Sfpq (splicing factor proline and glutamine rich) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sfpq (splicing factor proline and glutamine rich) Rattus norvegicus
Analyze
Symbol: Sfpq
Name: splicing factor proline and glutamine rich
RGD ID: 727923
Description: Predicted to enable several functions, including chromatin binding activity; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including alternative mRNA splicing, via spliceosome; dendritic transport of messenger ribonucleoprotein complex; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromosome organization; double-strand break repair via homologous recombination; and positive regulation of sister chromatid cohesion. Predicted to be located in chromatin; nuclear matrix; and paraspeckles. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SFPQ (splicing factor proline and glutamine rich); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC252855; MGC112723; NonO/p54nrb homolog; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine-rich; splicing factor, proline- and glutamine-rich
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,621,678 - 144,637,930 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5144,622,476 - 144,637,926 (+)EnsemblGRCr8
mRatBN7.25139,338,034 - 139,353,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,338,075 - 139,353,472 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5142,034,218 - 142,042,921 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,804,194 - 143,812,897 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,804,996 - 143,813,699 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,079,803 - 145,088,517 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,079,803 - 145,088,498 (+)Ensemblrn6Rnor6.0
Rnor_5.05148,849,944 - 148,858,919 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45146,460,306 - 146,469,289 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5137,833,201 - 137,841,438 (+)NCBICelera
RGSC_v3.15146,474,790 - 146,479,335 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic UMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
butyric acid  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dihydroartemisinin  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
iron dichloride  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. Marko M, etal., Exp Cell Res. 2010 Feb 1;316(3):390-400. doi: 10.1016/j.yexcr.2009.10.021. Epub 2009 Oct 27.
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Prolactin induces expression of FGF-2 and a novel FGF-responsive NonO/p54nrb-related mRNA in rat lymphoma cells. Too CK, etal., Mol Cell Endocrinol 1998 Feb;137(2):187-95.
Additional References at PubMed
PMID:12477932   PMID:15312650   PMID:15607978   PMID:15790595   PMID:16731528   PMID:19389484   PMID:20813759   PMID:21444682   PMID:21507896   PMID:21680841   PMID:22215678   PMID:22658674  
PMID:22669741   PMID:22681889   PMID:22783022   PMID:22966205   PMID:23979707   PMID:25326457   PMID:25765647   PMID:28712728   PMID:35352799   PMID:36790503  


Genomics

Comparative Map Data
Sfpq
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,621,678 - 144,637,930 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5144,622,476 - 144,637,926 (+)EnsemblGRCr8
mRatBN7.25139,338,034 - 139,353,476 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5139,338,075 - 139,353,472 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5142,034,218 - 142,042,921 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,804,194 - 143,812,897 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,804,996 - 143,813,699 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05145,079,803 - 145,088,517 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5145,079,803 - 145,088,498 (+)Ensemblrn6Rnor6.0
Rnor_5.05148,849,944 - 148,858,919 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45146,460,306 - 146,469,289 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5137,833,201 - 137,841,438 (+)NCBICelera
RGSC_v3.15146,474,790 - 146,479,335 (+)NCBI
Cytogenetic Map5q36NCBI
SFPQ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,176,380 - 35,193,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,176,378 - 35,193,446 (-)Ensemblhg38GRCh38
GRCh37135,641,981 - 35,658,746 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36135,421,788 - 35,431,322 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34135,318,295 - 35,327,828NCBI
Celera133,923,595 - 33,933,137 (-)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef133,767,918 - 33,777,460 (-)NCBIHuRef
CHM1_1135,764,572 - 35,774,114 (-)NCBICHM1_1
T2T-CHM13v2.0135,039,049 - 35,055,814 (-)NCBIT2T-CHM13v2.0
Sfpq
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,914,504 - 126,944,894 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,915,117 - 126,930,806 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384127,020,716 - 127,051,101 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4127,021,324 - 127,037,013 (+)Ensemblmm10GRCm38
MGSCv374126,698,545 - 126,708,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364126,523,639 - 126,533,100 (+)NCBIMGSCv36mm8
Celera4125,355,661 - 125,365,521 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map461.2NCBI
Sfpq
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,267,968 - 13,282,620 (-)Ensembl
ChiLan1.0NW_00495545213,267,968 - 13,283,823 (-)NCBIChiLan1.0ChiLan1.0
SFPQ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,650,480 - 191,668,748 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,772,773 - 190,789,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,444,105 - 34,461,012 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1135,624,862 - 35,641,551 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl135,632,917 - 35,641,551 (-)EnsemblpanPan2panpan1.1
SFPQ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,879,955 - 6,896,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,880,065 - 6,888,004 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha157,118,958 - 7,136,345 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0157,025,344 - 7,041,598 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl157,023,762 - 7,041,602 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,889,739 - 6,905,994 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,935,356 - 6,952,770 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,949,114 - 6,966,519 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sfpq
