Dnmt3l (DNA methyltransferase 3 like) - Rat Genome Database

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Gene: Dnmt3l (DNA methyltransferase 3 like) Rattus norvegicus
Analyze
Symbol: Dnmt3l
Name: DNA methyltransferase 3 like
RGD ID: 1303239
Description: Predicted to enable enzyme activator activity and enzyme binding activity. Involved in response to ethanol. Predicted to be located in condensed nuclear chromosome and heterochromatin. Predicted to be part of ESC/E(Z) complex. Predicted to be active in cytoplasm and nucleus. Biomarker of choline deficiency disease. Orthologous to human DNMT3L (DNA methyltransferase 3 like); PARTICIPATES IN cysteine and methionine metabolic pathway; INTERACTS WITH alpha-Zearalanol; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,614,591 - 10,628,989 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,614,591 - 10,629,168 (-)EnsemblGRCr8
mRatBN7.22010,614,933 - 10,629,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,614,934 - 10,629,516 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,314,285 - 11,328,650 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,675,187 - 10,689,553 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,147,204 - 11,161,604 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2010,939,023 - 10,953,382 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2011,934,863 - 11,949,221 (-)NCBILyon_Normotensive
Lyon_Hypertensive2011,937,919 - 11,952,277 (-)NCBILyon_Hypertensive
F344_StmMcwi2010,950,925 - 10,965,284 (-)NCBIF344_StmMcwi
Rnor_6.02011,344,513 - 11,359,090 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,344,514 - 11,359,090 (-)Ensemblrn6Rnor6.0
Rnor_5.02013,514,653 - 13,529,169 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42010,958,957 - 10,973,422 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,120,702 - 12,135,281 (-)NCBICelera
RGSC_v3.12010,959,183 - 10,973,649 (-)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-tert-Octylphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cypermethrin  (EXP)
diarsenic trioxide  (ISO)
dimethylselenide  (ISO)
ethylparaben  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
hypochlorous acid  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
stigmasterol  (ISO)
succimer  (ISO)
tebuconazole  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
condensed nuclear chromosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
ESC/E(Z) complex  (IEA,ISO,ISS)
heterochromatin  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Effect of DNA Demethylation in Experimental Encapsulating Peritoneal Sclerosis. Kim KH, etal., Ther Apher Dial. 2014 Sep 26. doi: 10.1111/1744-9987.12186.
3. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. Kovacheva VP, etal., J Biol Chem. 2007 Oct 26;282(43):31777-88. Epub 2007 Aug 27.
4. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Lees-Murdock DJ, etal., Genomics 2004 Jul;84(1):193-204.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Sakharkar AJ, etal., Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67. doi: 10.1017/S1461145714001047. Epub 2014 Jun 26.
Additional References at PubMed
PMID:11934864   PMID:12202768   PMID:15057822   PMID:15318244   PMID:16543361   PMID:16780588   PMID:16920095   PMID:18042343   PMID:24074865   PMID:25503965   PMID:27856912  


