Dgki (diacylglycerol kinase, iota) - Rat Genome Database

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Pathways
Gene: Dgki (diacylglycerol kinase, iota) Rattus norvegicus
Analyze
Symbol: Dgki
Name: diacylglycerol kinase, iota
RGD ID: 735049
Description: Enables ATP-dependent diacylglycerol kinase activity. Involved in diacylglycerol metabolic process; lipid phosphorylation; and phosphatidic acid biosynthetic process. Located in several cellular components, including postsynaptic density; presynaptic active zone; and synaptic membrane. Is active in glutamatergic synapse and synaptic vesicle. Is extrinsic component of postsynaptic density membrane and extrinsic component of presynaptic active zone membrane. Orthologous to human DGKI (diacylglycerol kinase iota); PARTICIPATES IN glycerolipid metabolic pathway; glycerophospholipid metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DAG kinase iota; DGK-iota; diacylglycerol kinase iota; diacylglycerol kinase iota-3; diglyceride kinase iota; LOC688705; rDGKi-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   NP.P-(D4Rat119-D4Rat55)/Iusm  
Candidate Gene For: Alc22
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8466,377,897 - 66,839,790 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl466,387,126 - 66,990,832 (-)EnsemblGRCr8
mRatBN7.2465,410,878 - 65,872,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx470,368,009 - 70,814,746 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0466,289,073 - 66,735,818 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0464,686,142 - 65,132,286 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,365,115 - 64,831,473 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,374,342 - 64,831,473 (-)Ensemblrn6Rnor6.0
Rnor_5.0464,193,188 - 64,653,936 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4464,207,192 - 64,663,627 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera460,450,503 - 60,895,770 (-)NCBICelera
RGSC_v3.1464,483,440 - 64,939,757 (-)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP)
Butylbenzyl phthalate  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
p-chloromercuribenzoic acid  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
pyridaben  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenomethionine  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of diacylglycerol kinase iota splice variants in rat brain. Ito T, etal., J Biol Chem 2004 May 28;279(22):23317-26. Epub 2004 Mar 15.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. DGKiota regulates presynaptic release during mGluR-dependent LTD. Yang J, etal., EMBO J. 2011 Jan 5;30(1):165-80. doi: 10.1038/emboj.2010.286. Epub 2010 Nov 30.
Additional References at PubMed
PMID:8889548   PMID:9830018   PMID:11244494   PMID:15894621  


Genomics

Comparative Map Data
Dgki
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8466,377,897 - 66,839,790 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl466,387,126 - 66,990,832 (-)EnsemblGRCr8
mRatBN7.2465,410,878 - 65,872,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx470,368,009 - 70,814,746 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0466,289,073 - 66,735,818 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0464,686,142 - 65,132,286 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0464,365,115 - 64,831,473 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl464,374,342 - 64,831,473 (-)Ensemblrn6Rnor6.0
Rnor_5.0464,193,188 - 64,653,936 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4464,207,192 - 64,663,627 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera460,450,503 - 60,895,770 (-)NCBICelera
RGSC_v3.1464,483,440 - 64,939,757 (-)NCBI
Cytogenetic Map4q22NCBI
DGKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387137,381,037 - 137,846,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7137,381,037 - 137,847,092 (-)Ensemblhg38GRCh38
GRCh377137,065,783 - 137,531,720 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367136,724,925 - 137,182,149 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347136,531,639 - 136,988,864NCBI
Celera7131,813,301 - 132,270,574 (-)NCBICelera
Cytogenetic Map7q33NCBI
HuRef7131,379,554 - 131,839,437 (-)NCBIHuRef
CHM1_17137,007,692 - 137,465,171 (-)NCBICHM1_1
T2T-CHM13v2.07138,690,170 - 139,156,064 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27136,418,404 - 136,876,991 (-)NCBI
Dgki
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39636,814,316 - 37,281,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl636,822,957 - 37,277,119 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38636,837,381 - 37,300,955 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl636,846,022 - 37,300,184 (-)Ensemblmm10GRCm38
