Prss27 (serine protease 27) - Rat Genome Database

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Gene: Prss27 (serine protease 27) Rattus norvegicus
Analyze
Symbol: Prss27
Name: serine protease 27
RGD ID: 1303256
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Orthologous to human PRSS27 (serine protease 27); INTERACTS WITH bisphenol A; cadmium dichloride; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: marapsin; Mpn; pancreasin; protease, serine 27
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,574,526 - 13,581,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,574,526 - 13,581,887 (+)EnsemblGRCr8
mRatBN7.21013,069,959 - 13,077,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,069,959 - 13,077,322 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,814,686 - 17,822,056 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,303,518 - 17,310,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,802,155 - 12,809,524 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,410,899 - 13,418,260 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,410,899 - 13,418,260 (+)Ensemblrn6Rnor6.0
Rnor_5.01013,226,705 - 13,234,066 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,288,981 - 13,296,342 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,755,870 - 12,763,235 (+)NCBICelera
RGSC_v3.11013,289,044 - 13,296,239 (+)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16143303   PMID:16936091  


Genomics

Comparative Map Data
Prss27
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,574,526 - 13,581,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,574,526 - 13,581,887 (+)EnsemblGRCr8
mRatBN7.21013,069,959 - 13,077,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,069,959 - 13,077,322 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,814,686 - 17,822,056 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,303,518 - 17,310,888 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,802,155 - 12,809,524 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,410,899 - 13,418,260 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,410,899 - 13,418,260 (+)Ensemblrn6Rnor6.0
Rnor_5.01013,226,705 - 13,234,066 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,288,981 - 13,296,342 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,755,870 - 12,763,235 (+)NCBICelera
RGSC_v3.11013,289,044 - 13,296,239 (+)NCBI
Cytogenetic Map10q12NCBI
PRSS27
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,712,422 - 2,720,224 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,712,419 - 2,721,166 (-)Ensemblhg38GRCh38
GRCh37162,762,423 - 2,770,225 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,702,424 - 2,710,553 (-)NCBIBuild 36Build 36hg18NCBI36
Celera162,961,991 - 2,970,120 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,730,154 - 2,738,283 (-)NCBIHuRef
CHM1_1162,762,454 - 2,770,583 (-)NCBICHM1_1
T2T-CHM13v2.0162,732,636 - 2,740,438 (-)NCBIT2T-CHM13v2.0
Prss27
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,257,217 - 24,264,923 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,257,118 - 24,264,928 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381724,038,243 - 24,045,949 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,038,144 - 24,045,954 (+)Ensemblmm10GRCm38
MGSCv371724,175,210 - 24,182,916 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361723,235,722 - 23,237,651 (+)NCBIMGSCv36mm8
MGSCv361723,765,865 - 23,773,571 (+)NCBIMGSCv36mm8
Cytogenetic Map17A3.3NCBI
cM Map1712.21NCBI
Prss27
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,651,902 - 14,656,877 (+)Ensembl
ChiLan1.0NW_00495544214,636,739 - 14,656,877 (+)NCBIChiLan1.0ChiLan1.0
PRSS27
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,217,706 - 3,226,751 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,998,724 - 7,007,601 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,572,545 - 1,581,422 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,826,571 - 2,834,700 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,826,571 - 2,834,700 (-)EnsemblpanPan2panpan1.1
LOC479874
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,339,066 - 38,343,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,333,024 - 38,343,470 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha639,578,707 - 39,582,704 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0638,649,314 - 38,653,329 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1638,334,707 - 38,338,701 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,306,155 - 38,311,358 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,783,348 - 38,787,361 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prss27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,294,320 - 105,301,451 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,407,861 - 1,415,228 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,408,379 - 1,415,137 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRSS27
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,395,274 - 39,399,970 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1339,395,014 - 39,399,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,781,259 - 42,786,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRSS27
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,471,950 - 2,480,118 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606828,438,218 - 28,440,689 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prss27
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824412,249 - 416,085 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624824412,947 - 419,024 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Prss27
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v191,333,094 - 1,340,440 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prss27
20 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:188
Count of miRNA genes:82
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000007392, ENSRNOT00000070981
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 9 11 37 34 40 12 23 12 6 117 44 30 47 31 28 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000007392   ⟹   ENSRNOP00000007392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,574,526 - 13,581,887 (+)Ensembl
mRatBN7.2 Ensembl1013,069,959 - 13,077,322 (+)Ensembl
Rnor_6.0 Ensembl1013,410,899 - 13,418,260 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000070981   ⟹   ENSRNOP00000066386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1013,410,963 - 13,418,154 (+)Ensembl
RefSeq Acc Id: NM_182949   ⟹   NP_891994
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,574,526 - 13,581,887 (+)NCBI
mRatBN7.21013,069,959 - 13,077,322 (+)NCBI
Rnor_6.01013,410,899 - 13,418,260 (+)NCBI
Rnor_5.01013,226,705 - 13,234,066 (+)NCBI
RGSC_v3.41013,288,981 - 13,296,342 (+)RGD
Celera1012,755,870 - 12,763,235 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_891994 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC81507 (Get FASTA)   NCBI Sequence Viewer  
  CAE48388 (Get FASTA)   NCBI Sequence Viewer  
  EDM03803 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007392
  ENSRNOP00000007392.3
GenBank Protein Q6BEA2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_891994   ⟸   NM_182949
- Peptide Label: precursor
- UniProtKB: Q6BEA2 (UniProtKB/Swiss-Prot),   Q6IE60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066386   ⟸   ENSRNOT00000070981
Ensembl Acc Id: ENSRNOP00000007392   ⟸   ENSRNOT00000007392
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6BEA2-F1-model_v2 AlphaFold Q6BEA2 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303256 AgrOrtholog
BioCyc Gene G2FUF-25881 BioCyc
Ensembl Genes ENSRNOG00000005336 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007392 ENTREZGENE
  ENSRNOT00000007392.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:287108 UniProtKB/Swiss-Prot
NCBI Gene 287108 ENTREZGENE
PANTHER SERINE PROTEASE 27 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss27 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005336 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A6HCP8_RAT UniProtKB/TrEMBL
  PRS27_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IE60 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Prss27  serine protease 27  Prss27  protease, serine 27  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Prss27  protease, serine 27  Mpn  marapsin  Symbol and Name updated 1299863 APPROVED
2005-07-14 Mpn  marapsin      Symbol and Name status set to provisional 70820 PROVISIONAL