Trpc4 (transient receptor potential cation channel, subfamily C, member 4) - Rat Genome Database

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Gene: Trpc4 (transient receptor potential cation channel, subfamily C, member 4) Mus musculus
Analyze
Symbol: Trpc4
Name: transient receptor potential cation channel, subfamily C, member 4
RGD ID: 733151
MGI Page MGI
Description: Enables inositol 1,4,5 trisphosphate binding activity. Acts upstream of or within gamma-aminobutyric acid secretion and oligodendrocyte differentiation. Located in caveola. Part of protein-containing complex. Is expressed in several structures, including brain; cochlea; ganglia; genitourinary system; and liver. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: capacitative calcium entry channel Trp4; CCE1; putative capacitative calcium entry channel; receptor-activated cation channel TRP4; short transient receptor potential channel 4; STR; STRPC4; Tr; transient receptor protein 4; Trp4; Trrp4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,063,441 - 54,225,892 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,063,456 - 54,225,892 (+)EnsemblGRCm39 Ensembl
GRCm38354,155,584 - 54,318,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,156,035 - 54,318,471 (+)EnsemblGRCm38mm10GRCm38
MGSCv37353,960,026 - 54,122,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36354,244,033 - 54,406,396 (+)NCBIMGSCv36mm8
Celera353,878,360 - 54,040,521 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension. Alzoubi A, etal., Am J Pathol. 2013 Dec;183(6):1779-1788. doi: 10.1016/j.ajpath.2013.08.016. Epub 2013 Oct 8.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. Tang Y, etal., J Biol Chem 2000 Dec 1;275(48):37559-64.
10. A rat knockout model implicates TRPC4 in visceral pain sensation. Westlund KN, etal., Neuroscience. 2014 Mar 14;262:165-75. doi: 10.1016/j.neuroscience.2013.12.043. Epub 2014 Jan 3.
11. Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study. Zhang Z, etal., Meta Gene. 2016 Jul 8;9:191-6. doi: 10.1016/j.mgene.2016.07.005. eCollection 2016 Sep.
12. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Zhu X, etal., Cell 1996 May 31;85(5):661-71.
Additional References at PubMed
PMID:7575478   PMID:8889548   PMID:9512398   PMID:9687496   PMID:9722956   PMID:10349636   PMID:10556287   PMID:10998353   PMID:11042159   PMID:11076861   PMID:11175743   PMID:11217851  
PMID:11356184   PMID:11390792   PMID:11815479   PMID:11856742   PMID:11897792   PMID:12114324   PMID:12477932   PMID:14505576   PMID:14668438   PMID:15044151   PMID:15336983   PMID:15611229  
PMID:15654973   PMID:16141072   PMID:16141073   PMID:16404161   PMID:16537542   PMID:16880404   PMID:17345099   PMID:17402970   PMID:17416589   PMID:17480026   PMID:17593972   PMID:17624425  
PMID:17706948   PMID:18230622   PMID:18287559   PMID:18701065   PMID:18758036   PMID:18796539   PMID:18854172   PMID:18989690   PMID:18990707   PMID:19070363   PMID:19139271   PMID:19322198  
PMID:19549525   PMID:19812031   PMID:19834762   PMID:20059953   PMID:20151419   PMID:20562229   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22144671   PMID:22210847   PMID:22411552  
PMID:22539836   PMID:22847694   PMID:23188715   PMID:23233529   PMID:23410158   PMID:23677990   PMID:23744639   PMID:23922735   PMID:24011658   PMID:24563462   PMID:24599464   PMID:24952961  
PMID:25347706   PMID:25471572   PMID:25605522   PMID:26317356   PMID:27177420   PMID:28671696   PMID:28790178   PMID:29373286   PMID:29915209   PMID:29920354   PMID:30038709   PMID:30082700  
PMID:30270038   PMID:30786075   PMID:31536487   PMID:31787886   PMID:32033274   PMID:32110987   PMID:32289348   PMID:32322252   PMID:32325033   PMID:32338378   PMID:32350291   PMID:32359120  
PMID:32414784   PMID:33884443   PMID:34851821   PMID:35544691   PMID:36257322   PMID:36476978   PMID:36592529  


Genomics

Comparative Map Data
Trpc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39354,063,441 - 54,225,892 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl354,063,456 - 54,225,892 (+)EnsemblGRCm39 Ensembl
GRCm38354,155,584 - 54,318,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl354,156,035 - 54,318,471 (+)EnsemblGRCm38mm10GRCm38
MGSCv37353,960,026 - 54,122,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36354,244,033 - 54,406,396 (+)NCBIMGSCv36mm8
