Mcpt3 (mast cell peptidase 3) - Rat Genome Database

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Gene: Mcpt3 (mast cell peptidase 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mcpt3
Name: mast cell peptidase 3
RGD ID: 735036
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); peptide binding (inferred); INVOLVED IN proteolysis (inferred); FOUND IN mast cell granule (inferred); INTERACTS WITH ammonium chloride; decabromodiphenyl ether; gentamycin
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mast cell protease 3; RMCP-3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,501,949 - 33,504,580 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1533,501,949 - 33,504,580 (+)EnsemblGRCr8
mRatBN7.21529,532,053 - 29,534,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,532,079 - 29,873,922 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1531,377,675 - 31,380,306 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,524,894 - 32,527,525 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,767,269 - 30,769,900 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,793,629 - 34,796,229 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,751,550 - 34,796,223 (+)Ensemblrn6Rnor6.0
Rnor_5.01538,686,655 - 38,689,251 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41534,198,534 - 34,201,129 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1529,106,527 - 29,109,122 (+)NCBICelera
RGSC_v3.11534,214,258 - 34,216,827 (+)NCBI
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Secretory granule proteases in rat mast cells. Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations. Lutzelschwab C, etal., J Exp Med 1997 Jan 6;185(1):13-29.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mcpt3
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:76
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000041631
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
renal system
4 1 13 22 14 1 4

Sequence


Ensembl Acc Id: ENSRNOT00000027895   ⟹   ENSRNOP00000027895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,751,563 - 34,782,310 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000027918   ⟹   ENSRNOP00000027918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1534,751,563 - 34,754,232 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000038253   ⟹   ENSRNOP00000032959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,532,079 - 29,873,922 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000041631   ⟹   ENSRNOP00000050681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,501,949 - 33,504,580 (+)Ensembl
mRatBN7.2 Ensembl1529,532,085 - 29,534,678 (+)Ensembl
Rnor_6.0 Ensembl1534,751,563 - 34,796,223 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089559   ⟹   ENSRNOP00000069727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,471,491 - 33,474,110 (+)Ensembl
mRatBN7.2 Ensembl1529,501,595 - 29,504,214 (+)Ensembl
Rnor_6.0 Ensembl1534,751,550 - 34,754,407 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091167   ⟹   ENSRNOP00000073561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1533,729,693 - 33,731,896 (+)Ensembl
mRatBN7.2 Ensembl1529,835,955 - 29,873,922 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091428   ⟹   ENSRNOP00000073868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,836,365 - 29,873,922 (+)Ensembl
RefSeq Acc Id: NM_001170466   ⟹   NP_001163937
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,501,949 - 33,504,580 (+)NCBI
mRatBN7.21529,532,053 - 29,534,684 (+)NCBI
Rnor_5.01538,686,655 - 38,689,251 (+)NCBI
RGSC_v3.41534,198,534 - 34,201,129 (+)RGD
Celera1529,106,527 - 29,109,122 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001163937 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD09539 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050681
  ENSRNOP00000050681.6
RefSeq Acc Id: NP_001163937   ⟸   NM_001170466
- Peptide Label: precursor
- UniProtKB: Q9Z1D3 (UniProtKB/TrEMBL),   E9PTQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069727   ⟸   ENSRNOT00000089559
Ensembl Acc Id: ENSRNOP00000050681   ⟸   ENSRNOT00000041631
Ensembl Acc Id: ENSRNOP00000027918   ⟸   ENSRNOT00000027918
Ensembl Acc Id: ENSRNOP00000027895   ⟸   ENSRNOT00000027895
Ensembl Acc Id: ENSRNOP00000032959   ⟸   ENSRNOT00000038253
Ensembl Acc Id: ENSRNOP00000073868   ⟸   ENSRNOT00000091428
Ensembl Acc Id: ENSRNOP00000073561   ⟸   ENSRNOT00000091167
Protein Domains
Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-13670 BioCyc
Ensembl Genes ENSRNOG00000024785 Ensembl
  ENSRNOG00000031792 Ensembl
  ENSRNOG00000073161 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041631 ENTREZGENE
  ENSRNOT00000041631.7 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
KEGG Report rno:290244 UniProtKB/TrEMBL
NCBI Gene 290244 ENTREZGENE
PANTHER CHYMASE 2, MAST CELL-RELATED UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Mcpt3 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024785 RatGTEx
  ENSRNOG00000031792 RatGTEx
  ENSRNOG00000073161 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP Pept_Ser_Cys UniProtKB/TrEMBL
UniProt E9PTQ9 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Mcpt3  mast cell peptidase 3  LOC681550  similar to Mast cell protease IV precursor (rMCP-IV) (rMCP-4)  Data merged from RGD:1594086 1643240 APPROVED
2006-11-20 LOC681550  similar to Mast cell protease IV precursor (rMCP-IV) (rMCP-4)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Mcpt3  mast cell peptidase 3  RMCP-3  mast cell protease 3  Symbol and Name updated 1299863 APPROVED