Gene: Babam2 (BRISC and BRCA1 A complex member 2) Rattus norvegicus
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Symbol:
Babam2
Name:
BRISC and BRCA1 A complex member 2
RGD ID:
735111
Description:
Predicted to enable polyubiquitin modification-dependent protein binding activity and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to be located in cytoplasm and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Bre; BRISC and BRCA1-A complex member 2; LOC362704
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
BABAM2 (BRISC and BRCA1 A complex member 2)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Babam2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Babam2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
BABAM2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
BABAM2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Babam2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
BABAM2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
BABAM2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Babam2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Babam2 (BRISC and BRCA1 A complex member 2)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
FAM83E (family with sequence similarity 83 member E)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
BABAM2 (BRISC and BRCA1 A complex member 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Babam2 (BRISC and BRCA1 A complex member 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
babam2
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
babam2
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 6 30,089,065 - 30,467,508 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 6 30,071,611 - 30,467,341 (-) Ensembl GRCr8 mRatBN7.2 6 24,369,021 - 24,788,416 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 6 24,369,022 - 24,833,951 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 6 24,668,565 - 25,048,192 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 6 24,984,452 - 25,364,083 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 6 24,473,585 - 24,843,247 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 6 25,666,654 - 26,135,888 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 25,666,655 - 26,051,229 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 6 35,490,053 - 35,875,866 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 6 24,406,837 - 24,791,918 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 6 23,862,750 - 24,241,551 (-) NCBI Celera RGSC_v3.1 6 24,409,789 - 24,794,871 (-) NCBI Cytogenetic Map 6 q14 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Babam2 Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Babam2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Babam2 Rat 1,2-dimethylhydrazine multiple interactions ISO Babam2 (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of BABAM2 mRNA CTD PMID:22206623 Babam2 Rat 1-fluoro-2,4-dinitrobenzene increases expression ISO BABAM2 (Homo sapiens) 6480464 Dinitrofluorobenzene results in increased expression of BABAM2 mRNA CTD PMID:23999411 Babam2 Rat 17beta-estradiol affects expression ISO BABAM2 (Homo sapiens) 6480464 Estradiol affects the expression of BABAM2 mRNA CTD PMID:21826169 Babam2 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Babam2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Babam2 Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Babam2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Babam2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of BABAM2 mRNA CTD PMID:16960034|PMID:18796159|PMID:21215274|PMID:33387578 Babam2 Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Babam2 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin affects the methylation of BABAM2 intron] which results in decreased expression of BABAM2 mRNA CTD PMID:33017471 Babam2 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Babam2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of BABAM2 mRNA CTD PMID:16960034|PMID:31961203 Babam2 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Babam2 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of BABAM2 mRNA CTD PMID:21570461 Babam2 Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Babam2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Babam2 Rat 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of BABAM2 mRNA CTD PMID:21346803 Babam2 Rat 4,4'-sulfonyldiphenol increases expression ISO Babam2 (Mus musculus) 6480464 bisphenol S results in increased expression of BABAM2 mRNA CTD PMID:39298647 Babam2 Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Babam2 Rat 4-(ethoxymethylene)-2-phenyloxazol-5-one increases expression ISO BABAM2 (Homo sapiens) 6480464 Oxazolone results in increased expression of BABAM2 mRNA CTD PMID:23999411 Babam2 Rat 4-hydroxynon-2-enal increases expression ISO Babam2 (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased expression of BABAM2 mRNA CTD PMID:19191707 Babam2 Rat aflatoxin B1 decreases