Celera353,878,360 - 54,040,521 (+)NCBICelera
Cytogenetic Map3CNCBI
cM Map325.43NCBI
TRPC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381337,632,063 - 37,869,772 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1337,632,063 - 37,869,802 (-)EnsemblGRCh38hg38GRCh38
GRCh371338,206,200 - 38,443,909 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361337,108,795 - 37,341,935 (-)NCBINCBI36Build 36hg18NCBI36
Build 341337,108,794 - 37,341,935NCBI
Celera1319,264,388 - 19,497,682 (-)NCBICelera
Cytogenetic Map13q13.3NCBI
HuRef1319,010,251 - 19,243,495 (-)NCBIHuRef
CHM1_11338,178,367 - 38,411,614 (-)NCBICHM1_1
T2T-CHM13v2.01336,851,454 - 37,089,250 (-)NCBIT2T-CHM13v2.0
Trpc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82140,457,841 - 140,629,556 (+)NCBIGRCr8
mRatBN7.22138,307,676 - 138,476,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2138,308,084 - 138,476,768 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2144,918,944 - 145,044,642 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02143,030,992 - 143,156,703 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02137,662,818 - 137,788,527 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02143,433,102 - 143,605,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2143,475,323 - 143,604,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02163,115,873 - 163,282,223 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42143,350,286 - 143,485,716 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12143,254,891 - 143,435,776 (+)NCBI
Celera2132,835,300 - 132,958,908 (+)NCBICelera
Cytogenetic Map2q26NCBI
Trpc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554318,282,812 - 8,479,944 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554318,283,585 - 8,479,524 (+)NCBIChiLan1.0ChiLan1.0
TRPC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21437,165,899 - 37,395,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11328,272,271 - 28,501,184 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01318,852,991 - 19,081,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11337,445,015 - 37,673,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1337,445,015 - 37,592,115 (-)Ensemblpanpan1.1panPan2
TRPC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1252,927,347 - 3,133,935 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl252,981,518 - 3,132,829 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha253,022,599 - 3,229,148 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0253,025,824 - 3,232,420 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl253,025,926 - 3,231,292 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,930,561 - 3,136,488 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,920,321 - 3,126,347 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0252,990,669 - 3,197,659 (+)NCBIUU_Cfam_GSD_1.0
Trpc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945164,042,735 - 164,240,721 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647231,711,040 - 31,843,876 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647231,710,873 - 31,909,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRPC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1113,298,992 - 13,517,502 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11113,300,288 - 13,519,001 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21113,275,420 - 13,336,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21113,401,850 - 13,486,078 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRPC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1316,135,822 - 16,358,902 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605727,929,460 - 28,150,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trpc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624920641,917 - 903,171 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624920641,931 - 903,229 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Trpc4
5607 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:79
Interacting mature miRNAs:86
Transcripts:ENSMUST00000029311
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
1558925Hivan1_mHIV-associated nephropathy 1 (mouse)Not determined3758617468716946Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
