Ppargc1b (PPARG coactivator 1 beta) - Rat Genome Database

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Gene: Ppargc1b (PPARG coactivator 1 beta) Rattus norvegicus
Analyze
Symbol: Ppargc1b
Name: PPARG coactivator 1 beta
RGD ID: 727948
Description: Predicted to enable AF-2 domain binding activity; nuclear estrogen receptor binding activity; and transcription coactivator activity. Involved in response to cAMP; response to glucocorticoid; and response to nutrient. Predicted to be part of mediator complex. Predicted to be active in nucleus. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta); INTERACTS WITH (R)-lipoic acid; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Perc; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1-beta; PGC1beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,029,264 - 57,131,466 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1857,029,275 - 57,131,466 (-)EnsemblGRCr8
mRatBN7.21854,758,891 - 54,861,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,758,902 - 54,861,194 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1856,852,399 - 56,954,689 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,567,002 - 57,669,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,382,768 - 55,484,982 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,626,725 - 56,650,524 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,626,712 - 56,728,968 (-)Ensemblrn6Rnor6.0
Rnor_5.01855,857,439 - 55,880,661 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41857,277,749 - 57,301,024 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,911,177 - 52,934,708 (-)NCBICelera
RGSC_v3.11857,349,991 - 57,451,796 (-)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
angiotensin II  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
Ile(5)-angiotensin II  (EXP)
isoprenaline  (ISO)
ketoconazole  (EXP)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
meldonium  (EXP)
menadione  (ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
okadaic acid  (ISO)
oxaloacetic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosphatidylcholine  (ISO)
phosphatidylethanolamine  (ISO)
phytol  (ISO)
phytosterols  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
very-low-density lipoprotein triglyceride  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mediator complex  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. Andersen G, etal., J Med Genet. 2005 May;42(5):402-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids. Hoeks J, etal., Diabetologia. 2006 Oct;49(10):2419-26. Epub 2006 Aug 1.
4. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. Lelliott CJ, etal., PLoS Biol. 2006 Nov;4(11):e369. doi: 10.1371/journal.pbio.0040369.
5. PGC-1beta in the regulation of hepatic glucose and energy metabolism. Lin J, etal., J Biol Chem. 2003 Aug 15;278(33):30843-8. Epub 2003 Jun 13.
6. Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle. Menconi MJ, etal., Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E533-43. Epub 2010 Jul 20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Putative association of peroxisome proliferator-activated receptor gamma co-activator 1beta (PPARGC1B) polymorphism with Type 2 diabetes mellitus. Park KS, etal., Diabet Med. 2006 Jun;23(6):635-42.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat. Varatharajalu R, etal., Am J Pathol. 2014 Jul;184(7):2035-44. doi: 10.1016/j.ajpath.2014.03.005. Epub 2014 May 6.
15. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
Additional References at PubMed
PMID:11854298   PMID:12678921   PMID:15057822   PMID:17932310   PMID:19252502   PMID:19254570   PMID:19542216   PMID:21331471   PMID:22008020   PMID:23264620   PMID:23836911   PMID:27631411  
PMID:30635067  


