Napepld (N-acyl phosphatidylethanolamine phospholipase D) - Rat Genome Database

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Gene: Napepld (N-acyl phosphatidylethanolamine phospholipase D) Rattus norvegicus
Analyze
Symbol: Napepld
Name: N-acyl phosphatidylethanolamine phospholipase D
RGD ID: 735197
Description: Enables phospholipase activity. Involved in several processes, including negative regulation of eating behavior; response to ethanol; and response to isolation stress. Predicted to be located in Golgi apparatus; early endosome; and nucleus. Predicted to be active in several cellular components, including hippocampal mossy fiber to CA3 synapse; smooth endoplasmic reticulum membrane; and synaptic membrane. Biomarker of osteoarthritis. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; NAPE-hydrolyzing phospholipase D; NAPE-PLD
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,251,591 - 14,291,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl414,252,692 - 14,291,014 (+)EnsemblGRCr8
mRatBN7.2413,360,532 - 13,398,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,361,006 - 13,398,748 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx418,515,917 - 18,536,222 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,324,467 - 14,344,734 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,701,560 - 12,721,865 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,965,323 - 10,004,650 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,966,891 - 10,002,247 (+)Ensemblrn6Rnor6.0
Rnor_5.049,966,483 - 10,005,809 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,821,727 - 8,845,709 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,954,741 - 8,975,084 (+)NCBICelera
RGSC_v3.148,821,726 - 8,845,709 (+)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
alcohol  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
chromium(6+)  (ISO)
cocaine hydrochloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
GR 113808  (ISO)
granisetron  (ISO)
hydrogen peroxide  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
nickel atom  (ISO)
orlistat  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
rimonabant  (EXP)
rotenone  (EXP)
serotonin  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
theophylline  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
WIN 55212-2  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. In vitro and in vivo models of Huntington's disease show alterations in the endocannabinoid system. Bari M, etal., FEBS J. 2013 Jul;280(14):3376-88. doi: 10.1111/febs.12329. Epub 2013 Jun 10.
2. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. Fu J, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jul;295(1):R45-50. doi: 10.1152/ajpregu.00126.2008. Epub 2008 Apr 23.
3. The endocannabinoid system is modulated in response to spinal cord injury in rats. Garcia-Ovejero D, etal., Neurobiol Dis. 2009 Jan;33(1):57-71. Epub 2008 Sep 30.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. Marcos A, etal., Neuropharmacology. 2022 Mar 15;206:108937. doi: 10.1016/j.neuropharm.2021.108937. Epub 2021 Dec 26.
6. Age dependent accumulation of N-acyl-ethanolamine phospholipids in ischemic rat brain. A (31)P NMR and enzyme activity study. Moesgaard B, etal., J Lipid Res. 2000 Jun;41(6):985-90.
7. Molecular characterization of a phospholipase D generating anandamide and its congeners. Okamoto Y, etal., J Biol Chem 2004 Feb 13;279(7):5298-305. Epub 2003 Nov 21.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Sagar DR, etal., Arthritis Rheum. 2010 Dec;62(12):3666-76. doi: 10.1002/art.27698.
11. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. Sanchez-Marin L, etal., Eur Neuropsychopharmacol. 2020 Apr;33:126-138. doi: 10.1016/j.euroneuro.2020.01.012. Epub 2020 Feb 10.
