Qrfp (pyroglutamylated RFamide peptide) - Rat Genome Database

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Gene: Qrfp (pyroglutamylated RFamide peptide) Rattus norvegicus
Analyze
Symbol: Qrfp
Name: pyroglutamylated RFamide peptide
RGD ID: 735020
Description: Enables G protein-coupled receptor binding activity. Predicted to be involved in several processes, including grooming behavior; neuropeptide signaling pathway; and regulation of feeding behavior. Predicted to be located in extracellular region; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; genistein; PCB138.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 26RFa; neuropeptide; orexigenic neuropeptide QRFP; P518; P518 precursor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,485,579 - 35,487,902 (-)NCBIGRCr8
mRatBN7.2315,088,045 - 15,088,419 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,088,045 - 15,088,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,161,522 - 18,161,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,746,525 - 26,746,899 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,993,882 - 24,994,256 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.039,402,397 - 9,404,354 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,036,461 - 10,036,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,403,840 - 9,404,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,395,829 - 15,396,203 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,912,141 - 10,912,515 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1310,808,304 - 10,808,679 (-)NCBI
Celera39,835,764 - 9,836,138 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A new peptidic ligand and its receptor regulating adrenal function in rats. Fukusumi S, etal., J Biol Chem 2003 Nov 21;278(47):46387-95. Epub 2003 Sep 05.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14657341   PMID:15891009   PMID:16543265   PMID:16648250   PMID:19341706   PMID:19520126   PMID:21473894   PMID:23979792   PMID:26823127  


Genomics

Comparative Map Data
Qrfp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,485,579 - 35,487,902 (-)NCBIGRCr8
mRatBN7.2315,088,045 - 15,088,419 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,088,045 - 15,088,425 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,161,522 - 18,161,896 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,746,525 - 26,746,899 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,993,882 - 24,994,256 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.039,402,397 - 9,404,354 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,036,461 - 10,036,841 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,403,840 - 9,404,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,395,829 - 15,396,203 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,912,141 - 10,912,515 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1310,808,304 - 10,808,679 (-)NCBI
Celera39,835,764 - 9,836,138 (-)NCBICelera
Cytogenetic Map3p12NCBI
QRFP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,892,707 - 130,896,812 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9130,892,707 - 130,896,812 (-)EnsemblGRCh38hg38GRCh38
GRCh379133,768,094 - 133,772,199 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,758,636 - 132,759,046 (-)NCBINCBI36Build 36hg18NCBI36
Celera9104,307,102 - 104,307,512 (-)NCBICelera
Cytogenetic Map9q34.12NCBI
HuRef9103,255,480 - 103,255,890 (-)NCBIHuRef
CHM1_19133,917,427 - 133,917,837 (-)NCBICHM1_1
T2T-CHM13v2.09143,097,580 - 143,101,684 (-)NCBIT2T-CHM13v2.0
Qrfp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,696,180 - 31,700,592 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,696,178 - 31,700,592 (-)EnsemblGRCm39 Ensembl
GRCm38231,806,168 - 31,810,580 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,806,166 - 31,810,580 (-)EnsemblGRCm38mm10GRCm38
MGSCv37231,661,688 - 31,666,038 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36231,628,177 - 31,632,527 (-)NCBIMGSCv36mm8
Celera231,508,856 - 31,513,205 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.89NCBI
Qrfp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513803,630 - 804,034 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955513802,809 - 805,835 (-)NCBIChiLan1.0ChiLan1.0
QRFP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,460,368 - 8,467,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan198,461,084 - 8,465,203 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09102,008,900 - 102,013,194 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19130,658,415 - 130,662,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9130,659,140 - 130,659,550 (-)Ensemblpanpan1.1panPan2
QRFP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,110,763 - 53,113,743 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl953,112,586 - 53,112,996 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,310,894 - 52,313,876 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,011,306 - 54,014,289 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,013,135 - 54,013,545 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,788,911 - 52,791,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,109,442 - 53,112,428 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,202,385 - 53,205,368 (+)NCBIUU_Cfam_GSD_1.0
Qrfp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947198,055,921 - 198,058,340 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648717,824,630 - 17,824,977 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648717,824,474 - 17,826,867 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QRFP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,911,878 - 270,912,282 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11270,909,323 - 270,917,674 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,834,154 - 304,837,026 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QRFP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,247,841 - 7,256,677 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660798,214,329 - 8,217,588 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qrfp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247604,873,578 - 4,874,921 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Qrfp
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:137
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000071380, ENSRNOT00000073731
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 13 6 5 6 7 16 8 4 4 13 5