4141116Lgaq4_mlate growth adjusted QTL 4 (mouse)Not determined1024922183184946Mouse
4141255W10q3_mweight 10 weeks QTL 3 (mouse)Not determined1024922183184946Mouse
4141563Lgq3_mlate growth QTL 3 (mouse)Not determined1024922183184946Mouse
39128206Lwq18_mliver weight QTL 18 (mouse)31024922183184946Mouse
1357584Splq6_mspleen weight QTL 6 (mouse)Not determined31024922183184946Mouse
1357440Hrtpq1_mheart weight percentage QTL 1 (mouse)Not determined31024922183184946Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
1301114Ssial2_msusceptibility to sialadenitis 2 (mouse)Not determined32017486254180103Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1300961Bh4p_mbar holding four paws (mouse)Not determined33183785465837997Mouse
12910778Pwgrq13_mpost-weaning growth rate QTL 13 (mouse)33263576058017363Mouse
12910781Pwgrq12_mpost-weaning growth rate QTL 12 (mouse)33263576058017363Mouse
10412073Ssen2_msuseptibility to Sendai virus 2 (mouse)Not determined33353546567535615Mouse
9587784Afw13_mabdominal fat weight QTL 13 (mouse)Not determined33375204567752228Mouse
10043882Bwtq13_mbody weight QTL 13 (mouse)Not determined33375204567752228Mouse
15039332Nmrs6_mNAFLD-associated magnetic resonance shift 6 (mouse)33417074168170741Mouse
15039336Nmrs2_mNAFLD-associated magnetic resonance shift 2 (mouse)33457610368576103Mouse
18337272Bmd46_mbone mineral density 46, males (mouse)33540742169407421Mouse
14746977Manh53_mmandible shape 53 (mouse)33592528069925280Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
1300587Aod2_mautoimmune ovarian dysgenesis 2 (mouse)Not determined33717974268716946Mouse
11041901Lmr11b_mleishmaniasis resistance 11b (mouse)33970410273704231Mouse
11039513Ltpr3a_mLeishmania tropica response 3a (mouse)33970410273704231Mouse
1301585Cd4ts1_mCD4 T cell subset 1 (mouse)Not determined33970410273704231Mouse
10755516Amzn1_manatomical modifier of Zfp423 1 (mouse)33970410273704231Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884389Skwq10_mskull length QTL 10, 16 week (mouse)34395443565307421Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
4141079Ath23_matherosclerosis 23 (mouse)Not determined4935758183357581Mouse
1300895Hdl5_mHDL level 5 (mouse)Not determined34949500583495118Mouse
1301824Susp_msuppressor of superoxide production (mouse)Not determined34949500583495118Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
1357585Manln3_mmandible length 3 (mouse)Not determined35262550986625745Mouse
1301917Tshp4_mtooth shape 4 (mouse)Not determined35262550986625745Mouse
1300593Skull4_mskull morphology 4 (mouse)Not determined35262550986625745Mouse
13464139Nhdlq17_mnon-HDL QTL 17 (mouse)35292318386923183Mouse

Markers in Region
D3Mit66  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38354,212,913 - 54,213,082UniSTSGRCm38
MGSCv37354,016,835 - 54,017,004UniSTSGRCm37
Celera353,935,170 - 53,935,339UniSTS
Cytogenetic Map3DUniSTS
cM Map328.0UniSTS
Whitehead Genetic320.8UniSTS
Whitehead/MRC_RH3495.62UniSTS
Whitehead_YAC3 UniSTS
Trpc4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38354,317,908 - 54,318,016UniSTSGRCm38
MGSCv37354,121,830 - 54,121,938UniSTSGRCm37
Celera354,039,962 - 54,040,070UniSTS
Cytogenetic Map3DUniSTS
cM Map328.6UniSTS
Trrp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3DUniSTS
cM Map328.6UniSTS
Trpc4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3DUniSTS
Trpc4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38354,317,457 - 54,318,209UniSTSGRCm38
MGSCv37354,121,379 - 54,122,131UniSTSGRCm37
Celera354,039,511 - 54,040,263UniSTS
Cytogenetic Map3DUniSTS
Trpc4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3DUniSTS
Trpc4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3DUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001253682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001253683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_046161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006501298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036163021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF011543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF190646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC120729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC131915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO043592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U50922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000029311   ⟹   ENSMUSP00000029311
