Angptl4 (angiopoietin-like 4) - Rat Genome Database

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Gene: Angptl4 (angiopoietin-like 4) Rattus norvegicus
Analyze
Symbol: Angptl4
Name: angiopoietin-like 4
RGD ID: 735058
Description: Enables identical protein binding activity. Involved in response to hypoxia. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human ANGPTL4 (angiopoietin like 4); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; lipid metabolic pathway; INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiopoietin-like protein 4; angiopoietin-related protein 4; hepatic fibrinogen/angiopoietin-related protein; HFARP; LOC362850
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,252,450 - 15,259,971 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl715,252,473 - 15,258,681 (-)EnsemblGRCr8
mRatBN7.2714,550,288 - 14,557,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,550,311 - 14,556,519 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx717,558,811 - 17,565,052 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,424,076 - 19,430,320 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,304,441 - 17,310,678 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,627,814 - 18,634,043 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,627,808 - 18,634,079 (-)Ensemblrn6Rnor6.0
Rnor_5.0718,805,414 - 18,811,643 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4716,261,623 - 16,267,852 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera713,448,819 - 13,455,048 (-)NCBICelera
RGSC_v3.1716,261,624 - 16,267,852 (-)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-bipyridine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,5-hexanedione  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (EXP)
bexarotene  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP,ISO)
Clofop  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl malate  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
esketamine  (ISO)
ethanol  (ISO)
fenfluramine  (ISO)
fenofibrate  (EXP,ISO)
fluoranthene  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gardiquimod  (ISO)
gemfibrozil  (EXP)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycerol  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
GW 501516  (ISO)
hexadecanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
ibuprofen  (ISO)
imidacloprid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
isobutanol  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
Muraglitazar  (EXP)
myriocin  (ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nimesulide  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentane-2,3-dione  (EXP)
perflubutane  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
Pf-06840003  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
PhIP  (EXP)
phloretin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium lactate  (ISO)
sotorasib  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trametinib  (ISO)
tributylstannane  (EXP,ISO)
tricetin  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vandetanib  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Backhed F, etal., Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):979-84. Epub 2007 Jan 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4. Ge H, etal., J Biol Chem 2004 Jan 16;279(3):2038-45. Epub 2003 Oct 21.
4. Differential regulation and properties of angiopoietin-like proteins 3 and 4. Ge H, etal., J Lipid Res. 2005 Jul;46(7):1484-90. Epub 2005 May 1.
5. Vascular response to hypoxic preconditioning in the immature brain. Gustavsson M, etal., J Cereb Blood Flow Metab. 2007 May;27(5):928-38. Epub 2006 Oct 11.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Xu A, etal., Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6086-91. Epub 2005 Apr 18.
13. Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase. Yoshida K, etal., J Lipid Res. 2002 Nov;43(11):1770-2.
Additional References at PubMed
PMID:10698685   PMID:10866690   PMID:15489334   PMID:17088546   PMID:18178314   PMID:19028676   PMID:19542565   PMID:19628874   PMID:19698832   PMID:21489049   PMID:22226882   PMID:22516433  
PMID:23783408   PMID:24565756   PMID:26352670   PMID:29339422   PMID:29899144   PMID:31108749   PMID:31494661   PMID:31981598   PMID:32686149   PMID:36409042   PMID:36537603  


