Serpina3m (serpin family A member 3M) - Rat Genome Database

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Gene: Serpina3m (serpin family A member 3M) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpina3m
Name: serpin family A member 3M
RGD ID: 735068
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in response to cytokine. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC299276; serine (or cysteine) proteinase inhibitor, clade A, member 3M; serine protease inhibitor 2.4; serine protease inhibitor A3M; serpin A3M; SPI-2.4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,829,569 - 128,836,844 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,829,569 - 128,836,839 (-)EnsemblGRCr8
mRatBN7.26123,064,796 - 123,072,087 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,064,796 - 123,072,066 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6123,205,731 - 123,212,956 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06123,501,031 - 123,508,256 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06122,837,927 - 122,845,245 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06127,808,785 - 127,816,067 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,808,785 - 127,816,055 (-)Ensemblrn6Rnor6.0
Rnor_5.06137,027,387 - 137,034,657 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,197,796 - 128,205,050 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,544,447 - 120,551,717 (-)NCBICelera
RGSC_v3.16128,201,548 - 128,206,796 (-)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning, structure and expression of cDNA for mouse contrapsin and a related protein. Ohkubo K, etal., Biochem J 1991 Jun 1;276 ( Pt 2):337-42.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Differential overexpression of SERPINA3 in human prion diseases. Vanni S, etal., Sci Rep. 2017 Nov 15;7(1):15637. doi: 10.1038/s41598-017-15778-8.
Additional References at PubMed
PMID:15638460   PMID:16502470   PMID:19056867   PMID:22516433   PMID:23376485   PMID:23533145   PMID:25645918  


Genomics

Variants

.
Variants in Serpina3m
75 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:97
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000013175
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 8 11 34 70 68 45 17 45 6 126 41 17 28 39 23

Sequence


Ensembl Acc Id: ENSRNOT00000013175   ⟹   ENSRNOP00000013175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,829,569 - 128,836,839 (-)Ensembl
mRatBN7.2 Ensembl6123,064,796 - 123,072,066 (-)Ensembl
Rnor_6.0 Ensembl6127,808,785 - 127,816,055 (-)Ensembl
RefSeq Acc Id: NM_001270982   ⟹   NP_001257911
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,829,569 - 128,836,839 (-)NCBI
mRatBN7.26123,064,796 - 123,072,066 (-)NCBI
Rnor_6.06127,808,785 - 127,816,055 (-)NCBI
Rnor_5.06137,027,387 - 137,034,657 (-)NCBI
Celera6120,544,447 - 120,551,717 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240466   ⟹   XP_006240528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,829,573 - 128,836,844 (-)NCBI
mRatBN7.26123,064,796 - 123,072,087 (-)NCBI
Rnor_6.06127,808,785 - 127,816,067 (-)NCBI
Rnor_5.06137,027,387 - 137,034,657 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001257911 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240528 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA49488 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013175
GenBank Protein Q63556 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001257911   ⟸   NM_001270982
- Peptide Label: precursor
- UniProtKB: F1LR92 (UniProtKB/TrEMBL),   A6JEQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240528   ⟸   XM_006240466
- Peptide Label: isoform X1
- UniProtKB: F1LR92 (UniProtKB/TrEMBL),   A6JEQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013175   ⟸   ENSRNOT00000013175
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63556-F1-model_v2 AlphaFold Q63556 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694803
Promoter ID:EPDNEW_R5328
Type:multiple initiation site
Name:Serpina3m_1
Description:serine proteinase inhibitor, clade A, member 3M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06127,816,055 - 127,816,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735068 AgrOrtholog
BioCyc Gene G2FUF-36392 BioCyc
Ensembl Genes ENSRNOG00000009921 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013175 ENTREZGENE
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
NCBI Gene 299276 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR A3A-RELATED UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpina3m PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009921 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt A6JEQ4 ENTREZGENE, UniProtKB/TrEMBL
  F1LR92 ENTREZGENE, UniProtKB/TrEMBL
  Q63556 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Serpina3m  serpin family A member 3M  Serpina3m  serine (or cysteine) proteinase inhibitor, clade A, member 3M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Serpina3m  serine (or cysteine) proteinase inhibitor, clade A, member 3M  LOC299276  serine protease inhibitor 2.4  Symbol and Name updated 1299863 APPROVED