Spint5p (serine peptidase inhibitor, Kunitz type 5) - Rat Genome Database

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Gene: Spint5p (serine peptidase inhibitor, Kunitz type 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Spint5p
Name: serine peptidase inhibitor, Kunitz type 5
RGD ID: 1302989
Description: Predicted to enable serine-type endopeptidase inhibitor activity.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Tpil4; trypsin protease inhibitor-like 4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,868,509 - 173,870,301 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,868,509 - 173,871,383 (+)EnsemblGRCr8
mRatBN7.23153,449,161 - 153,450,953 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,449,233 - 153,451,531 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3157,257,862 - 157,259,660 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,756,831 - 165,758,629 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,500,605 - 163,502,405 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3171,957,325 - 171,959,123 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3178,818,245 - 178,820,043 (+)NCBILyon_Normotensive
Lyon_Hypertensive3170,785,462 - 170,787,260 (+)NCBILyon_Hypertensive
F344_StmMcwi3151,682,086 - 151,683,884 (+)NCBIF344_StmMcwi
Rnor_6.03161,178,117 - 161,179,744 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,178,117 - 161,179,744 (+)Ensemblrn6Rnor6.0
Rnor_5.03167,365,260 - 167,366,887 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,730,519 - 155,732,146 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3152,057,432 - 152,059,059 (+)NCBICelera
RGSC_v3.13155,636,554 - 155,638,182 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
3. GOA pipeline RGD automated data pipeline

Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:123
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000051826
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
mesenchyme
nervous system
renal system
reproductive system
2 1 2 2 2 18

Sequence


Ensembl Acc Id: ENSRNOT00000051826   ⟹   ENSRNOP00000047439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,868,509 - 173,870,301 (+)Ensembl
mRatBN7.2 Ensembl3153,449,233 - 153,451,531 (+)Ensembl
Rnor_6.0 Ensembl3161,178,117 - 161,179,744 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141826   ⟹   ENSRNOP00000109383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,868,581 - 173,871,383 (+)Ensembl
RefSeq Acc Id: NM_001395121   ⟹   NP_001382050
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,868,509 - 173,870,301 (+)NCBI
mRatBN7.23153,449,161 - 153,450,953 (+)NCBI
Dahl_SR_JrHsd3171,957,325 - 171,959,123 (+)NCBI
Lyon_Normotensive3178,818,245 - 178,820,043 (+)NCBI
Lyon_Hypertensive3170,785,462 - 170,787,260 (+)NCBI
F344_StmMcwi3151,682,086 - 151,683,884 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382050 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51400 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047439
  ENSRNOP00000047439.6
  ENSRNOP00000109383.1
Ensembl Acc Id: ENSRNOP00000047439   ⟸   ENSRNOT00000051826
RefSeq Acc Id: NP_001382050   ⟸   NM_001395121
- Peptide Label: precursor
- UniProtKB: Q6IE45 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109383   ⟸   ENSRNOT00000141826
Protein Domains
BPTI/Kunitz inhibitor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTI0-F1-model_v2 AlphaFold E9PTI0 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692662
Promoter ID:EPDNEW_R3186
Type:single initiation site
Name:Spint5p_1
Description:serine peptidase inhibitor, Kunitz type 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03161,178,174 - 161,178,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302989 AgrOrtholog
BioCyc Gene G2FUF-46834 BioCyc
Ensembl Genes ENSRNOG00000014807 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051826 ENTREZGENE
  ENSRNOT00000051826.6 UniProtKB/TrEMBL
  ENSRNOT00000141826.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.410.10 UniProtKB/TrEMBL
InterPro Kunitz-type_SerProtInhib UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  Prot_inh_Kunz-m UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
NCBI Gene 408232 ENTREZGENE
PANTHER BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KUNITZ-TYPE PROTEASE INHIBITOR-RELATED UniProtKB/TrEMBL
Pfam Kunitz_BPTI UniProtKB/TrEMBL
PhenoGen Spint5p PhenoGen
PRINTS BASICPTASE UniProtKB/TrEMBL
PROSITE BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014807 RatGTEx
SMART SM00131 UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_Kunz-m UniProtKB/TrEMBL
UniProt A0ABK0LYT2_RAT UniProtKB/TrEMBL
  E9PTI0_RAT UniProtKB/TrEMBL
  Q6IE45 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-16 Spint5p  serine peptidase inhibitor, Kunitz type 5  Tpil4  trypsin protease inhibitor-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Tpil4  trypsin protease inhibitor-like 4      Symbol and Name status set to provisional 70820 PROVISIONAL