Sequence


Ensembl Acc Id: ENSRNOT00000071380   ⟹   ENSRNOP00000064225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl39,403,840 - 9,404,214 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073731   ⟹   ENSRNOP00000066916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,088,045 - 15,088,425 (-)Ensembl
Rnor_6.0 Ensembl310,036,461 - 10,036,841 (+)Ensembl
RefSeq Acc Id: NM_198200   ⟹   NP_937843
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,485,822 - 35,486,196 (-)NCBI
mRatBN7.2315,088,045 - 15,088,419 (-)NCBI
Rnor_6.039,403,840 - 9,404,214 (+)NCBI
Rnor_5.0315,395,829 - 15,396,203 (+)NCBI
RGSC_v3.4310,912,141 - 10,912,515 (-)RGD
Celera39,835,764 - 9,836,138 (-)RGD
Sequence:
RefSeq Acc Id: XM_063284298   ⟹   XP_063140368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,485,579 - 35,487,902 (-)NCBI
Protein Sequences
Protein RefSeqs NP_937843 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140368 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR24355 (Get FASTA)   NCBI Sequence Viewer  
  BAC98936 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066916.1
  ENSRNOP00055011540
  ENSRNOP00060047464
  ENSRNOP00065038988
GenBank Protein P83860 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_937843   ⟸   NM_198200
- Peptide Label: precursor
- UniProtKB: P83860 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064225   ⟸   ENSRNOT00000071380
Ensembl Acc Id: ENSRNOP00000066916   ⟸   ENSRNOT00000073731
RefSeq Acc Id: XP_063140368   ⟸   XM_063284298
- Peptide Label: isoform X1
- UniProtKB: A6JU31 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83860-F1-model_v2 AlphaFold P83860 1-124 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-50171 BioCyc
Ensembl Genes ENSRNOG00000046473 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000050781 Ensembl
  ENSRNOG00055008543 UniProtKB/Swiss-Prot
  ENSRNOG00060033127 UniProtKB/Swiss-Prot
  ENSRNOG00065027569 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073731.3 UniProtKB/Swiss-Prot
  ENSRNOT00055014413 UniProtKB/Swiss-Prot
  ENSRNOT00060057448 UniProtKB/Swiss-Prot
  ENSRNOT00065047517 UniProtKB/Swiss-Prot
InterPro P518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:379044 UniProtKB/Swiss-Prot
NCBI Gene 379044 ENTREZGENE
PANTHER OREXIGENIC NEUROPEPTIDE QRFP UniProtKB/Swiss-Prot
  OREXIGENIC NEUROPEPTIDE QRFP UniProtKB/TrEMBL
  OREXIGENIC NEUROPEPTIDE QRFP UniProtKB/TrEMBL
  PTHR36476 UniProtKB/Swiss-Prot
Pfam RFamide_26RFa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Qrfp PhenoGen
RatGTEx ENSRNOG00000046473 RatGTEx
  ENSRNOG00000050781 RatGTEx
  ENSRNOG00055008543 RatGTEx
  ENSRNOG00060033127 RatGTEx
  ENSRNOG00065027569 RatGTEx
UniProt A6JU31 ENTREZGENE, UniProtKB/TrEMBL
  OX26_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Qrfp  pyroglutamylated RFamide peptide  P518  P518 precursor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 P518  P518 precursor protein  QRFP  QRFP protein  Symbol and Name updated 1299863 APPROVED