Znf354b (zinc finger protein 354B)

Gene: Znf354b (zinc finger protein 354B) Rattus norvegicus

Analyze

Symbol:

Znf354b (Ensembl: Znf454)

Name:

zinc finger protein 354B (Ensembl:zinc finger protein 454)

RGD ID:

7562538

Description:

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF354B (zinc finger protein 354B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate; gentamycin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102556119; zinc finger protein 354B-like

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZNF354B (zinc finger protein 354B)	HGNC	HomoloGene, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Mus musculus (house mouse):	Zfp354b (zinc finger protein 354B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZNF354B (zinc finger protein 354B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC119863940 (zinc finger protein 354B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101958065 (zinc finger protein 91)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZNF354B (zinc finger protein 354B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ZNF354B (zinc finger protein 354B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ZNF354A (zinc finger protein 354A)	HGNC	OrthoDB, Treefam
Homo sapiens (human):	ZNF485 (zinc finger protein 485)	HGNC	PhylomeDB
Homo sapiens (human):	ZNF454 (zinc finger protein 454)	HGNC	EggNOG
Alliance orthologs ³
Homo sapiens (human):	ZNF354B (zinc finger protein 354B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Zfp354b (zinc finger protein 354B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:cabz01032454.3	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	si:ch1073-127d16.1	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	si:ch73-367f21.4	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	zgc:162972	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	si:ch73-367f21.6	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	znf1155 (zinc finger protein 1155)	Alliance	DIOPT (Ensembl Compara\|OMA)
Saccharomyces cerevisiae (baker's yeast):	ZAP1	Alliance	DIOPT (Hieranoid\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ube2c	Alliance	DIOPT (Ensembl Compara\|OMA)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,734,794 - 35,752,882 (-)	NCBI		GRCr8
mRatBN7.2	10	35,233,783 - 35,251,110 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,185,028 - 35,245,505 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	39,922,655 - 39,933,784 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	39,412,966 - 39,424,095 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	34,916,338 - 34,927,467 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	36,411,730 - 36,423,346 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	36,411,963 - 36,419,926 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,184,506 - 36,201,761 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	34,592,474 - 34,604,090 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

Ehlers-Danlos syndrome spondylodysplastic type 2 (ISO)

genetic disease (ISO)

Sotos syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

acrylamide (ISO)

benzo[a]pyrene (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

dibutyl phthalate (EXP)

dichloromethane (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

gentamycin (EXP)

hydroquinone O-beta-D-glucopyranoside (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

sunitinib (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

chromatin binding (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

metal ion binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

transcription corepressor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:24105743

Genomics

Comparative Map Data

Znf354b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,734,794 - 35,752,882 (-)	NCBI		GRCr8
mRatBN7.2	10	35,233,783 - 35,251,110 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	35,185,028 - 35,245,505 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	39,922,655 - 39,933,784 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	39,412,966 - 39,424,095 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	34,916,338 - 34,927,467 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	36,411,730 - 36,423,346 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	36,411,963 - 36,419,926 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	36,184,506 - 36,201,761 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	34,592,474 - 34,604,090 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

ZNF354B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	178,859,953 - 178,885,020 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	178,859,953 - 178,888,122 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	178,286,954 - 178,312,021 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	178,219,607 - 178,244,021 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	178,219,606 - 178,244,021	NCBI
Celera	5	173,914,525 - 173,938,862 (+)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	173,013,482 - 173,037,948 (+)	NCBI		HuRef
CHM1_1	5	177,720,108 - 177,744,632 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	179,413,219 - 179,438,286 (+)	NCBI		T2T-CHM13v2.0

Zfp354b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	50,812,613 - 50,822,486 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	50,812,650 - 50,822,460 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	50,921,786 - 50,931,661 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	50,921,823 - 50,931,633 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	50,735,288 - 50,745,137 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	50,765,246 - 50,774,408 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	51,341,268 - 51,350,430 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	30.95	NCBI

ZNF354B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	173,778,244 - 173,833,973 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	171,917,784 - 171,973,513 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	174,022,352 - 174,046,169 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	181,278,382 - 181,303,119 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	181,278,382 - 181,303,119 (+)	Ensembl	panpan1.1		panPan2

