Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp27a1 (cytochrome P450, family 27, subfamily a, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp27a1
Name: cytochrome P450, family 27, subfamily a, polypeptide 1
RGD ID: 727915
Description: Enables Hsp70 protein binding activity; cholesterol 26-hydroxylase activity; and vitamin D3 25-hydroxylase activity. Involved in cholesterol metabolic process. Located in mitochondrial inner membrane. Biomarker of extrahepatic cholestasis. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1); PARTICIPATES IN bile acid biosynthetic pathway; bile acid signaling pathway; cerebrotendinous xanthomatosis pathway; INTERACTS WITH (+)-schisandrin B; (25R)-cholest-5-ene-3beta,26-diol; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase; Cyp27; cytochrome P-450c27/25; cytochrome P450 27; P450C27; sterol 26-hydroxylase, mitochondrial; sterol 27-hydroxylase; vitamin D(3) 25-hydroxylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,712,402 - 83,743,222 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,713,293 - 83,743,215 (+)EnsemblGRCr8
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,709,826 - 84,739,736 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,838,774 - 89,868,679 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,224,941 - 88,254,850 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)Ensemblrn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera973,837,312 - 73,867,002 (+)NCBICelera
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Cytogenetic Map9q33NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(5alpha)-cholestan-3beta-ol  (ISO)
(S)-amphetamine  (EXP)
(S)-colchicine  (ISO)
1,2,3-trilinolenoylglycerol  (ISO)
1,2,3-trilinoleoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-arachidonoylglycerol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-methylfuran  (EXP)
3beta-hydroxycholest-5-en-26-oic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
Augmentin  (ISO)
benzalkonium chloride  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caesium atom  (EXP)
cafestol  (EXP)
calciol  (EXP)
calcitriol  (EXP,ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP,ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clavulanic acid  (ISO)
clofibric acid  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
DDE  (ISO)
deoxycholic acid  (EXP,ISO)
deoxynivalenol  (ISO)
desmosterol  (ISO)
dexamethasone  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
diosgenin  (EXP)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
eugenol  (ISO)
flumequine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
ibuprofen  (ISO)
indometacin  (EXP)
irinotecan  (EXP)
isoniazide  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lanosterol  (ISO)
lead diacetate  (ISO)
levofloxacin  (EXP)
Licochalcone B  (ISO)
linalool  (ISO)
lithocholic acid  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP)
methyltestosterone  (ISO)
metronidazole  (ISO)
morphine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
Nivalenol  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorodecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
physcion  (EXP)
pirinixic acid  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
Senkirkine  (ISO)
serpentine asbestos  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
sodium dodecyl sulfate  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
taurocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triolein  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
trovafloxacin  (ISO)
uranium atom  (EXP)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zymosterol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. Anandatheerthavarada HK, etal., J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.
2. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. Cali JJ, etal., J Biol Chem. 1991 Apr 25;266(12):7779-83.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Jiao N, etal., Gut. 2018 Oct;67(10):1881-1891. doi: 10.1136/gutjnl-2017-314307. Epub 2017 Aug 3.
5. Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets. Kitanaka S, etal., N Engl J Med. 1998 Mar 5;338(10):653-61.
6. Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model. Kovacs WJ, etal., Mol Cell Biol. 2004 Jan;24(1):1-13.
7. The upstream open reading frame mediates constitutive effects on translation of cytochrome p-450c27 from the seventh in-frame AUG codon in rat liver. Lodhi KM, etal., J Biol Chem. 2003 Oct 17;278(42):40647-57. Epub 2003 Aug 7.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Localization of a transcription promoter within the second exon of the cytochrome P-450c27/25 gene for the expression of the major species of two-kilobase mRNA. Mullick J, etal., Biochemistry 1995 Oct 24;34(42):13729-42.
10. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
11. Reverse cholesterol transport and cholesterol efflux in atherosclerosis. Ohashi R, etal., QJM. 2005 Dec;98(12):845-56. Epub 2005 Oct 28.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Sequence complementarity between the 5'-terminal regions of mRNAs for rat mitochondrial cytochrome P-450c27/25 and a growth hormone-inducible serine protease inhibitor. A possible gene overlap. Shayiq RM and Avadhani NG, J Biol Chem 1992 Feb 5;267(4):2421-8.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. A cDNA encoding a rat mitochondrial cytochrome P450 catalyzing both the 26-hydroxylation of cholesterol and 25-hydroxylation of vitamin D3: gonadotropic regulation of the cognate mRNA in ovaries. Su P, etal., DNA Cell Biol 1990 Nov;9(9):657-67.
