Gstk1 (glutathione S-transferase kappa 1) - Rat Genome Database

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Gene: Gstk1 (glutathione S-transferase kappa 1) Rattus norvegicus
Analyze
Symbol: Gstk1
Name: glutathione S-transferase kappa 1
RGD ID: 735188
Description: Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Predicted to be involved in epithelial cell differentiation and glutathione metabolic process. Located in mitochondrial matrix. Orthologous to human GSTK1 (glutathione S-transferase kappa 1); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adiponectin multimerization protein; DsbA-L; glutathione S-transferase subunit 13; glutathione S-transferase, mitochondrial; GST 13-13; GST class-kappa; GST13-13; GSTK1-1; GSTkappa; rGSTK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,085,532 - 72,089,934 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl472,085,531 - 72,089,927 (+)EnsemblGRCr8
mRatBN7.2471,118,979 - 71,123,298 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,118,896 - 71,123,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx476,038,785 - 76,043,096 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,952,032 - 71,956,343 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,371,499 - 70,375,808 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,621,777 - 71,626,096 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,621,729 - 71,626,107 (+)Ensemblrn6Rnor6.0
Rnor_5.04136,427,328 - 136,431,713 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4469,999,767 - 70,004,086 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera466,050,514 - 66,054,833 (+)NCBICelera
RGSC_v3.1470,275,896 - 70,280,216 (+)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(S)-nicotine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3-methylcholanthrene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bleomycin A5  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dichlorine  (EXP)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
Evodiamine  (ISO)
flutamide  (EXP)
genistein  (EXP)
glutathione  (ISO)
glycidyl methacrylate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (EXP)
isoflavones  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lutein  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin  (EXP)
microcystin-LR  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenytoin  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
progesterone  (EXP)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triazines  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
XL147  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
mitochondrial matrix  (IDA,IEA)
mitochondrion  (IBA,IEA,ISO)
peroxisome  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Daily Intake of Grape Powder Prevents the Progression of Kidney Disease in Obese Type 2 Diabetic ZSF1 Rats. Almomen SM, etal., Nutrients. 2017 Mar 31;9(4):345. doi: 10.3390/nu9040345.
2. Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. Bogdani M, etal., J Endocrinol. 2013 Jan 18;216(2):111-23. doi: 10.1530/JOE-12-0385. Print 2013 Feb.
3. Expression of CYP and GST in human normal and colon tumor tissues. Bulus H, etal., Biotech Histochem. 2019 Jan;94(1):1-9. doi: 10.1080/10520295.2018.1493220. Epub 2018 Aug 9.
4. Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells. Burlet E and Jain SK, Mol Cell Biochem. 2017 May;429(1-2):1-10. doi: 10.1007/s11010-016-2931-7. Epub 2017 Jan 13.
5. The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway. Chen L, etal., Front Pharmacol. 2021 Mar 8;12:619311. doi: 10.3389/fphar.2021.619311. eCollection 2021.
6. Prepubertal exposure to arsenic alters male reproductive parameters in pubertal and adult rats. Couto-Santos F, etal., Toxicol Appl Pharmacol. 2020 Dec 15;409:115304. doi: 10.1016/j.taap.2020.115304. Epub 2020 Oct 27.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes. Harris JM, etal., Biochem J. 1991 Aug 15;278 ( Pt 1)(Pt 1):137-41. doi: 10.1042/bj2780137.
9. Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase. Jowsey IR, etal., Biochem J. 2003 Jul 15;373(Pt 2):559-69. doi: 10.1042/BJ20030415.
10. An investigation of cytochrome p450 (CYP) and glutathione S-transferase (GST) isoenzyme protein expression and related interactions with phototherapy in patients with psoriasis vulgaris. Karadag AS, etal., Int J Dermatol. 2017 Feb;56(2):225-231. doi: 10.1111/ijd.13343. Epub 2016 Sep 9.
11. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
12. Studies on diagnostic biomarkers and therapeutic mechanism of Alzheimer's disease through metabolomics and hippocampal proteomics. Lin W, etal., Eur J Pharm Sci. 2017 Jul 15;105:119-126. doi: 10.1016/j.ejps.2017.05.003. Epub 2017 May 8.