expression ISO BABAM2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased expression of BABAM2 mRNA CTD PMID:22100608 Babam2 Rat aflatoxin B1 increases methylation ISO BABAM2 (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of BABAM2 intron CTD PMID:30157460 Babam2 Rat aflatoxin B1 decreases expression ISO Babam2 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of BABAM2 mRNA CTD PMID:19770486 Babam2 Rat aflatoxin B1 decreases methylation ISO BABAM2 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of BABAM2 gene CTD PMID:27153756 Babam2 Rat Aflatoxin B2 alpha increases methylation ISO BABAM2 (Homo sapiens) 6480464 aflatoxin B2 results in increased methylation of BABAM2 intron CTD PMID:30157460 Babam2 Rat aristolochic acid A decreases expression ISO BABAM2 (Homo sapiens) 6480464 aristolochic acid I results in decreased expression of BABAM2 mRNA CTD PMID:33212167 Babam2 Rat arsane affects expression ISO BABAM2 (Homo sapiens) 6480464 Arsenic affects the expression of BABAM2 mRNA CTD PMID:18414638 Babam2 Rat arsenic atom affects expression ISO BABAM2 (Homo sapiens) 6480464 Arsenic affects the expression of BABAM2 mRNA CTD PMID:18414638 Babam2 Rat benzo[a]pyrene decreases expression ISO BABAM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of BABAM2 mRNA CTD PMID:20064835|PMID:20106945|PMID:21632981|PMID:22316170|PMID:26238291|PMID:32234424 Babam2 Rat benzo[a]pyrene decreases methylation ISO BABAM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of BRE 3' UTR; Benzo(a)pyrene results in decreased methylation of more ... CTD PMID:27901495 Babam2 Rat benzo[a]pyrene increases methylation ISO BABAM2 (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of BRE 5' UTR CTD PMID:27901495 Babam2 Rat benzo[a]pyrene increases expression ISO Babam2 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of BABAM2 mRNA CTD PMID:22228805 Babam2 Rat benzo[a]pyrene decreases expression ISO Babam2 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of BABAM2 mRNA CTD PMID:19770486|PMID:21715664 Babam2 Rat benzo[a]pyrene diol epoxide I decreases expression ISO BABAM2 (Homo sapiens) 6480464 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BABAM2 mRNA CTD PMID:26238291 Babam2 Rat biochanin A increases expression ISO BABAM2 (Homo sapiens) 6480464 biochanin A results in increased expression of BABAM2 mRNA CTD PMID:12111696 Babam2 Rat bis(2-ethylhexyl) phthalate increases expression ISO Babam2 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of BABAM2 mRNA CTD PMID:21318169 Babam2 Rat bisphenol A affects expression ISO BABAM2 (Homo sapiens) 6480464 bisphenol A affects the expression of BABAM2 mRNA CTD PMID:21826169 Babam2 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Babam2 Rat bisphenol A decreases expression ISO Babam2 (Mus musculus) 6480464 bisphenol A results in decreased expression of BABAM2 mRNA CTD PMID:32156529 Babam2 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of BABAM2 mRNA CTD PMID:30816183 Babam2 Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of BRE gene CTD PMID:28505145 Babam2 Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ... CTD PMID:36041667 Babam2 Rat cadmium atom increases expression ISO BABAM2 (Homo sapiens) 6480464 Cadmium results in increased expression of BABAM2 mRNA CTD PMID:21120746 Babam2 Rat cadmium dichloride increases expression ISO BABAM2 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of BABAM2 mRNA CTD PMID:38174414|PMID:38568856 Babam2 Rat CGP 52608 multiple interactions ISO BABAM2 (Homo sapiens) 6480464 CGP 52608 promotes the reaction [RORA protein binds to BRE gene] CTD PMID:28238834 Babam2 Rat chlorpyrifos increases expression ISO Babam2 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of BABAM2 mRNA CTD PMID:37019170 Babam2 Rat chromium(6+) multiple interactions ISO BABAM2 (Homo sapiens) 6480464 [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ... CTD PMID:38479592 Babam2 Rat cisplatin decreases expression ISO BABAM2 (Homo sapiens) 6480464 Cisplatin results in decreased expression of BRE mRNA CTD PMID:27594783 Babam2 Rat cisplatin decreases expression ISO Babam2 (Mus musculus) 6480464 Cisplatin results in decreased expression of BABAM2 mRNA CTD PMID:21151649 Babam2 Rat copper(II) sulfate decreases expression ISO BABAM2 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of BABAM2 mRNA CTD PMID:19549813 Babam2 Rat crocidolite asbestos increases expression ISO BABAM2 (Homo sapiens) 6480464 Asbestos, Crocidolite results in increased expression of BABAM2 mRNA CTD PMID:18687144 Babam2 Rat diazinon affects expression EXP 6480464 Diazinon affects the expression of BABAM2 mRNA CTD PMID:22546817 Babam2 Rat Dibutyl phosphate affects expression ISO BABAM2 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of BABAM2 mRNA CTD PMID:37042841 Babam2 Rat dicrotophos increases expression ISO BABAM2 (Homo sapiens) 6480464 dicrotophos results in increased expression of BRE mRNA CTD PMID:28302478 Babam2 Rat dieldrin affects