Genomics

Comparative Map Data
Angptl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,252,450 - 15,259,971 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl715,252,473 - 15,258,681 (-)EnsemblGRCr8
mRatBN7.2714,550,288 - 14,557,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,550,311 - 14,556,519 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx717,558,811 - 17,565,052 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,424,076 - 19,430,320 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,304,441 - 17,310,678 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,627,814 - 18,634,043 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,627,808 - 18,634,079 (-)Ensemblrn6Rnor6.0
Rnor_5.0718,805,414 - 18,811,643 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4716,261,623 - 16,267,852 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera713,448,819 - 13,455,048 (-)NCBICelera
RGSC_v3.1716,261,624 - 16,267,852 (-)NCBI
Cytogenetic Map7q13NCBI
ANGPTL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,364,155 - 8,374,370 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,363,223 - 8,374,371 (+)Ensemblhg38GRCh38
GRCh37198,429,039 - 8,439,254 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,335,011 - 8,345,257 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34198,335,010 - 8,345,257NCBI
Celera198,285,662 - 8,295,909 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,082,622 - 8,092,869 (+)NCBIHuRef
CHM1_1198,428,469 - 8,438,718 (+)NCBICHM1_1
T2T-CHM13v2.0198,350,623 - 8,360,841 (+)NCBIT2T-CHM13v2.0
Angptl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,993,874 - 34,000,549 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,992,724 - 34,000,804 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381733,774,900 - 33,781,575 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,773,750 - 33,781,830 (-)Ensemblmm10GRCm38
MGSCv371733,911,845 - 33,918,520 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361733,381,780 - 33,388,386 (-)NCBIMGSCv36mm8
Celera1736,532,223 - 36,538,898 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Angptl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,021,414 - 1,029,894 (-)Ensembl
ChiLan1.0NW_0049555631,024,163 - 1,030,816 (-)NCBIChiLan1.0ChiLan1.0
ANGPTL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22013,028,071 - 13,042,072 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,144,718 - 12,158,742 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,649,429 - 7,660,154 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,499,858 - 8,510,148 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,499,858 - 8,510,148 (+)EnsemblpanPan2panpan1.1
ANGPTL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,942,090 - 52,948,126 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,942,259 - 52,947,475 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2052,743,450 - 52,749,452 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02053,470,391 - 53,476,264 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,470,244 - 53,475,997 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,672,449 - 52,678,325 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,117,927 - 53,123,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,349,638 - 53,355,519 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Angptl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,639,859 - 212,645,931 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365885,188,850 - 5,194,931 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365885,188,866 - 5,194,924 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGPTL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,904,531 - 70,912,974 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1270,905,767 - 70,912,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,272,459 - 71,279,585 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q21-q24NCBI
ANGPTL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,719,359 - 7,728,799 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,719,400 - 7,729,302 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607412,534,796 - 12,545,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angptl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,152,891 - 1,158,420 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248281,152,788 - 1,158,864 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Angptl4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11158,635,220 - 158,641,639 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Angptl4
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:62
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000010031
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 90 59 6 354 190 11 140 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000010031   ⟹   ENSRNOP00000010031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl715,252,473 - 15,258,681 (-)Ensembl
mRatBN7.2 Ensembl714,550,311 - 14,556,519 (-)Ensembl
Rnor_6.0 Ensembl718,627,808 - 18,634,079 (-)Ensembl
RefSeq Acc Id: NM_199115   ⟹   NP_954546
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,252,452 - 15,258,681 (-)NCBI
mRatBN7.2714,550,290 - 14,556,519 (-)NCBI
Rnor_6.0718,627,814 - 18,634,043 (-)NCBI
Rnor_5.0718,805,414 - 18,811,643 (-)NCBI
RGSC_v3.4716,261,623 - 16,267,852 (-)RGD
Celera713,448,819 - 13,455,048 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079418   ⟹   XP_038935346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,252,450 - 15,259,971 (-)NCBI
mRatBN7.2714,550,288 - 14,557,796 (-)NCBI
RefSeq Acc Id: XM_039079419   ⟹   XP_038935347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,252,450 - 15,259,971 (-)NCBI
mRatBN7.2714,550,288 - 14,557,797 (-)NCBI
Protein Sequences
Protein RefSeqs NP_954546 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935346 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935347 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78944 (Get FASTA)   NCBI Sequence Viewer  
  AAQ93383 (Get FASTA)   NCBI Sequence Viewer  
  EDL86621 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010031
  ENSRNOP00000010031.3
GenBank Protein Q6TMA8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_954546   ⟸   NM_199115
- Peptide Label: precursor
- UniProtKB: Q6TMA8 (UniProtKB/Swiss-Prot),   A6KQI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010031   ⟸   ENSRNOT00000010031
RefSeq Acc Id: XP_038935347   ⟸   XM_039079419
- Peptide Label: isoform X1
- UniProtKB: Q6TMA8 (UniProtKB/Swiss-Prot),   A6KQI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935346   ⟸   XM_039079418
- Peptide Label: isoform X1
- UniProtKB: Q6TMA8 (UniProtKB/Swiss-Prot),   A6KQI0 (UniProtKB/TrEMBL)
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TMA8-F1-model_v2 AlphaFold Q6TMA8 1-405 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695086
Promoter ID:EPDNEW_R5610
Type:single initiation site
Name:Angptl4_1
Description:angiopoietin-like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,634,053 - 18,634,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735058 AgrOrtholog
BioCyc Gene G2FUF-34709 BioCyc
Ensembl Genes ENSRNOG00000007545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010031 ENTREZGENE
  ENSRNOT00000010031.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.215.10 UniProtKB/Swiss-Prot
  Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109431 IMAGE-MGC_LOAD
InterPro FIB_ANG-like UniProtKB/Swiss-Prot
  Fibrinogen-like_C UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot
  Fibrinogen_a/b/g_C_dom UniProtKB/Swiss-Prot
  Fibrinogen_CS UniProtKB/Swiss-Prot
KEGG Report rno:362850 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93779 IMAGE-MGC_LOAD
NCBI Gene 362850 ENTREZGENE
PANTHER FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot
  FIBRINOGEN ALPHA CHAIN UniProtKB/Swiss-Prot
Pfam Fibrinogen_C UniProtKB/Swiss-Prot
PhenoGen Angptl4 PhenoGen
PROSITE FIBRINOGEN_C_1 UniProtKB/Swiss-Prot
  FIBRINOGEN_C_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007545 RatGTEx
SMART FBG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56496 UniProtKB/Swiss-Prot
UniProt A6KQI0 ENTREZGENE, UniProtKB/TrEMBL
  ANGL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Angptl4  angiopoietin-like 4    angiopoietin-like protein 4  Name updated 1299863 APPROVED
2004-09-10 Angptl4  angiopoietin-like protein 4  LOC362850    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an amino-terminal coiled-coil domain and a carboxyl-terminal fibrinogen-like domain 1302799
gene_protein full length protein is a disulfide-bonded oligomer which undergoes proteolytic processing to release the fibrinogen-like domain which circulates as a monomer 1302799