Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit) - Rat Genome Database

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Gene: Cacna1s (calcium channel, voltage-dependent, L type, alpha 1S subunit) Mus musculus
Analyze
Symbol: Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
RGD ID: 733918
MGI Page MGI
Description: Enables voltage-gated calcium channel activity. Acts upstream of or within several processes, including extraocular skeletal muscle development; myotube differentiation; and skeletal muscle adaptation. Located in T-tubule and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hindlimb musculature. Used to study hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in congenital myopathy 18; hypokalemic periodic paralysis; and malignant hyperthermia. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW493108; calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; Cav1; Cav1.1; Cchl1; Cchl1a3; DHPR; DHPR alpha1s; dihydropyridine receptor alpha 1S; fmd; mdg; muscle dysgenesis; s; sj; voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel subunit alpha Cav1.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,980,549 - 136,047,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,980,488 - 136,047,560 (+)EnsemblGRCm39 Ensembl
GRCm381136,052,806 - 136,119,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,052,750 - 136,119,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,949,478 - 138,016,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,869,312 - 137,936,233 (+)NCBIMGSCv36mm8
Celera1138,687,405 - 138,754,983 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal axial skeleton morphology  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal diaphragm morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal embryo size  (IEA)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal facial morphology  (IEA)
abnormal fetal size  (IAGP)
abnormal innervation pattern to muscle  (IAGP)
abnormal joint morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal mitochondrial physiology  (IAGP)
abnormal muscle contractility  (IAGP)
abnormal muscle development  (IAGP)
abnormal muscle electrophysiology  (IAGP)
abnormal muscle fiber morphology  (IAGP)
abnormal muscle morphology  (IAGP)
abnormal muscle physiology  (IAGP)
abnormal phrenic nerve morphology  (IAGP)
abnormal placenta vasculature  (IEA)
abnormal rib morphology  (IAGP)
abnormal sarcomere morphology  (IAGP)
abnormal skeletal muscle fiber mitochondrial morphology  (IAGP)
abnormal skeletal muscle fiber morphology  (IAGP)
abnormal skeletal muscle fiber type ratio  (IAGP)
abnormal spinal cord ventral horn morphology  (IAGP)
abnormal spine curvature  (IAGP)
abnormal sternebra morphology  (IAGP)
abnormal sternum morphology  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal tongue muscle morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal Z line morphology  (IAGP)
absent deltoid tuberosity  (IAGP)
absent skeletal muscle  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
cervical vertebral fusion  (IAGP)
cleft secondary palate  (IAGP)
cyanosis  (IEA)
decreased aerobic running capacity  (IAGP)
decreased circulating glucose level  (IEA)
decreased diameter of long bones  (IAGP)
decreased grip strength  (IAGP)
decreased mitochondrial number  (IAGP)
decreased mitochondrial size  (IAGP)
decreased skeletal muscle mass  (IAGP)
decreased tongue size  (IAGP)
dilated mitochondrion  (IAGP)
dilated sarcoplasmic reticulum  (IAGP)
edema  (IAGP)
enlarged interparietal bone  (IAGP)
enlarged occipital bone  (IAGP)
extremity edema  (IAGP)
hemorrhage  (IEA)
impaired muscle contractility  (IAGP)
impaired skeletal muscle contractility  (IAGP)
increased brown adipose tissue amount  (IAGP)
kyphosis  (IAGP)
limb grasping  (IAGP)
long ribs  (IAGP)
loose skin  (IAGP)
micrognathia  (IAGP)
muscle degeneration  (IAGP)
myopathy  (IAGP)
no spontaneous movement  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
respiratory system phenotype  (IEA)
short mandible  (IAGP)
short sternum  (IAGP)
shortened head  (IAGP)
small clavicle  (IAGP)
small mandibular condyloid process  (IAGP)
small mandibular coronoid process  (IAGP)
small scapula  (IAGP)
sternebra fusion  (IAGP)
thin diaphragm muscle  (IAGP)
thin ribs  (IAGP)
thoracic vertebral fusion  (IAGP)
unresponsive to tactile stimuli  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
2. The gene for the alpha 1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (Cchl1a3) maps to mouse chromosome 1. Chin H, etal., Genomics 1992 Dec;14(4):1089-91.
