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Gene: Tmem178a (transmembrane protein 178A) Rattus norvegicus

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Symbol:

Tmem178a

Name:

transmembrane protein 178A

RGD ID:

1303057

Description:

Predicted to be involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMEM178A (transmembrane protein 178A); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC94782; similar to hypothetical protein MGC33926; Tmem178; transmembrane protein 178

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM178A (transmembrane protein 178A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmem178 (transmembrane protein 178)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem178a (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM178A (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM178A (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem178a (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM178A (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM178A (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem178a (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem178a (transmembrane protein 178A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tmem178 (transmembrane protein 178)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem178 (transmembrane protein 178)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM178A (transmembrane protein 178A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem178 (transmembrane protein 178)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	tmem178 (transmembrane protein 178)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem178a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tmem178a	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	19,756,919 - 19,815,961 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	19,756,920 - 19,815,839 (-)	Ensembl				GRCr8
mRatBN7.2	6	14,004,629 - 14,063,677 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	14,004,630 - 14,063,549 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	14,308,253 - 14,369,866 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	14,624,754 - 14,684,299 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	14,121,522 - 14,180,414 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	3,657,355 - 3,716,079 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	3,657,325 - 3,716,078 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	3,625,205 - 3,683,555 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	3,886,308 - 3,946,693 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	13,686,560 - 13,745,736 (-)	NCBI		Celera
RGSC_v3.1	6	3,886,307 - 3,946,692 (+)	NCBI
Cytogenetic Map	6	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

chloroprene (ISO)

choline (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

fenamidone (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

inulin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

methoxychlor (EXP)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP)

pentane-2,3-dione (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of osteoclast differentiation (IBA,IEA,ISO,ISS)

regulation of cytosolic calcium ion concentration (IBA,IEA,ISO,ISS)

Cellular Component

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

membrane (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:26644563

Genomics

Comparative Map Data

Tmem178a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	19,756,919 - 19,815,961 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	19,756,920 - 19,815,839 (-)	Ensembl				GRCr8
mRatBN7.2	6	14,004,629 - 14,063,677 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	14,004,630 - 14,063,549 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	14,308,253 - 14,369,866 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	14,624,754 - 14,684,299 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	14,121,522 - 14,180,414 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	3,657,355 - 3,716,079 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	3,657,325 - 3,716,078 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	3,625,205 - 3,683,555 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	3,886,308 - 3,946,693 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	13,686,560 - 13,745,736 (-)	NCBI		Celera
RGSC_v3.1	6	3,886,307 - 3,946,692 (+)	NCBI
Cytogenetic Map	6	q12	NCBI

TMEM178A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	39,665,483 - 39,735,960 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	39,664,982 - 39,717,963 (+)	Ensembl			hg38	GRCh38
GRCh37	2	39,892,623 - 39,945,103 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	39,746,594 - 39,798,607 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	2	39,733,602 - 39,786,061 (+)	NCBI		Celera
Cytogenetic Map	2	p22.1	NCBI
HuRef	2	39,632,450 - 39,684,528 (+)	NCBI		HuRef
CHM1_1	2	39,822,930 - 39,875,395 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	39,673,667 - 39,744,956 (+)	NCBI		T2T-CHM13v2.0

Tmem178
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	81,252,061 - 81,309,245 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	81,252,061 - 81,309,245 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	80,944,632 - 81,001,816 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	80,944,632 - 81,001,816 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	81,343,972 - 81,401,156 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	80,852,958 - 80,910,136 (+)	NCBI		MGSCv36	mm8
Celera	17	85,276,621 - 85,333,739 (+)	NCBI		Celera
Cytogenetic Map	17	E3	NCBI
cM Map	17	50.97	NCBI

Tmem178a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	7,296,200 - 7,309,556 (+)	Ensembl
ChiLan1.0	NW_004955441	7,296,200 - 7,309,556 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM178A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	86,750,936 - 86,803,683 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	86,754,909 - 86,807,664 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	39,702,860 - 39,755,605 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	40,228,451 - 40,508,505 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

