Prss30 (protease, serine, 30) - Rat Genome Database

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Gene: Prss30 (protease, serine, 30) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss30
Name: protease, serine, 30
RGD ID: 735142
Description: Enables serine-type endopeptidase activity and sodium channel regulator activity. Involved in proteolysis and sodium ion transport. Predicted to be located in side of membrane. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: distal intestinal serine protease; serine protease 30; Tmprss8; tmsp-1; transmembrane protease, serine 8; transmembrane protease, serine 8 (intestinal); transmembrane serine protease 1; transmembrane serine protease 8; transmembrane serine protease-1
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,511,916 - 13,519,968 (-)NCBIGRCr8
mRatBN7.21013,007,341 - 13,014,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,007,341 - 13,011,030 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,752,491 - 17,756,185 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,241,323 - 17,245,017 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,740,126 - 12,743,820 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,348,289 - 13,355,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,348,307 - 13,352,371 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,164,168 - 13,175,692 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,226,053 - 13,229,742 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,226,052 - 13,229,742 (-)NCBI
Celera1012,692,979 - 12,696,668 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IDA,IEA)
sodium ion transport  (IDA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator. Okumura Y, etal., Biol Chem. 2003 Oct-Nov;384(10-11):1483-95.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Characterisation of a novel murine intestinal serine protease, DISP. Shaw-Smith CJ, etal., Biochim Biophys Acta 2000 Jan 31;1490(1-2):131-6.

Genomics

Variants

.
Variants in Prss30
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:114
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000034340
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 9 3
Low 6 6 4 2 4 35 26 32 9
Below cutoff 20 27 18 12 18 3 3 37 6 2 3

Sequence


RefSeq Acc Id: ENSRNOT00000034340   ⟹   ENSRNOP00000037368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,007,341 - 13,011,030 (-)Ensembl
Rnor_6.0 Ensembl1013,348,307 - 13,352,371 (-)Ensembl
RefSeq Acc Id: NM_199371   ⟹   NP_955403
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,916 - 13,515,605 (-)NCBI
mRatBN7.21013,007,341 - 13,011,030 (-)NCBI
Rnor_6.01013,348,289 - 13,351,978 (-)NCBI
Rnor_5.01013,164,168 - 13,175,692 (-)NCBI
RGSC_v3.41013,226,053 - 13,229,742 (-)RGD
Celera1012,692,979 - 12,696,668 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245923   ⟹   XP_006245985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,519,968 (-)NCBI
mRatBN7.21013,007,341 - 13,014,827 (-)NCBI
Rnor_6.01013,348,289 - 13,355,833 (-)NCBI
Rnor_5.01013,164,168 - 13,175,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268551   ⟹   XP_063124621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,516,264 (-)NCBI
RefSeq Acc Id: XM_063268553   ⟹   XP_063124623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,516,264 (-)NCBI
RefSeq Acc Id: XM_063268554   ⟹   XP_063124624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,519,968 (-)NCBI
RefSeq Acc Id: XM_063268555   ⟹   XP_063124625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,516,266 (-)NCBI
RefSeq Acc Id: NP_955403   ⟸   NM_199371
- Peptide Label: precursor
- UniProtKB: P83748 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245985   ⟸   XM_006245923
- Peptide Label: isoform X1
- UniProtKB: P83748 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037368   ⟸   ENSRNOT00000034340
RefSeq Acc Id: XP_063124624   ⟸   XM_063268554
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124625   ⟸   XM_063268555
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063124623   ⟸   XM_063268553
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124621   ⟸   XM_063268551
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83748-F1-model_v2 AlphaFold P83748 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697000
Promoter ID:EPDNEW_R7525
Type:initiation region
Name:Prss30_1
Description:protease, serine, 30
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,352,289 - 13,352,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735142 AgrOrtholog
BioCyc Gene G2FUF-25884 BioCyc
Ensembl Genes ENSRNOG00000033266 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034340 ENTREZGENE
  ENSRNOT00000034340.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287106 UniProtKB/Swiss-Prot
NCBI Gene 287106 ENTREZGENE
PANTHER FI06405P-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss30 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033266 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LQU8_RAT UniProtKB/TrEMBL
  P83748 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-26 Prss30  protease, serine, 30  Tmprss8  transmembrane protease, serine 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-13 Tmprss8  transmembrane protease, serine 8  Tmprss8  transmembrane protease, serine 8 (intestinal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tmprss8  transmembrane protease, serine 8 (intestinal)  tmsp-1  transmembrane serine protease-1  Symbol and Name updated 1299863 APPROVED