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505851,951,708 - 51,967,202 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647417,783,789 - 17,791,957 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647417,776,490 - 17,791,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFPQ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl691,391,555 - 91,408,219 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1691,391,552 - 91,408,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SFPQ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12097,698,953 - 97,715,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2097,698,411 - 97,711,294 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603319,006,801 - 19,023,608 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfpq
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,228,365 - 18,240,340 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476418,223,845 - 18,239,748 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Sfpq
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1131,246,424 - 31,261,660 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sfpq
151 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:180
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000018049
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5130678987145274255Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5134369218156289444Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5125969677156302135Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH129398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,347,448 - 139,347,643 (+)MAPPERmRatBN7.2
Rnor_6.05145,089,187 - 145,089,381NCBIRnor6.0
Rnor_5.05148,859,589 - 148,859,783UniSTSRnor5.0
RGSC_v3.45146,469,959 - 146,470,153UniSTSRGSC3.4
Celera5137,842,108 - 137,842,302UniSTS
RH 3.4 Map5929.9UniSTS
Cytogenetic Map5q36UniSTS
RH126927  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,346,949 - 139,347,170 (+)MAPPERmRatBN7.2
Rnor_6.05145,088,688 - 145,088,908NCBIRnor6.0
Rnor_5.05148,859,090 - 148,859,310UniSTSRnor5.0
RGSC_v3.45146,469,460 - 146,469,680UniSTSRGSC3.4
Celera5137,841,609 - 137,841,829UniSTS
Cytogenetic Map5q36UniSTS
RH139231  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25139,344,263 - 139,344,481 (+)MAPPERmRatBN7.2
Rnor_6.05145,086,002 - 145,086,219NCBIRnor6.0
Rnor_5.05148,856,404 - 148,856,621UniSTSRnor5.0
RGSC_v3.45146,466,774 - 146,466,991UniSTSRGSC3.4
Celera5137,838,923 - 137,839,140UniSTS
RH 3.4 Map5922.2UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000084202   ⟹   ENSRNOP00000074636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5144,622,491 - 144,632,187 (+)Ensembl
mRatBN7.2 Ensembl5139,338,075 - 139,346,768 (+)Ensembl
Rnor_6.0 Ensembl5145,079,803 - 145,088,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112060   ⟹   ENSRNOP00000087689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5144,622,606 - 144,632,187 (+)Ensembl
mRatBN7.2 Ensembl5139,338,148 - 139,347,289 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112801   ⟹   ENSRNOP00000087754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5144,622,476 - 144,637,926 (+)Ensembl
mRatBN7.2 Ensembl5139,338,075 - 139,353,472 (+)Ensembl
RefSeq Acc Id: NM_001025271   ⟹   NP_001020442
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,622,533 - 144,631,237 (+)NCBI
mRatBN7.25139,338,075 - 139,346,779 (+)NCBI
Rnor_6.05145,079,803 - 145,088,517 (+)NCBI
Rnor_5.05148,849,944 - 148,858,919 (+)NCBI
RGSC_v3.45146,460,306 - 146,469,289 (+)RGD
Celera5137,833,201 - 137,841,438 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287175   ⟹   XP_063143245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,621,678 - 144,637,930 (+)NCBI
RefSeq Acc Id: XR_010066343
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,621,678 - 144,637,930 (+)NCBI
RefSeq Acc Id: XR_010066344
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85144,621,678 - 144,637,930 (+)NCBI
RefSeq Acc Id: NP_001020442   ⟸   NM_001025271
- UniProtKB: Q4KM71 (UniProtKB/TrEMBL),   A0A0G2K8K0 (UniProtKB/TrEMBL),   A0A8I6GFD8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074636   ⟸   ENSRNOT00000084202
Ensembl Acc Id: ENSRNOP00000087754   ⟸   ENSRNOT00000112801
Ensembl Acc Id: ENSRNOP00000087689   ⟸   ENSRNOT00000112060
RefSeq Acc Id: XP_063143245   ⟸   XM_063287175
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7U6 (UniProtKB/TrEMBL),   A0A8I6GFD8 (UniProtKB/TrEMBL)
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K8K0-F1-model_v2 AlphaFold A0A0G2K8K0 1-696 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694044
Promoter ID:EPDNEW_R4569
Type:multiple initiation site
Name:Sfpq_1
Description:splicing factor proline and glutamine rich
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05145,079,780 - 145,079,840EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727923 AgrOrtholog
BioCyc Gene G2FUF-39863 BioCyc
Ensembl Genes ENSRNOG00000058461 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084202 ENTREZGENE
  ENSRNOT00000084202.3 UniProtKB/TrEMBL
  ENSRNOT00000112060.2 UniProtKB/TrEMBL
  ENSRNOT00000112801 ENTREZGENE
  ENSRNOT00000112801.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
  6.10.250.1170 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384804 IMAGE-MGC_LOAD
InterPro NOPS UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  PSF_NOPS UniProtKB/TrEMBL
  PSF_RRM1 UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
KEGG Report rno:252855 UniProtKB/TrEMBL
MGC_CLONE MGC:112723 IMAGE-MGC_LOAD
NCBI Gene 252855 ENTREZGENE
PANTHER RNA RECOGNITION MOTIF-CONTAINING UniProtKB/TrEMBL
Pfam NOPS UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PhenoGen Sfpq PhenoGen
PROSITE RRM UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058461 RatGTEx
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0G2K8K0 ENTREZGENE
  A0A8I6A7U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFD8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABZ3NND6_RAT UniProtKB/TrEMBL
  A6ISC0_RAT UniProtKB/TrEMBL
  Q4KM71 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2K8K0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-15 Sfpq  splicing factor proline and glutamine rich  Sfpq  splicing factor proline/glutamine-rich  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Sfpq  splicing factor proline/glutamine-rich  Sfpq  splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Sfpq  splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)    NonO/p54nrb homolog  Name updated 1299863 APPROVED
2004-09-10 Sfpq  NonO/p54nrb homolog  LOC252855    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology has homology with a family of RNA- and DNA-binding proteins 1299599
gene_regulation induced in Nb2-11C lymphoma cell line upon treatment with fibroblast growth factor (FGF) 1299599