Genomics

Comparative Map Data
Ppargc1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,029,264 - 57,131,466 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1857,029,275 - 57,131,466 (-)EnsemblGRCr8
mRatBN7.21854,758,891 - 54,861,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1854,758,902 - 54,861,194 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1856,852,399 - 56,954,689 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,567,002 - 57,669,290 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,382,768 - 55,484,982 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,626,725 - 56,650,524 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,626,712 - 56,728,968 (-)Ensemblrn6Rnor6.0
Rnor_5.01855,857,439 - 55,880,661 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41857,277,749 - 57,301,024 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1852,911,177 - 52,934,708 (-)NCBICelera
RGSC_v3.11857,349,991 - 57,451,796 (-)NCBI
Cytogenetic Map18q12.1NCBI
PPARGC1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,730,310 - 149,857,959 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,729,994 - 149,855,022 (+)Ensemblhg38GRCh38
GRCh375149,109,873 - 149,234,585 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,090,057 - 149,207,474 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345149,090,056 - 149,207,460NCBI
Celera5145,191,258 - 145,315,947 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5144,256,984 - 144,381,544 (+)NCBIHuRef
CHM1_15148,542,243 - 148,667,243 (+)NCBICHM1_1
T2T-CHM13v2.05150,266,870 - 150,394,600 (+)NCBIT2T-CHM13v2.0
Ppargc1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,424,516 - 61,533,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,431,207 - 61,533,502 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381861,291,445 - 61,400,756 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,298,136 - 61,400,431 (-)Ensemblmm10GRCm38
MGSCv371861,457,790 - 61,560,085 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361861,423,505 - 61,525,800 (-)NCBIMGSCv36mm8
Celera1862,581,981 - 62,683,996 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.41NCBI
Ppargc1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554154,644,998 - 4,757,093 (-)Ensembl
ChiLan1.0NW_0049554154,638,057 - 4,756,885 (-)NCBIChiLan1.0ChiLan1.0
PPARGC1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24144,955,386 - 145,119,813 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15143,098,132 - 143,223,525 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05145,154,517 - 145,315,567 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15151,172,020 - 151,286,285 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5151,203,088 - 151,278,837 (+)EnsemblpanPan2panpan1.1
PPARGC1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,167,041 - 59,278,977 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,174,604 - 59,279,464 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha458,935,873 - 59,044,751 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0459,651,179 - 59,761,207 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl459,651,182 - 59,761,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,439,467 - 59,548,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,553,927 - 59,662,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,085,118 - 60,194,024 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppargc1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213143,518,121 - 143,624,571 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365045,099,470 - 5,198,584 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365045,099,334 - 5,198,279 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPARGC1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,823,373 - 150,919,376 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12150,823,338 - 150,924,871 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,649,522 - 157,739,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPARGC1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12352,337,802 - 52,462,553 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2352,428,052 - 52,455,089 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603425,255,708 - 25,379,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppargc1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247749,056,322 - 9,174,388 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247749,056,138 - 9,178,645 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppargc1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11570,547,112 - 70,650,777 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppargc1b
695 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:78
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000023661, ENSRNOT00000066048
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1331736Bp227Blood pressure QTL 2272.791arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)184891705460064728Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185384517561982387Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184918722662647720Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
1331806Bp229Blood pressure QTL 2294.36484arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
1331780Bp238Blood pressure QTL 2383.269arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184891705460064728Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Chm35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21854,780,558 - 54,780,754 (+)MAPPERmRatBN7.2
Rnor_6.01856,648,393 - 56,648,590NCBIRnor6.0
Rnor_5.01855,878,530 - 55,878,727UniSTSRnor5.0
RGSC_v3.41857,298,893 - 57,299,090UniSTSRGSC3.4
Celera1852,932,504 - 52,932,774UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 355 192 11 141 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023661   ⟹   ENSRNOP00000023661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,029,275 - 57,131,466 (-)Ensembl
mRatBN7.2 Ensembl1854,758,902 - 54,861,194 (-)Ensembl
Rnor_6.0 Ensembl1856,626,712 - 56,728,968 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066048   ⟹   ENSRNOP00000058932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,029,275 - 57,131,402 (-)Ensembl
mRatBN7.2 Ensembl1854,758,902 - 54,861,039 (-)Ensembl
Rnor_6.0 Ensembl1856,626,736 - 56,728,185 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123015   ⟹   ENSRNOP00000108299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,029,275 - 57,131,466 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149305   ⟹   ENSRNOP00000105690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1857,029,275 - 57,061,985 (-)Ensembl
RefSeq Acc Id: NM_176075   ⟹   NP_788264
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81857,029,264 - 57,131,466 (-)NCBI
mRatBN7.21854,758,891 - 54,861,103 (-)NCBI
Rnor_6.01856,626,725 - 56,650,524 (-)NCBI
Rnor_5.01855,857,439 - 55,880,661 (-)NCBI
RGSC_v3.41857,277,749 - 57,301,024 (-)RGD
Celera1852,911,177 - 52,934,708 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_788264 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO40026 (Get FASTA)   NCBI Sequence Viewer  
  EDM14598 (Get FASTA)   NCBI Sequence Viewer  
  EDM14599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023661
  ENSRNOP00000023661.3
GenBank Protein Q811R2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_788264   ⟸   NM_176075
- UniProtKB: Q811R2 (UniProtKB/Swiss-Prot),   A6IXG7 (UniProtKB/TrEMBL),   A0A8L2QTA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023661   ⟸   ENSRNOT00000023661
Ensembl Acc Id: ENSRNOP00000058932   ⟸   ENSRNOT00000066048
Ensembl Acc Id: ENSRNOP00000105690   ⟸   ENSRNOT00000149305
Ensembl Acc Id: ENSRNOP00000108299   ⟸   ENSRNOT00000123015
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811R2-F1-model_v2 AlphaFold Q811R2 1-1010 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727948 AgrOrtholog
BioCyc Gene G2FUF-7334 BioCyc
Ensembl Genes ENSRNOG00000017503 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023661 ENTREZGENE
  ENSRNOT00000023661.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  PGC-1 UniProtKB/Swiss-Prot
  PPARGC1B_RRM UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:291567 UniProtKB/Swiss-Prot
NCBI Gene 291567 ENTREZGENE
PANTHER PTHR15528 UniProtKB/Swiss-Prot
  PTHR15528:SF12 UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Ppargc1b PhenoGen
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017503 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt A0A8L2QTA8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LQV3_RAT UniProtKB/TrEMBL
  A0ABK0LXR6_RAT UniProtKB/TrEMBL
  A6IXG7 ENTREZGENE, UniProtKB/TrEMBL
  A6IXG8_RAT UniProtKB/TrEMBL
  PRGC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ppargc1b  PPARG coactivator 1 beta  Ppargc1b  peroxisome proliferator-activated receptor gamma, coactivator 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppargc1b  peroxisome proliferator-activated receptor gamma, coactivator 1 beta  Ppargc1b  peroxisome proliferative activated receptor, gamma, coactivator 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Ppargc1b  peroxisome proliferative activated receptor, gamma, coactivator 1 beta      Symbol and Name updated 1299863 APPROVED
2004-02-11 Il1rapl1  peroxisome proliferator-activated receptor gamma coactivator 1 beta  Perc  peroxisome proliferator-activated receptor gamma coactivator 1beta-2a  Name updated to reflect Human and Mouse nomenclature 625702 APPROVED