Gene:	AMBN ( Homo sapiens ) ameloblastin (enamel matrix protein)
Description:	Ameloblastin is thought to represent an unique ameloblast-specific gene product that may be important in enamel matrix formation and mineralization. The gene is located on chromosome 4 near other genes associated with mineralized tissues: osteopontin, bone sialoprotein, and bone morphogenetic protein 3. Based on its cytogenetic location, this gene is a candidate gene for one form of the disorder, dentinogenesis imperfecta, and/or the disorder, autosomal dominant amylogenesis imperfecta. [provided by RefSeq]
Synonyms:	ameloblastin;
Gene Type:	protein-coding
Additional Data
Homologs
Mus musculus: Ambn     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Rattus norvegicus: Ambn     See the Rat gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ambn genome assembly 3.1 14 21183341 - 21196650     Rat Celera Assembly 14 18940132 - 18975936     RGSC genome assembly v3.4 14 21183338 - 21196650     Cytogenetic 14 p21 Mus musculus Ambn Mouse genome assembly build 36.1 5 88885036 - 88897556     Cytogenetic 5 5 E1 Homo sapiens AMBN human genome assembly 4 71638760 - 71653762     Human genome assembly build 36.2 4 71492590 - 71507594     Cytogenetic 4 q21   View comparative maps:      NCBI MapViewer
Annotation
Molecular Function	Gene Ontology growth factor activity,  structural constituent of tooth enamel (details...)
Biological Process	Gene Ontology bone mineralization,  cell proliferation,  cell adhesion ...  (details...)
Cellular Component	Gene Ontology extracellular region,  proteinaceous extracellular matrix (details...)
External Links
Databases	DATABASE ID SOURCE OMIM: 601259 ENTREZGENE HGNC ID: AMBN ENTREZGENE Entrez Gene: AMBN ENTREZGENE KEGG Report: hsa:258 ENTREZGENE HomoloGene Group ID: 7625 ENTREZGENE HPRD ID: 03160 ENTREZGENE
Sequences	Nucleotide: CH471057 Get FASTA Search GEO Profiles Nucleotide: AF263464 Get FASTA Search GEO Profiles Nucleotide: AF209780 Get FASTA Search GEO Profiles Nucleotide: AJ537437 Get FASTA Search GEO Profiles Nucleotide: AK314918 Get FASTA Search GEO Profiles Nucleotide: AF219994 Get FASTA Search GEO Profiles Nucleotide: BC106931 Get FASTA Search GEO Profiles Nucleotide: AY009124 Get FASTA Search GEO Profiles Nucleotide: AC134919 Get FASTA Search GEO Profiles Nucleotide: BC106932 Get FASTA Search GEO Profiles Nucleotide: NM_016519 Get FASTA Search GEO Profiles (View all 11 Nucleotide Accessions) Protein: CAD60938 Get FASTA Protein: EAX05623 Get FASTA Protein: BAG37429 Get FASTA Protein: AAG27036 Get FASTA Protein: AAI06932 Get FASTA Protein: EAX05624 Get FASTA Protein: AAF73048 Get FASTA Protein: AAG35772 Get FASTA Protein: AAI06933 Get FASTA Protein: NP_057603 Get FASTA Protein: AAF37355 Get FASTA Protein: Q3B861 Get FASTA Protein: Q9NP70 Get FASTA Protein: Q546D7 Get FASTA Protein: Q3B862 Get FASTA (View all 15 Protein Accessions)
Clusters	UniGene: 272396
References
Curated References	1 references in RGD related to AMBN
Other References	9 other references at PubMed related to AMBN
Database Information
RGD ID	736409
History	No Nomenclature events are recorded for this object