21. Molecular cloning of cDNA for vitamin D3 25-hydroxylase from rat liver mitochondria. Usui E, etal., FEBS Lett 1990 Mar 12;262(1):135-8.
22. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
Additional References at PubMed
PMID:9660774   PMID:11412116   PMID:12077124   PMID:12865426   PMID:14651853   PMID:15465040   PMID:15489334   PMID:17118558   PMID:18614015   PMID:19665519   PMID:24280213   PMID:34800366  


Genomics

Comparative Map Data
Cyp27a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8983,712,402 - 83,743,222 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl983,713,293 - 83,743,215 (+)EnsemblGRCr8
mRatBN7.2976,264,655 - 76,294,551 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx984,709,826 - 84,739,736 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0989,838,774 - 89,868,679 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0988,224,941 - 88,254,850 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0981,968,285 - 81,998,213 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)Ensemblrn6Rnor6.0
Rnor_5.0981,730,705 - 81,760,595 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4974,039,204 - 74,068,648 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera973,837,312 - 73,867,002 (+)NCBICelera
RGSC_v3.1974,186,068 - 74,215,629 (+)NCBI
Cytogenetic Map9q33NCBI
CYP27A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,782,147 - 218,815,293 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,781,738 - 218,815,293 (+)Ensemblhg38GRCh38
GRCh372219,646,870 - 219,680,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,354,949 - 219,388,259 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342219,472,209 - 219,505,520NCBI
Celera2213,414,219 - 213,447,784 (+)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2211,499,575 - 211,533,141 (+)NCBIHuRef
CHM1_12219,653,385 - 219,686,914 (+)NCBICHM1_1
T2T-CHM13v2.02219,268,705 - 219,301,851 (+)NCBIT2T-CHM13v2.0
Cyp27a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,752,311 - 74,777,056 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl174,752,733 - 74,777,051 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38174,713,148 - 74,737,897 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,713,574 - 74,737,892 (+)Ensemblmm10GRCm38
MGSCv37174,760,148 - 74,784,464 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36174,646,781 - 74,671,097 (+)NCBIMGSCv36mm8
Celera175,268,638 - 75,292,903 (+)NCBICelera
Cytogenetic Map1C4NCBI
cM Map138.54NCBI
LOC102004889
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545314,601,444 - 14,647,366 (-)Ensembl
ChiLan1.0NW_00495545314,601,495 - 14,647,383 (-)NCBIChiLan1.0ChiLan1.0
CYP27A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213121,414,455 - 121,449,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B121,430,782 - 121,464,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B106,042,235 - 106,076,840 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B224,637,238 - 224,671,474 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B224,637,238 - 224,671,474 (+)EnsemblpanPan2panpan1.1
CYP27A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13725,366,475 - 25,401,978 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3725,366,472 - 25,401,509 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3726,186,269 - 26,221,708 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03725,381,673 - 25,417,125 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3725,382,000 - 25,602,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13725,286,426 - 25,321,814 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03725,221,115 - 25,256,548 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03725,241,871 - 25,277,345 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101963150
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303174,870,819 - 174,907,409 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365691,213,573 - 1,250,589 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365691,213,700 - 1,250,181 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP27A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15120,809,959 - 120,852,192 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115120,809,886 - 120,852,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,798,107 - 133,831,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP27A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,682,437 - 104,723,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10104,682,673 - 104,726,687 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604094,685,776 - 94,722,151 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101700018
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248236,200,047 - 6,258,001 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248236,199,807 - 6,258,273 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116899511
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14148,129,007 - 148,157,627 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cyp27a1