TMEM178A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	31,633,547 - 31,684,126 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	31,633,467 - 31,683,786 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	31,394,023 - 31,444,174 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	32,292,237 - 32,342,890 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	32,292,246 - 32,342,890 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	31,513,833 - 31,563,971 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	31,583,180 - 31,633,522 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	31,797,465 - 31,847,843 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem178a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	40,201,459 - 40,262,301 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936508	11,627,406 - 11,689,925 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936508	11,630,068 - 11,689,924 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM178A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	100,613,881 - 100,669,651 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	100,613,878 - 100,887,023 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	106,616,289 - 106,677,793 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM178A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	67,650,660 - 67,703,630 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	67,648,515 - 67,704,429 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666045	44,263,502 - 44,315,594 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem178a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	21,152,816 - 21,212,770 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624738	21,153,660 - 21,211,592 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem178a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	12,048,505 - 12,107,330 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem178a
475 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	111
Count of miRNA genes:	86
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000010927
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1975879	46975879	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1975879	46975879	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	44788383	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1975879	46975879	Rat
8693699	Alc37	Alcohol consumption QTL 37	2.6	0.224	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	13717169	27053860	Rat
2293706	Bmd20	Bone mineral density QTL 20	4.3	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	1	25740059	Rat
2292616	Ept15	Estrogen-induced pituitary tumorigenesis QTL 15	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1975879	46975879	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	3239989	48239989	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	3239989	48239989	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	1	40163351	Rat
70196	BpQTLcluster7	Blood pressure QTL cluster 7	6.82		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	20510098	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	3239989	48239989	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1358190	Ept1	Estrogen-induced pituitary tumorigenesis QTL 1	4.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	6	1	44788383	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	3239989	48239989	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1975879	46975879	Rat
8693690	Alc35	Alcohol consumption QTL 35	2.2	0.606	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	6	13717169	27053860	Rat

Markers in Region

RH127583

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	14,004,713 - 14,004,930 (-)	MAPPER	mRatBN7.2
Rnor_6.0	6	3,715,778 - 3,715,994	NCBI	Rnor6.0
Rnor_5.0	6	3,683,254 - 3,683,470	UniSTS	Rnor5.0
RGSC_v3.4	6	3,946,392 - 3,946,608	UniSTS	RGSC3.4
Celera	6	13,686,645 - 13,686,861	UniSTS
Cytogenetic Map	6	q11-q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	48	59	6	312	148	11	141	81	92	31	16	16

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010927 ⟹ ENSRNOP00000010927

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	19,756,920 - 19,815,839 (-)	Ensembl
mRatBN7.2 Ensembl	6	14,004,630 - 14,063,549 (-)	Ensembl
Rnor_6.0 Ensembl	6	3,657,325 - 3,716,078 (+)	Ensembl

RefSeq Acc Id:

NM_001004282 ⟹ NP_001004282

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	19,756,919 - 19,815,809 (-)	NCBI
mRatBN7.2	6	14,004,629 - 14,063,519 (-)	NCBI
Rnor_6.0	6	3,657,355 - 3,716,079 (+)	NCBI
Rnor_5.0	6	3,625,205 - 3,683,555 (+)	NCBI
RGSC_v3.4	6	3,886,308 - 3,946,693 (+)	RGD
Celera	6	13,686,560 - 13,745,736 (-)	RGD

Sequence:

