Kcnb1 (potassium voltage gated channel, Shab-related subfamily, member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Kcnb1 (potassium voltage gated channel, Shab-related subfamily, member 1) Mus musculus
Analyze
Symbol: Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
RGD ID: 732212
MGI Page MGI
Description: Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kcr1-; Kcr1-1; Kv2.; Kv2.1; mShab; potassium voltage-gated channel subfamily B member 1; Sh; Shab; voltage-gated potassium channel subunit Kv2.1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,937,889 - 167,032,088 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,937,889 - 167,032,075 (-)EnsemblGRCm39 Ensembl
GRCm382167,095,969 - 167,190,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,095,969 - 167,190,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,928,878 - 167,014,299 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,794,583 - 166,880,004 (-)NCBIMGSCv36mm8
Celera2173,043,474 - 173,128,977 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (ISO)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (EXP)
dichlorine  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ferrostatin-1  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
Licochalcone B  (ISO)
medroxyprogesterone acetate  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (EXP)
sulfadimethoxine  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Developmental and epilepsy spectrum of KCNB1 encephalopathy with long-term outcome. Bar C, etal., Epilepsia. 2020 Nov;61(11):2461-2473. doi: 10.1111/epi.16679. Epub 2020 Sep 21.
2. Neurodevelopmental Disorders Caused by De Novo Variants in KCNB1 Genotypes and Phenotypes. de Kovel CGF, etal., JAMA Neurol. 2017 Oct 1;74(10):1228-1236. doi: 10.1001/jamaneurol.2017.1714.
3. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Fletcher EV, etal., Nat Neurosci. 2017 Jul;20(7):905-916. doi: 10.1038/nn.4561. Epub 2017 May 15.
4. Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Hawkins NA, etal., Neurobiol Dis. 2021 Jan;147:105141. doi: 10.1016/j.nbd.2020.105141. Epub 2020 Oct 22.
5. Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets. MacDonald PE and Wheeler MB, Diabetologia. 2003 Aug;46(8):1046-62. Epub 2003 Jun 27.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Redistribution of Kv2.1 ion channels on spinal motoneurons following peripheral nerve injury. Romer SH, etal., Brain Res. 2014 Feb 14;1547:1-15. doi: 10.1016/j.brainres.2013.12.012. Epub 2013 Dec 16.
13. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability. Speca DJ, etal., Genes Brain Behav. 2014 Apr;13(4):394-408. doi: 10.1111/gbb.12120. Epub 2014 Mar 7.
Additional References at PubMed
PMID:1383027   PMID:2002364   PMID:2333511   PMID:7781998   PMID:7905852   PMID:8034307   PMID:8576199   PMID:8889548   PMID:8943282   PMID:9852577   PMID:10506487   PMID:10894496  
PMID:12477932   PMID:12529256   PMID:15046870   PMID:15240882   PMID:15322114   PMID:15894573   PMID:16008572   PMID:16014354   PMID:16452087   PMID:16643512   PMID:16985003   PMID:17114649  
PMID:17767909   PMID:18065659   PMID:18615577   PMID:18799693   PMID:19357235   PMID:19616547   PMID:19723774   PMID:19889960   PMID:20005822   PMID:20079839   PMID:20643768   PMID:21562308  
PMID:21873635   PMID:22056818   PMID:22411134   PMID:22422395   PMID:23161216   PMID:23275378   PMID:24194600   PMID:24316575   PMID:24962901   PMID:25030910   PMID:25337656   PMID:25670860  
PMID:25798587   PMID:25979088   PMID:26240432   PMID:26378152   PMID:26538660   PMID:27626380   PMID:27798188   PMID:28283561   PMID:28383553   PMID:28461216   PMID:28671696   PMID:29403353  
PMID:30012696   PMID:30091655   PMID:30820446   PMID:30824538   PMID:31315048   PMID:31594866   PMID:31663850   PMID:32015129   PMID:32038174   PMID:32290105   PMID:32325033   PMID:33060203  
PMID:33502442   PMID:34063002   PMID:34280489   PMID:35119221   PMID:36130488   PMID:36207442   PMID:36417873   PMID:36604605   PMID:38485094  


Genomics

Comparative Map Data
Kcnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392166,937,889 - 167,032,088 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2166,937,889 - 167,032,075 (-)EnsemblGRCm39 Ensembl
GRCm382167,095,969 - 167,190,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,095,969 - 167,190,155 (-)EnsemblGRCm38mm10GRCm38
MGSCv372166,928,878 - 167,014,299 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,794,583 - 166,880,004 (-)NCBIMGSCv36mm8
Celera2173,043,474 - 173,128,977 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
KCNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,363,877 - 49,483,362 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,293,394 - 49,484,297 (-)EnsemblGRCh38hg38GRCh38