Additional References at PubMed
PMID:15249196   PMID:15992380   PMID:16818490   PMID:19056867   PMID:25684574   PMID:25757720  


Genomics

Comparative Map Data
Napepld
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,251,591 - 14,291,010 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl414,252,692 - 14,291,014 (+)EnsemblGRCr8
mRatBN7.2413,360,532 - 13,398,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,361,006 - 13,398,748 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx418,515,917 - 18,536,222 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,324,467 - 14,344,734 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,701,560 - 12,721,865 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,965,323 - 10,004,650 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,966,891 - 10,002,247 (+)Ensemblrn6Rnor6.0
Rnor_5.049,966,483 - 10,005,809 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,821,727 - 8,845,709 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,954,741 - 8,975,084 (+)NCBICelera
RGSC_v3.148,821,726 - 8,845,709 (+)NCBI
Cytogenetic Map4q11NCBI
NAPEPLD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,099,776 - 103,150,001 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,099,776 - 103,151,172 (-)Ensemblhg38GRCh38
GRCh377102,740,223 - 102,790,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,527,459 - 102,576,741 (-)NCBIBuild 36Build 36hg18NCBI36
Celera797,547,949 - 97,597,471 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,103,121 - 97,152,369 (-)NCBIHuRef
CHM1_17102,673,431 - 102,722,953 (-)NCBICHM1_1
T2T-CHM13v2.07104,414,920 - 104,465,123 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,100,389 - 102,149,935 (-)NCBI
Napepld
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39521,867,899 - 21,906,620 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl521,867,899 - 21,906,394 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38521,662,901 - 21,701,622 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,662,901 - 21,701,396 (-)Ensemblmm10GRCm38
MGSCv37521,168,721 - 21,207,163 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36521,174,727 - 21,213,169 (-)NCBIMGSCv36mm8
Celera518,631,024 - 18,671,982 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
Napepld
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,220,400 - 8,247,486 (-)Ensembl
ChiLan1.0NW_0049554108,217,684 - 8,233,302 (-)NCBIChiLan1.0ChiLan1.0
NAPEPLD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26139,942,431 - 140,005,769 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,214,784 - 188,269,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,074,084 - 95,123,936 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17107,923,952 - 107,973,269 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7107,923,960 - 107,973,269 (-)EnsemblpanPan2panpan1.1
NAPEPLD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,945,096 - 16,990,752 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,945,253 - 17,009,607 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1816,599,554 - 16,650,199 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01817,253,389 - 17,307,355 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,253,376 - 17,307,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11817,011,890 - 17,062,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,950,687 - 17,001,305 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,219,297 - 17,269,945 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Napepld
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511859,135,563 - 59,172,683 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,275,319 - 20,292,688 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,259,260 - 20,293,116 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAPEPLD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,210,748 - 103,262,910 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19103,210,655 - 103,309,018 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,620,593 - 113,632,997 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAPEPLD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,174,451 - 72,224,932 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,178,041 - 72,224,559 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604231,777,904 - 31,826,799 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Napepld
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473926,117,665 - 26,152,322 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Napepld
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16150,969,365 - 151,017,690 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Napepld
155 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:75
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000015322
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 88 59 6 351 188 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015322   ⟹   ENSRNOP00000015322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,253,707 - 14,291,014 (+)Ensembl
mRatBN7.2 Ensembl413,370,975 - 13,398,748 (+)Ensembl
Rnor_6.0 Ensembl49,981,958 - 10,002,247 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086609   ⟹   ENSRNOP00000073608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,253,239 - 14,291,014 (+)Ensembl
mRatBN7.2 Ensembl413,361,006 - 13,398,748 (+)Ensembl
