Vom2r53 (vomeronasal 2 receptor, 53) - Rat Genome Database

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Gene: Vom2r53 (vomeronasal 2 receptor, 53) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r53
Name: vomeronasal 2 receptor, 53
RGD ID: 727942
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH ammonium chloride; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC286915; putative pheromone receptor (Go-VN1); RGD1310577; vomeronasal 2 receptor 53
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,912,012 - 10,950,649 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl710,917,984 - 10,950,648 (+)EnsemblGRCr8
mRatBN7.2710,267,390 - 10,300,054 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl710,267,390 - 10,300,054 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx713,139,194 - 13,175,871 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0715,017,279 - 15,053,956 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,879,132 - 12,911,778 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd713,659,132 - 13,691,775 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive713,822,579 - 13,855,222 (+)NCBILyon_Normotensive
Lyon_Hypertensive713,897,423 - 13,930,066 (+)NCBILyon_Hypertensive
F344_StmMcwi712,263,137 - 12,295,780 (+)NCBIF344_StmMcwi
Rnor_6.0713,146,062 - 13,184,258 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl713,151,592 - 13,184,257 (+)Ensemblrn6Rnor6.0
Rnor_5.0713,333,416 - 13,383,013 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4711,785,460 - 11,818,126 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera78,430,179 - 8,462,846 (+)NCBICelera
RGSC_v3.1711,785,459 - 11,818,125 (+)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Herrada G and Dulac C, Cell 1997 Aug 22;90(4):763-73.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r53
202 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:12
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000010203
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 3 70 10 2 21 43 30 65 9 27 2 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000010203   ⟹   ENSRNOP00000010203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl710,917,984 - 10,950,648 (+)Ensembl
mRatBN7.2 Ensembl710,267,390 - 10,300,054 (+)Ensembl
Rnor_6.0 Ensembl713,151,592 - 13,184,257 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097531   ⟹   ENSRNOP00000096889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl710,267,390 - 10,300,054 (+)Ensembl
RefSeq Acc Id: NM_173131   ⟹   NP_775154
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,917,984 - 10,950,648 (+)NCBI
mRatBN7.2710,267,390 - 10,300,054 (+)NCBI
Dahl_SR_JrHsd713,659,132 - 13,691,775 (+)NCBI
Lyon_Normotensive713,822,579 - 13,855,222 (+)NCBI
Lyon_Hypertensive713,897,423 - 13,930,066 (+)NCBI
F344_StmMcwi712,263,137 - 12,295,780 (+)NCBI
Rnor_6.0713,151,592 - 13,184,258 (+)NCBI
Rnor_5.0713,333,416 - 13,383,013 (+)NCBI
RGSC_v3.4711,785,460 - 11,818,126 (+)RGD
Celera78,430,179 - 8,462,846 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263079   ⟹   XP_063119149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,912,012 - 10,950,649 (+)NCBI
RefSeq Acc Id: XM_063263080   ⟹   XP_063119150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8710,912,195 - 10,950,649 (+)NCBI
Protein Sequences
Protein RefSeqs NP_775154 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119149 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119150 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53325 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010203
  ENSRNOP00000010203.4
RefSeq Acc Id: NP_775154   ⟸   NM_173131
- Peptide Label: precursor
- UniProtKB: E9PSS7 (UniProtKB/TrEMBL),   A6K914 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010203   ⟸   ENSRNOT00000010203
Ensembl Acc Id: ENSRNOP00000096889   ⟸   ENSRNOT00000097531
RefSeq Acc Id: XP_063119149   ⟸   XM_063263079
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063119150   ⟸   XM_063263080
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ARU7 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PSS7-F1-model_v2 AlphaFold E9PSS7 1-548 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727942 AgrOrtholog
BioCyc Gene G2FUF-34866 BioCyc
Ensembl Genes ENSRNOG00000007730 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010203 ENTREZGENE
  ENSRNOT00000010203.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
KEGG Report rno:286915 UniProtKB/TrEMBL
NCBI Gene 286915 ENTREZGENE
PANTHER EC1-V2R PHEROMONE RECEPTOR PROTEIN-RELATED UniProtKB/TrEMBL
  PTHR24061 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r53 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007730 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A8I6ARU7 ENTREZGENE
  A6K914 ENTREZGENE, UniProtKB/TrEMBL
  E9PSS7 ENTREZGENE, UniProtKB/TrEMBL
  O35265_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-23 Vom2r53  vomeronasal 2 receptor, 53    vomeronasal 2 receptor 53  Symbol and Name updated 1299863 APPROVED
2008-05-01 Vom2r53  vomeronasal 2 receptor 53  LOC286915  putative pheromone receptor (Go-VN1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-10-12 LOC286915        Symbol and Name status set to provisional 70820 PROVISIONAL