GRCh372047,980,414 - 48,099,205 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,421,912 - 47,532,588 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,421,911 - 47,532,588NCBI
Celera2044,693,122 - 44,803,814 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,737,067 - 44,847,754 (-)NCBIHuRef
CHM1_12047,892,894 - 48,003,606 (-)NCBICHM1_1
T2T-CHM13v2.02051,133,489 - 51,253,649 (-)NCBIT2T-CHM13v2.0
Kcnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,239,285 - 176,332,408 (-)NCBIGRCr8
mRatBN7.23155,820,255 - 155,913,383 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,822,963 - 155,916,194 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,621,853 - 159,714,946 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,120,826 - 168,213,919 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,862,536 - 165,955,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,850,785 - 163,935,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3163,850,785 - 163,935,617 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,010,756 - 170,094,507 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,250,001 - 158,345,927 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,156,036 - 158,248,459 (-)NCBI
Celera3154,408,682 - 154,493,576 (-)NCBICelera
RH 3.4 Map31476.0RGD
Cytogenetic Map3q42NCBI
Kcnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,680,965 - 8,774,110 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,680,979 - 8,779,662 (+)NCBIChiLan1.0ChiLan1.0
KCNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,039,862 - 55,225,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,032,968 - 55,218,159 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,636,371 - 45,821,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,761,428 - 46,885,521 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,776,274 - 46,885,521 (-)Ensemblpanpan1.1panPan2
KCNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,016,800 - 36,118,873 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,025,472 - 36,117,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,259,329 - 35,359,756 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,721,821 - 36,822,593 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,729,609 - 36,823,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12435,962,506 - 36,063,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,096,677 - 36,197,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,638,300 - 36,739,394 (-)NCBIUU_Cfam_GSD_1.0
Kcnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,373,582 - 189,447,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,827,127 - 4,900,707 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,827,156 - 4,902,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,039,987 - 51,142,644 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,032,163 - 51,152,566 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,354,303 - 57,464,782 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,510,176 - 14,623,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,510,464 - 14,619,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,995,224 - 63,111,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,902,077 - 6,003,591 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,901,809 - 6,007,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnb1
2700 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:460
Count of miRNA genes:334
Interacting mature miRNAs:386
Transcripts:ENSMUST00000059826, ENSMUST00000131267
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160611165169794802Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160611165169794802Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
1301378Hpdty_mhindlimb polydactyly (mouse)Not determined2165664893168623678Mouse

Markers in Region
AI852064  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,095,974 - 167,096,120UniSTSGRCm38
MGSCv372166,921,474 - 166,921,620UniSTSGRCm37
Celera2173,036,072 - 173,036,218UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS
Whitehead/MRC_RH21900.01UniSTS
D2Mit413  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,146,982 - 167,147,098UniSTSGRCm38
MGSCv372166,972,482 - 166,972,598UniSTSGRCm37
Celera2173,087,074 - 173,087,190UniSTS
Cytogenetic Map2H3UniSTS
cM Map284.2UniSTS
Whitehead Genetic284.2UniSTS
Kcnb1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,104,738 - 167,104,848UniSTSGRCm38
MGSCv372166,930,238 - 166,930,348UniSTSGRCm37
Celera2173,044,834 - 173,044,944UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS
RH134778  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,098,930 - 167,099,158UniSTSGRCm38
MGSCv372166,924,430 - 166,924,658UniSTSGRCm37
Celera2173,039,026 - 173,039,254UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS
D20S549E  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,100,176 - 167,100,256UniSTSGRCm38
