Crocc2 (ciliary rootlet coiled-coil, rootletin family member 2) - Rat Genome Database

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Gene: Crocc2 (ciliary rootlet coiled-coil, rootletin family member 2) Rattus norvegicus
Analyze
Symbol: Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
RGD ID: 7728853
Description: Predicted to be active in centriole and centrosome. Orthologous to human CROCC2 (ciliary rootlet coiled-coil, rootletin family member 2); INTERACTS WITH 4,4'-sulfonyldiphenol (ortholog); benzo[a]pyrene (ortholog); bisphenol F (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ciliary rootlet coiled-coil protein 2; LOC102551034; LOC685219; putative ciliary rootlet coiled-coil protein 2; putative ciliary rootlet coiled-coil protein-like 3 protein-like; similar to ciliary rootlet coiled-coil, rootletin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,155,815 - 101,217,036 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,156,158 - 101,216,057 (+)EnsemblGRCr8
mRatBN7.2993,708,786 - 93,769,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,708,684 - 93,769,402 (+)EnsemblmRatBN7.2
Rnor_6.09100,314,988 - 100,376,006 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,967,218 - 100,033,051 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4992,456,914 - 92,503,028 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,244,020 - 91,304,746 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriole  (IBA)
centrosome  (IBA)

References

Genomics

Comparative Map Data
Crocc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,155,815 - 101,217,036 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl9101,156,158 - 101,216,057 (+)EnsemblGRCr8
mRatBN7.2993,708,786 - 93,769,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,708,684 - 93,769,402 (+)EnsemblmRatBN7.2
Rnor_6.09100,314,988 - 100,376,006 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0999,967,218 - 100,033,051 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4992,456,914 - 92,503,028 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera991,244,020 - 91,304,746 (+)NCBICelera
Cytogenetic Map9q36NCBI
CROCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,906,336 - 240,993,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,906,330 - 240,993,311 (+)Ensemblhg38GRCh38
GRCh372241,845,753 - 241,932,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,491,914 - 241,581,401 (+)NCBIBuild 36Build 36hg18NCBI36
Celera2235,525,451 - 235,600,411 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,630,832 - 233,647,812 (+)NCBIHuRef
CHM1_12241,878,338 - 241,911,575 (+)NCBICHM1_1
T2T-CHM13v2.02241,405,412 - 241,492,295 (+)NCBIT2T-CHM13v2.0
Crocc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,096,145 - 93,158,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,096,447 - 93,158,794 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38193,168,423 - 93,231,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,168,725 - 93,231,072 (+)Ensemblmm10GRCm38
MGSCv37195,065,302 - 95,127,649 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36194,999,131 - 95,061,480 (+)NCBIMGSCv36mm8
Celera196,113,378 - 96,175,767 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.17NCBI
Crocc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542646,143 - 694,682 (-)Ensembl
ChiLan1.0NW_004955542647,145 - 694,523 (-)NCBIChiLan1.0ChiLan1.0
CROCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,594,943 - 143,678,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,609,908 - 143,693,824 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,164,643 - 128,248,255 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B246,967,325 - 247,048,780 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B246,967,325 - 247,050,201 (+)EnsemblpanPan2panpan1.1
CROCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12550,994,194 - 51,046,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,004,465 - 51,038,700 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2551,216,846 - 51,266,381 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02551,198,427 - 51,248,148 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12551,030,968 - 51,095,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02550,786,031 - 50,835,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,062,010 - 51,111,670 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Crocc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,378,922 - 192,438,562 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936745782,495 - 840,280 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CROCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15139,766,414 - 139,811,999 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115139,749,160 - 139,817,779 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215154,902,554 - 154,934,056 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CROCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110126,983,470 - 127,052,328 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604072,333,885 - 72,413,862 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crocc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,095,451 - 5,142,313 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248475,095,183 - 5,145,196 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Crocc2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14165,102,047 - 165,163,006 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Crocc2
372 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
1 16 35 15 64 41 11 27 23 32 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000117096   ⟹   ENSRNOP00000088979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,156,158 - 101,216,057 (+)Ensembl
mRatBN7.2 Ensembl993,708,684 - 93,769,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150447   ⟹   ENSRNOP00000108987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl9101,156,158 - 101,216,057 (+)Ensembl
RefSeq Acc Id: XM_017596918   ⟹   XP_017452407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,155,816 - 101,217,036 (+)NCBI
mRatBN7.2993,708,786 - 93,769,617 (+)NCBI
Rnor_6.09100,314,988 - 100,376,006 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084759   ⟹   XP_038940687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,155,816 - 101,217,036 (+)NCBI
mRatBN7.2993,708,786 - 93,769,617 (+)NCBI
RefSeq Acc Id: XM_063268171   ⟹   XP_063124241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,155,815 - 101,217,036 (+)NCBI
RefSeq Acc Id: XM_063268172   ⟹   XP_063124242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,168,686 - 101,217,036 (+)NCBI
RefSeq Acc Id: XP_017452407   ⟸   XM_017596918
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_038940687   ⟸   XM_039084759
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABS7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088979   ⟸   ENSRNOT00000117096
RefSeq Acc Id: XP_063124241   ⟸   XM_063268171
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124242   ⟸   XM_063268172
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000108987   ⟸   ENSRNOT00000150447

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7728853 AgrOrtholog
BioCyc Gene G2FUF-26653 BioCyc
Ensembl Genes ENSRNOG00000063752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000117096 ENTREZGENE
  ENSRNOT00000117096.2 UniProtKB/TrEMBL
  ENSRNOT00000150447 ENTREZGENE
  ENSRNOT00000150447.1 UniProtKB/TrEMBL
InterPro Rootletin-like_CC UniProtKB/TrEMBL
NCBI Gene LOC102551034 ENTREZGENE
PANTHER CENTROSOMAL PROTEIN 2 UniProtKB/TrEMBL
  CILIARY ROOTLET COILED-COIL PROTEIN 2 UniProtKB/TrEMBL
Pfam Rootletin UniProtKB/TrEMBL
PhenoGen Crocc2 PhenoGen
RatGTEx ENSRNOG00000063752 RatGTEx
UniProt A0A8I6ABS7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M2M7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Crocc2  ciliary rootlet coiled-coil, rootletin family member 2  Crocc2  ciliary rootlet coiled-coil, rootletin family member 2  Data merged from RGD:149736489 737654 PROVISIONAL
2021-08-09 Crocc2  ciliary rootlet coiled-coil, rootletin family member 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-07-29 Crocc2  ciliary rootlet coiled-coil, rootletin family member 2  LOC685219  similar to ciliary rootlet coiled-coil, rootletin  Data merged from RGD:1596477 737654 PROVISIONAL
2015-07-01 Crocc2  ciliary rootlet coiled-coil, rootletin family member 2  LOC102551034  putative ciliary rootlet coiled-coil protein-like 3 protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102551034  putative ciliary rootlet coiled-coil protein-like 3 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC685219  similar to ciliary rootlet coiled-coil, rootletin  LOC684075  similar to ciliary rootlet coiled-coil, rootletin  Data merged from RGD:1595171 1643240 APPROVED
2006-11-20 LOC685219  similar to ciliary rootlet coiled-coil, rootletin      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684075  similar to ciliary rootlet coiled-coil, rootletin      Symbol and Name status set to provisional 70820 PROVISIONAL