13. Chinese herb extract improves liver steatosis by promoting the expression of high molecular weight adiponectin in NAFLD rats. Liu X, etal., Mol Med Rep. 2017 Oct;16(4):5580-5586. doi: 10.3892/mmr.2017.7284. Epub 2017 Aug 18.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Glutathione S-transferase class Kappa: characterization by the cloning of rat mitochondrial GST and identification of a human homologue. Pemble SE, etal., Biochem J 1996 Nov 1;319 ( Pt 3):749-54.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice. Rojanathammanee L, etal., J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1199-211. doi: 10.1093/gerona/glt178. Epub 2013 Nov 27.
20. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
21. Age-associated changes in GSH S-transferase gene/proteins in livers of rats. Xu S, etal., Redox Rep. 2018 Dec;23(1):213-218. doi: 10.1080/13510002.2018.1546985.
22. Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia. Yamada Y, etal., PLoS One. 2012;7(2):e31494. doi: 10.1371/journal.pone.0031494. Epub 2012 Feb 15.
Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:14651853   PMID:14742434   PMID:18614015   PMID:19199708   PMID:19946888   PMID:20178365   PMID:21492153   PMID:23376485  


Genomics

Comparative Map Data
Gstk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,085,532 - 72,089,934 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl472,085,531 - 72,089,927 (+)EnsemblGRCr8
mRatBN7.2471,118,979 - 71,123,298 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,118,896 - 71,123,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx476,038,785 - 76,043,096 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,952,032 - 71,956,343 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,371,499 - 70,375,808 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,621,777 - 71,626,096 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,621,729 - 71,626,107 (+)Ensemblrn6Rnor6.0
Rnor_5.04136,427,328 - 136,431,713 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4469,999,767 - 70,004,086 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera466,050,514 - 66,054,833 (+)NCBICelera
RGSC_v3.1470,275,896 - 70,280,216 (+)NCBI
Cytogenetic Map4q24NCBI
GSTK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,263,441 - 143,269,115 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,244,093 - 143,270,873 (+)Ensemblhg38GRCh38
GRCh377142,960,534 - 142,966,208 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,670,686 - 142,676,328 (+)NCBIBuild 36Build 36hg18NCBI36
Celera7137,797,393 - 137,803,091 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,297,887 - 137,303,587 (+)NCBIHuRef
CHM1_17142,897,388 - 142,903,108 (+)NCBICHM1_1
T2T-CHM13v2.07144,618,862 - 144,624,534 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,362,642 - 142,368,342 (+)NCBI
Gstk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,222,869 - 42,227,375 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,222,869 - 42,227,381 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38642,245,935 - 42,250,441 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,245,935 - 42,250,447 (+)Ensemblmm10GRCm38
MGSCv37642,195,934 - 42,200,440 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36642,175,542 - 42,180,048 (+)NCBIMGSCv36mm8
Celera642,190,122 - 42,194,626 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.52NCBI
Gstk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955494383,341 - 387,630 (-)Ensembl
ChiLan1.0NW_004955494383,107 - 387,483 (-)NCBIChiLan1.0ChiLan1.0
GSTK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26180,116,341 - 180,122,050 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1732,126,607 - 32,136,166 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,258,184 - 135,267,254 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,749,461 - 147,755,158 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,749,461 - 147,755,158 (+)EnsemblpanPan2panpan1.1
GSTK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,411,678 - 6,416,135 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,400,563 - 7,405,021 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0166,265,390 - 6,269,847 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,265,390 - 6,269,842 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,212,775 - 6,217,230 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,064,698 - 6,069,155 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,140,101 - 6,144,565 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gstk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,176,254 - 12,180,877 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527722,083 - 728,824 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936527722,548 - 727,169 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,992,647 - 6,999,068 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,992,623 - 6,999,068 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,234,405 - 7,239,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,149,949 - 112,155,579 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,149,970 - 112,155,300 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660728,874,033 - 8,879,741 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gstk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480011,478,510 - 11,486,122 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480011,481,664 - 11,486,256 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gstk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1697,972,612 - 97,976,974 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gstk1
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:33
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000022275
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46796011273752811Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
RH128940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2471,123,128 - 71,123,286 (+)MAPPERmRatBN7.2
Rnor_6.0471,625,927 - 71,626,084NCBIRnor6.0
Rnor_5.04136,431,543 - 136,431,700UniSTSRnor5.0
RGSC_v3.4470,003,917 - 70,004,074UniSTSRGSC3.4
Celera466,054,664 - 66,054,821UniSTS
RH 3.4 Map4434.82UniSTS
Cytogenetic Map4q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 91 59 6 355 191 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022275   ⟹   ENSRNOP00000022275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,085,531 - 72,089,927 (+)Ensembl
mRatBN7.2 Ensembl471,118,896 - 71,123,292 (+)Ensembl
Rnor_6.0 Ensembl471,621,729 - 71,626,107 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123912   ⟹   ENSRNOP00000103168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl472,085,531 - 72,089,927 (+)Ensembl
RefSeq Acc Id: NM_181371   ⟹   NP_852036
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,085,614 - 72,089,933 (+)NCBI
mRatBN7.2471,118,979 - 71,123,298 (+)NCBI
Rnor_6.0471,621,777 - 71,626,096 (+)NCBI
Rnor_5.04136,427,328 - 136,431,713 (+)NCBI
RGSC_v3.4469,999,767 - 70,004,086 (+)RGD
Celera466,050,514 - 66,054,833 (+)RGD
Sequence:
RefSeq Acc Id: XM_063285766   ⟹   XP_063141836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8472,085,532 - 72,089,934 (+)NCBI
Protein Sequences
Protein RefSeqs NP_852036 (Get FASTA)   NCBI Sequence Viewer  
  XP_063141836 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB50831 (Get FASTA)   NCBI Sequence Viewer  
  ACI32117 (Get FASTA)   NCBI Sequence Viewer  
  EDM15501 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022275
  ENSRNOP00000022275.2
GenBank Protein P24473 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_852036   ⟸   NM_181371
- UniProtKB: O09034 (UniProtKB/Swiss-Prot),   P24473 (UniProtKB/Swiss-Prot),   B6DYQ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022275   ⟸   ENSRNOT00000022275
RefSeq Acc Id: XP_063141836   ⟸   XM_063285766
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000103168   ⟸   ENSRNOT00000123912
Protein Domains
DSBA-like thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24473-F1-model_v2 AlphaFold P24473 1-226 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693007
Promoter ID:EPDNEW_R3530
Type:initiation region
Name:Gstk1_1
Description:glutathione S-transferase kappa 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0471,621,761 - 71,621,821EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735188 AgrOrtholog
BioCyc Gene G2FUF-45097 BioCyc
Ensembl Genes ENSRNOG00000016484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022275 ENTREZGENE
  ENSRNOT00000022275.5 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro DSBA-like_thioredoxin_dom UniProtKB/Swiss-Prot
  GST_Kappa/NadH UniProtKB/Swiss-Prot
  GSTK UniProtKB/Swiss-Prot
  HCCAis_GSTk UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:297029 UniProtKB/Swiss-Prot
NCBI Gene 297029 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE KAPPA UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE KAPPA 1 UniProtKB/Swiss-Prot
Pfam DSBA UniProtKB/Swiss-Prot
PhenoGen Gstk1 PhenoGen
PIRSF HCCAis_GSTk UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016484 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A0ABK0LI68_RAT UniProtKB/TrEMBL
  B6DYQ0 ENTREZGENE, UniProtKB/TrEMBL
  GSTK1_RAT UniProtKB/Swiss-Prot
  O09034 ENTREZGENE
  P24473 ENTREZGENE
UniProt Secondary O09034 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Gstk1  glutathione S-transferase kappa 1  GST13-13  glutathione S-transferase, mitochondrial  Symbol and Name updated 1299863 APPROVED