MGSCv37636,796,022 - 37,249,976 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36636,776,174 - 37,229,582 (-)NCBIMGSCv36mm8
Celera636,822,759 - 37,278,859 (-)NCBICelera
Cytogenetic Map6B1NCBI
Dgki
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554945,264,414 - 5,539,540 (+)Ensembl
ChiLan1.0NW_0049554945,119,419 - 5,541,058 (+)NCBIChiLan1.0ChiLan1.0
DGKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26174,189,524 - 174,669,483 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1726,202,852 - 26,677,863 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07129,339,330 - 129,812,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17141,833,815 - 142,142,262 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7141,841,852 - 142,142,310 (-)EnsemblpanPan2panpan1.1
DGKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11610,975,394 - 11,250,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1610,682,935 - 11,248,029 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1611,843,635 - 12,272,254 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01610,791,210 - 11,215,338 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1610,790,994 - 11,235,389 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11611,253,927 - 11,684,568 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01610,355,968 - 10,784,441 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01610,498,287 - 10,926,978 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dgki
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511817,082,903 - 17,377,888 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365921,844,315 - 2,270,814 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365921,843,438 - 2,136,905 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1811,705,093 - 12,177,267 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11811,705,055 - 12,187,098 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21812,574,313 - 12,854,605 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DGKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121106,074,522 - 106,544,009 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21106,076,928 - 106,317,825 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660722,926,590 - 3,409,867 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgki
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476517,669,645 - 18,124,967 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476517,663,347 - 18,128,007 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dgki
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16102,586,460 - 103,027,970 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dgki
2524 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:152
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000033268
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat

Markers in Region
D4Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8466,684,381 - 66,684,629 (+)Marker Load Pipeline
mRatBN7.2465,717,317 - 65,717,565 (+)MAPPERmRatBN7.2
Rnor_6.0464,679,412 - 64,679,659NCBIRnor6.0
Rnor_5.0464,502,357 - 64,502,604UniSTSRnor5.0
RGSC_v3.4464,507,593 - 64,507,841RGDRGSC3.4
RGSC_v3.4464,507,594 - 64,507,841UniSTSRGSC3.4
Celera460,746,336 - 60,746,575UniSTS
RGSC_v3.1464,783,723 - 64,783,971RGD
SHRSP x BN Map434.06UniSTS
SHRSP x BN Map434.06RGD
Cytogenetic Map4q22UniSTS
D4Rat135  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8466,687,745 - 66,687,907 (+)Marker Load Pipeline
mRatBN7.2465,720,681 - 65,720,843 (+)MAPPERmRatBN7.2
Rnor_6.0464,682,772 - 64,682,933NCBIRnor6.0
Rnor_5.0464,505,717 - 64,505,878UniSTSRnor5.0
RGSC_v3.4464,510,953 - 64,511,115RGDRGSC3.4
RGSC_v3.4464,510,954 - 64,511,115UniSTSRGSC3.4
Celera460,749,688 - 60,749,859UniSTS
RGSC_v3.1464,787,084 - 64,787,245RGD
RH 3.4 Map4412.7UniSTS
RH 3.4 Map4412.7RGD
SHRSP x BN Map434.0UniSTS
SHRSP x BN Map434.0RGD
FHH x ACI Map444.7199RGD
Cytogenetic Map4q22UniSTS
D4Got50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,554,706 - 65,554,918 (+)MAPPERmRatBN7.2
Rnor_6.0464,518,305 - 64,518,516NCBIRnor6.0
Rnor_5.0464,340,830 - 64,341,041UniSTSRnor5.0
RGSC_v3.4464,341,328 - 64,341,540RGDRGSC3.4
RGSC_v3.4464,341,329 - 64,341,540UniSTSRGSC3.4
Celera460,584,618 - 60,584,829UniSTS
RGSC_v3.1464,617,458 - 64,617,670RGD
Cytogenetic Map4q22UniSTS
RH144498  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,420,251 - 65,420,435 (+)MAPPERmRatBN7.2
Rnor_6.0464,374,486 - 64,374,669NCBIRnor6.0
Rnor_5.0464,199,355 - 64,199,538UniSTSRnor5.0
RGSC_v3.4464,207,337 - 64,207,520UniSTSRGSC3.4
Celera460,450,648 - 60,450,831UniSTS
RH 3.4 Map4412.8UniSTS
Cytogenetic Map4q22UniSTS
BE102640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,649,246 - 65,649,443 (+)MAPPERmRatBN7.2