LOC119863940
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	11	2,804,501 - 2,817,336 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	2,609,208 - 2,674,308 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	2,657,328 - 2,674,990 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	2,580,454 - 2,645,509 (-)	NCBI		UMICH_Zoey_3.1

LOC101958065
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	120,569,573 - 120,626,419 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936739	1,821,721 - 1,835,192 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936739	1,778,016 - 1,836,177 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZNF354B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	79,579,753 - 79,601,137 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	79,579,737 - 79,602,080 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	81,245,570 - 81,272,296 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZNF354B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	80,607,607 - 80,637,849 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	80,622,444 - 80,636,458 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	11,946,927 - 11,969,169 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Znf354b
130 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum immunoglobulin E level (CMO:0002101)	10	22918268	36400810	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	34490559	45579777	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low		41	34	24	4	24	8	9	74	35	40	11	8
Below cutoff	3	2	23	17	15	17		2			1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006220654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115666	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000004902 ⟹ ENSRNOP00000004902

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,234,766 - 35,239,745 (-)	Ensembl
Rnor_6.0 Ensembl	10	36,411,963 - 36,419,926 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000039827 ⟹ ENSRNOP00000031832

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,185,028 - 35,197,529 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095817 ⟹ ENSRNOP00000096622

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,185,830 - 35,242,961 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099878 ⟹ ENSRNOP00000092663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	35,234,766 - 35,245,505 (-)	Ensembl

RefSeq Acc Id:

NM_001399458 ⟹ NP_001386387

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,734,794 - 35,745,913 (-)	NCBI
mRatBN7.2	10	35,233,783 - 35,244,903 (-)	NCBI

RefSeq Acc Id:

XM_017597625 ⟹ XP_017453114

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,735,353 - 35,743,685 (-)	NCBI
mRatBN7.2	10	35,233,783 - 35,242,675 (-)	NCBI
Rnor_6.0	10	36,411,730 - 36,420,578 (-)	NCBI

Sequence:

show sequence

CCCGGGACGAGTGGAAGAAGCTGGATCTCTCTCAGAGAAGCCTGTACCGTGAGGTGATGCTGGA
GAACTACAGCAACCTGGCCTCGCTGGATGATCTCCGTGCTGCAGCAAGGAGAAGAACCCTGGAA
AGCGGAGAAAGAAAGCCATGGATGCTCCTCTCTTGGATGTAATAGCAGTCTTCAAACCACAAAA
TCAACTCAAACTAAAGAGTCATCATTTCAGGAATTAAAGAGGAAACAACTCAAAAGGGATGAGG
ACTGGGACTTTACCTCAGGAAAATCCTGCAGACCTGACAACAGTTTTAAAAAACAGAACAAAAA
TGAAAGCTTACAAATAATTTCTATCACCCATACAAAAATTCTTACTGTAGATAAAAGCCATAAG
AATTTTGAGTTTGGTCCAAGTGTCAGCCTGAAGTCAATCAGTAAGCAAAAGATTGCTAGAGAAA
AAACACAAAGAAATAGCCTCAAGGAAAATTCAACTTCACTTAATCAACCAAAAATCAAGACATT
AGAGAAACGCTTTAAATGTAGTACTTGTGAAAAGGCCTTCATTCACAGCTCATCCCTTCGCAAA
CATCTGAAAAACCATAGTGGAGAGAGATTATTTCAATGTAAAGACTGTTTGAAAGCTTTCAGCC
AAAGTTCCGCTCTTATTCAACATCAAAGAACTCATACTGGAGAGAAGCCCTACATATGTAATGA
GTGTGGGAAGGCCTTCAGCCACAGTGCATCCCTTTGTAAGCACCTAAGAACTCATACTTTGGAG
AAATCCTATACATGCAAAGAATGTGGAAAATCTTTTAGCAGAAGGTCTAGTCTTTTTTTGCATC
AAAAAATCCATGCCCGAGAAAACCCTCATAGATATAACCCAGGAAGGAAGGCATCCGCTTCGCT
CTCAGGATGCCAGAGAGCTCATTCCAGGAAGAAGACCTACTTGTGTAACGAATGCGGCAACACC
TTCAAGTCTAGCTCCTCCCTCCGTTACCATCAGAGAATCCACACTGGAGAGAAACCTTTCAGAT
GTAGTGAATGCGGCAGAGCCTTCAGTCAGAGCGCATCACTTATTCAGCACGAAAGAATCCACAC
GGGAGAAAAGCCCTACAGGTGTGGCGAGTGTGGAAAAGGCTTTACTTCTATCTCAAGACTCAAT
AGACACCGGATAATTCATACAGGAGAGAAATTGTATAATTGCAATGAGTGTGGCAAAGCCTTAA
GTTCCCACTCAACTCTTATTATTCACGAACGAATCCACACTGGAGAGAAACCATGTAAGTGTAA
AGTTTGTGGGAAAGCCTTCAGACAGAGTTCAGCTCTGATCCAACATCAGAGAATGCACACTGGG
GAAAGACCCTATAAATGTAACGAGTGCGGGAAAACATTCAGGTGTAACTCATCCCTAAGTAACC
ACCAGCGAATCCACACTGGAGAGAAACCTTATCAATGTATAGAATGTGGGATGTCGTTTGGACA
AAGTGCAGCTCTTATTCAGCACCAGAGGATTCACACGGGAGAGAAACCCTTTAAATGTAACACC
TGTGGGAGGAGTTTTAGGCAAAGCTCCTCCCTTATTGCCCATCAGCGGATTCATACTGGAGAGA
AACCCTATGAATGTAGTGCATGTGGAAAGCTCTTCAGTCAGAGGTCCTCCCTTACCAATCATTA
TAAAATTCACATTGAAGAGGACTCCTTGAACATAGATTTGCATGAGTAAAAGCAATTGACCAAA
GTTCTTCAGAGGATATATACTTCATATTGACAATAAATATAGTGAATATAAGACAACTTATTTA
GCCCTATGAGATATTAAAATTGCAAGAATAAACTGTGATCATATAATAACAGAGAAAATTTCAC
ACCTGTCAGTCACATTTTGTGATCAGATACTTTACCATAGCAGACATTGACAATGGCCATTTAT
AAGGTAACAGAAATGCTTTTTTATTTTATCCACATTATATAATATATGCAATATATAAACACTA
GAAAGATCTGAGTTCTGGAGTGTTAGTTTGTCATTAGAAAAAGGAGTATCACCTATTAGCATAT
TTACTACAGCTAATATTTTAATAGTAAACCATTAAAATATATGCATTTTTAAATCAGTGGACCA
AATTAAACAAACAAAAACCAAAATACTACCTCATACTATCTTTTCCTAAACTATTGTCAAACTG
CATGATTTTTATTAAAGAGGAAGAAAGAGAACTGTTTTAAATTTTCATTCTTCTAATTTTCTAA
CTGCCCTACACTCCTCCCACACTTAATACACATAATCTAATTTTGTGCTGTGAATGAATTATTC
TCCTTCATTGCCTTGAAACATTTATTATGTCCTGAGTGGTAATGTTAAATACTAGTCTTAGCCA
CCCTGGAGCAAACAGACTAGCTAAGCTTGCCAGAATGAGTTGAAAGAGAACAATGAGGGATGGC
AGTTGACATCAACCACCCCCAGCTTACATCATACAGATGAACCCCCAAACGTGCACACCACACG
CAGACATACGTGGAGCAAATTCCCATTTTCCGGTGCTAGTACGTAGACATAACTAATTTCTACA
ACTTACCTTGTATGAGTAACCTGGTTGATTTATGTCTGCATGGTACTTGTGTGCATACAACTTT
CCTTCTTTCTAATAGTGTATTTGTAGATTCTTGGCATTCACAATCTTTTTATCTGCAAATTCCA
TTTTTTTCTCTCTTCTAATCAGTGTCTTATTTTCTGACAATGTGGCACTACCTAAACAATTCTA
GTTTTTCTCTCCTG

hide sequence

RefSeq Acc Id:

XM_039087182 ⟹ XP_038943110

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,735,353 - 35,752,882 (-)	NCBI
mRatBN7.2	10	35,233,783 - 35,251,110 (-)	NCBI