3. Hypokalemic periodic paralysis and the dihydropyridine receptor (CACNL1A3): genotype/phenotype correlations for two predominant mutations and evidence for the absence of a founder effect in 16 caucasian families. Elbaz A, etal., Am J Hum Genet 1995 Feb;56(2):374-80.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle. Monnier N, etal., Am J Hum Genet 1997 Jun;60(6):1316-25.
8. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Decreased intracellular [Ca2+ ] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis. Wang MM, etal., Muscle Nerve. 2017 Dec;56(6):1128-1136. doi: 10.1002/mus.25554. Epub 2017 Mar 23.
Additional References at PubMed
PMID:146110   PMID:289331   PMID:1237429   PMID:1281468   PMID:1663002   PMID:2173707   PMID:2197156   PMID:2419767   PMID:2536362   PMID:2903448   PMID:4738109   PMID:5041196  
PMID:6500174   PMID:6501560   PMID:6692971   PMID:6692972   PMID:6708965   PMID:6708966   PMID:7286424   PMID:7549908   PMID:7635187   PMID:7734731   PMID:8004673   PMID:8118099  
PMID:8143864   PMID:8381753   PMID:8462749   PMID:8666981   PMID:8889548   PMID:8943043   PMID:9004034   PMID:9023306   PMID:9045648   PMID:9540851   PMID:9929471   PMID:10349636  
PMID:10444070   PMID:10929205   PMID:10949052   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11956331   PMID:12023238   PMID:12397396   PMID:12407098   PMID:12466851   PMID:12477932  
PMID:12900400   PMID:12954602   PMID:14300095   PMID:14300096   PMID:14618389   PMID:15536090   PMID:15582152   PMID:15849247   PMID:16141072   PMID:16141073   PMID:16148029   PMID:16357209  
PMID:16403451   PMID:16602821   PMID:16985003   PMID:16987237   PMID:17289261   PMID:17767505   PMID:17899167   PMID:17906876   PMID:18077436   PMID:18434328   PMID:18556650   PMID:19134469  
PMID:19460349   PMID:20033060   PMID:20059955   PMID:20188150   PMID:20937870   PMID:21262376   PMID:21267068   PMID:21575570   PMID:21677750   PMID:21750035   PMID:21789999   PMID:21858002  
PMID:21873635   PMID:22140091   PMID:22162637   PMID:22357600   PMID:22411552   PMID:22928916   PMID:22982493   PMID:23071115   PMID:23187123   PMID:23321639   PMID:23443569   PMID:23785297  
PMID:23818578   PMID:24044893   PMID:24142145   PMID:24194600   PMID:24453333   PMID:24519419   PMID:24806927   PMID:25277766   PMID:25431931   PMID:25548159   PMID:25717360   PMID:25757744  
PMID:25926361   PMID:26062940   PMID:26078055   PMID:26245899   PMID:26486172   PMID:26815481   PMID:26892246   PMID:26910427   PMID:26965373   PMID:27129199   PMID:27340545   PMID:27471951  
PMID:27626380   PMID:27914912   PMID:28008709   PMID:28302382   PMID:28883413   PMID:29130937   PMID:29326166   PMID:29467163   PMID:29543863   PMID:29632175   PMID:29913145   PMID:29949772  
PMID:30071129   PMID:30689883   PMID:30745426   PMID:31199454   PMID:31694926   PMID:31804576   PMID:31812241   PMID:32719120   PMID:32736698   PMID:32866694   PMID:32994313   PMID:33904400  
PMID:33969828   PMID:34061024   PMID:35340430   PMID:35759432   PMID:36709857   PMID:37408453   PMID:37468485   PMID:37995181  


Genomics

Comparative Map Data
Cacna1s
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,980,549 - 136,047,268 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,980,488 - 136,047,560 (+)EnsemblGRCm39 Ensembl
GRCm381136,052,806 - 136,119,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,052,750 - 136,119,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,949,478 - 138,016,399 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,869,312 - 137,936,233 (+)NCBIMGSCv36mm8
Celera1138,687,405 - 138,754,983 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.55NCBI
CACNA1S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,039,512 - 201,112,426 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,039,512 - 201,112,451 (-)EnsemblGRCh38hg38GRCh38
GRCh371201,008,640 - 201,081,554 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,275,263 - 199,348,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 341197,740,298 - 197,813,351NCBI
Celera1174,132,677 - 174,205,677 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,175,337 - 172,248,318 (-)NCBIHuRef
CHM1_11202,431,280 - 202,504,354 (-)NCBICHM1_1
T2T-CHM13v2.01200,296,459 - 200,369,410 (-)NCBIT2T-CHM13v2.0
Cacna1s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,045,668 - 50,115,903 (+)NCBIGRCr8
mRatBN7.21347,493,949 - 47,564,194 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,493,949 - 47,564,318 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,102,064 - 50,172,290 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,390,147 - 51,460,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,653,326 - 48,727,699 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,889,570 - 52,964,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,889,737 - 52,964,155 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,945,479 - 58,018,760 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,096,012 - 49,103,925 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1347,809,765 - 47,877,622 (+)NCBICelera
