Flvcr2 (FLVCR choline and putative heme transporter 2) - Rat Genome Database

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Gene: Flvcr2 (FLVCR choline and putative heme transporter 2) Rattus norvegicus
Analyze
Symbol: Flvcr2
Name: FLVCR choline and putative heme transporter 2
RGD ID: 735098
Description: Predicted to enable several functions, including choline binding activity; heme binding activity; and organic cation transmembrane transporter activity. Predicted to be involved in choline transport; heme export; and transport across blood-brain barrier. Predicted to act upstream of or within several processes, including endothelial tip cell fate specification; in utero embryonic development; and lung development. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium-chelate transporter; CCT; choline/ethanolamine transporter FLVCR2; feline leukemia virus subgroup C cellular receptor family, member 2; feline leukemia virus subgroup C receptor-related protein 2; FLVCR heme transporter 2; heme transporter FLVCR2; LOC314323; MGC124539; transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86111,139,352 - 111,203,345 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6111,139,295 - 111,203,345 (+)EnsemblGRCr8
mRatBN7.26105,408,355 - 105,472,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,408,339 - 105,472,353 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6105,578,205 - 105,641,984 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,877,083 - 105,940,860 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06105,246,731 - 105,310,503 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,617,348 - 109,681,495 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,617,355 - 109,681,495 (+)Ensemblrn6Rnor6.0
Rnor_5.06118,926,062 - 118,989,790 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46109,853,763 - 109,933,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6103,235,369 - 103,299,032 (+)NCBICelera
RGSC_v3.16109,857,466 - 109,935,200 (+)NCBI
Cytogenetic Map6q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clodronic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gardiquimod  (ISO)
gentamycin  (EXP)
ifosfamide  (ISO)
inulin  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tetrachloroethene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endoplasmic reticulum membrane  (IEA,ISO,ISS)
membrane  (IBA)
mitochondrial membrane  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis. Brasier G, etal., Exp Cell Res 2004 Feb 1;293(1):31-42.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:20823265  