Genomics

Comparative Map Data
Dnmt3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,614,591 - 10,628,989 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2010,614,591 - 10,629,168 (-)EnsemblGRCr8
mRatBN7.22010,614,933 - 10,629,337 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2010,614,934 - 10,629,516 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2011,314,285 - 11,328,650 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,675,187 - 10,689,553 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,147,204 - 11,161,604 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd2010,939,023 - 10,953,382 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive2011,934,863 - 11,949,221 (-)NCBILyon_Normotensive
Lyon_Hypertensive2011,937,919 - 11,952,277 (-)NCBILyon_Hypertensive
F344_StmMcwi2010,950,925 - 10,965,284 (-)NCBIF344_StmMcwi
Rnor_6.02011,344,513 - 11,359,090 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,344,514 - 11,359,090 (-)Ensemblrn6Rnor6.0
Rnor_5.02013,514,653 - 13,529,169 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42010,958,957 - 10,973,422 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2012,120,702 - 12,135,281 (-)NCBICelera
RGSC_v3.12010,959,183 - 10,973,649 (-)NCBI
Cytogenetic Map20p12NCBI
DNMT3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,246,339 - 44,261,897 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,246,339 - 44,262,216 (-)Ensemblhg38GRCh38
GRCh372145,666,222 - 45,681,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,490,651 - 44,506,527 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342144,490,650 - 44,506,527NCBI
Celera2130,771,480 - 30,787,356 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,036,675 - 31,052,591 (-)NCBIHuRef
CHM1_12145,226,863 - 45,242,733 (-)NCBICHM1_1
T2T-CHM13v2.02142,600,400 - 42,615,957 (-)NCBIT2T-CHM13v2.0
Dnmt3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391077,878,121 - 77,899,456 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1077,877,781 - 77,899,456 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381078,042,287 - 78,063,622 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,041,947 - 78,063,622 (+)Ensemblmm10GRCm38
MGSCv371077,505,032 - 77,526,360 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361077,452,971 - 77,466,744 (+)NCBIMGSCv36mm8
Celera1079,081,287 - 79,102,649 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Dnmt3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540741,177,582 - 41,186,965 (+)Ensembl
ChiLan1.0NW_00495540741,177,582 - 41,186,965 (+)NCBIChiLan1.0ChiLan1.0
DNMT3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,255,079 - 40,269,622 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12135,105,200 - 35,119,723 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02130,503,194 - 30,520,237 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12143,798,778 - 43,814,283 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2143,798,778 - 43,814,283 (-)EnsemblpanPan2panpan1.1
DNMT3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13138,099,100 - 38,111,432 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3137,256,521 - 37,272,413 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03137,646,747 - 37,659,063 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3137,645,326 - 37,659,391 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13137,513,901 - 37,526,213 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03137,497,879 - 37,510,191 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,992,522 - 38,008,421 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dnmt3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497137,307,350 - 37,324,745 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500143,078 - 160,212 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936500143,078 - 160,318 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13207,119,051 - 207,132,538 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113207,119,025 - 207,141,990 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213216,998,088 - 217,011,839 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1287,991,868 - 88,006,399 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl287,991,936 - 88,005,459 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605416,105,634 - 16,119,773 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnmt3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474529,869,196 - 29,878,169 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474529,869,174 - 29,878,189 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dnmt3l
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1181,337,010 - 1,351,603 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dnmt3l
87 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000001610
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 3 53 63 53 61 32 33 32 6 192 93 1 51 52 75 29 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000001610   ⟹   ENSRNOP00000001610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,614,592 - 10,629,168 (-)Ensembl
mRatBN7.2 Ensembl2010,614,934 - 10,629,516 (-)Ensembl
Rnor_6.0 Ensembl2011,344,514 - 11,359,090 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110206   ⟹   ENSRNOP00000080143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2010,614,591 - 10,628,989 (-)Ensembl
mRatBN7.2 Ensembl2010,614,934 - 10,629,275 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111099   ⟹   ENSRNOP00000092377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2010,614,934 - 10,629,275 (-)Ensembl
RefSeq Acc Id: NM_001003964   ⟹   NP_001003964
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,614,591 - 10,628,989 (-)NCBI
mRatBN7.22010,614,933 - 10,629,337 (-)NCBI
Dahl_SR_JrHsd2010,939,023 - 10,953,382 (-)NCBI
Lyon_Normotensive2011,934,863 - 11,949,221 (-)NCBI
Lyon_Hypertensive2011,937,919 - 11,952,277 (-)NCBI
F344_StmMcwi2010,950,925 - 10,965,284 (-)NCBI
Rnor_6.02011,344,514 - 11,359,090 (-)NCBI
Rnor_5.02013,514,653 - 13,529,169 (-)NCBI
RGSC_v3.42010,958,957 - 10,973,422 (-)RGD
Celera2012,120,702 - 12,135,281 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279155   ⟹   XP_063135225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,614,591 - 10,622,549 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001003964 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135225 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE52320 (Get FASTA)   NCBI Sequence Viewer  
  EDL97062 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080143
GenBank Protein Q1LZ50 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001003964   ⟸   NM_001003964
- UniProtKB: Q1LZ50 (UniProtKB/Swiss-Prot),   A0A8I6AHQ5 (UniProtKB/TrEMBL),   A6JK46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001610   ⟸   ENSRNOT00000001610
Ensembl Acc Id: ENSRNOP00000092377   ⟸   ENSRNOT00000111099
Ensembl Acc Id: ENSRNOP00000080143   ⟸   ENSRNOT00000110206
RefSeq Acc Id: XP_063135225   ⟸   XM_063279155
- Peptide Label: isoform X1
- UniProtKB: F1LQE0 (UniProtKB/TrEMBL)
Protein Domains
ADD   PHD-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1LZ50-F1-model_v2 AlphaFold Q1LZ50 1-422 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303239 AgrOrtholog
BioCyc Gene G2FUF-4275 BioCyc
Ensembl Genes ENSRNOG00000001212 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000110206 ENTREZGENE
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot
InterPro ADD UniProtKB/Swiss-Prot
  DNMT3_ADD UniProtKB/Swiss-Prot
  DNMT3_ADD_PHD UniProtKB/Swiss-Prot
  SAM-dependent_MTases UniProtKB/Swiss-Prot
KEGG Report rno:309680 UniProtKB/Swiss-Prot
NCBI Gene 309680 ENTREZGENE
PANTHER DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED UniProtKB/Swiss-Prot
  PTHR23068:SF13 UniProtKB/Swiss-Prot
Pfam ADD_DNMT3 UniProtKB/Swiss-Prot
  ADDz_Dnmt3b UniProtKB/Swiss-Prot
PhenoGen Dnmt3l PhenoGen
PROSITE ADD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001212 RatGTEx
UniProt A0A8I5ZPM6_RAT UniProtKB/TrEMBL
  A0A8I6AHQ5 ENTREZGENE
  A6JK46 ENTREZGENE, UniProtKB/TrEMBL
  DNM3L_RAT UniProtKB/Swiss-Prot
  F1LQE0 ENTREZGENE, UniProtKB/TrEMBL
  Q1LZ50 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Dnmt3l  DNA methyltransferase 3 like  Dnmt3l  DNA (cytosine-5-)-methyltransferase 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dnmt3l  DNA (cytosine-5-)-methyltransferase 3-like      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Dnmt3l  DNA (cytosine-5-)-methyltransferase 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product appears to be a pseudogene 1304004