expression EXP 6480464 Dieldrin affects the expression of BABAM2 mRNA CTD PMID:22546817 Babam2 Rat epoxiconazole decreases expression ISO Babam2 (Mus musculus) 6480464 epoxiconazole results in decreased expression of BABAM2 mRNA CTD PMID:35436446 Babam2 Rat fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of BABAM2 mRNA CTD PMID:30307764 Babam2 Rat flutamide increases expression EXP 6480464 Flutamide results in increased expression of BABAM2 mRNA CTD PMID:24136188 Babam2 Rat folic acid multiple interactions ISO Babam2 (Mus musculus) 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of BABAM2 mRNA CTD PMID:22206623 Babam2 Rat formaldehyde decreases expression ISO BABAM2 (Homo sapiens) 6480464 Formaldehyde results in decreased expression of BABAM2 mRNA CTD PMID:23649840 Babam2 Rat genistein increases expression EXP 6480464 Genistein results in increased expression of BABAM2 mRNA CTD PMID:17341692 Babam2 Rat glycidyl methacrylate decreases expression ISO BABAM2 (Homo sapiens) 6480464 glycidyl methacrylate results in decreased expression of BABAM2 protein CTD PMID:36641056 Babam2 Rat hydrogen peroxide multiple interactions ISO BABAM2 (Homo sapiens) 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BABAM2 protein CTD PMID:18951874 Babam2 Rat hydrogen peroxide increases expression ISO BABAM2 (Homo sapiens) 6480464 Hydrogen Peroxide results in increased expression of BABAM2 mRNA CTD PMID:18951874 Babam2 Rat ivermectin decreases expression ISO BABAM2 (Homo sapiens) 6480464 Ivermectin results in decreased expression of BABAM2 protein CTD PMID:32959892 Babam2 Rat Lasiocarpine multiple interactions ISO BABAM2 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased expression of BABAM2 more ... CTD PMID:33884520 Babam2 Rat leflunomide increases expression EXP 6480464 leflunomide results in increased expression of BABAM2 mRNA CTD PMID:24136188 Babam2 Rat Methylazoxymethanol acetate decreases expression EXP 6480464 Methylazoxymethanol Acetate results in decreased expression of BABAM2 mRNA CTD PMID:28349193 Babam2 Rat monocrotaline multiple interactions ISO BABAM2 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 more ... CTD PMID:33884520 Babam2 Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of BABAM2 gene CTD PMID:33148267 Babam2 Rat O-methyleugenol decreases expression ISO BABAM2 (Homo sapiens) 6480464 methyleugenol results in decreased expression of BABAM2 mRNA CTD PMID:32234424 Babam2 Rat p-menthan-3-ol decreases expression ISO BABAM2 (Homo sapiens) 6480464 Menthol results in decreased expression of BRE mRNA CTD PMID:26760959 Babam2 Rat paracetamol decreases expression ISO BABAM2 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of BABAM2 mRNA; Acetaminophen results in decreased expression of BRE more ... CTD PMID:21420995|PMID:29067470 Babam2 Rat PCB138 multiple interactions ISO Babam2 (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Babam2 Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of BABAM2 gene CTD PMID:33148267 Babam2 Rat riddelliine multiple interactions ISO BABAM2 (Homo sapiens) 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 more ... CTD PMID:33884520 Babam2 Rat rotenone decreases expression ISO BABAM2 (Homo sapiens) 6480464 Rotenone results in decreased expression of BABAM2 protein CTD PMID:39603559 Babam2 Rat sunitinib increases expression ISO BABAM2 (Homo sapiens) 6480464 Sunitinib results in increased expression of BABAM2 mRNA CTD PMID:31533062 Babam2 Rat tert-butyl hydroperoxide increases expression ISO Babam2 (Mus musculus) 6480464 tert-Butylhydroperoxide results in increased expression of BABAM2 mRNA CTD PMID:15003993 Babam2 Rat theophylline multiple interactions ISO BABAM2 (Homo sapiens) 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of BABAM2 protein CTD PMID:18951874 Babam2 Rat thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of BABAM2 mRNA CTD PMID:34492290 Babam2 Rat triphenyl phosphate affects expression ISO BABAM2 (Homo sapiens) 6480464 triphenyl phosphate affects the expression of BABAM2 mRNA CTD PMID:37042841 Babam2 Rat urethane decreases expression ISO BABAM2 (Homo sapiens) 6480464 Urethane results in decreased expression of BRE mRNA CTD PMID:28818685 Babam2 Rat usnic acid decreases expression ISO BABAM2 (Homo sapiens) 6480464 usnic acid results in decreased expression of BABAM2 mRNA CTD PMID:32508146 Babam2 Rat valproic acid affects expression ISO BABAM2 (Homo sapiens) 6480464 Valproic Acid affects the expression of BABAM2 mRNA CTD PMID:25979313 Babam2 Rat valproic acid affects expression ISO Babam2 (Mus musculus) 6480464 Valproic Acid affects the expression of BABAM2 mRNA CTD PMID:17963808 Babam2 Rat valproic acid increases expression ISO BABAM2 (Homo sapiens) 6480464 Valproic Acid results in increased expression of BABAM2 mRNA CTD PMID:23179753|PMID:27188386 Babam2 Rat vitamin E increases expression ISO BABAM2 (Homo sapiens) 6480464 Vitamin E results in increased expression of BABAM2 mRNA CTD PMID:19244175