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,063,478 - 54,225,892 (+)Ensembl
GRCm38.p6 Ensembl354,156,057 - 54,318,471 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198444
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,063,456 - 54,085,263 (+)Ensembl
GRCm38.p6 Ensembl354,156,035 - 54,177,842 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,063,794 - 54,131,658 (+)Ensembl
GRCm38.p6 Ensembl354,156,373 - 54,224,237 (+)Ensembl
RefSeq Acc Id: ENSMUST00000199399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,063,487 - 54,175,360 (+)Ensembl
GRCm38.p6 Ensembl354,156,066 - 54,267,939 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200048   ⟹   ENSMUSP00000143593
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,063,525 - 54,225,888 (+)Ensembl
GRCm38.p6 Ensembl354,156,104 - 54,318,467 (+)Ensembl
RefSeq Acc Id: ENSMUST00000200341   ⟹   ENSMUSP00000142921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl354,064,036 - 54,225,837 (+)Ensembl
GRCm38.p6 Ensembl354,156,615 - 54,318,416 (+)Ensembl
RefSeq Acc Id: NM_001253682   ⟹   NP_001240611
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,478 - 54,225,892 (+)NCBI
GRCm38354,156,057 - 54,318,471 (+)NCBI
Celera353,878,313 - 54,040,525 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001253683   ⟹   NP_001240612
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,478 - 54,175,360 (+)NCBI
GRCm38354,156,057 - 54,267,939 (+)NCBI
Celera353,878,313 - 54,040,525 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_016984   ⟹   NP_058680
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,478 - 54,225,892 (+)NCBI
GRCm38354,156,057 - 54,318,471 (+)NCBI
MGSCv37353,960,026 - 54,122,389 (+)RGD
Celera353,878,313 - 54,040,525 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_046161
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,478 - 54,225,892 (+)NCBI
GRCm38354,156,057 - 54,318,471 (+)NCBI
Celera353,878,313 - 54,040,525 (+)ENTREZGENE
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501296   ⟹   XP_006501359
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,677 - 54,225,837 (+)NCBI
GRCm38354,156,256 - 54,318,416 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501297   ⟹   XP_006501360
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,720 - 54,225,890 (+)NCBI
GRCm38354,156,294 - 54,318,467 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006501298   ⟹   XP_006501361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,597 - 54,225,888 (+)NCBI
GRCm38354,266,330 - 54,318,467 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319534   ⟹   XP_017175023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,441 - 54,225,888 (+)NCBI
GRCm38354,155,584 - 54,318,467 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163019   ⟹   XP_036018912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,115,921 - 54,225,890 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163020   ⟹   XP_036018913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,597 - 54,225,888 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163021   ⟹   XP_036018914
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39354,063,736 - 54,225,890 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001240611 (Get FASTA)   NCBI Sequence Viewer  
  NP_001240612 (Get FASTA)   NCBI Sequence Viewer  
  NP_001415637 (Get FASTA)   NCBI Sequence Viewer  
  NP_058680 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501359 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501360 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501361 (Get FASTA)   NCBI Sequence Viewer  
  XP_017175023 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018912 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018913 (Get FASTA)   NCBI Sequence Viewer  
  XP_036018914 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC05178 (Get FASTA)   NCBI Sequence Viewer  
  AAC05179 (Get FASTA)   NCBI Sequence Viewer  
  AAD10167 (Get FASTA)   NCBI Sequence Viewer  
  AAD10168 (Get FASTA)   NCBI Sequence Viewer  
