Hcn2 (hyperpolarization-activated, cyclic nucleotide-gated K+ 2) - Rat Genome Database

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Gene: Hcn2 (hyperpolarization-activated, cyclic nucleotide-gated K+ 2) Mus musculus
Analyze
Symbol: Hcn2
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2
RGD ID: 732306
MGI Page MGI
Description: Predicted to enable several functions, including PDZ domain binding activity; identical protein binding activity; and monoatomic cation channel activity. Acts upstream of or within regulation of membrane potential. Located in membrane. Is expressed in central nervous system and heart. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BCNG-2; BCNG2; brain cyclic nucleotide-gated channel 2; HAC; HAC-1; HAC1; hyperpolarization-activated cation channel 1; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; t; trls
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)EnsemblGRCm39 Ensembl
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBIMGSCv36mm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. HCN1 and HCN2 in Rat DRG neurons: levels in nociceptors and non-nociceptors, NT3-dependence and influence of CFA-induced skin inflammation on HCN2 and NT3 expression. Acosta C, etal., PLoS One. 2012;7(12):e50442. doi: 10.1371/journal.pone.0050442. Epub 2012 Dec 7.
2. Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Brewster AL, etal., Neurobiol Dis. 2005 Jun-Jul;19(1-2):200-7.
3. Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine. Cho HJ, etal., Neuroscience. 2009 Aug 18;162(2):453-61. Epub 2009 May 3.
4. Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion. Li CJ, etal., Mol Neurobiol. 2014 Oct;50(2):704-20. doi: 10.1007/s12035-014-8736-3. Epub 2014 May 18.
5. Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes. Lin H, etal., Cell Physiol Biochem. 2009;23(4-6):317-26. doi: 10.1159/000218178. Epub 2009 May 6.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells. Tu H, etal., Neuroscience. 2010 Jan 13;165(1):39-52. doi: 10.1016/j.neuroscience.2009.10.002. Epub 2009 Oct 6.
11. Hyperpolarization-activated channels in trigeminal ganglia innervating healthy and pulp-exposed teeth. Wells JE, etal., Int Endod J. 2007 Sep;40(9):715-21. Epub 2007 Jul 23.
12. Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. Zha Q, etal., J Neurochem. 2008 Apr;105(1):68-77. Epub 2007 Nov 5.
Additional References at PubMed
PMID:8889548   PMID:9405696   PMID:9630217   PMID:9634236   PMID:10962006   PMID:11096117   PMID:11420311   PMID:11553787   PMID:11741901   PMID:12121985   PMID:12193608   PMID:12433951  
PMID:12514127   PMID:12562911   PMID:12928435   PMID:12968185   PMID:14633990   PMID:14726518   PMID:15240882   PMID:15292205   PMID:15525777   PMID:15564593   PMID:15644313   PMID:15687126  
PMID:16079136   PMID:16177047   PMID:16500960   PMID:16542642   PMID:16602821   PMID:16760342   PMID:16777944   PMID:16806719   PMID:16923750   PMID:16985003   PMID:17074978   PMID:17114649  
PMID:17261842   PMID:17473172   PMID:17482496   PMID:17553794   PMID:17562313   PMID:17578902   PMID:18033814   PMID:18252758   PMID:18579800   PMID:18768480   PMID:19150498   PMID:19171659  
PMID:19269964   PMID:19421833   PMID:19524546   PMID:19570998   PMID:19574228   PMID:20130205   PMID:20140458   PMID:20623157   PMID:21076425   PMID:21147989   PMID:21187420   PMID:21267068  
PMID:21347269   PMID:21354395   PMID:21593326   PMID:21873635   PMID:21903816   PMID:21945247   PMID:22090507   PMID:22279546   PMID:22550182   PMID:22652004   PMID:22662315   PMID:22880098  
PMID:22948144   PMID:23048023   PMID:23525108   PMID:23609807   PMID:24085296   PMID:24638995   PMID:24958877   PMID:25042871   PMID:25423599   PMID:25562801   PMID:25761792   PMID:25800552  
PMID:25917818   PMID:26559974   PMID:27137910   PMID:27568927   PMID:27956497   PMID:28671696   PMID:28767511   PMID:28954930   PMID:29107716   PMID:29256865   PMID:29466436   PMID:29519998  
PMID:29980633   PMID:30270038   PMID:30877792   PMID:30886335   PMID:31045576   PMID:31087220   PMID:31290157   PMID:31496517   PMID:31503201   PMID:31615893   PMID:32079660   PMID:32184125  
PMID:32212902   PMID:32325033   PMID:32341127   PMID:32581705   PMID:33181864   PMID:34206649   PMID:34341156   PMID:34429357   PMID:34818058   PMID:34948328   PMID:36538279   PMID:37762124  
PMID:38187761  


