Apela (apelin receptor early endogenous ligand) - Rat Genome Database

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Gene: Apela (apelin receptor early endogenous ligand) Rattus norvegicus
Analyze
Symbol: Apela
Name: apelin receptor early endogenous ligand
RGD ID: 9299863
Description: Enables apelin receptor binding activity. Involved in apelin receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of heart contraction. Predicted to be located in extracellular space. Orthologous to human APELA (apelin receptor early endogenous ligand); INTERACTS WITH 17beta-estradiol (ortholog); 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ortholog); 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ELA; LOC100912649; LOC103693925; Tdl; uncharacterized LOC100912649; uncharacterized LOC103693925
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,460,855 - 29,469,962 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1629,460,812 - 29,469,955 (+)EnsemblGRCr8
mRatBN7.21624,694,356 - 24,703,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,694,324 - 24,703,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1628,060,134 - 28,069,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01631,494,493 - 31,503,593 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01627,449,627 - 27,458,747 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1629,349,661 - 29,358,761 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1630,720,481 - 30,729,581 (+)NCBILyon_Normotensive
Lyon_Hypertensive1631,137,649 - 31,146,749 (+)NCBILyon_Hypertensive
F344_StmMcwi1628,367,088 - 28,376,191 (+)NCBIF344_StmMcwi
Rnor_6.01626,582,103 - 26,583,828 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Celera1624,779,756 - 24,788,926 (+)NCBICelera
Cytogenetic Map16p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IEA,ISO,ISS)

Molecular Function
apelin receptor binding  (IDA,IEA,ISO)
hormone activity  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart. Perjes A, etal., Basic Res Cardiol. 2016 Jan;111(1):2. doi: 10.1007/s00395-015-0521-6. Epub 2015 Nov 26.
Additional References at PubMed
PMID:34453661   PMID:35472496   PMID:36878020  


Genomics

Comparative Map Data
Apela
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,460,855 - 29,469,962 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1629,460,812 - 29,469,955 (+)EnsemblGRCr8
mRatBN7.21624,694,356 - 24,703,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,694,324 - 24,703,465 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1628,060,134 - 28,069,234 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01631,494,493 - 31,503,593 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01627,449,627 - 27,458,747 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1629,349,661 - 29,358,761 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1630,720,481 - 30,729,581 (+)NCBILyon_Normotensive
Lyon_Hypertensive1631,137,649 - 31,146,749 (+)NCBILyon_Hypertensive
F344_StmMcwi1628,367,088 - 28,376,191 (+)NCBIF344_StmMcwi
Rnor_6.01626,582,103 - 26,583,828 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Celera1624,779,756 - 24,788,926 (+)NCBICelera
Cytogenetic Map16p13NCBI
APELA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384164,877,178 - 164,899,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4164,876,944 - 164,899,007 (+)Ensemblhg38GRCh38
GRCh374165,798,330 - 165,818,679 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera4163,130,354 - 163,150,890 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,551,632 - 161,572,198 (+)NCBIHuRef
CHM1_14165,774,724 - 165,795,263 (+)NCBICHM1_1
T2T-CHM13v2.04168,224,846 - 168,246,738 (+)NCBIT2T-CHM13v2.0
Apela
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,481,069 - 65,489,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,481,069 - 65,489,988 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38865,028,417 - 65,037,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl865,028,417 - 65,037,336 (-)Ensemblmm10GRCm38
MGSCv37867,552,316 - 67,561,235 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera867,592,177 - 67,600,984 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.52NCBI
Apela
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540340,254,697 - 40,266,458 (-)Ensembl
ChiLan1.0NW_00495540340,257,467 - 40,266,275 (-)NCBIChiLan1.0ChiLan1.0
APELA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,679,066 - 162,699,828 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,037,099 - 163,057,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,125,485 - 157,145,999 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,176,909 - 169,197,001 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4169,176,910 - 169,195,553 (+)EnsemblpanPan2panpan1.1
APELA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11560,967,944 - 60,990,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,278,318 - 61,300,216 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01561,830,832 - 61,852,734 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1561,830,906 - 61,852,794 (+)EnsemblROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl376,136,934 - 6,137,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11560,994,927 - 61,016,846 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,056,116 - 61,078,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,429,794 - 61,451,703 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Apela
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494317,591,770 - 17,600,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555968,603 - 978,856 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936555969,902 - 978,736 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APELA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1853,703,735 - 53,736,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2856,863,643 - 56,896,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APELA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603791,103,501 - 91,123,641 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apela
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475811,944,563 - 11,954,027 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Apela
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11324,118,305 - 24,127,640 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Apela
68 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
sensory system
visual system
7 8 12 1 52 9 16 36 23 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000107155   ⟹   ENSRNOP00000082744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1629,460,812 - 29,469,955 (+)Ensembl
mRatBN7.2 Ensembl1624,694,324 - 24,703,465 (+)Ensembl
RefSeq Acc Id: NM_001399424   ⟹   NP_001386353
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81629,460,855 - 29,469,962 (+)NCBI
mRatBN7.21624,694,356 - 24,703,466 (+)NCBI
Dahl_SR_JrHsd1629,349,661 - 29,358,761 (+)NCBI
Lyon_Normotensive1630,720,481 - 30,729,581 (+)NCBI
Lyon_Hypertensive1631,137,649 - 31,146,749 (+)NCBI
F344_StmMcwi1628,367,088 - 28,376,191 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386353 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082744
  ENSRNOP00000082744.1
GenBank Protein P0DP76 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000082744   ⟸   ENSRNOT00000107155
RefSeq Acc Id: NP_001386353   ⟸   NM_001399424
- Peptide Label: precursor
- UniProtKB: P0DP76 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DP76-F1-model_v2 AlphaFold P0DP76 1-54 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:9299863 AgrOrtholog
BioCyc Gene G2FUF-11637 BioCyc
Ensembl Genes ENSRNOG00000067022 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000107155 ENTREZGENE
  ENSRNOT00000107155.1 UniProtKB/Swiss-Prot
InterPro ELA UniProtKB/Swiss-Prot
NCBI Gene LOC103693925 ENTREZGENE
Pfam Toddler UniProtKB/Swiss-Prot
PhenoGen Apela PhenoGen
RatGTEx ENSRNOG00000067022 RatGTEx
RNAcentral URS0000CCFF9F RNACentral
UniProt ELA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Apela  apelin receptor early endogenous ligand  Apela  apelin receptor early endogenous ligand  Data merged from RGD:149736342 737654 PROVISIONAL
2022-02-03 Apela  apelin receptor early endogenous ligand  LOC100912649  uncharacterized LOC100912649  Data merged from RGD:6486141 737654 PROVISIONAL
2021-08-09 Apela  apelin receptor early endogenous ligand      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-01-28 Apela  apelin receptor early endogenous ligand  LOC103693925  uncharacterized LOC103693925  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103693925  uncharacterized LOC103693925      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100912649  uncharacterized LOC100912649      Symbol and Name status set to provisional 70820 PROVISIONAL