show sequence

GGGAAGCCATGGAGCCACGGGCGCTCGTCACGGCGCTAAGCCTCGGCCTCAGCCTTTGCTCCCT
GGGGCTGCTCGTCACGGCCATCTTCACCGATCACTGGTACGAGACCGACCCCCGGCGCCACAAG
GAGAGCTGCGAGCGCAGCCGCGCGGGCGCCGACCCCCCGGATCAGAAGAACCGCCTGATGCCGC
TGTCGCACCTGCCGCTGCGGGACTCGCCTCCCTTGGGGCGCCGGCTGCTCCCCGGCGGCCCTGG
GCGCTCTGACCCGGAGTCCTGGCGCTCGCTGCTGGGGCTCGGTGGGTTGGACGCCGAGTGTGGC
CGGCCGCTGTTCGCCACCTACTCCGGCCTCTGGAGGAAGTGCTACTTCCTGGGCATCGACCGGG
ACATCGACACCCTCATCCTGAAAGGTATTGCACAGCGATGCACTGCGGTCAAGTACCACTTCTC
TCAGCCAATCCGCTTACGGAACATTCCTTTCAATTTAACCAAGATAATCCAGCAAGATGAATGG
CACCTGCTTCATCTAAGAAGAATAACAGCTGGATTCCTGGGCATGGCGGTGGCTGTCCTGCTGT
GTGGCTGCATCGTGGCCACGGTCAGCTTCTTCTGGGAGGAAAGCCTGACCCAGCACGTGGCTGG
ACTCCTATTCCTCATGACAGGGATATTTTGCACCATCTCACTCTGCACGTACGCTGCCAGCGTC
TCCTATGATTTGAACCGGGTCCCAAAGCTAATTTACAGCCTGCCTCATGATGTGGAACATGGCT
ACAGCTGGTCTATCTTCTGCGCCTGGTGCAGTTTAGGCTTTATTGTGGCAGCTGGAGGTCTCTG
CATCGCTTATCCGTTTATTAGCCGGACCAAGATTGCACATCTAAAGTCTGGCAGGGACTCCACG
GTATGACTGCCTGCATCGAAGAAGGCCCAGCTACAGAGCGGAGCGGGTCTGAGTTCCATTAGGA
GCAGTACTGAGTTCACATCAGGGTTCCAAGCACAAAGAGGTCTTTTACATTCCAACCTGTTGCC
TGCAGCCCTTTCCGGATGACTGACTGGAAACCTTGCAGAACTTCCCAACCTTTCCAAGGATAAG
ACAACTGTGGGTTCAAGTGCTTTAATGACTATTTATGCTTTGGTTGAGCGAAGTGAGCAACGGG
CTGGAGGACATTTGTAGGCATCAGAGAAGAGGGGCGGCGGTGGAAAAATTTGTACGATTTCCAC
TTATTTCAGAAAGTTTGTATATAACGATTACGGGAGAGTCGTTTCTATTTGTGAAAGGATTCAT
GACAAAAACGAGCATAATTTTCTTGTCACTGTGCCAGGCTTGTTGGACTTTAATGCAGCATCTT
CAGAACTTGTCCTGGTGGCGTCCTGTTGTGTCAGCACCTGATATTTATGCATTACTTGTGAATG
TTCCTTGTCACAAGAGGATTCTCCTTCTGTTGCCTTATTATTACTTTTAATGAATTGAAGTCCC
CTCTCTGTCTTTGTACTGGAGTTCAAATGCATAAGAATAACAGACCAACTGTGTAAGAGCTGAT
CCGTAACACTATGCAGCATCCTTTGAGGTCTTCTCCGTTCCTTGGCTTGTGTCTCTTTATGTTA
ACTGGATTTCTGCATTAAATGACTGCCCCCCTTGTTAATTTAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XR_005505533

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	19,772,649 - 19,815,961 (-)	NCBI
mRatBN7.2	6	14,016,710 - 14,063,677 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004282	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79338	(Get FASTA)	NCBI Sequence Viewer
	EDM02753	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010927
	ENSRNOP00000010927.6
GenBank Protein	Q68FV0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004282 ⟸ NM_001004282
- Peptide Label:	precursor
- UniProtKB:	Q68FV0 (UniProtKB/Swiss-Prot), A6H9P8 (UniProtKB/TrEMBL), R9PXT5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSH LPLRDSPPLGRRLLPGGPGRSDPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDID TLILKGIAQRCTAVKYHFSQPIRLRNIPFNLTKIIQQDEWHLLHLRRITAGFLGMAVAVLLCGC IVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASVSYDLNRVPKLIYSLPHDVEHGYSW SIFCAWCSLGFIVAAGGLCIAYPFISRTKIAHLKSGRDSTV hide sequence

Ensembl Acc Id:

ENSRNOP00000010927 ⟸ ENSRNOT00000010927

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FV0-F1-model_v2	AlphaFold	Q68FV0	1-297	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694368

Promoter ID:

EPDNEW_R4893

Type:

single initiation site

Name:

Tmem178a_1

Description:

transmembrane protein 178A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	3,657,303 - 3,657,363	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303057	AgrOrtholog
BioCyc Gene	G2FUF-38546	BioCyc
Ensembl Genes	ENSRNOG00000007907	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010927	ENTREZGENE
	ENSRNOT00000010927.6	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.140.150	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7106500	IMAGE-MGC_LOAD
InterPro	PMP22/EMP/MP20/Claudin	UniProtKB/Swiss-Prot
	T178A/B	UniProtKB/Swiss-Prot
KEGG Report	rno:362691	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94782	IMAGE-MGC_LOAD
NCBI Gene	362691	ENTREZGENE
PANTHER	PTHR32005	UniProtKB/Swiss-Prot
	TRANSMEMBRANE PROTEIN 178A	UniProtKB/Swiss-Prot
Pfam	Claudin_2	UniProtKB/Swiss-Prot
PhenoGen	Tmem178a	PhenoGen
RatGTEx	ENSRNOG00000007907	RatGTEx
UniProt	A6H9P8	ENTREZGENE, UniProtKB/TrEMBL
	Q68FV0	ENTREZGENE
	R9PXT5	ENTREZGENE, UniProtKB/TrEMBL
	T178A_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-16	Tmem178a	transmembrane protein 178A	Tmem178	transmembrane protein 178	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Tmem178	transmembrane protein 178	MGC94782	similar to hypothetical protein MGC33926	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	MGC94782				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD