Oxgr1 (oxoglutarate receptor 1) - Rat Genome Database

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Gene: Oxgr1 (oxoglutarate receptor 1) Rattus norvegicus
Analyze
Symbol: Oxgr1
Name: oxoglutarate receptor 1
RGD ID: 1303155
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within phospholipase C-activating serotonin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human OXGR1 (oxoglutarate receptor 1); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-oxoglutarate receptor 1; alpha-ketoglutarate receptor 1; G protein-coupled receptor 80; G-protein coupled receptor 80; Gpr80; oxoglutarate (alpha-ketoglutarate) receptor 1; P2Y purinoceptor 15; P2Y15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815103,551,338 - 103,573,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15103,552,861 - 103,553,874 (-)EnsemblGRCr8
mRatBN7.21597,145,947 - 97,146,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1597,144,293 - 97,166,612 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx15101,065,589 - 101,066,602 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015102,178,845 - 102,179,858 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01599,114,760 - 99,115,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.015105,399,596 - 105,422,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15105,401,695 - 105,402,708 (-)Ensemblrn6Rnor6.0
Rnor_5.015108,805,931 - 108,826,992 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415105,089,715 - 105,090,728 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1595,968,176 - 95,969,189 (-)NCBICelera
RGSC_v3.115105,105,494 - 105,106,508 (-)NCBI
Cytogenetic Map15q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. Inbe H, etal., J Biol Chem 2004 May 7;279(19):19790-9. Epub 2004 Mar 04.
3. A novel model of spontaneous otitis media with effusion (OME) in the Oxgr1 knock-out mouse. Kerschner JE, etal., Int J Pediatr Otorhinolaryngol. 2013 Jan;77(1):79-84. doi: 10.1016/j.ijporl.2012.09.037. Epub 2012 Nov 30.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Oxgr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815103,551,338 - 103,573,611 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl15103,552,861 - 103,553,874 (-)EnsemblGRCr8
mRatBN7.21597,145,947 - 97,146,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1597,144,293 - 97,166,612 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx15101,065,589 - 101,066,602 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015102,178,845 - 102,179,858 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01599,114,760 - 99,115,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.015105,399,596 - 105,422,559 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15105,401,695 - 105,402,708 (-)Ensemblrn6Rnor6.0
Rnor_5.015108,805,931 - 108,826,992 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415105,089,715 - 105,090,728 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1595,968,176 - 95,969,189 (-)NCBICelera
RGSC_v3.115105,105,494 - 105,106,508 (-)NCBI
Cytogenetic Map15q24NCBI
OXGR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381396,985,713 - 96,994,730 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1396,985,713 - 96,994,730 (-)Ensemblhg38GRCh38
GRCh371397,637,967 - 97,646,984 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361396,435,974 - 96,444,605 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341396,435,973 - 96,444,605NCBI
Celera1378,485,394 - 78,494,031 (-)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1378,234,827 - 78,243,464 (-)NCBIHuRef
CHM1_11397,608,350 - 97,616,984 (-)NCBICHM1_1
T2T-CHM13v2.01396,189,803 - 96,198,827 (-)NCBIT2T-CHM13v2.0
Oxgr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914120,256,997 - 120,279,847 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14120,256,997 - 120,279,847 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3814120,019,585 - 120,042,435 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14120,019,585 - 120,042,435 (-)Ensemblmm10GRCm38
MGSCv3714120,418,807 - 120,441,657 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3614119,154,767 - 119,177,617 (-)NCBIMGSCv36mm8
Celera14118,578,849 - 118,602,956 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1463.63NCBI
Oxgr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540413,337,607 - 13,344,789 (+)Ensembl
ChiLan1.0NW_00495540413,337,607 - 13,344,789 (+)NCBIChiLan1.0ChiLan1.0
OXGR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21498,502,352 - 98,511,039 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11397,171,013 - 97,179,702 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01378,145,794 - 78,154,555 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11397,302,555 - 97,311,307 (-)NCBIPanPan1.1PanPan1.1panPan2
OXGR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12247,371,020 - 47,377,389 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2247,371,381 - 47,372,394 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2247,151,464 - 47,157,881 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02247,796,855 - 47,803,273 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2247,797,255 - 47,798,268 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12247,460,735 - 47,467,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02247,493,049 - 47,499,466 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02247,529,906 - 47,536,325 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oxgr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945182,902,647 - 182,904,237 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647213,047,930 - 13,048,943 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647213,047,918 - 13,049,041 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OXGR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11166,289,131 - 66,295,826 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OXGR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1375,709,387 - 75,718,009 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl375,709,693 - 75,710,706 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604632,153,998 - 32,156,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oxgr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248793,540,845 - 3,548,239 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248793,540,737 - 3,548,239 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Oxgr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1124,746,707 - 4,787,074 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:63
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000057564
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1588677086104695021Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)1588677086104695021Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
6 1 3 2 2 2 2 81 1 3 72 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000057564   ⟹   ENSRNOP00000054374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1597,144,293 - 97,166,612 (-)Ensembl
Rnor_6.0 Ensembl15105,401,695 - 105,402,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150824   ⟹   ENSRNOP00000098804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15103,552,861 - 103,553,874 (-)Ensembl
RefSeq Acc Id: NM_207588   ⟹   NP_997471
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815103,552,861 - 103,553,874 (-)NCBI
mRatBN7.21597,145,947 - 97,146,960 (-)NCBI
Rnor_6.015105,401,695 - 105,402,708 (-)NCBI
Rnor_5.015108,805,931 - 108,826,992 (-)NCBI
RGSC_v3.415105,089,715 - 105,090,728 (-)RGD
Celera1595,968,176 - 95,969,189 (-)RGD
Sequence:
RefSeq Acc Id: XM_063274175   ⟹   XP_063130245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815103,551,338 - 103,573,611 (-)NCBI
Protein Sequences
Protein RefSeqs NP_997471 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130245 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP32736 (Get FASTA)   NCBI Sequence Viewer  
  CAG26851 (Get FASTA)   NCBI Sequence Viewer  
  EDM02542 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054374.1
  ENSRNOP00000098804
GenBank Protein Q6Y1R5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_997471   ⟸   NM_207588
- UniProtKB: Q6Y1R5 (UniProtKB/Swiss-Prot),   A6HUH9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054374   ⟸   ENSRNOT00000057564
RefSeq Acc Id: XP_063130245   ⟸   XM_063274175
- Peptide Label: isoform X1
- UniProtKB: Q6Y1R5 (UniProtKB/Swiss-Prot),   A6HUH9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098804   ⟸   ENSRNOT00000150824
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6Y1R5-F1-model_v2 AlphaFold Q6Y1R5 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303155 AgrOrtholog
BioCyc Gene G2FUF-12410 BioCyc
Ensembl Genes ENSRNOG00000037884 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000075479 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000057564.2 UniProtKB/Swiss-Prot
  ENSRNOT00000150824 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:290493 UniProtKB/Swiss-Prot
NCBI Gene 290493 ENTREZGENE
PANTHER 2-OXOGLUTARATE RECEPTOR 1 UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Oxgr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  P2YPURNOCPTR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000037884 RatGTEx
  ENSRNOG00000075479 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HUH9 ENTREZGENE, UniProtKB/TrEMBL
  OXGR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Oxgr1  oxoglutarate receptor 1  Oxgr1  oxoglutarate (alpha-ketoglutarate) receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Oxgr1  oxoglutarate (alpha-ketoglutarate) receptor 1  Gpr80  G protein-coupled receptor 80  Symbol and Name updated 1299863 APPROVED
2005-02-14 Gpr80  G protein-coupled receptor 80      Symbol and Name status set to provisional 70820 PROVISIONAL