Genomics

Comparative Map Data
Hcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,552,468 - 79,571,942 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)EnsemblGRCm39 Ensembl
GRCm381079,716,634 - 79,736,108 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)EnsemblGRCm38mm10GRCm38
MGSCv371079,179,379 - 79,198,853 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,119,763 - 79,139,237 (+)NCBIMGSCv36mm8
Celera1080,731,157 - 80,750,702 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
HCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819589,881 - 617,159 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19589,881 - 617,159 (+)EnsemblGRCh38hg38GRCh38
GRCh3719589,881 - 617,159 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3619540,893 - 568,159 (+)NCBINCBI36Build 36hg18NCBI36
Build 3419540,892 - 568,157NCBI
Celera19200,463 - 228,092 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19373,968 - 384,301 (+)NCBIHuRef
CHM1_119589,749 - 616,575 (+)NCBICHM1_1
T2T-CHM13v2.019543,772 - 571,465 (+)NCBIT2T-CHM13v2.0
Hcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,620,422 - 10,639,457 (-)NCBIGRCr8
mRatBN7.279,969,801 - 9,988,839 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,970,368 - 9,988,841 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,850,727 - 12,869,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,728,808 - 14,747,876 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,588,170 - 12,607,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,851,730 - 12,870,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,851,739 - 12,874,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0713,021,934 - 13,051,802 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,485,257 - 11,503,614 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1711,485,256 - 11,503,614 (-)NCBI
Celera78,143,888 - 8,161,946 (-)NCBICelera
Cytogenetic Map7q11NCBI
Hcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554957,124,640 - 7,194,223 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554957,124,060 - 7,143,730 (-)NCBIChiLan1.0ChiLan1.0
HCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2204,914,303 - 4,942,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,153,083 - 4,180,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019521,348 - 528,203 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119559,108 - 584,128 (+)NCBIpanpan1.1PanPan1.1panPan2
HCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,920,089 - 57,941,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,920,740 - 57,938,374 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,722,746 - 57,741,278 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,663,358 - 58,681,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,663,358 - 58,681,919 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,717,402 - 57,735,597 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02058,196,864 - 58,215,545 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,400,096 - 58,421,283 (-)NCBIUU_Cfam_GSD_1.0
Hcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,625,528 - 217,639,390 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588142,786 - 208,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588202,101 - 209,255 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,708,162 - 77,730,881 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,708,159 - 77,730,881 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16326,437 - 358,119 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6324,517 - 358,119 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,626,637 - 8,752,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,889,025 - 7,908,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,889,616 - 7,908,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcn2
438 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:514
Count of miRNA genes:224
Interacting mature miRNAs:245
Transcripts:ENSMUST00000020581, ENSMUST00000099513
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000020581   ⟹   ENSMUSP00000020581
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)Ensembl
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)Ensembl
RefSeq Acc Id: ENSMUST00000099513   ⟹   ENSMUSP00000097113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1079,552,468 - 79,571,942 (+)Ensembl
GRCm38.p6 Ensembl1079,716,634 - 79,736,108 (+)Ensembl
RefSeq Acc Id: NM_008226   ⟹   NP_032252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391079,552,468 - 79,571,942 (+)NCBI
GRCm381079,716,634 - 79,736,108 (+)ENTREZGENE
MGSCv371079,179,379 - 79,198,853 (+)RGD
Celera1080,731,157 - 80,750,702 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032252   ⟸   NM_008226
- UniProtKB: O70506 (UniProtKB/Swiss-Prot),   O88703 (UniProtKB/Swiss-Prot),   C9K0Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000097113   ⟸   ENSMUST00000099513
RefSeq Acc Id: ENSMUSP00000020581   ⟸   ENSMUST00000020581
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88703-F1-model_v2 AlphaFold O88703 1-863 view protein structure

Promoters
RGD ID:6819425
Promoter ID:MM_KWN:4777
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell
Transcripts:ENSMUST00000020581,   NM_008226
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361079,178,681 - 79,179,937 (+)MPROMDB
RGD ID:8672540
Promoter ID:EPDNEW_M14300
Type:initiation region
Name:Hcn2_1
Description:Mus musculus hyperpolarization-activated, cyclic nucleotide-gatedK+ 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381079,716,607 - 79,716,667EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1298210 AgrOrtholog
Ensembl Genes ENSMUSG00000020331 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020581.3 UniProtKB/Swiss-Prot
  ENSMUST00000099513 ENTREZGENE
  ENSMUST00000099513.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15166 UniProtKB/Swiss-Prot
MGD MGI:1298210 ENTREZGENE
NCBI Gene 15166 ENTREZGENE
PANTHER I[[H]] CHANNEL, ISOFORM E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HCN2 RGD
PhenoGen Hcn2 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C9K0Z8 ENTREZGENE, UniProtKB/TrEMBL
  HCN2_MOUSE UniProtKB/Swiss-Prot
  O70506 ENTREZGENE
  O88703 ENTREZGENE
UniProt Secondary O70506 UniProtKB/Swiss-Prot