Prss30 (protease, serine, 30) - Rat Genome Database

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Gene: Prss30 (protease, serine, 30) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss30
Name: protease, serine, 30
RGD ID: 735142
Description: Enables serine-type endopeptidase activity and sodium channel regulator activity. Involved in proteolysis and sodium ion transport. Predicted to be located in plasma membrane. Predicted to be active in extracellular space; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: distal intestinal serine protease; serine protease 30; Tmprss8; tmsp-1; transmembrane protease, serine 8; transmembrane protease, serine 8 (intestinal); transmembrane serine protease 1; transmembrane serine protease 8; transmembrane serine protease-1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,511,916 - 13,519,968 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1013,511,916 - 13,515,605 (-)EnsemblGRCr8
mRatBN7.21013,007,341 - 13,014,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,007,341 - 13,011,030 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1017,752,491 - 17,756,185 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,241,323 - 17,245,017 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,740,126 - 12,743,820 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,348,289 - 13,355,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,348,307 - 13,352,371 (-)Ensemblrn6Rnor6.0
Rnor_5.01013,164,168 - 13,175,692 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41013,226,053 - 13,229,742 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1012,692,979 - 12,696,668 (-)NCBICelera
RGSC_v3.11013,226,052 - 13,229,742 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator. Okumura Y, etal., Biol Chem. 2003 Oct-Nov;384(10-11):1483-95.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Characterisation of a novel murine intestinal serine protease, DISP. Shaw-Smith CJ, etal., Biochim Biophys Acta 2000 Jan 31;1490(1-2):131-6.

Genomics

Variants

.
Variants in Prss30
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:114
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000034340
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 3 44 132 66 70 39 70 39 6 269 130 1 123 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000034340   ⟹   ENSRNOP00000037368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,511,916 - 13,515,605 (-)Ensembl
mRatBN7.2 Ensembl1013,007,341 - 13,011,030 (-)Ensembl
Rnor_6.0 Ensembl1013,348,307 - 13,352,371 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128735   ⟹   ENSRNOP00000106835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1013,511,916 - 13,514,791 (-)Ensembl
RefSeq Acc Id: NM_199371   ⟹   NP_955403
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,916 - 13,515,605 (-)NCBI
mRatBN7.21013,007,341 - 13,011,030 (-)NCBI
Rnor_6.01013,348,289 - 13,351,978 (-)NCBI
Rnor_5.01013,164,168 - 13,175,692 (-)NCBI
RGSC_v3.41013,226,053 - 13,229,742 (-)RGD
Celera1012,692,979 - 12,696,668 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245923   ⟹   XP_006245985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,519,968 (-)NCBI
mRatBN7.21013,007,341 - 13,014,827 (-)NCBI
Rnor_6.01013,348,289 - 13,355,833 (-)NCBI
Rnor_5.01013,164,168 - 13,175,692 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268551   ⟹   XP_063124621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,516,264 (-)NCBI
RefSeq Acc Id: XM_063268553   ⟹   XP_063124623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,516,264 (-)NCBI
RefSeq Acc Id: XM_063268554   ⟹   XP_063124624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,519,968 (-)NCBI
RefSeq Acc Id: XM_063268555   ⟹   XP_063124625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,511,917 - 13,516,266 (-)NCBI
RefSeq Acc Id: NP_955403   ⟸   NM_199371
- Peptide Label: precursor
- UniProtKB: P83748 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245985   ⟸   XM_006245923
- Peptide Label: isoform X1
- UniProtKB: P83748 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037368   ⟸   ENSRNOT00000034340
RefSeq Acc Id: XP_063124624   ⟸   XM_063268554
- Peptide Label: isoform X2
- UniProtKB: A6HCP4 (UniProtKB/TrEMBL),   F1LQU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124625   ⟸   XM_063268555
- Peptide Label: isoform X2
- UniProtKB: A6HCP4 (UniProtKB/TrEMBL),   F1LQU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124623   ⟸   XM_063268553
- Peptide Label: isoform X1
- UniProtKB: P83748 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063124621   ⟸   XM_063268551
- Peptide Label: isoform X1
- UniProtKB: P83748 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000106835   ⟸   ENSRNOT00000128735
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83748-F1-model_v2 AlphaFold P83748 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697000
Promoter ID:EPDNEW_R7525
Type:initiation region
Name:Prss30_1
Description:protease, serine, 30
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,352,289 - 13,352,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735142 AgrOrtholog
BioCyc Gene G2FUF-25884 BioCyc
Ensembl Genes ENSRNOG00000033266 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000034340 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:287106 UniProtKB/Swiss-Prot
NCBI Gene 287106 ENTREZGENE
PANTHER SERINE PROTEASE HEPSIN UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot
PhenoGen Prss30 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_HIS UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033266 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
UniProt A0ABK0L959_RAT UniProtKB/TrEMBL
  A6HCP4 ENTREZGENE, UniProtKB/TrEMBL
  F1LQU8 ENTREZGENE, UniProtKB/TrEMBL
  P83748 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-26 Prss30  protease, serine, 30  Tmprss8  transmembrane protease, serine 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-06-13 Tmprss8  transmembrane protease, serine 8  Tmprss8  transmembrane protease, serine 8 (intestinal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tmprss8  transmembrane protease, serine 8 (intestinal)  tmsp-1  transmembrane serine protease-1  Symbol and Name updated 1299863 APPROVED