Rnor_6.0464,611,731 - 64,611,927NCBIRnor6.0
Rnor_5.0464,434,651 - 64,434,847UniSTSRnor5.0
RGSC_v3.4464,436,884 - 64,437,080UniSTSRGSC3.4
Celera460,678,845 - 60,679,041UniSTS
RH 3.4 Map4414.8UniSTS
Cytogenetic Map4q22UniSTS
AU048384  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2465,538,376 - 65,538,654 (+)MAPPERmRatBN7.2
Rnor_6.0464,501,797 - 64,502,074NCBIRnor6.0
Rnor_5.0464,324,525 - 64,324,802UniSTSRnor5.0
RGSC_v3.4464,325,024 - 64,325,301UniSTSRGSC3.4
Celera460,568,284 - 60,568,561UniSTS
Cytogenetic Map4q22UniSTS


Related Rat Strains
The following Strains have been annotated to Dgki


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 9 67 165 60 59 28 58 28 6 263 155 11 142 62 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB058962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB058963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB058964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW526027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN544764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000033268   ⟹   ENSRNOP00000034571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)Ensembl
Rnor_6.0 Ensembl464,374,342 - 64,831,473 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079285   ⟹   ENSRNOP00000072665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,587,308 - 65,872,733 (-)Ensembl
Rnor_6.0 Ensembl464,548,530 - 64,831,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095496   ⟹   ENSRNOP00000097838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108173   ⟹   ENSRNOP00000093014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,489,921 - 65,872,733 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120235   ⟹   ENSRNOP00000079887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl465,420,108 - 65,872,733 (-)Ensembl
RefSeq Acc Id: NM_198782   ⟹   NP_942077
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,387,125 - 66,839,790 (-)NCBI
mRatBN7.2465,420,107 - 65,872,733 (-)NCBI
Rnor_6.0464,374,341 - 64,831,473 (-)NCBI
Rnor_5.0464,193,188 - 64,653,936 (-)NCBI
RGSC_v3.4464,207,192 - 64,663,627 (-)RGD
Celera460,450,503 - 60,895,770 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236333   ⟹   XP_006236395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
mRatBN7.2465,410,878 - 65,872,527 (-)NCBI
Rnor_6.0464,365,115 - 64,831,285 (-)NCBI
Rnor_5.0464,193,188 - 64,653,936 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592894   ⟹   XP_017448383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
mRatBN7.2465,410,878 - 65,872,527 (-)NCBI
Rnor_6.0464,365,115 - 64,831,285 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039108367   ⟹   XP_038964295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,586 (-)NCBI
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108368   ⟹   XP_038964296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,586 (-)NCBI
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108369   ⟹   XP_038964297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
mRatBN7.2465,410,878 - 65,872,527 (-)NCBI
RefSeq Acc Id: XM_039108370   ⟹   XP_038964298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108371   ⟹   XP_038964299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
mRatBN7.2465,410,878 - 65,872,528 (-)NCBI
RefSeq Acc Id: XM_039108372   ⟹   XP_038964300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,551,886 - 66,839,594 (-)NCBI
mRatBN7.2465,584,827 - 65,872,532 (-)NCBI
RefSeq Acc Id: XM_039108374   ⟹   XP_038964302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,551,890 - 66,839,590 (-)NCBI
mRatBN7.2465,584,830 - 65,872,529 (-)NCBI
RefSeq Acc Id: XM_063286709   ⟹   XP_063142779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
RefSeq Acc Id: XM_063286710   ⟹   XP_063142780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8466,377,897 - 66,839,585 (-)NCBI
RefSeq Acc Id: NP_942077   ⟸   NM_198782
- UniProtKB: Q810C5 (UniProtKB/Swiss-Prot),   Q810C4 (UniProtKB/Swiss-Prot),   Q810C3 (UniProtKB/Swiss-Prot),   F1MAB7 (UniProtKB/Swiss-Prot),   A0A8I6GM87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236395   ⟸   XM_006236333
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZPA8 (UniProtKB/TrEMBL),   A0A8I6GM87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448383   ⟸   XM_017592894
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072665   ⟸   ENSRNOT00000079285
Ensembl Acc Id: ENSRNOP00000034571   ⟸   ENSRNOT00000033268
RefSeq Acc Id: XP_038964299   ⟸   XM_039108371
- Peptide Label: isoform X8
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964298   ⟸   XM_039108370
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964296   ⟸   XM_039108368
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964295   ⟸   XM_039108367