  AAF01469 (Get FASTA)   NCBI Sequence Viewer  
  AAI20730 (Get FASTA)   NCBI Sequence Viewer  
  AAI31916 (Get FASTA)   NCBI Sequence Viewer  
  BAC37973 (Get FASTA)   NCBI Sequence Viewer  
  BAC39124 (Get FASTA)   NCBI Sequence Viewer  
  CAA62230 (Get FASTA)   NCBI Sequence Viewer  
  EDL35253 (Get FASTA)   NCBI Sequence Viewer  
  EDL35254 (Get FASTA)   NCBI Sequence Viewer  
  EDL35255 (Get FASTA)   NCBI Sequence Viewer  
  EDL35256 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000029311
  ENSMUSP00000029311.7
  ENSMUSP00000142921.2
  ENSMUSP00000143593
  ENSMUSP00000143593.2
GenBank Protein Q9QUQ5 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_058680   ⟸   NM_016984
- Peptide Label: isoform 1
- UniProtKB: Q9QUQ9 (UniProtKB/Swiss-Prot),   Q62350 (UniProtKB/Swiss-Prot),   Q9QZC0 (UniProtKB/Swiss-Prot),   Q9QUQ5 (UniProtKB/Swiss-Prot),   Q0VB97 (UniProtKB/TrEMBL),   Q8BNT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001240611   ⟸   NM_001253682
- Peptide Label: isoform 2
- UniProtKB: Q8BNT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001240612   ⟸   NM_001253683
- Peptide Label: isoform 3
- UniProtKB: Q8BNB6 (UniProtKB/TrEMBL),   A0A0G2JEV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501359   ⟸   XM_006501296
- Peptide Label: isoform X1
- UniProtKB: Q9QUQ9 (UniProtKB/Swiss-Prot),   Q62350 (UniProtKB/Swiss-Prot),   Q9QZC0 (UniProtKB/Swiss-Prot),   Q9QUQ5 (UniProtKB/Swiss-Prot),   Q0VB97 (UniProtKB/TrEMBL),   Q8BNT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006501360   ⟸   XM_006501297
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006501361   ⟸   XM_006501298
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017175023   ⟸   XM_017319534
- Peptide Label: isoform X2
- UniProtKB: Q8BNT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000029311   ⟸   ENSMUST00000029311
RefSeq Acc Id: ENSMUSP00000143593   ⟸   ENSMUST00000200048
RefSeq Acc Id: ENSMUSP00000142921   ⟸   ENSMUST00000200341
RefSeq Acc Id: XP_036018913   ⟸   XM_036163020
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036018914   ⟸   XM_036163021
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036018912   ⟸   XM_036163019
- Peptide Label: isoform X3
Protein Domains
Transient receptor ion channel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUQ5-F1-model_v2 AlphaFold Q9QUQ5 1-974 view protein structure

Promoters
RGD ID:6880650
Promoter ID:EPDNEW_M3776
Type:multiple initiation site
Name:Trpc4_1
Description:Mus musculus transient receptor potential cation channel, subfamilyC, member 4 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3777  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38354,156,066 - 54,156,126EPDNEW
RGD ID:6880652
Promoter ID:EPDNEW_M3777
Type:single initiation site
Name:Trpc4_2
Description:Mus musculus transient receptor potential cation channel, subfamilyC, member 4 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M3776  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38354,238,136 - 54,238,196EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109525 AgrOrtholog
Ensembl Genes ENSMUSG00000027748 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029311 ENTREZGENE
  ENSMUST00000029311.11 UniProtKB/Swiss-Prot
  ENSMUST00000199399 ENTREZGENE
  ENSMUST00000200048 ENTREZGENE
  ENSMUST00000200048.5 UniProtKB/Swiss-Prot
  ENSMUST00000200341.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC4_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPC_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22066 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:109525 ENTREZGENE
NCBI Gene 22066 ENTREZGENE
PANTHER PTHR10117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10117:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trpc4 PhenoGen
PRINTS TRNSRECEPTRP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRPCHANNEL4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JEV6 ENTREZGENE, UniProtKB/TrEMBL
  Q0VB97 ENTREZGENE, UniProtKB/TrEMBL
  Q62350 ENTREZGENE
  Q8BNB6 ENTREZGENE, UniProtKB/TrEMBL
  Q8BNT2 ENTREZGENE, UniProtKB/TrEMBL
  Q9QUQ5 ENTREZGENE
  Q9QUQ9 ENTREZGENE
  Q9QZC0 ENTREZGENE
  TRPC4_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q62350 UniProtKB/Swiss-Prot
  Q9QUQ9 UniProtKB/Swiss-Prot
  Q9QZC0 UniProtKB/Swiss-Prot