Genomics

Comparative Map Data
Flvcr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86111,139,352 - 111,203,345 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6111,139,295 - 111,203,345 (+)EnsemblGRCr8
mRatBN7.26105,408,355 - 105,472,355 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,408,339 - 105,472,353 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6105,578,205 - 105,641,984 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,877,083 - 105,940,860 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06105,246,731 - 105,310,503 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,617,348 - 109,681,495 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,617,355 - 109,681,495 (+)Ensemblrn6Rnor6.0
Rnor_5.06118,926,062 - 118,989,790 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46109,853,763 - 109,933,029 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6103,235,369 - 103,299,032 (+)NCBICelera
RGSC_v3.16109,857,466 - 109,935,200 (+)NCBI
Cytogenetic Map6q31NCBI
FLVCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,578,620 - 75,648,167 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,578,594 - 75,663,214 (+)Ensemblhg38GRCh38
GRCh371476,044,963 - 76,114,510 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361475,114,745 - 75,184,263 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341475,114,744 - 75,184,260NCBI
Celera1456,083,035 - 56,152,616 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1456,212,884 - 56,282,462 (+)NCBIHuRef
CHM1_11475,982,702 - 76,052,275 (+)NCBICHM1_1
T2T-CHM13v2.01469,787,736 - 69,857,276 (+)NCBIT2T-CHM13v2.0
Flvcr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,793,313 - 85,860,359 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,793,313 - 85,860,359 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381285,746,539 - 85,813,586 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,746,539 - 85,813,585 (+)Ensemblmm10GRCm38
MGSCv371287,087,489 - 87,154,535 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361286,635,642 - 86,702,688 (+)NCBIMGSCv36mm8
Celera1287,206,720 - 87,273,824 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.8NCBI
Flvcr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495561246,724 - 97,729 (+)Ensembl
ChiLan1.0NW_00495561246,723 - 99,012 (+)NCBIChiLan1.0ChiLan1.0
FLVCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,657,474 - 76,733,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,873,987 - 75,949,309 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01456,132,370 - 56,209,882 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,975,027 - 75,045,971 (+)NCBIPanPan1.1PanPan1.1panPan2
FLVCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,588,294 - 48,640,339 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,587,863 - 48,653,488 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha848,266,908 - 48,323,256 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0848,808,288 - 48,864,727 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,812,862 - 48,877,652 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,481,173 - 48,537,580 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,502,591 - 48,559,009 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,898,900 - 48,955,237 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Flvcr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,356,714 - 27,415,105 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,653,692 - 4,712,313 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,653,891 - 4,713,982 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLVCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,718,097 - 98,823,839 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1798,718,319 - 98,772,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,423,885 - 104,479,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLVCR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,820,221 - 52,892,367 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,820,592 - 52,890,667 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605341,039,531 - 41,110,596 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flvcr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,033,790 - 26,085,014 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473426,033,790 - 26,085,027 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Flvcr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1799,856,705 - 99,919,372 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Flvcr2
668 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:199
Count of miRNA genes:138
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000011599
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
BG378868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,472,464 - 105,472,579 (+)MAPPERmRatBN7.2
Rnor_6.06109,681,605 - 109,681,719NCBIRnor6.0
Rnor_5.06118,989,900 - 118,990,014UniSTSRnor5.0
RGSC_v3.46109,933,139 - 109,933,253UniSTSRGSC3.4
Celera6103,299,142 - 103,299,256UniSTS
RH 3.4 Map3708.4UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 83 59 6 347 183 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011599   ⟹   ENSRNOP00000011599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6111,139,295 - 111,203,345 (+)Ensembl
mRatBN7.2 Ensembl6105,408,339 - 105,472,353 (+)Ensembl
Rnor_6.0 Ensembl6109,617,355 - 109,681,495 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082402   ⟹   ENSRNOP00000073434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6109,617,643 - 109,680,030 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085031   ⟹   ENSRNOP00000071003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6111,139,295 - 111,197,861 (+)Ensembl
mRatBN7.2 Ensembl6105,408,339 - 105,466,871 (+)Ensembl
Rnor_6.0 Ensembl6109,617,596 - 109,680,135 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089972   ⟹   ENSRNOP00000075721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6109,617,643 - 109,680,030 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162623   ⟹   ENSRNOP00000107395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6111,139,295 - 111,202,958 (+)Ensembl
RefSeq Acc Id: NM_199109   ⟹   NP_954540
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86111,139,352 - 111,203,345 (+)NCBI
mRatBN7.26105,408,355 - 105,472,355 (+)NCBI
Rnor_6.06109,617,348 - 109,681,495 (+)NCBI
Rnor_5.06118,926,062 - 118,989,790 (+)NCBI
RGSC_v3.46109,853,763 - 109,933,029 (+)RGD
Celera6103,235,369 - 103,299,032 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_954540 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01900 (Get FASTA)   NCBI Sequence Viewer  
  AAP86634 (Get FASTA)   NCBI Sequence Viewer  
  EDL81582 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011599
GenBank Protein P60815 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954540   ⟸   NM_199109
- UniProtKB: P60815 (UniProtKB/Swiss-Prot),   F1LSF8 (UniProtKB/TrEMBL),   A6JE38 (UniProtKB/TrEMBL),   Q3T1I6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011599   ⟸   ENSRNOT00000011599
Ensembl Acc Id: ENSRNOP00000073434   ⟸   ENSRNOT00000082402
Ensembl Acc Id: ENSRNOP00000071003   ⟸   ENSRNOT00000085031
Ensembl Acc Id: ENSRNOP00000075721   ⟸   ENSRNOT00000089972
Ensembl Acc Id: ENSRNOP00000107395   ⟸   ENSRNOT00000162623
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60815-F1-model_v2 AlphaFold P60815 1-546 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694754
Promoter ID:EPDNEW_R5268
Type:multiple initiation site
Name:Flvcr2_1
Description:feline leukemia virus subgroup C cellular receptor family, member2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06109,617,334 - 109,617,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735098 AgrOrtholog
BioCyc Gene G2FUF-36768 BioCyc
Ensembl Genes ENSRNOG00000008754 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000011599 ENTREZGENE
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7932187 IMAGE-MGC_LOAD
InterPro MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  SLC49-like UniProtKB/Swiss-Prot
MGC_CLONE MGC:124539 IMAGE-MGC_LOAD
NCBI Gene 314323 ENTREZGENE
PANTHER FELINE LEUKEMIA VIRUS SUBGROUP C RECEPTOR-RELATED PROTEIN 2 UniProtKB/Swiss-Prot
  MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Flvcr2 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008754 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A0G2JZD2_RAT UniProtKB/TrEMBL
  A0ABK0LY47_RAT UniProtKB/TrEMBL
  A6JE38 ENTREZGENE, UniProtKB/TrEMBL
  F1LSF8 ENTREZGENE, UniProtKB/TrEMBL
  FLVC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3T1I6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-03 Flvcr2  FLVCR choline and putative heme transporter 2  Flvcr2  FLVCR heme transporter 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-11-11 Flvcr2  FLVCR heme transporter 2  Flvcr2  feline leukemia virus subgroup C cellular receptor family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Flvcr2  feline leukemia virus subgroup C cellular receptor family, member 2  LOC314323  transporter  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 LOC314323        Symbol and Name status set to provisional 70820 PROVISIONAL