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964297   ⟸   XM_039108369
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964300   ⟸   XM_039108372
- Peptide Label: isoform X10
- UniProtKB: A0A0G2K3J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964302   ⟸   XM_039108374
- Peptide Label: isoform X11
- UniProtKB: A0A0G2K3J7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097838   ⟸   ENSRNOT00000095496
Ensembl Acc Id: ENSRNOP00000079887   ⟸   ENSRNOT00000120235
Ensembl Acc Id: ENSRNOP00000093014   ⟸   ENSRNOT00000108173
RefSeq Acc Id: XP_063142780   ⟸   XM_063286710
- Peptide Label: isoform X9
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142779   ⟸   XM_063286709
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GM87 (UniProtKB/TrEMBL)
Protein Domains
DAGKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAB7-F1-model_v2 AlphaFold F1MAB7 1-1050 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735049 AgrOrtholog
BioCyc Gene G2FUF-45224 BioCyc
Ensembl Genes ENSRNOG00000026705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033268 ENTREZGENE
  ENSRNOT00000033268.5 UniProtKB/Swiss-Prot
  ENSRNOT00000079285 ENTREZGENE
  ENSRNOT00000120235 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  2.60.200.40 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Probable inorganic polyphosphate/atp-NAD kinase, domain 1 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  ATP-NAD_kinase_N UniProtKB/Swiss-Prot
  C1_DGKiota_rpt1 UniProtKB/Swiss-Prot
  C1_DGKiota_rpt2 UniProtKB/Swiss-Prot
  DGK UniProtKB/Swiss-Prot
  DGKI-like_dom UniProtKB/Swiss-Prot
  Diacylglycerol_kin_accessory UniProtKB/Swiss-Prot
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
KEGG Report rno:688705 UniProtKB/Swiss-Prot
NCBI Gene Dgki ENTREZGENE
PANTHER DIACYLGLYCEROL KINASE IOTA UniProtKB/Swiss-Prot
  PTHR11255 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  C1_1 UniProtKB/Swiss-Prot
  DAGK_acc UniProtKB/Swiss-Prot
  DAGK_cat UniProtKB/Swiss-Prot
  DGKI UniProtKB/Swiss-Prot
PhenoGen Dgki PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  DAGK UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026705 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  DAGKa UniProtKB/Swiss-Prot
  DAGKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
UniProt A0A0G2K3J7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZPA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWF3_RAT UniProtKB/TrEMBL
  A0A8I6GM87 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LGH9_RAT UniProtKB/TrEMBL
  A0ABK0LTT0_RAT UniProtKB/TrEMBL
  DGKI_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q810C3 ENTREZGENE
  Q810C4 ENTREZGENE
  Q810C5 ENTREZGENE
UniProt Secondary Q810C3 UniProtKB/Swiss-Prot
  Q810C4 UniProtKB/Swiss-Prot
  Q810C5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-14 Dgki  diacylglycerol kinase, iota  LOC688705  similar to Diacylglycerol kinase iota (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota)  Data merged from RGD:1585302 737654 APPROVED
2006-11-19 LOC688705  similar to Diacylglycerol kinase iota (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Dgki  diacylglycerol kinase, iota      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization detected only in the cytoplasm of neuronal cells, despite the inclusion of a nuclear localization signal in the protein 1302915
gene_expression in Northern blot analysis, a major transcript of 3.3 kb was detected exclusively in brain and eye out of 11 tissues tested; testis showed only a shorter trascript (1.2 kb) of unknown origin 1302915
gene_expression in brain, in situ hybridization showed strong signals in the hippocampus, cerebellar cortex, olfactory bulb and olfactory tubercle, and moderate signals in cerebral cortex, caudate putamen and thalamus 1302915
gene_physical_interaction the reduced enzymatic activity of varient 2 appears to be due to a reduced affinity for ATP 1302915
gene_protein tanscript varient 1 codes for the full length Dgki protein; transcript varients 2 and 3 code for proteins which lack the C-terminal ankyrin repeats and varient 3 also lacks a portion of the DGK catalytic domain 1302915
gene_protein enzymatic activity of the protein encoded by transcript varient 2 is approximately half that of varient 1; activity of the varient 3 protein is essentially background 1302915
gene_transcript of 100 normal rat brain cDNA clones, 53% represented varient 1, 5% varient 2 and 42% varient 3 1302915
gene_transcript three transcript varients have been characterized in the brain; varients 2 and 3 contain 19 bp and 71 bp inserts, respectively, resulting in frameshift mutations which give rise to premature stop codons 1302915