Rnor_6.0 Ensembl49,966,891 - 9,997,267 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104090   ⟹   ENSRNOP00000082713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,253,560 - 14,291,014 (+)Ensembl
mRatBN7.2 Ensembl413,361,026 - 13,398,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116230   ⟹   ENSRNOP00000082705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,262,766 - 14,291,014 (+)Ensembl
mRatBN7.2 Ensembl413,361,026 - 13,398,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117324   ⟹   ENSRNOP00000094226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,253,257 - 14,291,014 (+)Ensembl
mRatBN7.2 Ensembl413,361,031 - 13,398,748 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000136190   ⟹   ENSRNOP00000108050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,252,692 - 14,291,014 (+)Ensembl
RefSeq Acc Id: NM_199381   ⟹   NP_955413
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,253,260 - 14,291,010 (+)NCBI
mRatBN7.2413,361,046 - 13,398,803 (+)NCBI
Rnor_6.049,981,958 - 10,002,247 (+)NCBI
Rnor_5.049,966,483 - 10,005,809 (+)NCBI
RGSC_v3.448,821,727 - 8,845,709 (+)RGD
Celera48,954,741 - 8,975,084 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235908   ⟹   XP_006235970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,251,591 - 14,291,010 (+)NCBI
mRatBN7.2413,360,532 - 13,398,815 (+)NCBI
Rnor_6.049,965,323 - 10,004,650 (+)NCBI
Rnor_5.049,966,483 - 10,005,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235910   ⟹   XP_006235972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,253,223 - 14,291,010 (+)NCBI
mRatBN7.2413,361,015 - 13,398,815 (+)NCBI
Rnor_6.049,966,859 - 10,004,650 (+)NCBI
Rnor_5.049,966,483 - 10,005,809 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107244   ⟹   XP_038963172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,253,216 - 14,291,010 (+)NCBI
mRatBN7.2413,361,008 - 13,398,815 (+)NCBI
RefSeq Acc Id: XM_063285707   ⟹   XP_063141777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,267,298 - 14,291,010 (+)NCBI
RefSeq Acc Id: XM_063285708   ⟹   XP_063141778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,266,297 - 14,291,010 (+)NCBI
RefSeq Acc Id: NP_955413   ⟸   NM_199381
- UniProtKB: Q769K2 (UniProtKB/Swiss-Prot),   A6K5B2 (UniProtKB/TrEMBL),   A0A8I6AKD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235970   ⟸   XM_006235908
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AKD5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235972   ⟸   XM_006235910
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K5Y7 (UniProtKB/TrEMBL),   A0A8I6AKD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073608   ⟸   ENSRNOT00000086609
Ensembl Acc Id: ENSRNOP00000015322   ⟸   ENSRNOT00000015322
RefSeq Acc Id: XP_038963172   ⟸   XM_039107244
- Peptide Label: isoform X3
- UniProtKB: Q769K2 (UniProtKB/Swiss-Prot),   A6K5B2 (UniProtKB/TrEMBL),   A0A8I6AKD5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094226   ⟸   ENSRNOT00000117324
Ensembl Acc Id: ENSRNOP00000082705   ⟸   ENSRNOT00000116230
Ensembl Acc Id: ENSRNOP00000082713   ⟸   ENSRNOT00000104090
RefSeq Acc Id: XP_063141778   ⟸   XM_063285708
- Peptide Label: isoform X3
- UniProtKB: Q769K2 (UniProtKB/Swiss-Prot),   A6K5B2 (UniProtKB/TrEMBL),   A0A8I6AKD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141777   ⟸   XM_063285707
- Peptide Label: isoform X3
- UniProtKB: Q769K2 (UniProtKB/Swiss-Prot),   A6K5B2 (UniProtKB/TrEMBL),   A0A8I6AKD5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108050   ⟸   ENSRNOT00000136190
Protein Domains
Metallo-beta-lactamase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q769K2-F1-model_v2 AlphaFold Q769K2 1-396 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692818
Promoter ID:EPDNEW_R3332
Type:initiation region
Name:Napepld_1
Description:N-acyl phosphatidylethanolamine phospholipase D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.049,966,894 - 9,966,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735197 AgrOrtholog
BioCyc Gene G2FUF-45982 BioCyc
Ensembl Genes ENSRNOG00000011363 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015322 ENTREZGENE
  ENSRNOT00000086609 ENTREZGENE
  ENSRNOT00000104090 ENTREZGENE
  ENSRNOT00000116230.1 UniProtKB/Swiss-Prot
  ENSRNOT00000136190 ENTREZGENE
Gene3D-CATH 3.60.15.10 UniProtKB/Swiss-Prot
InterPro Metallo-B-lactamas UniProtKB/Swiss-Prot
  NAPE-PLD UniProtKB/Swiss-Prot
  RibonucZ/Hydroxyglut_hydro UniProtKB/Swiss-Prot
KEGG Report rno:296757 UniProtKB/Swiss-Prot
NCBI Gene 296757 ENTREZGENE
PANTHER N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D UniProtKB/Swiss-Prot
  N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D UniProtKB/Swiss-Prot
Pfam Lactamase_B_2 UniProtKB/Swiss-Prot
PhenoGen Napepld PhenoGen
PIRSF NAPE-PLD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011363 RatGTEx
Superfamily-SCOP SSF56281 UniProtKB/Swiss-Prot
UniProt A0A0G2K5Y7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKD5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G7S2_RAT UniProtKB/TrEMBL
  A0A8L2Q779_RAT UniProtKB/TrEMBL
  A0ABK0LBJ3_RAT UniProtKB/TrEMBL
  A6K5B2 ENTREZGENE, UniProtKB/TrEMBL
  NAPEP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Napepld  N-acyl phosphatidylethanolamine phospholipase D  NAPE-PLD  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 NAPE-PLD        Symbol and Name status set to provisional 70820 PROVISIONAL