RefSeq Acc Id:

XM_063268251 ⟹ XP_063124321

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	35,735,353 - 35,742,733 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386387	(Get FASTA)	NCBI Sequence Viewer
	XP_017453114	(Get FASTA)	NCBI Sequence Viewer
	XP_038943110	(Get FASTA)	NCBI Sequence Viewer
	XP_063124321	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004902.6
	ENSRNOP00000092663
	ENSRNOP00000092663.1
	ENSRNOP00000096622.1

RefSeq Acc Id:	XP_017453114 ⟸ XM_017597625
- Peptide Label:	isoform X3
- UniProtKB:	D3ZUE7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MISVLQQGEEPWKAEKESHGCSSLGCNSSLQTTKSTQTKESSFQELKRKQLKRDEDWDFTSGKS CRPDNSFKKQNKNESLQIISITHTKILTVDKSHKNFEFGPSVSLKSISKQKIAREKTQRNSLKE NSTSLNQPKIKTLEKRFKCSTCEKAFIHSSSLRKHLKNHSGERLFQCKDCLKAFSQSSALIQHQ RTHTGEKPYICNECGKAFSHSASLCKHLRTHTLEKSYTCKECGKSFSRRSSLFLHQKIHARENP HRYNPGRKASASLSGCQRAHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFRCSECGRAFS QSASLIQHERIHTGEKPYRCGECGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIH ERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRIHTGEK PYQCIECGMSFGQSAALIQHQRIHTGEKPFKCNTCGRSFRQSSSLIAHQRIHTGEKPYECSACG KLFSQRSSLTNHYKIHIEEDSLNIDLHE hide sequence

RefSeq Acc Id:

ENSRNOP00000004902 ⟸ ENSRNOT00000004902

RefSeq Acc Id:	XP_038943110 ⟸ XM_039087182
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000092663 ⟸ ENSRNOT00000099878

RefSeq Acc Id:

ENSRNOP00000096622 ⟸ ENSRNOT00000095817

RefSeq Acc Id:

ENSRNOP00000031832 ⟸ ENSRNOT00000039827

RefSeq Acc Id:

NP_001386387 ⟸ NM_001399458

RefSeq Acc Id:	XP_063124321 ⟸ XM_063268251
- Peptide Label:	isoform X2
- UniProtKB:	D3ZUE7 (UniProtKB/TrEMBL)

Protein Domains

C2H2-type KRAB KRAB-related

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZUE7-F1-model_v2	AlphaFold	D3ZUE7	1-540	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:7562538	AgrOrtholog
BioCyc Gene	G2FUF-25224	BioCyc
Ensembl Genes	ENSRNOG00000029678	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004902.6	UniProtKB/TrEMBL
	ENSRNOT00000095817.1	UniProtKB/TrEMBL
	ENSRNOT00000099878	ENTREZGENE
	ENSRNOT00000099878.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.140	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	aKRAB	UniProtKB/TrEMBL
	KRAB	UniProtKB/TrEMBL
	KRAB_dom_sf	UniProtKB/TrEMBL
	Znf_C2H2/integrase_DNA-bd	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
KEGG Report	rno:102556119	UniProtKB/TrEMBL
NCBI Gene	LOC102556119	ENTREZGENE
PANTHER	KRAB DOMAIN C2H2 ZINC FINGER	UniProtKB/TrEMBL
	KRAB DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 78	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN 879	UniProtKB/TrEMBL
Pfam	KRAB	UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/TrEMBL
PhenoGen	Znf354b	PhenoGen
PROSITE	KRAB	UniProtKB/TrEMBL
	KRAB_RELATED	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000029678	RatGTEx
SMART	KRAB	UniProtKB/TrEMBL
	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF109640	UniProtKB/TrEMBL
	SSF57667	UniProtKB/TrEMBL
UniProt	A0A8I6AE42_RAT	UniProtKB/TrEMBL
	A0A8I6AQX0_RAT	UniProtKB/TrEMBL
	D3ZUE7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-06-26	Znf354b	zinc finger protein 354B	LOC102556119	zinc finger protein 354B-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-12-17	LOC102556119	zinc finger protein 354B-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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