Mrgprb4 (MAS-related GPR, member B4) - Rat Genome Database

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Gene: Mrgprb4 (MAS-related GPR, member B4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mrgprb4
Name: MAS-related GPR, member B4
RGD ID: 738043
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human MRGPRX2 (MAS related GPR family member X2); MRGPRX3 (MAS related GPR family member X3); and MRGPRX4 (MAS related GPR family member X4); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAS-related G protein-coupled receptor, member B4; mas-related G-protein coupled receptor member B4; MAS-related gene B4; MrgB4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,988,947 - 106,989,918 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1106,988,947 - 106,990,017 (-)EnsemblGRCr8
mRatBN7.2197,852,704 - 97,853,675 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,852,704 - 97,853,774 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1103,231,368 - 103,232,339 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,703,312 - 111,704,283 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,000,965 - 105,001,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,425,496 - 103,426,467 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,425,496 - 103,426,467 (-)Ensemblrn6Rnor6.0
Rnor_5.01104,488,718 - 104,489,689 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4197,967,375 - 97,968,346 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera192,092,086 - 92,093,057 (-)NCBICelera
RGSC_v3.1198,045,485 - 98,046,457 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.

Genomics

Variants

.
Variants in Mrgprb4
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:9
Count of miRNA genes:9
Interacting mature miRNAs:9
Transcripts:ENSRNOT00000045792
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH133811  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2197,852,518 - 97,852,735 (+)MAPPERmRatBN7.2
Rnor_6.01103,425,311 - 103,425,527NCBIRnor6.0
Rnor_5.01104,488,533 - 104,488,749UniSTSRnor5.0
RGSC_v3.4197,967,190 - 97,967,406UniSTSRGSC3.4
Celera192,091,901 - 92,092,117UniSTS
RH 3.4 Map1910.7UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
mesenchyme
mesoderm
nervous system
sensory system
visual system
3 1 1 1 2 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000045792   ⟹   ENSRNOP00000043206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1106,988,947 - 106,990,017 (-)Ensembl
mRatBN7.2 Ensembl197,852,704 - 97,853,774 (-)Ensembl
Rnor_6.0 Ensembl1103,425,496 - 103,426,467 (-)Ensembl
RefSeq Acc Id: NM_001002287   ⟹   NP_001002287
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81106,988,947 - 106,989,918 (-)NCBI
mRatBN7.2197,852,704 - 97,853,675 (-)NCBI
Rnor_6.01103,425,496 - 103,426,467 (-)NCBI
Rnor_5.01104,488,718 - 104,489,689 (-)NCBI
RGSC_v3.4197,967,375 - 97,968,346 (-)RGD
Celera192,092,086 - 92,093,057 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001002287 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ08314 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043206
GenBank Protein Q7TN45 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001002287   ⟸   NM_001002287
- UniProtKB: Q7TN45 (UniProtKB/Swiss-Prot),   W8W3G0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043206   ⟸   ENSRNOT00000045792
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TN45-F1-model_v2 AlphaFold Q7TN45 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:738043 AgrOrtholog
BioCyc Gene G2FUF-59588 BioCyc
Ensembl Genes ENSRNOG00000033021 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000045792 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  MRGPCRFAMILY UniProtKB/Swiss-Prot
KEGG Report rno:404658 UniProtKB/Swiss-Prot
NCBI Gene 404658 ENTREZGENE
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER B4-RELATED UniProtKB/Swiss-Prot
  PTHR11334 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Mrgprb4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MRGPCRFAMILY UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033021 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt MRGB4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  W8W3G0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Mrgprb4  MAS-related GPR, member B4  Mrgprb4  MAS-related G protein-coupled receptor, member B4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Mrgprb4        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_evolution genome comparisons with mouse and gerbil suggest Mrgprb genes diverged from a single ancestral gene 65-70 million years ago 737883
gene_expression expressed in nociceptive sensory neurons and in newborn dorsal root ganglia 737883
gene_mapping Mrgpra, Mrgprb and Mrgprc are located within a 760-kb cluster on chr 1 737883
gene_product member of the Mas-related gene (Mrg) family, based on ligand which activates the receptor 737883