MGSCv372166,925,676 - 166,925,756UniSTSGRCm37
Celera2173,040,272 - 173,040,352UniSTS
Cytogenetic Map2H3UniSTS
cM Map297.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_008420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017315732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001781070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_374417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_374418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL591711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY678533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ646376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ646377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF437378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000059826   ⟹   ENSMUSP00000057981
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2166,945,332 - 167,032,075 (-)Ensembl
GRCm38.p6 Ensembl2167,103,412 - 167,190,155 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2166,940,714 - 166,943,746 (-)Ensembl
GRCm38.p6 Ensembl2167,098,794 - 167,101,826 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148226
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2166,940,828 - 166,943,090 (-)Ensembl
GRCm38.p6 Ensembl2167,098,908 - 167,101,170 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207917   ⟹   ENSMUSP00000147093
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2166,937,889 - 167,030,738 (-)Ensembl
GRCm38.p6 Ensembl2167,095,969 - 167,188,818 (-)Ensembl
RefSeq Acc Id: NM_008420   ⟹   NP_032446
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392166,937,889 - 167,030,738 (-)NCBI
GRCm382167,095,969 - 167,188,818 (-)NCBI
MGSCv372166,928,878 - 167,014,299 (-)RGD
Celera2173,036,067 - 173,128,996 (-)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017315732   ⟹   XP_017171221
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392166,937,889 - 167,032,088 (-)NCBI
GRCm382167,095,969 - 167,190,072 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001781070
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392166,937,889 - 167,032,088 (-)NCBI
GRCm382167,095,969 - 167,190,072 (-)NCBI
Sequence:
RefSeq Acc Id: XR_374417
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392166,937,889 - 167,032,088 (-)NCBI
GRCm382167,095,969 - 167,190,072 (-)NCBI
Sequence:
RefSeq Acc Id: XR_374418
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392166,937,889 - 167,032,088 (-)NCBI
GRCm382167,095,969 - 167,190,072 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032446   ⟸   NM_008420
- UniProtKB: Q8K0D1 (UniProtKB/Swiss-Prot),   Q03717 (UniProtKB/Swiss-Prot),   Q80X33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017171221   ⟸   XM_017315732
- Peptide Label: isoform X1
- UniProtKB: Q8K0D1 (UniProtKB/Swiss-Prot),   Q03717 (UniProtKB/Swiss-Prot),   Q80X33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000057981   ⟸   ENSMUST00000059826
RefSeq Acc Id: ENSMUSP00000147093   ⟸   ENSMUST00000207917
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03717-F1-model_v2 AlphaFold Q03717 1-857 view protein structure

Promoters
RGD ID:6831648
Promoter ID:MM_KWN:33091
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000002242
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,013,701 - 167,014,201 (-)MPROMDB
RGD ID:6879790
Promoter ID:EPDNEW_M3346
Type:single initiation site
Name:BC054394_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,101,577 - 167,101,637EPDNEW
RGD ID:6879796
Promoter ID:EPDNEW_M3349
Type:initiation region
Name:Kcnb1_1
Description:Mus musculus potassium voltage gated channel, Shab-related subfamily,member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,190,133 - 167,190,193EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96666 AgrOrtholog
Ensembl Genes ENSMUSG00000050556 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059826 ENTREZGENE
  ENSMUST00000059826.10 UniProtKB/Swiss-Prot
  ENSMUST00000207917 ENTREZGENE
  ENSMUST00000207917.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv2.1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv9 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16500 UniProtKB/Swiss-Prot
MGD MGI:96666 ENTREZGENE
NCBI Gene 16500 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY B MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11537 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kv2channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnb1 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV21CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KV9CHANNEL UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B0LAE2_MOUSE UniProtKB/TrEMBL
  KCNB1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0N2S5_MOUSE UniProtKB/TrEMBL
  Q80X33 ENTREZGENE, UniProtKB/TrEMBL
  Q8K0D1 ENTREZGENE
UniProt Secondary Q8K0D1 UniProtKB/Swiss-Prot