Cytogenetic Map13q13NCBI
Cacna1s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,201,180 - 37,263,371 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540637,201,180 - 37,263,328 (-)NCBIChiLan1.0ChiLan1.0
CACNA1S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2148,268,156 - 48,341,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1148,231,735 - 48,304,843 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,639,189 - 176,712,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11180,941,836 - 181,014,823 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1180,941,836 - 181,014,823 (-)Ensemblpanpan1.1panPan2
CACNA1S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.172,108,716 - 2,172,246 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl72,108,455 - 2,303,220 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha71,793,187 - 1,856,620 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.071,755,440 - 1,818,918 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl71,755,328 - 1,818,919 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.171,738,797 - 1,802,223 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,841,461 - 1,904,933 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,871,249 - 1,934,698 (+)NCBIUU_Cfam_GSD_1.0
Cacna1s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934474,034,420 - 74,097,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,269,355 - 3,331,460 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,269,283 - 3,331,858 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA1S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,502,898 - 23,568,058 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11023,503,701 - 23,567,797 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21027,934,779 - 27,999,415 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA1S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,288,483 - 28,363,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,289,342 - 28,363,327 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605529,088,659 - 29,162,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacna1s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,559,954 - 9,619,132 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248079,560,004 - 9,618,942 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacna1s
2528 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1174
Count of miRNA genes:342
Interacting mature miRNAs:391
Transcripts:ENSMUST00000112064, ENSMUST00000112068, ENSMUST00000159106, ENSMUST00000160641, ENSMUST00000161700, ENSMUST00000161865
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134760138150193871Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134760138150193871Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134760138150193871Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163920002153557562Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173755175147125370Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74516235148715579Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)175976637148775742Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782291982147125370Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194127725148775742Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195527725162027569Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1102968534136968667Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109495943143495943Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109638262143638479Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110553179144553298Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110553179144553298Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112131005146131085Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116290836150290937Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118099720152099816Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121727729139727738Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121727729153775746Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121727729153875746Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1122927738156927738Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
13504831Bacszq1_mbaculum size QTL 1 (mouse)1134331161148128608Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse

Markers in Region
AW493108  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381136,119,242 - 136,119,342UniSTSGRCm38
MGSCv371138,015,819 - 138,015,919UniSTSGRCm37
Celera1138,754,403 - 138,754,503UniSTS
Cytogenetic Map1FUniSTS
cM Map169.9UniSTS
Whitehead/MRC_RH11928.4UniSTS
Cacna1s  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1FUniSTS
cM Map169.9UniSTS
cM Map169.9UniSTS
Cacna1s  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1FUniSTS
cM Map169.9UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000112064   ⟹   ENSMUSP00000107695
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,980,639 - 136,047,560 (+)Ensembl
