303272
Description: Predicted to enable molecular carrier activity. Predicted to be involved in cobalamin metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblD. Orthologous to human MMADHC (metabolism of cobalamin associated D); INTERACTS WITH 17beta-estradiol; 3,4-methylenedioxymethamphetamine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CblD; cobalamin trafficking protein CblD; methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; methylmalonic aciduria and homocystinuria type D homolog, mitochondrial; methylmalonic aciduria and homocystinuria, cblD type; MGC93805; RGD1303272; similar to RIKEN cDNA 2010311D03
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Kidm53
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,117,832 - 55,135,735 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl355,117,833 - 55,135,851 (-)EnsemblGRCr8
mRatBN7.2334,708,649 - 34,726,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,708,649 - 34,726,771 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx338,102,766 - 38,120,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0346,687,484 - 46,705,415 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0344,478,719 - 44,496,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0335,783,511 - 35,801,474 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,783,623 - 35,801,614 (-)Ensemblrn6Rnor6.0
Rnor_5.0340,897,289 - 40,915,271 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4331,224,132 - 31,242,473 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera332,887,861 - 32,905,961 (-)NCBICelera
RGSC_v3.1331,120,504 - 31,138,845 (-)NCBI
Cytogenetic Map3q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cobalamin metabolic process  (IBA,IEA,ISO,ISS)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:23270877   PMID:24722857  


Genomics

Comparative Map Data
Mmadhc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8355,117,832 - 55,135,735 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl355,117,833 - 55,135,851 (-)EnsemblGRCr8
mRatBN7.2334,708,649 - 34,726,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,708,649 - 34,726,771 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx338,102,766 - 38,120,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0346,687,484 - 46,705,415 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0344,478,719 - 44,496,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0335,783,511 - 35,801,474 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,783,623 - 35,801,614 (-)Ensemblrn6Rnor6.0
Rnor_5.0340,897,289 - 40,915,271 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4331,224,132 - 31,242,473 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera332,887,861 - 32,905,961 (-)NCBICelera
RGSC_v3.1331,120,504 - 31,138,845 (-)NCBI
Cytogenetic Map3q12NCBI
MMADHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382149,569,637 - 149,587,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2149,569,634 - 149,587,812 (-)Ensemblhg38GRCh38
GRCh372150,426,151 - 150,444,289 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362150,134,397 - 150,152,523 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342150,251,659 - 150,269,785NCBI
Celera2144,039,995 - 144,058,186 (-)NCBICelera
Cytogenetic Map2q23.2NCBI
HuRef2142,325,245 - 142,343,436 (-)NCBIHuRef
CHM1_12150,432,065 - 150,450,246 (-)NCBICHM1_1
T2T-CHM13v2.02150,020,083 - 150,038,221 (-)NCBIT2T-CHM13v2.0
Mmadhc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39250,169,893 - 50,189,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl250,169,893 - 50,186,813 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38250,279,881 - 50,299,021 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl250,279,881 - 50,296,801 (-)Ensemblmm10GRCm38
MGSCv37250,135,401 - 50,152,197 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36250,101,890 - 50,118,686 (-)NCBIMGSCv36mm8
Celera251,952,182 - 51,968,978 (-)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.92NCBI
Mmadhc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544015,316,822 - 15,337,688 (-)Ensembl
ChiLan1.0NW_00495544015,317,877 - 15,338,139 (-)NCBIChiLan1.0ChiLan1.0
MMADHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21325,345,073 - 25,363,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B25,360,062 - 25,380,111 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B10,278,656 - 10,298,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B153,924,371 - 153,942,537 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B153,924,371 - 153,942,537 (-)EnsemblpanPan2panpan1.1
MMADHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11951,154,227 - 51,177,950 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1951,154,249 - 51,177,836 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1951,275,857 - 51,300,346 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01952,628,133 - 52,652,640 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1952,628,045 - 52,652,584 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11951,296,784 - 51,321,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01951,405,022 - 51,429,713 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01952,805,790 - 52,830,278 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mmadhc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303113,830,468 - 113,846,017 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646927,771,937 - 27,787,233 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646927,771,741 - 27,804,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMADHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl152,499,154 - 2,520,799 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1152,499,080 - 2,517,361 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2151,931,294 - 1,949,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMADHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11034,999,856 - 35,019,575 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1034,999,067 - 35,019,389 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040164,518,012 - 164,535,986 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmadhc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248662,314,864 - 2,342,079 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248662,314,864 - 2,342,069 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mmadhc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1528,139,114 - 28,157,098 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mmadhc
298 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:193
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000066058
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)34542360958601291Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)33777225855937853Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)33779691959119581Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat

Markers in Region
AI314967  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,708,811 - 34,709,040 (+)MAPPERmRatBN7.2
Rnor_6.0335,783,674 - 35,783,902NCBIRnor6.0
Rnor_5.0340,897,452 - 40,897,680UniSTSRnor5.0
RGSC_v3.4331,224,295 - 31,224,523UniSTSRGSC3.4
Celera332,888,024 - 32,888,253UniSTS
Cytogenetic Map3q12UniSTS
RH142327  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,708,887 - 34,709,079 (+)MAPPERmRatBN7.2
Rnor_6.0335,783,750 - 35,783,941NCBIRnor6.0
Rnor_5.0340,897,528 - 40,897,719UniSTSRnor5.0
RGSC_v3.4331,224,371 - 31,224,562UniSTSRGSC3.4
Celera332,888,100 - 32,888,291UniSTS
RH 3.4 Map3415.4UniSTS
Cytogenetic Map3q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066058   ⟹   ENSRNOP00000058814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl355,117,833 - 55,135,836 (-)Ensembl
mRatBN7.2 Ensembl334,708,650 - 34,726,771 (-)Ensembl
Rnor_6.0 Ensembl335,783,623 - 35,801,614 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083776   ⟹   ENSRNOP00000072504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl355,117,833 - 55,132,122 (-)Ensembl
mRatBN7.2 Ensembl334,708,649 - 34,722,941 (-)Ensembl
Rnor_6.0 Ensembl335,783,822 - 35,797,804 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156984   ⟹   ENSRNOP00000100141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl355,117,833 - 55,135,851 (-)Ensembl
RefSeq Acc Id: NM_001004280   ⟹   NP_001004280
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8355,117,832 - 55,135,729 (-)NCBI
mRatBN7.2334,708,649 - 34,726,548 (-)NCBI
Rnor_6.0335,783,511 - 35,801,407 (-)NCBI
Rnor_5.0340,897,289 - 40,915,271 (-)NCBI
RGSC_v3.4331,224,132 - 31,242,473 (-)RGD
Celera332,887,861 - 32,905,961 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234158   ⟹   XP_006234220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8355,117,832 - 55,135,735 (-)NCBI
mRatBN7.2334,708,649 - 34,726,554 (-)NCBI
Rnor_6.0335,783,511 - 35,801,474 (-)NCBI
Rnor_5.0340,897,289 - 40,915,271 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001004280   ⟸   NM_001004280
- Peptide Label: precursor
- UniProtKB: Q6AYQ6 (UniProtKB/Swiss-Prot),   A6JF02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234220   ⟸   XM_006234158
- Peptide Label: isoform X1
- UniProtKB: Q6AYQ6 (UniProtKB/Swiss-Prot),   A6JF02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058814   ⟸   ENSRNOT00000066058
Ensembl Acc Id: ENSRNOP00000072504   ⟸   ENSRNOT00000083776
Ensembl Acc Id: ENSRNOP00000100141   ⟸   ENSRNOT00000156984

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYQ6-F1-model_v2 AlphaFold Q6AYQ6 1-296 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692071
Promoter ID:EPDNEW_R2596
Type:multiple initiation site
Name:Mmadhc_1
Description:methylmalonic aciduria and homocystinuria, cblD type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0335,801,394 - 35,801,454EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303272 AgrOrtholog
BioCyc Gene G2FUF-49752 BioCyc
Ensembl Genes ENSRNOG00000004740 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000156984 ENTREZGENE
IMAGE_CLONE IMAGE:7110154 IMAGE-MGC_LOAD
InterPro MMADHC UniProtKB/Swiss-Prot
KEGG Report rno:362134 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93805 IMAGE-MGC_LOAD
NCBI Gene 362134 ENTREZGENE
PANTHER COBALAMIN TRAFFICKING PROTEIN CBLD UniProtKB/Swiss-Prot
  PTHR13192 UniProtKB/Swiss-Prot
Pfam MMADHC UniProtKB/Swiss-Prot
PhenoGen Mmadhc PhenoGen
RatGTEx ENSRNOG00000004740 RatGTEx
UniProt A0A0G2K352_RAT UniProtKB/TrEMBL
  A0A8L2QRQ4_RAT UniProtKB/TrEMBL
  A0ABK0L663_RAT UniProtKB/TrEMBL
  A6JF02 ENTREZGENE, UniProtKB/TrEMBL
  MMAD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-15 Mmadhc  metabolism of cobalamin associated D  Mmadhc  methylmalonic aciduria and homocystinuria, cblD type  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-13 Mmadhc  methylmalonic aciduria and homocystinuria, cblD type  Mmadhc  methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Mmadhc  methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria  RGD1303272  similar to RIKEN cDNA 2010311D03  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 RGD1303272  similar to RIKEN cDNA 2010311D03  MGC93805    Symbol updated 1299863 APPROVED
2005-09-30 MGC93805        Symbol and Name status set to provisional 70820 PROVISIONAL