154 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000023152
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)98216882386720295Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
UniSTS:256607  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8983,740,280 - 83,740,673 (+)Marker Load Pipeline
mRatBN7.2976,291,609 - 76,292,002 (+)MAPPERmRatBN7.2
Rnor_6.0981,995,272 - 81,995,664NCBIRnor6.0
Rnor_5.0981,757,654 - 81,758,046UniSTSRnor5.0
RGSC_v3.4974,065,707 - 74,066,099UniSTSRGSC3.4
Celera973,864,061 - 73,864,453UniSTS
Cytogenetic Map9q33UniSTS
BM387198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,265,766 - 76,265,939 (+)MAPPERmRatBN7.2
Rnor_6.0981,969,430 - 81,969,602NCBIRnor6.0
Rnor_5.0981,731,812 - 81,731,984UniSTSRnor5.0
RGSC_v3.4974,039,865 - 74,040,037UniSTSRGSC3.4
Celera973,838,219 - 73,838,391UniSTS
RH 3.4 Map9768.59UniSTS
Cytogenetic Map9q33UniSTS
PMC199420P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,291,248 - 76,291,771 (+)MAPPERmRatBN7.2
Rnor_6.0981,994,911 - 81,995,433NCBIRnor6.0
Rnor_5.0981,757,293 - 81,757,815UniSTSRnor5.0
RGSC_v3.4974,065,346 - 74,065,868UniSTSRGSC3.4
Celera973,863,700 - 73,864,222UniSTS
Cytogenetic Map9q33UniSTS
RH130485  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2976,294,203 - 76,294,408 (+)MAPPERmRatBN7.2
Rnor_6.0981,997,866 - 81,998,070NCBIRnor6.0
Rnor_5.0981,760,248 - 81,760,452UniSTSRnor5.0
RGSC_v3.4974,068,301 - 74,068,505UniSTSRGSC3.4
Celera973,866,655 - 73,866,859UniSTS
RH 3.4 Map9713.19UniSTS
Cytogenetic Map9q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 157 91 90 59 87 59 6 351 187 11 136 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000023152   ⟹   ENSRNOP00000023152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl983,713,293 - 83,743,215 (+)Ensembl
mRatBN7.2 Ensembl976,264,860 - 76,294,551 (+)Ensembl
Rnor_6.0 Ensembl981,968,332 - 81,998,169 (+)Ensembl
RefSeq Acc Id: NM_178847   ⟹   NP_849178
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,713,532 - 83,743,222 (+)NCBI
mRatBN7.2976,264,860 - 76,294,551 (+)NCBI
Rnor_6.0981,968,523 - 81,998,213 (+)NCBI
Rnor_5.0981,730,705 - 81,760,595 (+)NCBI
RGSC_v3.4974,039,204 - 74,068,648 (+)RGD
Celera973,837,312 - 73,867,002 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083360   ⟹   XP_038939288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,712,402 - 83,743,218 (+)NCBI
mRatBN7.2976,264,655 - 76,294,551 (+)NCBI
RefSeq Acc Id: XM_063266976   ⟹   XP_063123046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,712,402 - 83,742,716 (+)NCBI
RefSeq Acc Id: XM_063266977   ⟹   XP_063123047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8983,730,822 - 83,743,218 (+)NCBI
RefSeq Acc Id: NP_849178   ⟸   NM_178847
- UniProtKB: Q64615 (UniProtKB/Swiss-Prot),   Q64639 (UniProtKB/Swiss-Prot),   P17178 (UniProtKB/Swiss-Prot),   A0A0H2UHN7 (UniProtKB/TrEMBL),   A6JVV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023152   ⟸   ENSRNOT00000023152
RefSeq Acc Id: XP_038939288   ⟸   XM_039083360
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123046   ⟸   XM_063266976
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123047   ⟸   XM_063266977
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17178-F1-model_v2 AlphaFold P17178 1-533 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696758
Promoter ID:EPDNEW_R7282
Type:single initiation site
Name:Cyp27a1_2
Description:cytochrome P450, family 27, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7283  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0981,968,328 - 81,968,388EPDNEW
RGD ID:13696759
Promoter ID:EPDNEW_R7283
Type:multiple initiation site
Name:Cyp27a1_1
Description:cytochrome P450, family 27, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7282  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0981,968,737 - 81,968,797EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727915 AgrOrtholog
BioCyc Gene G2FUF-27119 BioCyc
BioCyc Pathway PWY-6061 [bile acid biosynthesis, neutral pathway] BioCyc
BioCyc Pathway Image PWY-6061 BioCyc
Ensembl Genes ENSRNOG00000017188 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023152 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621918 IMAGE-MGC_LOAD
InterPro CYP11_CYP27_families UniProtKB/Swiss-Prot
  Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
KEGG Report rno:301517 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72265 IMAGE-MGC_LOAD
NCBI Gene 301517 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 27 SUBFAMILY A MEMBER 1 UniProtKB/Swiss-Prot
  PTHR24279 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp27a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017188 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0H2UHN7 ENTREZGENE, UniProtKB/TrEMBL
  A6JVV9 ENTREZGENE, UniProtKB/TrEMBL
  CP27A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64615 ENTREZGENE
  Q64639 ENTREZGENE
UniProt Secondary Q64615 UniProtKB/Swiss-Prot
  Q64639 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cyp27a1  cytochrome P450, family 27, subfamily a, polypeptide 1  Cyp27    Symbol updated 1299863 APPROVED