GRCm38.p6 Ensembl1136,052,901 - 136,119,822 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112068   ⟹   ENSMUSP00000107699
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,980,522 - 136,047,273 (+)Ensembl
GRCm38.p6 Ensembl1136,052,784 - 136,119,535 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159106
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,044,994 - 136,047,267 (+)Ensembl
GRCm38.p6 Ensembl1136,117,256 - 136,119,529 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160641   ⟹   ENSMUSP00000125278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,980,488 - 136,047,268 (+)Ensembl
GRCm38.p6 Ensembl1136,052,750 - 136,119,530 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,033,144 - 136,039,796 (+)Ensembl
GRCm38.p6 Ensembl1136,105,406 - 136,112,058 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161865   ⟹   ENSMUSP00000125262
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1136,001,292 - 136,047,267 (+)Ensembl
GRCm38.p6 Ensembl1136,073,554 - 136,119,529 (+)Ensembl
RefSeq Acc Id: NM_001081023   ⟹   NP_001074492
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,980,549 - 136,047,268 (+)NCBI
GRCm381136,052,811 - 136,119,822 (+)NCBI
MGSCv371137,949,478 - 138,016,399 (+)RGD
Celera1138,687,405 - 138,754,983 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001402949   ⟹   NP_001389878
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,980,549 - 136,047,268 (+)NCBI
RefSeq Acc Id: NM_014193   ⟹   NP_055008
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,980,549 - 136,047,268 (+)NCBI
GRCm381136,052,811 - 136,119,822 (+)NCBI
MGSCv371137,949,478 - 138,016,399 (+)RGD
Celera1138,687,405 - 138,754,983 (+)RGD
cM Map1 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001074492   ⟸   NM_001081023
- Peptide Label: isoform 2
- UniProtKB: Q3UPG8 (UniProtKB/Swiss-Prot),   Q02789 (UniProtKB/Swiss-Prot),   E9QPX8 (UniProtKB/Swiss-Prot),   E9Q7B5 (UniProtKB/Swiss-Prot),   Q99240 (UniProtKB/Swiss-Prot),   F8VQE0 (UniProtKB/TrEMBL),   F7CNJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_055008   ⟸   NM_014193
- Peptide Label: isoform 1
- UniProtKB: F7CNJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000107699   ⟸   ENSMUST00000112068
RefSeq Acc Id: ENSMUSP00000107695   ⟸   ENSMUST00000112064
RefSeq Acc Id: ENSMUSP00000125278   ⟸   ENSMUST00000160641
RefSeq Acc Id: ENSMUSP00000125262   ⟸   ENSMUST00000161865
RefSeq Acc Id: NP_001389878   ⟸   NM_001402949
- Peptide Label: isoform 3
- UniProtKB: A0A8I4RSM0 (UniProtKB/TrEMBL)
Protein Domains
Voltage-dependent calcium channel alpha-1 subunit

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q02789-F1-model_v2 AlphaFold Q02789 1-1852 view protein structure

Promoters
RGD ID:6875096
Promoter ID:EPDNEW_M999
Type:single initiation site
Name:Cacna1s_1
Description:Mus musculus calcium channel, voltage-dependent, L type, alpha1S subunit , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381136,052,953 - 136,053,013EPDNEW
RGD ID:6817456
Promoter ID:MM_KWN:2239
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000085068
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361138,002,111 - 138,002,611 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88294 AgrOrtholog
Ensembl Genes ENSMUSG00000026407 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000112064 ENTREZGENE
  ENSMUST00000112064.8 UniProtKB/Swiss-Prot
  ENSMUST00000112068 ENTREZGENE
  ENSMUST00000112068.10 UniProtKB/Swiss-Prot
  ENSMUST00000160641 ENTREZGENE
  ENSMUST00000160641.8 UniProtKB/TrEMBL
  ENSMUST00000161865.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2500 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CAC1F_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPHH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_a1su_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_a1ssu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_a1su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCAlpha1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12292 UniProtKB/Swiss-Prot
MGD MGI:88294 ENTREZGENE
NCBI Gene 12292 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ca_chan_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAC1F_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPHH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacna1s PhenoGen
PRINTS CACHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LVDCCALPHA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LVDCCALPHA1S UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Ca_chan_IQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I4RSM0 ENTREZGENE, UniProtKB/TrEMBL
  A3KPC9_MOUSE UniProtKB/TrEMBL
  CAC1S_MOUSE UniProtKB/Swiss-Prot
  E9Q7B5 ENTREZGENE
  E9QPX8 ENTREZGENE
  F7CNJ1 ENTREZGENE, UniProtKB/TrEMBL
  F8VQE0 ENTREZGENE
  Q02789 ENTREZGENE
  Q3UPG8 ENTREZGENE
  Q3UQQ0_MOUSE UniProtKB/TrEMBL
  Q99240 ENTREZGENE
UniProt Secondary E9Q7B5 UniProtKB/Swiss-Prot
  E9QPX8 UniProtKB/Swiss-Prot
  F8VQE0 UniProtKB/Swiss-Prot
  Q3UPG8 UniProtKB/Swiss-Prot
  Q99240 UniProtKB/Swiss-Prot